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Volumn 19, Issue 12, 2008, Pages 848-855

Pomegranate polyphenols down-regulate expression of androgen-synthesizing genes in human prostate cancer cells overexpressing the androgen receptor

Author keywords

Androgen independence; Androgen receptor; Ellagic acid; Pomegranate; Prostate cancer; Punicalagin

Indexed keywords

ANDROGEN; ANDROGEN RECEPTOR; ELLAGITANNIN; HYDROXYSTEROID DEHYDROGENASE; OXIDOREDUCTASE; POLYPHENOL DERIVATIVE; POMEGRANATE EXTRACT; POMEGRANATE POLYPHENOL; STEROID 5ALPHA REDUCTASE 1; UNCLASSIFIED DRUG;

EID: 53249094494     PISSN: 09552863     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jnutbio.2007.11.006     Document Type: Article
Times cited : (129)

References (52)
  • 1
    • 0033788223 scopus 로고    scopus 로고
    • Antioxidant activity of pomegranate juice and its relationship with phenolic composition and processing
    • Gil M.I., Tomas-Barberan F.A., Hess-Pierce B., Holcroft D.M., and Kader A.A. Antioxidant activity of pomegranate juice and its relationship with phenolic composition and processing. J Agric Food Chem 48 (2000) 4581-4589
    • (2000) J Agric Food Chem , vol.48 , pp. 4581-4589
    • Gil, M.I.1    Tomas-Barberan, F.A.2    Hess-Pierce, B.3    Holcroft, D.M.4    Kader, A.A.5
  • 2
    • 0034013311 scopus 로고    scopus 로고
    • Pomegranate juice consumption reduces oxidative stress, atherogenic modifications to LDL, and platelet aggregation: studies in humans and in atherosclerotic apolipoprotein E-deficient mice
    • Aviram M., Dornfield L., Rosenblatt M., Volkova N., Kaplan M., Coleman R., et al. Pomegranate juice consumption reduces oxidative stress, atherogenic modifications to LDL, and platelet aggregation: studies in humans and in atherosclerotic apolipoprotein E-deficient mice. Am J Clin Nutr 71 (2000) 1062-1076
    • (2000) Am J Clin Nutr , vol.71 , pp. 1062-1076
    • Aviram, M.1    Dornfield, L.2    Rosenblatt, M.3    Volkova, N.4    Kaplan, M.5    Coleman, R.6
  • 3
    • 0034900739 scopus 로고    scopus 로고
    • Pomegranate juice supplementation to atherosclerotic mice reduces macrophage lipid peroxidation, cellular cholesterol accumulation and development of atherosclerosis
    • Kaplan M., Hayek T., Raz A., Coleman R., Dornfield L., Vaya J., et al. Pomegranate juice supplementation to atherosclerotic mice reduces macrophage lipid peroxidation, cellular cholesterol accumulation and development of atherosclerosis. J Nutr 131 (2001) 2082-2089
    • (2001) J Nutr , vol.131 , pp. 2082-2089
    • Kaplan, M.1    Hayek, T.2    Raz, A.3    Coleman, R.4    Dornfield, L.5    Vaya, J.6
  • 4
    • 0036201937 scopus 로고    scopus 로고
    • Chemopreventive and adjuvant therapeutic potential of pomegranate (Punica granatum) for human breast cancer
    • Kim N.D., Mehta R., Yu W., Neeman I., Livney T., Amichay A., et al. Chemopreventive and adjuvant therapeutic potential of pomegranate (Punica granatum) for human breast cancer. Breast Cancer Res Treat 71 (2002) 203-217
    • (2002) Breast Cancer Res Treat , vol.71 , pp. 203-217
    • Kim, N.D.1    Mehta, R.2    Yu, W.3    Neeman, I.4    Livney, T.5    Amichay, A.6
  • 5
    • 0038284925 scopus 로고    scopus 로고
    • Repeated oral administration of high doses of pomegranate ellagitannin punicalagin to rats for 37 days is not toxic
    • Cerda B., Ceron J.J., Tomas-Barberan F.A., and Espin J.C. Repeated oral administration of high doses of pomegranate ellagitannin punicalagin to rats for 37 days is not toxic. J Agric Food Chem 51 (2003) 3493-3501
