Fluvastatin inhibits regulated secretion of endothelial cell von Willebrand factor in response to diverse secretagogues

Biochemical Journal

Volumn 405, Issue 3, 2007, Pages 597-604

  Fish, Richard J ^a   Yang, Hong ^a,b   Viglino, Christelle ^a   Schorer, Raoul ^a   Dunoyer Geindre, Sylvie ^a   Kruithof, Egbert K O ^a  

^a GENEVA UNIVERSITY HOSPITALS   (Switzerland)

^b ST MICHAEL'S HOSPITAL   (Canada)

Author keywords

Calcium; cAMP; Endothelial cell; Regulated secretion; Statin; Von Willebrand factor

Indexed keywords

CALCIUM; CARDIOVASCULAR SURGERY; CHOLESTEROL; ENZYME INHIBITION; PEPTIDES;

FLUVASTATIN INHIBITS; HAEMOSTATIC RESPONSE; PROTEASE-ACTIVATED RECEPTOR-1; REGULATED SECRETION; WILLEBRAND FACTOR;

ENDOTHELIAL CELLS;

ADENOVIRUS VECTOR; ADRENALIN; CYCLIC AMP; FLUINDOSTATIN; FORSKOLIN; GERANYLGERANYL PYROPHOSPHATE; GUANOSINE TRIPHOSPHATASE; HISTAMINE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; MEVALONIC ACID; PROTEINASE ACTIVATED RECEPTOR 1; RAC1 PROTEIN; RHO GUANINE NUCLEOTIDE BINDING PROTEIN; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; STATIN; VON WILLEBRAND FACTOR;

ARTICLE; CALCIUM CELL LEVEL; CELL SECRETION; CHOLESTEROL SYNTHESIS; CONTROLLED STUDY; DRUG INHIBITION; DRUG MECHANISM; ENDOTHELIUM CELL; ENZYME ACTIVITY; ENZYME INHIBITION; HEMOSTASIS; HUMAN; HUMAN CELL; PRIORITY JOURNAL;

CALCIUM; CELLS, CULTURED; ENDOTHELIAL CELLS; FATTY ACIDS, MONOUNSATURATED; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; INDOLES; NITRIC OXIDE; PROTEIN ISOPRENYLATION; VON WILLEBRAND FACTOR;

EID: 34547492326     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20070404     Document Type: Article

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