Fluvastatin upregulates endothelial nitric oxide synthase activity via enhancement of its phosphorylation and expression and via an increase in tetrahydrobiopterin in vascular endothelial cells

International Journal of Cardiology

Volumn 156, Issue 1, 2012, Pages 55-61

  Aoki, Chie ^a   Nakano, Ayuko ^a   Tanaka, Seiichi ^a   Yanagi, Kazunori ^a   Ohta, Satoshi ^a   Jojima, Teruo ^a   Kasai, Kikuo ^a   Takekawa, Hidehiro ^a   Hirata, Koichi ^a   Hattori, Yoshiyuki ^a  

^a DOKKYO MEDICAL UNIVERSITY   (Japan)

Author keywords

Endothelial cells; eNOS; Fluvastatin; Terahydrobiopterin

Indexed keywords

CITRULLINE; CYCLIC AMP DEPENDENT PROTEIN KINASE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; FLUINDOSTATIN; GUANOSINE TRIPHOSPHATE CYCLOHYDROLASE I; MESSENGER RNA; PROTEIN KINASE B; SERINE; TETRAHYDROBIOPTERIN;

AMINO ACID SEQUENCE; AMINO ACID SYNTHESIS; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME INDUCTION; ENZYME PHOSPHORYLATION; ENZYME RELEASE; ENZYME SYNTHESIS; GENE; GENE EXPRESSION; GTPCH GENE; HUMAN; HUMAN CELL; PLAQUE FORMING CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; UMBILICAL VEIN ENDOTHELIAL CELL;

ANIMALS; ANTIOXIDANTS; BIOPTERIN; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOTHELIAL CELLS; ENZYME ACTIVATION; FATTY ACIDS, MONOUNSATURATED; GENE EXPRESSION REGULATION; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; INDOLES; MICE; NITRIC OXIDE SYNTHASE TYPE III; PHOSPHORYLATION; UP-REGULATION;

EID: 84858069506     PISSN: 01675273     EISSN: 18741754     Source Type: Journal    
DOI: 10.1016/j.ijcard.2010.10.029     Document Type: Article

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