Stabilization of TRAIL, an all-β-sheet multimeric protein, using computational redesign

Protein Engineering, Design and Selection

Volumn 17, Issue 9, 2004, Pages 673-680

  Van Der Sloot, Almer M ^a   Mullally, Margaret M ^a   Fernandez Ballester, Gregorio ^b   Serrano, Luis ^b   Quax, Wim J ^a  

^a UNIVERSITY OF GRONINGEN   (Netherlands)

^b EUROPEAN MOLECULAR BIOLOGY LABORATORY   (Germany)

Author keywords

Computational protein design; Stability; TNF ligand family; TRAIL

Indexed keywords

ALGORITHMS; MONOMERS; PHARMACOKINETICS; THERMODYNAMIC STABILITY; TUMORS;

CIRCULAR DICHROISM; INTERFACE MODIFICATIONS; PROTEIN THERMAL STABILITY; TUMOR NECROSIS FACTOR (TNF);

PROTEINS;

MONOMER; TUMOR NECROSIS FACTOR; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND;

ALGORITHM; ARTICLE; BETA SHEET; CIRCULAR DICHROISM; DENATURATION; HUMAN; MUTANT; PRIORITY JOURNAL; PROTEIN STABILITY; RECEPTOR BINDING; THERMOSTABILITY;

ALGORITHMS; APOPTOSIS REGULATORY PROTEINS; CELL LINE, TUMOR; CELL SURVIVAL; COLONIC NEOPLASMS; COMPUTATIONAL BIOLOGY; COMPUTER SIMULATION; DRUG STABILITY; HEAT; HUMANS; MEMBRANE GLYCOPROTEINS; MUTAGENESIS, SITE-DIRECTED; PROTEIN CONFORMATION; PROTEIN DENATURATION; PROTEIN ENGINEERING; RECEPTORS, TNF-RELATED APOPTOSIS-INDUCING LIGAND; RECEPTORS, TUMOR NECROSIS FACTOR; THERMODYNAMICS; TNF-RELATED APOPTOSIS-INDUCING LIGAND; TUMOR NECROSIS FACTOR-ALPHA;

EID: 18044387255     PISSN: 17410126     EISSN: None     Source Type: Journal    
DOI: 10.1093/protein/gzh079     Document Type: Article

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