Substrate specificity and kinetic mechanism of purine nucleoside phosphorylase from Mycobacterium tuberculosis

Archives of Biochemistry and Biophysics

Volumn 486, Issue 2, 2009, Pages 155-164

  Ducati, Rodrigo G ^a   Santos, Diógenes S ^a   Basso, Luiz A ^a  

^a PONTIFICAL CATHOLIC UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

Author keywords

Enzyme kinetic mechanism; Fluorescence titration; Initial velocity; pH rate profiles; PNP; Pre steady state kinetics; Product inhibition; Purine nucleoside phosphorylase; Solvent isotope effects; Substrate specificity

Indexed keywords

DEOXYGUANOSINE; GUANINE; PHOSPHATE; PURINE NUCLEOSIDE PHOSPHORYLASE; RIBOSE 1 PHOSPHATE;

ARTICLE; CATALYSIS; COMPLEX FORMATION; CONTROLLED STUDY; ENZYME KINETICS; ENZYME SPECIFICITY; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PH; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTON TRANSPORT; STEADY STATE; SURFACE PLASMON RESONANCE; TEMPERATURE DEPENDENCE;

BACTERIAL PROTEINS; HYDROGEN-ION CONCENTRATION; KINETICS; MYCOBACTERIUM TUBERCULOSIS; PURINE-NUCLEOSIDE PHOSPHORYLASE; RECOMBINANT PROTEINS; SPECTROMETRY, FLUORESCENCE; SUBSTRATE SPECIFICITY;

MYCOBACTERIUM TUBERCULOSIS;

EID: 67349183401     PISSN: 00039861     EISSN: 10960384     Source Type: Journal    
DOI: 10.1016/j.abb.2009.04.011     Document Type: Article

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