    • (2003) J Agric Food Chem , vol.51 , pp. 3493-3501
    • Cerda, B.1    Ceron, J.J.2    Tomas-Barberan, F.A.3    Espin, J.C.4
  • 6
    • 0037219635 scopus 로고    scopus 로고
    • Evaluation of the bioavailability and metabolism in the rat of punicalagin, an antioxidant polyphenol from pomegranate juice
    • Cerda B., Llorach R., Ceron J.J., Espin J.C., and Tomas-Barberan F.A. Evaluation of the bioavailability and metabolism in the rat of punicalagin, an antioxidant polyphenol from pomegranate juice. Eur J Nutr 42 (2003) 18-28
    • (2003) Eur J Nutr , vol.42 , pp. 18-28
    • Cerda, B.1    Llorach, R.2    Ceron, J.J.3    Espin, J.C.4    Tomas-Barberan, F.A.5
  • 7
    • 0032923360 scopus 로고    scopus 로고
    • p53/p21 (WAF1/CIP1) expression and its possible role in G1 arrest and apoptosis in ellagic acid treated cancer cells
    • Narayanan B.A., Geoffrey O., Willingham M.C., Re G.G., and Nixon D.W. p53/p21 (WAF1/CIP1) expression and its possible role in G1 arrest and apoptosis in ellagic acid treated cancer cells. Cancer Lett 136 (1999) 215-221
    • (1999) Cancer Lett , vol.136 , pp. 215-221
    • Narayanan, B.A.1    Geoffrey, O.2    Willingham, M.C.3    Re, G.G.4    Nixon, D.W.5
  • 8
    • 0032782963 scopus 로고    scopus 로고
    • Prevention of N-nitrosodiethylamine-induced lung tumorigenesis by ellagic acid and quercetin in mice
    • Khanduja K.L., Gandhi R.K., Pathania V., and Syanl N. Prevention of N-nitrosodiethylamine-induced lung tumorigenesis by ellagic acid and quercetin in mice. Food Chem Toxicol 137 (1999) 313-318
    • (1999) Food Chem Toxicol , vol.137 , pp. 313-318
    • Khanduja, K.L.1    Gandhi, R.K.2    Pathania, V.3    Syanl, N.4
  • 9
    • 0041709308 scopus 로고    scopus 로고
    • Low concentrations of quercetin and ellagic acid synergistically influence proliferation, cytotoxicity and apoptosis in MOLT-4 human leukemia cells
    • Mertens-Talcott S.U., Talcott S.T., and Percival S.S. Low concentrations of quercetin and ellagic acid synergistically influence proliferation, cytotoxicity and apoptosis in MOLT-4 human leukemia cells. J Nutr 133 (2003) 2669-2674
    • (2003) J Nutr , vol.133 , pp. 2669-2674
    • Mertens-Talcott, S.U.1    Talcott, S.T.2    Percival, S.S.3
  • 10
    • 33244454723 scopus 로고    scopus 로고
    • Pomegranate juice, total pomegranate ellagitannins, and punicalagin suppress inflammatory cell signaling in colon cancer cells
    • Adams L.S., Seeram N.P., Aggarwal B.B., Takada Y., Sand D., and Heber D. Pomegranate juice, total pomegranate ellagitannins, and punicalagin suppress inflammatory cell signaling in colon cancer cells. J Agric Food Chem 54 (2006) 980-985
    • (2006) J Agric Food Chem , vol.54 , pp. 980-985
    • Adams, L.S.1    Seeram, N.P.2    Aggarwal, B.B.3    Takada, Y.4    Sand, D.5    Heber, D.6
  • 11
    • 4644311403 scopus 로고    scopus 로고
    • Pomegranate extracts potently suppress proliferation, xenograft growth, and invasion of human prostate cancer cells
    • Albrecht M., Jiang W., Kumi-Diaka J., Lansky E.P., Gommersall L.M., Mansel R.E., et al. Pomegranate extracts potently suppress proliferation, xenograft growth, and invasion of human prostate cancer cells. J Med Food 7 (2004) 274-283
    • (2004) J Med Food , vol.7 , pp. 274-283
    • Albrecht, M.1    Jiang, W.2    Kumi-Diaka, J.3    Lansky, E.P.4    Gommersall, L.M.5    Mansel, R.E.6
  • 12
