Early feeding and risk of type 1 diabetes: Experiences from the Trial to Reduce Insulin-dependent diabetes mellitus in the Genetically at Risk (TRIGR)

American Journal of Clinical Nutrition

Volumn 94, Issue 6, 2011, Pages

  Knip, Mikael ^a,b,c,d   Virtanen, Suvi M ^d,e,f   Becker, Dorothy ^g   Dupré, John ^h   Krischer, Jeffrey P ⁱ   Åkerblom, Hans K ^a  

^a UNIVERSITY OF HELSINKI   (Finland)

^b HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

^c FOLKHÄLSAN RESEARCH CENTER   (Finland)

^d TAMPERE UNIVERSITY HOSPITAL   (Finland)

^e NATIONAL PUBLIC HEALTH INSTITUTE   (Finland)

^f UNIVERSITY OF TAMPERE   (Finland)

^g CHILDREN S HOSPITAL OF PITTSBURGH   (United States)

^h ROBARTS RESEARCH INSTITUTE   (Canada)

ⁱ UNIVERSITY OF SOUTH FLORIDA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CASEIN; AUTOANTIBODY; HLA DQA1 ANTIGEN; HLA DQB1 ANTIGEN;

ARTIFICIAL MILK; BREAST FEEDING; CONFERENCE PAPER; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; EARLY FEEDING; FAMILY HISTORY; FEEDING; FOLLOW UP; GENOTYPE; HLA SYSTEM; HUMAN; INFANT; INFANT FEEDING; INSULIN DEPENDENT DIABETES MELLITUS; MAJOR CLINICAL STUDY; MILK; NEWBORN; RANDOMIZED CONTROLLED TRIAL; RISK; WEANING; AUTOIMMUNITY; GENETIC RISK; HYDROLYSIS; INCIDENCE; PANCREAS ISLET BETA CELL; REVIEW; T LYMPHOCYTE;

AUTOIMMUNITY; BREAST FEEDING; CHILD; CHILD, PRESCHOOL; DIABETES MELLITUS, TYPE 1; DIETARY PROTEINS; DOUBLE-BLIND METHOD; FOLLOW-UP STUDIES; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HLA ANTIGENS; HUMANS; INCIDENCE; INFANT; INFANT FORMULA; INFANT, NEWBORN; MILK PROTEINS; MULTICENTER STUDIES AS TOPIC; PILOT PROJECTS; RANDOMIZED CONTROLLED TRIALS AS TOPIC; RISK FACTORS; WEANING;

EID: 82355163472     PISSN: 00029165     EISSN: 19383207     Source Type: Journal    
DOI: 10.3945/ajcn.110.000711     Document Type: Conference Paper

References (39)

