A balance between tissue-destructive and tissue-protective immunities: A role of toll-like receptors in regulation of adaptive immunity

Immunobiology

Volumn 217, Issue 4, 2012, Pages 430-435

  Seledtsov, V I ^a   Seledtsova, G V ^b  

^a IMMANUEL KANT BALTIC FEDERAL UNIVERSITY   (Russian Federation)

^b INSTITUTE OF CLINICAL IMMUNOLOGY   (Russian Federation)

Author keywords

Autoimmunity; Immune responses; T cell mediated; Tissue destruction; Tissue protection; Toll like receptors

Indexed keywords

DNA; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; RNA; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 3; TOLL LIKE RECEPTOR 7; TOLL LIKE RECEPTOR 8; TOLL LIKE RECEPTOR 9;

ADAPTIVE IMMUNITY; ANTIGEN PRESENTING CELL; AUTOIMMUNITY; BINDING AFFINITY; BIOACCUMULATION; CD4+ T LYMPHOCYTE; CELL INTERACTION; CELL SURVIVAL; DENDRITIC CELL; DOWN REGULATION; GROWTH INHIBITION; HOST PATHOGEN INTERACTION; HUMAN; IMMUNE RESPONSE; IMMUNOMODULATION; IMMUNOREGULATION; INNATE IMMUNITY; MACROPHAGE ACTIVATION; MOLECULAR DYNAMICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; REVIEW; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION; TH1 TH2 BALANCE; TH2 CELL; TISSUE INJURY; UPREGULATION;

ADAPTIVE IMMUNITY; ANIMALS; ANTIGEN-PRESENTING CELLS; AUTOANTIGENS; CD4-POSITIVE T-LYMPHOCYTES; CELL DEATH; CYTOPROTECTION; HUMANS; IMMUNOMODULATION; MODELS, IMMUNOLOGICAL; NUCLEIC ACIDS; PHAGOCYTOSIS; RECEPTOR CROSS-TALK; TH1-TH2 BALANCE; TOLL-LIKE RECEPTORS;

EID: 84858004854     PISSN: 01712985     EISSN: 18783279     Source Type: Journal    
DOI: 10.1016/j.imbio.2011.10.011     Document Type: Review

References (56)