    • 1842423822 scopus 로고    scopus 로고
    • Differentiation-promoting activity of pomegranate (Punica granatum) fruit extracts in HL-60 human promyelocytic leukemia cells
    • Kawaii S., and Lansky E.P. Differentiation-promoting activity of pomegranate (Punica granatum) fruit extracts in HL-60 human promyelocytic leukemia cells. J Med Food 7 (2004) 13-18
    • (2004) J Med Food , vol.7 , pp. 13-18
    • Kawaii, S.1    Lansky, E.P.2
  • 13
    • 0842333242 scopus 로고    scopus 로고
    • Preliminary studies on the anti-angiogenic potential of pomegranate fractions in vitro and in vivo
    • Toi M., Bando H., Ramachandran C., Melnick S.J., Imai A., Fife R.S., et al. Preliminary studies on the anti-angiogenic potential of pomegranate fractions in vitro and in vivo. Angiogenesis 6 (2003) 121-128
    • (2003) Angiogenesis , vol.6 , pp. 121-128
    • Toi, M.1    Bando, H.2    Ramachandran, C.3    Melnick, S.J.4    Imai, A.5    Fife, R.S.6
  • 14
    • 0344845219 scopus 로고    scopus 로고
    • Chemopreventive effects of pomegranate seed oil on skin tumor development in CD1 mice
    • Hora J.J., Maydew E.R., Lansky E.P., and Dwivedi C. Chemopreventive effects of pomegranate seed oil on skin tumor development in CD1 mice. J Med Food 6 (2003) 157-161
    • (2003) J Med Food , vol.6 , pp. 157-161
    • Hora, J.J.1    Maydew, E.R.2    Lansky, E.P.3    Dwivedi, C.4
  • 15
    • 3042551491 scopus 로고    scopus 로고
    • Pomegranate seed oil rich in conjugated linolenic acid suppresses chemically induced colon carcinogenesis in rats
    • Kohno H., Suzuki R., Yasui Y., Hosokawa M., Miyashita K., and Tanaka T. Pomegranate seed oil rich in conjugated linolenic acid suppresses chemically induced colon carcinogenesis in rats. Cancer Sci 95 (2004) 481-486
    • (2004) Cancer Sci , vol.95 , pp. 481-486
    • Kohno, H.1    Suzuki, R.2    Yasui, Y.3    Hosokawa, M.4    Miyashita, K.5    Tanaka, T.6
  • 16
    • 33947593200 scopus 로고    scopus 로고
    • American Cancer Society Atlanta (Ga)
    • American Cancer Society. Cancer facts and figures 2007 (2007). http://www.cancer.org Atlanta (Ga)
    • (2007) Cancer facts and figures 2007
  • 17
    • 0027312365 scopus 로고
    • Risk factors for prostate cancer
    • Pienta K.J., and Esper P.S. Risk factors for prostate cancer. Ann Intern Med 118 (1993) 793-803
    • (1993) Ann Intern Med , vol.118 , pp. 793-803
    • Pienta, K.J.1    Esper, P.S.2
  • 18
    • 0033988067 scopus 로고    scopus 로고
    • Endocrine treatment in prostate cancer
    • Denis L.J., and Griffiths K. Endocrine treatment in prostate cancer. Semin Surg Oncol 18 (2000) 52-74
    • (2000) Semin Surg Oncol , vol.18 , pp. 52-74
    • Denis, L.J.1    Griffiths, K.2
  • 19
    • 0029176099 scopus 로고
    • Chemoprevention of prostate cancer with finasteride
    • Thompson I., Feigl P., and Coltman C. Chemoprevention of prostate cancer with finasteride. Important Adv Oncol (1995) 57-76
    • (1995) Important Adv Oncol , pp. 57-76
    • Thompson, I.1    Feigl, P.2    Coltman, C.3
  • 20
    • 2342558431 scopus 로고    scopus 로고
    • Androgen receptor in prostate cancer
    • Heinlein C.A., and Chang C. Androgen receptor in prostate cancer. Endocr Rev 25 (2004) 276-308
    • (2004) Endocr Rev , vol.25 , pp. 276-308
    • Heinlein, C.A.1    Chang, C.2
  • 21
    • 0035845558 scopus 로고    scopus 로고
    • Prostatic intraepithelial neoplasia in mice expressing an androgen receptor transgene in prostate epithelium