1. Knip M. Natural course of preclinical type 1 diabetes. Horm Res 2002; 57(suppl 1):6-11. (Pubitemid 34458074)
2. Ziegler A-G, Hummel M, Schenker M, Bonifacio E. Autoantibody appearance and risk for development of childhood diabetes in offspring of parents with type 1 diabetes: the 2-year analysis of the German BABYDIAB Study. Diabetes 1999;48:460-8. (Pubitemid 29106857)
3. Kimpimäki T, Kupila A, Hämäläinen A-M, et al. The first signs of β-cell autoimmunity appear in infancy in genetically susceptible children from the general population: The Finnish Type 1 Diabetes Prediction and Prevention Study. J Clin Endocrinol Metab 2001;86:4782-8. (Pubitemid 33020520)
4. Harjutsalo V, Sjöberg L, Tuomilehto J. Time trends in the incidence of type 1 diabetes in Finnish children: a cohort study. Lancet 2008;371: 1777-82. (Pubitemid 351697953)
5. Patterson CC, Dahlquist CG, Gyürus E, Green A, Soltesz G. the EURODIAB Study Group. Incidence trends for childhood type 1 diabetes in Europe during 1989-2003 and predicted new cases 2005-20: a multicentre prospective registration study. Lancet 2009;373:2027-33.
6. Virtanen SM, Knip M. Nutritional risk predictors of b cell autoimmunity and type 1 diabetes at a young age. Am J Clin Nutr 2003;78: 1053-67. (Pubitemid 40003749)
7. Virtanen SM, Kenward MG, Erkkola M, et al. Age at introduction of new foods and advanced beta-cell autoimmunity in young children with HLA-conferred susceptibility to type 1 diabetes. Diabetologia 2006;49:1512-21. (Pubitemid 43853015)
8. Karges W, Hammond-McKibben D, Cheung RK, et al. Immunological aspects of nutritional diabetes prevention in NOD mice: a pilot study for the cow's milk-based IDDM prevention trial. Diabetes 1997;46: 557-64. (Pubitemid 27143370)
9. Malkani S, Nompleggi D, Hansen JW, Greiner DL, Mordes JP, Rossini AA. Dietary cow's milk protein does not alter the frequency of diabetes in the BB rat. Diabetes 1997;46:1133-40. (Pubitemid 27271073)
10. Paxson JA, Weber JG, Kulzycki A Jr. Cow's milk-free diet does not prevent diabetes in NOD mice. Diabetes 1997;46:1711-7. (Pubitemid 27456401)
11. Simonson W, Ramanathan S, Bieg S, Poussier P, Lernmark A. Protein-free diets do not protect high-incidence diabetes-prone biobreeding rats from diabetes. Metabolism 2002;51:569-74. (Pubitemid 34516509)
12. Knip M, Virtanen SM, Åkerblom HK. Infant feeding and risk of type 1 diabetes. Am J Clin Nutr 2010;91:1506S-13S.
13. Streng J. Over de beoordeling van de voedingstoestand in de praktijk. [On the judgment of the state of nutrition in practice.] Maandschrift v Kindergen 1946;14:67-78 (in Dutch, summary in English).
14. The EURODIAB ACE Study Group and The EURODIAB ACE Substudy 2 Study Group. Familial risk of type 1 diabetes in European children. Diabetologia 1998;41:1151-6.
15. Åkerblom HK, Virtanen SM, Ilonen J, et al. Dietary manipulation of beta-cell autoimmunity in infants at increased risk for type 1 diabetes. Diabetologia 2005;48:829-37. (Pubitemid 40767974)
16. Åkerblom HK, Virtanen SM, Ilonen J, et al. Weaning to a highly hydrolyzed formula in infancy decreases the cumulative incidence of beta-cell autoimmunity in young children with increased genetic risk for type 1 diabetes. Pediatr Diabetes 2006;7(suppl 5):58-9.
17. The TRIGR Study Group. Study design of the Trial to Reduce IDDM in the Genetically at Risk (TRIGR). Pediatr Diabetes 2007;8:117-37.
18. Åkerblom HK, Knip M, Becker D, et al. The TRIGR trial: testing the potential link between weaning diet and type 1 diabetes. Immun Endoc Metab Agents Med Chem 2007;7:251-63. (Pubitemid 47009510)
19. Kimpimäki T, Kulmala P, Savola K, et al. Disease-associated autoantibodies as surrogate markers of type 1 diabetes in young children at increased genetic risk. J Clin Endocrinol Metab 2000;85:1126-30.
20. Savilahti E, Akerblom HK, Tainio VM, Koskimies S. Children with newly diagnosed insulin dependent diabetes mellitus have increased levels of cow's milk antibodies. Diabetes Res 1988;7:137-40.