1. Akira S. Pathogen recognition by innate immunity and its signaling. Proc. Jpn. Acad. Ser. B Phys. Biol. Sci. 2009, 85:143-156.
2. Ashton-Rickardt Ph.G., Tonegawa S. A differential-avidity model for T-cell selection. Immunol. Today 1994, 15:362-366.
3. Barouch R., Schwartz M. Autoreactive T cells induce neurotrophin production by immune and neural cells ininjured rat optic nerve: implications for protective autoimmunity. FASEB J. 2002, 16:1304-1309.
4. Byram S.C., Carson M.J., DeBoy C.A., Serpe C.J., Sanders V.M., Jones K.J. CD4-positive T cell-mediated neuroprotection requires dual compartment antigen presentation. J. Neurosci. 2004, 24:4333-4339.
5. Cameron J.S., Alexopoulou L., Sloane J.A., DiBernardo A.B., Ma Y., Kosaras B., Flavell R., Strittmatter S.M., Volpe J., Sidman R., Vartanian T. Toll-like receptor 3 is a potent negative regulator of axonal growth in mammals. J. Neurosci. 2007, 27:13033-13041.
6. Charles J., Chaperot L., Salameire D., Di Domizio J., Aspord C., Gressin R., Jacob M.C., Richard M.J., Beani J.C., Plumas J., Leccia M.T. Plasmacytoid dendritic cells and dermatological disorders: focus on their role in autoimmunity and cancer. Eur. J. Dermatol. 2010, 20:16-23.
7. Dabbagh K., Dahl M.E., Stepick-Biek P., Lewis D.B. Toll-like receptor 4 is required for optimal development of Th2 immune responses: role of dendritic cells. J. Immunol. 2002, 168:4524-4530.
8. Deonarine K., Panelli M.C., Stashower M.E., Jin P., Smith K., Slade H.B., Norwood C., Wang E., Marincola F.M., Stroncek D.F. Gene expression profiling of cutaneous wound healing. J. Trans. Med. 2007, 5:11-16.
9. Donnelly D.J., Popovich P.G. Inflammation and its role in neuroprotection, axonal regeneration and functional recovery after spinal cord injury. Exp. Neurol. 2008, 209:378-388.
10. Elias D., Meilin A., Ablamunits V., Birk O.S., Carmi P., Könen-Waisman S., Cohen I.R. Hsp60 peptide therapy of NOD mouse diabetes induces a Th2 cytokine burst and downregulates autoimmunity to various beta-cell antigens. Diabetes 1997, 46:758-764.
11. Fairweather D., Cihakova D. Alternatively activated macrophages in infection and autoimmunity. J. Autoimmun. 2009, 33:222-230.
12. Farkas L., Beiske K., Lund-Johansen F., Brandtzaeg P., Jahnsen F.L. Plasmacytoid dendritic cells (natural interferon-alpha/beta-producing cells) accumulate in cutaneous lupus erythematosus lesions. Am. J. Pathol. 2001, 159:237-243.
13. Goligorsky M.S. Immune system in renal injury and repair: burning the candle from both ends?. Pharmacol. Res. 2008, 58:122-128.
14. Graber J.J., Dhib-Jalbut S. Protective autoimmunity in the nervous system. Pharmacol. Ther. 2009, 121:147-159.
15. Gratchev A., Guillot P., Hakiy N., Politz O., Orfanos C.E., Schledzewski K., Goerdt S. Scand. J. Immunol. 2001, 53:386-392.
16. Gratchev A., Kzhyshkowska J., Utikal J., Goerdt S. Interleukin-4 and dexamethasone counterregulate extracellular matrix remodelling and phagocytosis in type-2 macrophages. Scand. J. Immunol. 2005, 61:10-17.
17. Hendrix S., Nitsch R. The role of T helper cells in neuroprotection and regeneration. J. Neuroimmunol. 2007, 184:100-112.
18. Jiang D., Liang J., Fan J., Yu S., Chen S., Luo Y., Prestwich G.D., Mascarenhas M.M., Garg H.G., Quinn D.A., Homer R.J., Goldstein D.R., Bucala R., Lee P.J., Medzhitov R., Noble P.W. Regulation of lung injury and repair by Toll-like receptors and hyaluronan. Nat. Med. 2005, 11:1173-1179.
19. Kigerl K.A., Gensel J.C., Ankeny D.P., Alexander J.K., Donnelly D.J., Popovich P.G. Identification of two distinct macrophage subsets with divergent effects causing either neurotoxicity or regeneration in the injured mouse spinal cord. J. Neurosci. 2009, 29:13435-21344.
