Mechanisms of manganese-induced neurotoxicity in primary neuronal cultures: The role of manganese speciation and cell type

Toxicological Sciences

Volumn 124, Issue 2, 2011, Pages 414-423

  Hernandez R B ^a,b,c   Farina, M ^a,d   Esposito B P ^c   Souza Pinto, N C ^c   Barbosa, F ^c   Sunol C ^a,e  

^a INSTITUT D INVESTIGACIONS BIOMÈDIQUES AUGUST PI I SUNYER IDIBAPS   (Spain)

^b FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

^c UNIVERSITY OF SÃO PAULO   (Brazil)

^d FEDERAL UNIVERSITY OF SANTA CATARINA   (Brazil)

^e CIBER EPIDEMIOLOGÍA Y SALUD PÚBLICA CIBERESP   (Spain)

Author keywords

Cerebellar granule neurons; Cortical neurons; Developmental neurotoxicity; Manganese speciation; Mitochondrial dysfunction

Indexed keywords

ASCORBIC ACID; GLUTATHIONE; LACTIC ACID; MANGANESE; MANGANESE CHLORIDE; MANGANESE CITRATE; MANGANESE PYROPHOSPHATE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTIOXIDANT ACTIVITY; ARTICLE; BRAIN MITOCHONDRION; BRAIN NERVE CELL; CELL VIABILITY; CEREBELLUM; CONTROLLED STUDY; CYTOTOXICITY; DEVELOPMENTAL STAGE; ELECTRON SPIN RESONANCE; EXPOSURE; FETUS; GRANULE CELL; MITOCHONDRIAL TOXICITY; MOUSE; NEOCORTEX; NERVE CELL CULTURE; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; RISK ASSESSMENT;

ANIMALS; ANIMALS, NEWBORN; ASCORBIC ACID; CELL CULTURE TECHNIQUES; CELL SURVIVAL; CELLS, CULTURED; CEREBELLUM; CEREBRAL CORTEX; ELECTRON SPIN RESONANCE SPECTROSCOPY; GLUTATHIONE; MANGANESE; MANGANESE COMPOUNDS; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICE; MICE, INBRED STRAINS; MITOCHONDRIA; NEURONS; NEUROTOXICITY SYNDROMES; ORGANOGENESIS; ORGANOMETALLIC COMPOUNDS; OXIDATION-REDUCTION; SPECTROPHOTOMETRY, ATOMIC; SPECTROPHOTOMETRY, ULTRAVIOLET;

EID: 81855168340     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfr234     Document Type: Article

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