Antigenic activation of Th1 cells in the gastric mucosa enhances dysregulated apoptosis and turnover of the epithelial cells

Biochemical and Biophysical Research Communications

Volumn 316, Issue 4, 2004, Pages 1015-1021

  Yamori, Masashi ^a   Yoshida, Masaru ^a   Watanabe, Tomohiro ^a   Shirai, Yasuhiko ^a   Iizuka, Tadahiko ^a   Kita, Toru ^a   Wakatsuki, Yoshio ^a  

^a KYOTO UNIVERSITY   (Japan)

Author keywords

Apoptosis; Cell turnover; Disease model; Gastritis; Helicobacter pylori; Immunology; Lymphokine; Pathology; T helper 1

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 12; INTERLEUKIN 4;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN EXPRESSION; APOPTOSIS; ARTICLE; CELL DIVISION; CELL INFILTRATION; CHRONIC GASTRITIS; CONTROLLED STUDY; EPITHELIUM CELL; HELICOBACTER PYLORI; MOUSE; NONHUMAN; PRIORITY JOURNAL; STOMACH EPITHELIUM; STOMACH MUCOSA; T LYMPHOCYTE;

ANIMALS; ANTIGENS; APOPTOSIS; CELLS, CULTURED; GASTRIC MUCOSA; GASTRITIS; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED BALB C; MICE, TRANSGENIC; REGENERATION; TH1 CELLS;

HELICOBACTER; HELICOBACTER PYLORI;

EID: 1642280339     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbrc.2004.02.145     Document Type: Article

References (20)

1. Parsonnet J., Hansen S., Rodriguez L., Gelb A.B., Warnke R.A., Jellum E., Orentreich N., Vogelman J.H., Friedman G.D. Helicobacter pylori infection and gastric lymphoma. N. Engl. J. Med. 330:1994;1267-1271.
2. Uemura N., Okamoto S., Yamamoto S., Matsumura N., Yamaguchi S., Yamakido M., Taniyama K., Sasaki N., Schlemper R.J. Helicobacter pylori infection and the development of gastric cancer. N. Engl. J. Med. 345:2001;784-789.
3. Censini S., Lange C., Xiang Z., Crabtree J.E., Ghiara P., Borodovsky M., Rappuoli R., Covacci A. cag, a pathogenicity island of Helicobacter pylori, encodes type I-specific and disease-associated virulence factors. Proc. Natl. Acad. Sci. USA. 93:1996;14648-14653.
4. Graham D.Y., Yamaoka Y. Disease-specific Helicobacter pylori virulence factors: the unfulfilled promise. Helicobacter. 5(Suppl. 1):2000;S3-S9. discussion S27-S31.
5. Matsukura N., Onda M., Kato S., Hasegawa H., Okawa K., Shirakawa T., Tokunaga A., Yamashita K., Hayashi A. Cytotoxin genes of Helicobacter pylori in chronic gastritis, gastroduodenal ulcer and gastric cancer: an age and gender matched case-control study. Jpn. J. Cancer Res. 88:1997;532-536.
6. Perez-Perez G.I., Peek R.M., Legath A.J., Heine P.R., Graff L.B. The role of CagA status in gastric and extragastric complications of Helicobacter pylori. J. Physiol. Pharmacol. 50:1999;833-845.
7. Higashi H., Tsutsumi R., Muto S., Sugiyama T., Azuma T., Asaka M., Hatakeyama M. SHP-2 tyrosine phosphatase as an intracellular target of Helicobacter pylori CagA protein. Science. 295:2002;683-686.
8. Selbach M., Moese S., Hurwitz R., Hauck C.R., Meyer T.F., Backert S. The Helicobacter pylori CagA protein induces cortactin dephosphorylation and actin rearrangement by c-Src inactivation. EMBO J. 22:2003;515-528.
9. Eaton K.A., Mefford M., Thevenot T. The role of T cell subsets and cytokines in the pathogenesis of Helicobacter pylori gastritis in mice. J. Immunol. 166:2001;7456-7461.
10. Itoh T., Wakatsuki Y., Yoshida M., Usui T., Matsunaga Y., Kaneko S., Chiba T., Kita T. The vast majority of gastric T cells are polarized to produce T helper 1 type cytokines upon antigenic stimulation despite the absence of Helicobacter pylori infection. J. Gastroenterol. 34:1999;560-570.
11. Itoh T., Yoshida M., Chiba T., Kita T., Wakatsuki Y. A coordinated cytotoxic effect of IFN-gamma and cross-reactive antibodies in the pathogenesis of Helicobacter pylori gastritis. Helicobacter. 8:2003;268-278.
12. Watanabe T., Yoshida M., Shirai Y., Yamori M., Yagita H., Itoh T., Chiba T., Kita T., Wakatsuki Y. Administration of an antigen at a high dose generates regulatory CD4+ T cells expressing CD95 ligand and secreting IL-4 in the liver. J. Immunol. 168:2002;2188-2199.
13. M.F. Dixon, R.M. Genta, J.H. Yardley, P. Correa, Classification and grading of gastritis. The updated Sydney System. International Workshop on the Histopathology of Gastritis, Houston 1994, Am. J. Surg. Pathol. 20 (1996) 1161-1181.
14. Watanabe T., Katsukura H., Shirai Y., Yamori M., Nishi T., Chiba T., Kita T., Wakatsuki Y., Yoshida M., Yagita H., Itoh T. A liver tolerates a portal antigen by generating CD11c+ cells, which select Fas ligand+ Th2 cells via apoptosis Administration of an antigen at a high dose generates regulatory CD4+ T cells expressing CD95 ligand and secreting IL-4 in the liver. Hepatology. 38:2003;403-412.
15. D'Elios M.M., Manghetti M., De Carli M., Costa F., Baldari C.T., Burroni D., Telford J.L., Romagnani S., Del Prete G. T helper 1 effector cells specific for Helicobacter pylori in the gastric antrum of patients with peptic ulcer disease. J. Immunol. 158(0022-1767):1997;962-967.
16. Sawai N., Kita M., Kodama T., Tanahashi T., Yamaoka Y., Tagawa Y., Iwakura Y., Imanishi J. Role of gamma interferon in Helicobacter pylori-induced gastric inflammatory responses in a mouse model. Infect. Immun. 67:1999;279-285.
17. Shirai Y., Wakatsuki Y., Kusumoto T., Nakata M., Yoshida M., Usui T., Iizuka T., Kita T. Induction and maintenance of immune effector cells in the gastric tissue of mice orally immunized to Helicobacter pylori requires salivary glands. Gastroenterology. 118:2000;749-759.
18. Sutton P., Danon S.J., Walker M., Thompson L.J., Wilson J., Kosaka T., Lee A. Post-immunisation gastritis and Helicobacter infection in the mouse: a long term study. Gut. 49:2001;467-473.
19. Mohammadi M., Nedrud J., Redline R., Lycke N., Czinn S.J. Murine CD4 T-cell response to Helicobacter infection: TH1 cells enhance gastritis and TH2 cells reduce bacterial load. Gastroenterology. 113:1997;1848-1857.
20. Fuss I.J., Marth T., Neurath M.F., Pearlstein G.R., Jain A., Strober W. Anti-interleukin 12 treatment regulates apoptosis of Th1 T cells in experimental colitis in mice. Gastroenterology. 117:1999;1078-1088.