Impaired cutaneous wound healing in transforming growth factor-β inducible early gene1 knockout mice

Wound Repair and Regeneration

Volumn 20, Issue 2, 2012, Pages 166-177

  Hori, Keijiro ^a,b   Ding, Jie ^a   Marcoux, Yvonne ^a   Iwashina, Takashi ^a   Sakurai, Hiroyuki ^b   Tredget, Edward E ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

^b TOKYO WOMEN'S MEDICAL UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

SMAD PROTEIN; SMAD7 PROTEIN; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COLLAGEN SYNTHESIS; CONTRACTURE; CONTROLLED STUDY; EARLY RESPONSE GENE; GRANULATION TISSUE; IMMUNOHISTOCHEMISTRY; KNOCKOUT MOUSE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; UPREGULATION; WOUND CLOSURE; WOUND HEALING IMPAIRMENT;

ANIMALS; CYTOKINES; DNA-BINDING PROTEINS; GRANULATION TISSUE; IMMUNOHISTOCHEMISTRY; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; REAL-TIME POLYMERASE CHAIN REACTION; SKIN; SMAD PROTEINS; TRANSCRIPTION FACTORS; TRANSFORMING GROWTH FACTOR BETA; UP-REGULATION; WOUND HEALING;

EID: 84858117267     PISSN: 10671927     EISSN: 1524475X     Source Type: Journal    
DOI: 10.1111/j.1524-475X.2012.00773.x     Document Type: Article

References (45)