    • Stanbrough M., Leav I., Kwan P.W., Bubley G.J., and Balk S.P. Prostatic intraepithelial neoplasia in mice expressing an androgen receptor transgene in prostate epithelium. Proc Natl Acad Sci U S A 98 (2001) 10823-10828
    • (2001) Proc Natl Acad Sci U S A , vol.98 , pp. 10823-10828
    • Stanbrough, M.1    Leav, I.2    Kwan, P.W.3    Bubley, G.J.4    Balk, S.P.5
  • 22
    • 33749345244 scopus 로고    scopus 로고
    • Improving the outcome of patients with castration-resistant prostate cancer through rational drug development
    • Attard G., Sarker D., Reid A., Molife R., Parker C., and de Bono J.S. Improving the outcome of patients with castration-resistant prostate cancer through rational drug development. Br J Cancer 95 (2006) 767-774
    • (2006) Br J Cancer , vol.95 , pp. 767-774
    • Attard, G.1    Sarker, D.2    Reid, A.3    Molife, R.4    Parker, C.5    de Bono, J.S.6
  • 24
    • 0032230358 scopus 로고    scopus 로고
    • Progression of LNCaP prostate tumor cells during androgen deprivation: hormone-independent growth, repression of proliferation by androgen, and role for p27Kip1 in androgen-induced cell cycle arrest
    • Kokontis J.M., Hay N., and Liao S. Progression of LNCaP prostate tumor cells during androgen deprivation: hormone-independent growth, repression of proliferation by androgen, and role for p27Kip1 in androgen-induced cell cycle arrest. Mol Endocrinol 12 (1998) 941-953
    • (1998) Mol Endocrinol , vol.12 , pp. 941-953
    • Kokontis, J.M.1    Hay, N.2    Liao, S.3
  • 25
    • 0032883932 scopus 로고    scopus 로고
    • Switch from antagonist to agonist of the androgen receptor bicalutamide is associated with prostate tumour progression in a new model system
    • Culig Z., Hoffmann J., Erdel M., Eder I.E., Hobisch A., Hittmair A., et al. Switch from antagonist to agonist of the androgen receptor bicalutamide is associated with prostate tumour progression in a new model system. Br J Cancer 81 (1999) 242-251
    • (1999) Br J Cancer , vol.81 , pp. 242-251
    • Culig, Z.1    Hoffmann, J.2    Erdel, M.3    Eder, I.E.4    Hobisch, A.5    Hittmair, A.6
  • 26
    • 0041633910 scopus 로고    scopus 로고
    • Interrogating androgen receptor function in recurrent prostate cancer
    • Zhang L., Johnson M., Le K.H., Sato M., Ilagan R., Iyer M., et al. Interrogating androgen receptor function in recurrent prostate cancer. Cancer Res 63 (2003) 4552-4560
    • (2003) Cancer Res , vol.63 , pp. 4552-4560
    • Zhang, L.1    Johnson, M.2    Le, K.H.3    Sato, M.4    Ilagan, R.5    Iyer, M.6
  • 27
    • 0026701521 scopus 로고
    • Fruit, vegetables and cancer prevention: a review of the epidemiological evidence
    • Block G., Patterson B., and Subar A. Fruit, vegetables and cancer prevention: a review of the epidemiological evidence. Nutr Cancer 18 (1992) 1-29
    • (1992) Nutr Cancer , vol.18 , pp. 1-29
    • Block, G.1    Patterson, B.2    Subar, A.3
  • 28
    • 7444220592 scopus 로고    scopus 로고
    • Large-scale purification of ellagitannins from pomegranate husk, a by-product of the commercial juice industry
    • Seeram N.P., Lee R., Hardy M.L., and Heber D. Large-scale purification of ellagitannins from pomegranate husk, a by-product of the commercial juice industry. Sep Purif Tech 41 (2005) 49-55
    • (2005) Sep Purif Tech , vol.41 , pp. 49-55
    • Seeram, N.P.1    Lee, R.2    Hardy, M.L.3    Heber, D.4
  • 29
    • 0037420189 scopus 로고    scopus 로고
    • The pomegranate: nature's power fruit?
