Structural insight into peroxisome proliferator-activated receptor γ binding of two ureidofibrate-like enantiomers by molecular dynamics, cofactor interaction analysis, and site-directed mutagenesis

Journal of Medicinal Chemistry

Volumn 53, Issue 11, 2010, Pages 4354-4366

  Pochetti, Giorgio ^a   Mitro, Nico ^b   Lavecchia, Antonio ^c   Gilardi, Federica ^b,g   Besker, Neva ^d   Scotti, Elena ^b,h   Aschi, Massimiliano ^e   Re, Nazzareno ^d   Fracchiolla, Giuseppe ^f   Laghezza, Antonio ^f   Tortorella, Paolo ^f   Montanari, Roberta ^a   Novellino, Ettore ^c   Mazza, Fernando ^a,e   Crestani, Maurizio ^b   Loiodice, Fulvio ^f  

^a CNR   (Italy)

^b UNIVERSITY OF MILAN   (Italy)

^c UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^d UNIVERSITY OF CHIETI   (Italy)

^e UNIVERSITY OF L'AQUILA   (Italy)

^f UNIVERSITY OF BARI   (Italy)

^g UNIVERSITY OF LAUSANNE   (Switzerland)

^h UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; FIBRIC ACID DERIVATIVE; NUCLEAR COREPRESSOR 1; NUCLEAR PROTEIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; RECEPTOR INTERACTING PROTEIN 140; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; DRUG EFFICACY; DRUG POTENCY; DRUG RECEPTOR BINDING; ENANTIOMER; FLUORESCENCE RESONANCE ENERGY TRANSFER; GENETIC TRANSCRIPTION; MOLECULAR DYNAMICS; MOLECULAR INTERACTION; MOLECULAR STABILITY; MOUSE; NONHUMAN; PARTIAL AGONISM; PROMOTER REGION; SITE DIRECTED MUTAGENESIS; STRUCTURE ANALYSIS;

BENZOXAZOLES; BUTYRATES; CO-REPRESSOR PROTEINS; HUMANS; MOLECULAR DYNAMICS SIMULATION; MUTAGENESIS, SITE-DIRECTED; PPAR GAMMA; PROMOTER REGIONS, GENETIC; PROTEIN BINDING; PROTEIN CONFORMATION; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLIDINEDIONES;

EID: 77953189887     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm9013899     Document Type: Article

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