1. Taipale J, Saharinen J, Keski-Oja J,. Extracellular matrix-associated transforming growth factor-beta: role in cancer cell growth and invasion. Adv Cancer Res 1998; 75: 87-134. (Pubitemid 28429034)
2. Faler BJ, Macsata RA, Plummer D, Mishra L, Sidawy AN,. Transforming growth factor-beta and wound healing. Perspec Vasc Surg Endovasc Ther 2006; 18: 55-62.
3. Chin D, Boyle GM, Parsons PG, Coman WB,. What is transforming growth factor-beta (TGF-beta)? Br J Plast Surg 2004; 57: 215-221. (Pubitemid 38380437)
4. Massagué J,. The transforming growth factor-beta family. Annu Rev Cell Biol 1990; 6: 597-641.
5. Shah M, Foreman DM, Ferguson MW,. Neutralisation of TGF-beta 1 and TGF-beta 2 or exogenous addition of TGF-beta 3 to cutaneous rat wounds reduces scarring. J Cell Sci 1995; 108 (Pt 3): 985-1002.
6. Frank S, Madlener M, Werner S,. Transforming growth factors beta1, beta2, and beta3 and their receptors are differentially regulated during normal and impaired wound healing. J Biol Chem 1996; 271: 10188-10193. (Pubitemid 26131583)
7. Martin P,. Wound healing-aiming for perfect skin regeneration. Science 1997; 276: 75-81. (Pubitemid 27161246)
8. Singer AJ, Clark RA,. Cutaneous wound healing. N Engl J Med 1999; 341: 738-746. (Pubitemid 29407375)
9. Desmouliere A, Geinoz A, Gabbiani F, Gabbiani G,. Transforming growth factor-beta 1 induces alpha-smooth muscle actin expression in granulation tissue myofibroblasts and in quiescent and growing cultured fibroblasts. J Cell Biol 1993; 122: 103-111. (Pubitemid 23188802)
10. Shi Y, Massague J,. Mechanisms of TGF-beta signaling from cell membrane to the nucleus. Cell 2003; 113: 685-700. (Pubitemid 36724933)
11. Ruiz-Ortega M, Rodriguez-Vita J, Sanchez-Lopez E, Carvajal G, Egido J,. TGF-beta signaling in vascular fibrosis. Cardiovasc Res 2007; 74: 196-206.
12. Subramaniam M, Hawse JR, Johnsen SA, Spelsberg TC,. Role of TIEG1 in biological processes and disease states. J Cell Biochem 2007; 102: 539-548. (Pubitemid 47557409)
13. Subramaniam M, Harris SA, Oursler MJ, Rasmussen K, Riggs BL, Spelsberg TC,. Identification of a novel TGF-beta-regulated gene encoding a putative zinc finger protein in human osteoblasts. Nucleic Acids Res 1995; 23: 4907-4912. (Pubitemid 3008385)
14. Tachibana I, Imoto M, Adjei PN, Gores GJ, Subramaniam M, Spelsberg TC, Urrutia R,. Overexpression of the TGFbeta-regulated zinc finger encoding gene, TIEG, induces apoptosis in pancreatic epithelial cells. J Clin Invest 1997; 99: 2365-2374. (Pubitemid 27227713)
15. Cook T, Urrutia R,. TIEG proteins join the Smads as TGF-beta-regulated transcription factors that control pancreatic cell growth. Am J Physiol Gastrointest Liver Physiol 2000; 278: G513-521. (Pubitemid 30213116)
16. Cook T, Gebelein B, Mesa K, Mladek A, Urrutia R,. Molecular cloning and characterization of TIEG2 reveals a new subfamily of transforming growth factor-beta-inducible Sp1-like zinc finger-encoding genes involved in the regulation of cell growth. J Biol Chem 1998; 273: 25929-25936. (Pubitemid 28475824)
17. Johnsen SA, Subramaniam M, Monroe DG, Janknecht R, Spelsberg TC,. Modulation of transforming growth factor beta (TGFbeta)/Smad transcriptional responses through targeted degradation of TGFbeta-inducible early gene-1 by human seven in absentia homologue. J Biol Chem 2002; 277: 30754-30759. (Pubitemid 34970772)
18. Wang Z, Peters B, Klussmann S, Bender H, Herb A, Krieglstein K,. Gene structure and evolution of Tieg3, a new member of the Tieg family of proteins. Gene 2004; 325: 25-34. (Pubitemid 38030373)
19. Fautsch MP, Vrabel A, Rickard D, Subramaniam M, Spelsberg TC, Wieben ED,. Characterization of the mouse TGFbeta-inducible early gene (TIEG): conservation of exon and transcriptional regulatory sequences with evidence of additional transcripts. Mamm Genome 1998; 9: 838-842. (Pubitemid 28440101)
20. Tsubone T, Moran SL, Subramaniam M, Amadio PC, Spelsberg TC, An KN,. Effect of TGF-beta inducible early gene deficiency on flexor tendon healing. J Orthop Res 2006; 24: 569-575. (Pubitemid 43773020)
21. Rajamannan NM, Subramaniam M, Abraham TP, Vasile VC, Ackerman MJ, Monroe DG, Chew TL, Spelsberg TC,. TGFbeta inducible early gene-1 (TIEG1) and cardiac hypertrophy: discovery and characterization of a novel signaling pathway. J Cell Biochem 2007; 100: 315-325. (Pubitemid 46146082)
22. Hawse JR, Iwaniec UT, Bensamoun SF, Monroe DG, Peters KD, Ilharreborde B, Rajamannan NM, Oursler MJ, Turner RT, Spelsberg TC, Subramaniam M,. TIEG-null mice display an osteopenic gender-specific phenotype. Bone 2008; 42: 1025-1031. Epub 2008 Mar 4.
23. Subramaniam M, Gorny G, Johnsen SA, Monroe DG, Evans GL, Fraser DG, Rickard DJ, Rasmussen K, van, Deursen JM, Turner RT, Oursler MJ, Spelsberg TC,. TIEG1 null mouse-derived osteoblasts are defective in mineralization and in support of osteoclast differentiation in vitro. Mol Cell Biol 2005; 25: 1191-1199. (Pubitemid 40165824)