20. Kluwe J., Mencin A., Schwabe R.F. Toll-like receptors, wound healing, and carcinogenesis. J. Mol. Med. 2009, 87:125-138.
21. Koff J.L., Shao M.X., Kim S., Ueki I.F., Nadel J.A. Pseudomonas lipopolysaccharide accelerates wound repair via activation of a novel epithelial cell signaling cascade. J. Immunol. 2006, 177:8693-8700.
22. Krieg A.M. Antiinfective applications of toll-like receptor 9 agonists. Proc. Am. Thorac. Soc. 2007, 4:289-294.
23. Kuper H., Adami H.O., Trichopoulos D. Infections as a major preventable cause of human cancer. J. Intern. Med. 2000, 248:171-183.
24. Kzhyshkowska J., Workman G., Cardó-Vila M., Arap W., Pasqualini R., Gratchev A., Krusell L., Goerdt S., Sage E.H. Novel function of alternatively activated macrophages: stabilin-1-mediated clearance of SPARC. J. Immunol. 2006, 176:5825-5832.
25. Lazarov-Spiegler O., Solomon A.S., Zeev-Brann A.B., Hirschberg D.L., Lavie V., Schwartz M. Transplantation of activated macrophages overcomes central nervous system regrowth failure. FASEB J. 1996, 10:1296-1302.
26. Leung P.Y., Packard A.E., Stenzel-Poore M.P. It's all in the family: multiple Toll-like receptors offer promise as novel therapeutic targets for stroke neuroprotection. Future Neurol. 2009, 4:201-208.
27. Lin W., Kemper A., Dupree J.L., Harding H.P., Ron D., Popko B. Interferon-gamma inhibits central nervous system remyelination through a process modulated by endoplasmic reticulum stress. Brain 2006, 129:1306-1318.
28. Marques V.P., Goncalves G.M., Feitoza C.Q., Cenedeze M.A., Fernandes Bertocchi A.P., Damiao M.J., Pinheiro H.S., Antunes Teixeira V.P., dos Reis M.A., Pacheco-Silva A., Saraiva Camara N.O. Influence of TH1/TH2 switched immune response on renal ischemia-reperfusion injury. Nephron. Exp. Nephrol. 2006, 104:e48-e56.
29. Mencin A., Kluwe J., Schwabe R.F. Toll-like receptors as targets in chronic liver diseases. Gut 2009, 58:704-720.
30. Methe H., Nanasato M., Spognardi A.M., Groothuis A., Edelman E.R. T-helper 2 cells are essential for modulation of vascular repair by allogeneic endothelial cells. J. Heart Lung Transplant. 2010, 29:479-486.
31. Mogensen T.H. Pathogen recognition and inflammatory signaling in innate immune defenses. Clin. Microbiol. Rev. 2009, 22:240-273.
32. Mosmann T.R., Sad S. The expanding universe of T-cell subsets: Th1, Th2 and more. Immunol. Today 1996, 17:138-146.
33. Murphy J.E., Padilla B.E., Hasdemir B., Cottrell G.S., Bunnett N.W. Endosomes: a legitimate platform for the signaling train. Proc. Natl. Acad. Sci. U.S.A. 2009, 106:17615-17622.
34. Nahrendorf M., Swirski F.K., Aikawa E., Stangenberg L., Wurdinger T., Figueiredo J.L., Libby P., Weissleder R., Pittet M.J. The healing myocardium sequentially mobilizes two monocyte subsets with divergent and complementary functions. J. Exp. Med. 2007, 204:3037-3047.
35. Nestle F.O., Conrad C., Tun-Kyi A., Homey B., Gombert M., Boyman O., Burg G., Liu Y.J., Gilliet M. Plasmacytoid predendritic cells initiate psoriasis through interferon-alpha production. J. Exp. Med. 2005, 202:135-143.
36. Quintana F.J., Carmi P., Mor F., Cohen I.R. Inhibition of adjuvant arthritis by a DNA vaccine encoding human heat shock protein 60. J. Immunol. 2002, 169:3422-3428.
37. Rakoff-Nahoum S., Medzhitov R. Role of toll-like receptors in tissue repair and tumorigenesis. Biochemistry (Mosc) 2008, 73:555-561.
38. Sano K., Shirota H., Terui T., Hattori T., Tamura G. Oligodeoxynucleotides without CpG motifs work as adjuvant for the induction of Th2 differentiation in a sequence-independent manner. J. Immunol. 2003, 170:2367-2373.
