Spontaneous adult-onset pulmonary arterial hypertension attributable to increased endothelial oxidative stress in a murine model of hereditary hemorrhagic telangiectasia

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 30, Issue 3, 2010, Pages 509-517

  Toporsian, Mourad ^a,d,e,g   Jerkic, Mirjana ^a,d   Zhou, Yu Qing ^b   Kabir, Mohammed G ^d,i   Yu, Lisa X ^b   McIntyre, Brendan A S ^c   Davis, Adrienne ^a   Wang, Yu Jing ^a   Stewart, Duncan J ^h   Belik, Jaques ^c   Husain, Mansoor ^b   Henkelman, Mark ^d,f,i   Letarte, Michelle ^a,d,e,f  

^a Mouse Imaging Centre   (Canada)

^b HOSPITAL FOR SICK CHILDREN   (Canada)

^c Heart and Stroke Richard Lewar Center of Excellence   (Canada)

^d Department of Immunology ^*  (Canada)

^e UNIVERSITY OF TORONTO   (Canada)

^f Division of Pulmonary Critical Care and Sleep Medicine   (Canada)

^g HARVARD MEDICAL SCHOOL   (United States)

^h OTTAWA HOSPITAL RESEARCH INSTITUTE   (Canada)

ⁱ TORONTO GENERAL HOSPITAL   (Canada)

Author keywords

Alk 1; Endoglin; Free radicals; Nitric oxide; Pulmonary arterial hypertension; Transforming growth factor

Indexed keywords

BONE MORPHOGENETIC PROTEIN RECEPTOR; DIHYDROBIOPTERIN; ENDOGLIN; ENDOTHELIAL NITRIC OXIDE SYNTHASE; HEAT SHOCK PROTEIN 90; REACTIVE OXYGEN METABOLITE; SUPEROXIDE; TEMPOL; TETRAHYDROBIOPTERIN; TRANSFORMING GROWTH FACTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; COMPUTED TOMOGRAPHIC ANGIOGRAPHY; CONTROLLED STUDY; DEGENERATION; DISEASE MODEL; ENDOTHELIAL DYSFUNCTION; ENZYME ACTIVATION; ENZYME ACTIVITY; HEART RIGHT VENTRICLE HYPERTROPHY; HEART RIGHT VENTRICLE PRESSURE; LUNG BLOOD FLOW; LUNG BLOOD VESSEL; LUNG ENDOTHELIUM; MICROANGIOGRAPHY; MICROVASCULATURE; MOUSE; NONHUMAN; ONSET AGE; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; PULMONARY HYPERTENSION; RENDU OSLER WEBER DISEASE; SIGNAL TRANSDUCTION; SYSTOLIC BLOOD PRESSURE; THORAX RADIOGRAPHY; TRANSGENIC MOUSE;

ANIMALS; ANTIOXIDANTS; BONE MORPHOGENETIC PROTEIN RECEPTORS; CYCLIC N-OXIDES; DISEASE MODELS, ANIMAL; ENDOTHELIUM, VASCULAR; HYPERTENSION, PULMONARY; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MICE; MICE, INBRED C57BL; MUTATION; NITRIC OXIDE SYNTHASE TYPE III; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES; SPIN LABELS; TELANGIECTASIA, HEREDITARY HEMORRHAGIC; TRANSFORMING GROWTH FACTOR BETA;

EID: 77649135502     PISSN: 10795642     EISSN: None     Source Type: Journal    
DOI: 10.1161/ATVBAHA.109.200121     Document Type: Article

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