24. Wang J, Jiao H, Stewart TL, Lyons MV, Shankowsky HA, Scott PG, Tredget EE,. Accelerated wound healing in leukocyte-specific, protein 1-deficient mouse is associated with increased infiltration of leukocytes and fibrocytes. J Leukoc Biol 2007; 82: 1554-1563. (Pubitemid 350276967)
25. Davis SC, Mertz PM, Eaglstein WH,. Second-degree burn healing: the effect of occlusive dressings and a cream. J Surg Res 1990; 48: 245-248. (Pubitemid 20108262)
26. Caldelari R, Suter MM, Baumann D, De Bruin A, Muller E,. Long-term culture of murine epidermal keratinocytes. J Invest Dermatol 2000; 114: 1064-1065. (Pubitemid 30252735)
27. Tomasek JJ, Gabbiani G, Hinz B, Chaponnier C, Brown RA,. Myofibroblasts and mechano-regulation of connective tissue remodelling. Nat Rev Mol Cell Biol 2002; 3: 349-363. (Pubitemid 34619269)
28. Hattori N, Mochizuki S, Kishi K, Nakajima T, Takaishi H, D'Armiento J, Okada Y,. MMP-13 plays a role in keratinocyte migration, angiogenesis, and contraction in mouse skin wound healing. Am J Pathol 2009; 175: 533-546.
29. Wang JF, Jiao H, Stewart TL, Shankowsky HA, Scott PG, Tredget EE,. Fibrocytes from burn patients regulate the activities of fibroblasts. Wound Rep Regen 2007; 15: 113-121. (Pubitemid 46146670)
30. Tredget EE, Falk N, Scott PG, Hogg AM, Burke JF,. Determination of 4-hydroxyproline in collagen by gas chromatography/mass spectrometry. Anal Biochem 1990; 190: 259-265. (Pubitemid 20371963)
31. Ashcroft GS, Yang X, Glick AB, Weinstein M, Letterio JL, Mizel DE, Anzano M, Greenwell-Wild T, Wahl SM, Deng C, Roberts AB,. Mice lacking Smad3 show accelerated wound healing and an impaired local inflammatory response. Nat Cell Biol 1999; 1: 260-266. (Pubitemid 129495775)
32. Pham TN, Cho K, Adamson LK, Hakimbashi M, Yang L, Tredget EE, Greenhalgh DG,. Burn injury induces an inhibitory signal in the lung smad pathway. Cytokine 2004; 27: 66-73. (Pubitemid 38881528)
33. Mori Y, Chen SJ, Varga J,. Modulation of endogenous smad expression in normal skin fibroblasts by transforming growth factor-beta. Exp Cell Res 2000; 258: 374-383. (Pubitemid 30483515)
34. Davidson JM,. Animal models for wound repair. Arch Dermatol Res 1998; 290 (Suppl.): S1-11.
35. Galiano RD, Michaels JS, Dobryansky M, Levine JP, Gurtner GC,. Quantitative and reproducible murine model of excisional wound healing. Wound Rep Regen 2004; 12: 485-492. (Pubitemid 39007049)
36. Johnsen SA, Subramaniam M, Janknecht R, Spelsberg TC,. TGFbeta inducible early gene enhances TGFbeta/Smad-dependent transcriptional responses. Oncogene 2002; 21: 5783-5790. (Pubitemid 35333012)
37. Sumiyoshi K, Nakao A, Setoguchi Y, Okumura K, Tsuboi R, Ogawa H,. Smads regulate collagen gel contraction by human dermal fibroblasts. Br J Dermatol 2003; 149: 464-470. (Pubitemid 37281576)
38. Johnsen SA, Subramaniam M, Katagiri T, Janknecht R, Spelsberg TC,. Transcriptional regulation of Smad2 is required for enhancement of TGFbeta/Smad signaling by TGFbeta inducible early gene. J Cell Biochem 2002; 87: 233-241.
39. Midwood KS, Williams LV, Schwarzbauer JE,. Tissue repair and the dynamics of the extracellular matrix. Int J Biochem Cell Biol 2004; 36: 1031-1037. (Pubitemid 38501555)
40. Chen SJ, Yuan W, Mori Y, Levenson A, Trojanowska M, Varga J,. Stimulation of type I collagen transcription in human skin fibroblasts by TGF-beta: involvement of smad 3. J Invest Dermatol 1999; 112: 49-57. (Pubitemid 29024705)
41. Verrecchia F, Chu ML, Mauviel A,. Identification of novel TGF-beta/Smad gene targets in dermal fibroblasts using a combined cDNA microarray/promoter transactivation approach. J Biol Chem 2001; 276: 17058-17062.
42. Lindert S, Wickert L, Sawitza I, Wiercinska E, Gressner AM, Dooley S, Breitkopf K,. Transdifferentiation-dependent expression of alpha-SMA in hepatic stellate cells does not involve TGF-beta pathways leading to coinduction of collagen type I and thrombospondin-2. Matrix Biol 2005; 24: 198-207. (Pubitemid 40732593)
43. Mawaki A, Nakatani T, Sugama J, Konya C,. Relationship between the distribution of myofibroblasts, and stellar and circular scar formation due to the contraction of square and circular wound healing. Anat Sci Int 2007; 82: 147-155. (Pubitemid 47103665)
44. Hosokawa R, Urata MM, Ito Y, Bringas P Jr, Chai Y,. Functional significance of Smad2 in regulating basal keratinocyte migration during wound healing. J Invest Dermatol 2005; 125: 1302-1309.
45. Reynolds LE, Conti FJ, Silva R, Robinson SD, Iyer V, Rudling R, Cross B, Nye E, Hart IR, Dipersio CM, Hodivala-Dilke KM,. alpha3beta1 integrin-controlled Smad7 regulates reepithelialization during wound healing in mice. J Clin Invest 2008; 118: 965-974. (Pubitemid 351364604)