39. Sato A., Iizuka M., Nakagomi O., Suzuki M., Horie Y., Konno S., Hirasawa F., Sasaki K., Shindo K., Watanabe S. Rotavirus double-stranded RNA induces apoptosis and diminishes wound repair in rat intestinal epithelial cells. J. Gastroenterol. Hepatol. 2006, 21:521-530.
40. Seledtsov V.I., Seledtsova G.V. An 'antigen ligand competition' model for antigen receptor-mediated lymphocyte selection. Biomed. Pharmacother. 1996, 50:170-177.
41. Seledtsov V.I., Seledtsova G.V. A possible role of preexisting IgM/IgG antibodies in determining immune response type. Immunol. Cell Biol. 1997, 75:176-180.
42. Shaykhiev R., Behr J., Bals R. Microbial patterns signaling via Toll-like receptors 2 and 5 contribute to epithelial repair, growth and survival. PLoS One 2008, 3:e1393.
43. Sloane J.A., Blitz D., Margolin Z., Vartanian T. A clear and present danger: endogenous ligands of Toll-like receptors. Neuromol. Med. 2010, 12:149-163.
44. Smits E.L., Ponsaerts P., Berneman Z.N., Van Tendeloo V.F. The use of TLR7 and TLR8 ligands for the enhancement of cancer immunotherapy. Oncologist 2008, 13:859-875.
45. Stein N.C., Kreutzmann C., Zimmermann S.P., Niebergall U., Hellmeyer L., Goettsch C., Schoppet M., Hofbauer L.C. Interleukin-4 and interleukin-13 stimulate the osteoclast inhibitor osteoprotegerin by human endothelial cells through the STAT6 pathway. J. Bone Miner Res. 2008, 23:750-758.
46. Su G.L., Wang S.C., Aminlari A., Tipoe G.L., Steinstraesser L., Nanji A. Impaired hepatocyte regeneration in toll-like receptor 4 mutant mice. Dig. Dis. Sci. 2004, 49:843-849.
47. Sun R., Gao B. Negative regulation of liver regeneration by innate immunity (natural killer cells/interferon-gamma). Gastroenterology 2004, 127:1525-1539.
48. Tiegs G. Cellular and cytokine-mediated mechanisms of inflammation and its modulation in immune-mediated liver injury. Gastroenterology 2007, 45:63-70.
49. Varin A., Gordon S. Alternative activation of macrophages: immune function and cellular biology. Immunobiology 2009, 214:630-641.
50. Vollmer J., Weeratna R.D., Jurk M., Samulowitz U., McCluskie M.J., Payette P., Davis H.L., Schetter C., Krieg A.M. Oligodeoxynucleotides lacking CpG dinucleotides mediate Toll-like receptor 9 dependent T helper type 2 biased immune stimulation. Immunology 2004, 113:212-223.
51. Wang C., Tay S.S., Tran G.T., Hodgkinson S.J., Allen R.D., Hall B.M., McCaughan G.W., Sharland A.F., Bishop G.A. Donor IL-4-treatment induces alternatively activated liver macrophages and IDO-expressing NK cells and promotes rat liver allograft acceptance. Transplant. Immunol. 2010, 22:172-178.
52. Yamori M., Yoshida M., Watanabe T., Shirai Y., Iizuka T., Kita T., Wakatsuki Y. Antigenic activation of Th1 cells in the gastric mucosa enhances dysregulated apoptosis and turnover of the epithelial cells. Biochem. Biophys. Res. Commun. 2004, 316:1015-1021.
53. Yong V.W., Marks S. The interplay between the immune and central nervous systems in neuronal injury. Neurology 2010, 74:S9-S16.
54. Young N., Mikhalkevich N., Yan Y., Chen D., Zheng W.P. Differential regulation of osteoblast activity by Th cell subsets mediated by parathyroid hormone and IFN-gamma. J. Immunol. 2005, 175:8287-8295.
55. Zemskov A.M., Zemskov V.M., Tokmakov A.I. Clinical efficacy of immunostimulating drugs in treatment of purulent infections. Khirurgiia (Mosk) 2011, 2:4-10. (Russian).
56. Ziv Y., Avidan H., Pluchino S., Martino G., Schwartz M. Synergy between immune cells and adult neural stem/progenitor cells promotes functional recovery from spinal cord injury. Proc. Natl. Acad. Sci. U.S.A. 2006, 103:13174-13179.