21. Vaarala O, Saukkonen T, Savilahti E, Klemola T, Akerblom HK. Development of immune response to cow's milk proteins in infants receiving cow's milk or hydrolyzed formula. J Allergy Clin Immunol 1995;96:917-23.
22. Aranda P, Sanchez L, Perez MD, Ena JM, Calvo M. Insulin in bovine colostrum and milk: evolution throughout lactation and binding to caseins. J Dairy Sci 1991;74:4320-5.
23. Vaarala O, Knip M, Paronen J, et al. Cow milk formula feeding induces primary immunization to insulin in infants at genetic risk for type 1 diabetes. Diabetes 1999;48:1389-94. (Pubitemid 29297300)
24. Dahlquist G, Savilahti E, Landin-Olsson M. An increased level of antibodies to beta-lactoglobulin is a risk determinant for early-onset type 1 (insulin-dependent) diabetes mellitus independent of islet cell antibodies and early introduction of cow's milk. Diabetologia 1992;35: 980-4.
25. Savilahti E, Saukkonen TT, Virtala ET, Tuomilehto J, Åkerblom HK. the Childhood Diabetes in Finland (DiMe) Study Group. Increased levels of cow's milk and beta-lactoglobulin antibodies in young children with newly diagnosed IDDM. Diabetes Care 1993;16:984-9.
26. Saukkonen T, Savilahti E, Vaarala O, et al. Children with newly diagnosed insulin-dependent diabetes mellitus have increased levels of antibodies to bovine serum albumin but not to ovalbumin. Diabetes Care 1994;17:970-6. (Pubitemid 24268606)
27. Vaarala O, Klemetti P, Savilahti E, Reijonen H, Ilonen J, Åkerblom HK. Cellular immune response to cow's milk beta-lactoglobulin in patients with newly diagnosed IDDM. Diabetes 1996;45:178-82. (Pubitemid 26045800)
28. Klemetti P, Savilahti E, Ilonen J, Åkerblom HK, Vaarala O. T-cell reactivity to wheat gluten in patients with insulin-dependent diabetes mellitus. Scand J Immunol 1998;47:48-53. (Pubitemid 28057351)
29. Luopajärvi K, Savilahti E, Virtanen SM, et al. Enhanced levels of cow's milk antibodies in infancy in children who develop type 1 diabetes later in childhood. Pediatr Diabetes 2008;9:434-41.
30. Westerholm-Ormio M, Vaarala O, Pihkala P, Ilonen J, Savilahti E. Immunological activity in the small intestinal mucosa of pediatric patients with type 1 diabetes. Diabetes 2003;52:2287-95. (Pubitemid 37059499)
31. Auricchio R, Paparo F, Maglio M, et al. In-vitro-deranged intestinal immune response to gliadin in type 1 diabetes. Diabetes 2004;53:1680-3. (Pubitemid 38857024)
32. Vaarala O, Atkinson M, Neu J. The "perfect storm" for type 1 diabetes: the complex interplay between intestinal microbiota, gut permeability, and mucosal immunity. Diabetes 2008;57:2555-62.
33. Penders J, Thijs C, Voink C, et al. Factors influencing the composition of the intestinal microbiota in early infancy. Pediatrics 2006;118:511-21. (Pubitemid 46085405)
34. Harmsen HJ, Wildeboer-Veloo AC, Raangs GC, et al. Analysis of intestinal flora development in breast-fed and formula-fed infants by using molecular identification and detection methods. J Pediatr Gastroenterol Nutr 2000;30:61-7. (Pubitemid 30349947)
35. Giongo A, Mukherjee N, Gano KA, et al. Toward defining the autoimmune microbiome for type 1 diabetes. ISME J 2011;5:82-91.
36. Visser JT, Bos NA, van Tool EA, Harthoorn LC, Rozing J. Differential preventive effect of casein hydrolysates in autoimmune diabetes development involves intestinal barrier integrity and gut flora composition. Eur J Immunol 2009;39(suppl1):S674 (abstr).
37. von Berg A, Koletzko S, Grübl A, et al. The effect of hydrolyzed cow's milk formula for allergy prevention in the first year of life: the German Infant Nutritional Intervention Study, a randomized double-blind trial. J Allergy Clin Immunol 2003;111:533-40. (Pubitemid 36337874)
38. von Berg A, Filipiak-Pittroff B, Krämer U, et al. Preventive effect of hydrolyzed infant formulas persists until age 6 years: long-term results from the German Infant Nutritional Intervention Study (GINI). J Allergy Clin Immunol 2008;121:1442-7. (Pubitemid 351787357)
39. Rzehak P, Sausenthaler S, Koletzko S. Short- and long-term effects of feeding hydrolyzed protein infant formulas on growth at, or = 6 y of age: results from the German Infant Nutritional Intervention Study. Am J Clin Nutr 2009;89:1846-56.