    • Longtin R. The pomegranate: nature's power fruit?. J Natl Cancer Inst 95 (2003) 346-348
    • (2003) J Natl Cancer Inst , vol.95 , pp. 346-348
    • Longtin, R.1
  • 30
    • 33746073732 scopus 로고    scopus 로고
    • Phase II study of pomegranate juice for men with rising prostate-specific antigen following surgery or radiation for prostate cancer
    • Pantuck A.J., Leppert J.T., Zomorodian N., Aronson W., Hong J., Barnard R.J., et al. Phase II study of pomegranate juice for men with rising prostate-specific antigen following surgery or radiation for prostate cancer. Clin Cancer Res 12 (2006) 4018-4026
    • (2006) Clin Cancer Res , vol.12 , pp. 4018-4026
    • Pantuck, A.J.1    Leppert, J.T.2    Zomorodian, N.3    Aronson, W.4    Hong, J.5    Barnard, R.J.6
  • 31
    • 34948873551 scopus 로고    scopus 로고
    • Pomegranate ellagitannin-derived metabolites inhibit prostate cancer growth and localize to the mouse prostate gland
    • Seeram N.P., Aronson W., Zhang Y., Henning S.M., Moro A., Lee R., et al. Pomegranate ellagitannin-derived metabolites inhibit prostate cancer growth and localize to the mouse prostate gland. J Agric Food Chem 55 (2007) 7732-7737
    • (2007) J Agric Food Chem , vol.55 , pp. 7732-7737
    • Seeram, N.P.1    Aronson, W.2    Zhang, Y.3    Henning, S.M.4    Moro, A.5    Lee, R.6
  • 33
    • 0036141411 scopus 로고    scopus 로고
    • Androgen receptor expression and cellular proliferation during transition from androgen-dependent to recurrent growth after castration in the CWR22 prostate cancer xenograft
    • Kim D., Gregory C.W., French F.S., Smith G.J., and Mohler J.L. Androgen receptor expression and cellular proliferation during transition from androgen-dependent to recurrent growth after castration in the CWR22 prostate cancer xenograft. Am J Pathol 160 (2002) 219-226
    • (2002) Am J Pathol , vol.160 , pp. 219-226
    • Kim, D.1    Gregory, C.W.2    French, F.S.3    Smith, G.J.4    Mohler, J.L.5
  • 34
    • 33644675811 scopus 로고    scopus 로고
    • Biology of progressive, castration-resistant prostate cancer: directed therapies targeting the androgen-receptor signaling axis
    • Scher H.I., and Sawyers C.L. Biology of progressive, castration-resistant prostate cancer: directed therapies targeting the androgen-receptor signaling axis. J Clin Oncol 23 (2005) 8253-8261
    • (2005) J Clin Oncol , vol.23 , pp. 8253-8261
    • Scher, H.I.1    Sawyers, C.L.2
  • 35
    • 31544451068 scopus 로고    scopus 로고
    • Interplay between two hormone-independent activation domains in the androgen receptor
    • Callewaert L., Van Tilborgh N., and Claessens F. Interplay between two hormone-independent activation domains in the androgen receptor. Cancer Res 66 (2006) 543-553
    • (2006) Cancer Res , vol.66 , pp. 543-553
    • Callewaert, L.1    Van Tilborgh, N.2    Claessens, F.3
  • 36
    • 0030801333 scopus 로고    scopus 로고
    • Genetic variation of 3 beta-hydroxysteroid dehydrogenase type II in three racial/ethnic groups: implications for prostate cancer risk
    • Devgan S.A., Henderson B.E., Yu M.C., Shi C.Y., Pike M.C., Ross R.K., et al. Genetic variation of 3 beta-hydroxysteroid dehydrogenase type II in three racial/ethnic groups: implications for prostate cancer risk. Prostate 33 (1997) 9-12
    • (1997) Prostate , vol.33 , pp. 9-12
    • Devgan, S.A.1    Henderson, B.E.2    Yu, M.C.3    Shi, C.Y.4    Pike, M.C.5    Ross, R.K.6
  • 37
    • 33645987281 scopus 로고    scopus 로고
    • Increased expression of type 2 3alpha-hydroxysteroid dehydrogenase/type 5 17beta-hydroxysteroid dehydrogenase (AKR1C3) and its relationship with androgen receptor in prostate carcinoma
    • Fung K.M., Samara E.N., Wong C., Metwalli A., Krlin R., Bane B., et al. Increased expression of type 2 3alpha-hydroxysteroid dehydrogenase/type 5 17beta-hydroxysteroid dehydrogenase (AKR1C3) and its relationship with androgen receptor in prostate carcinoma. Endocr Relat Cancer 13 (2006) 169-180
    • (2006) Endocr Relat Cancer , vol.13 , pp. 169-180
    • Fung, K.M.1    Samara, E.N.2    Wong, C.3    Metwalli, A.4    Krlin, R.5    Bane, B.6
  • 38
    • 0037904913 scopus 로고    scopus 로고
    • Development of a quantitative RT-PCR method to study 5alpha-reductase mRNA isozymes in rat prostate in different androgen status
    • Torres J.M., Ruiz E., and Ortega E. Development of a quantitative RT-PCR method to study 5alpha-reductase mRNA isozymes in rat prostate in different androgen status. Prostate 56 (2003) 74-79
    • (2003) Prostate , vol.56 , pp. 74-79
    • Torres, J.M.1    Ruiz, E.2    Ortega, E.3
  • 39
    • 33645056171 scopus 로고    scopus 로고
    • Increased expression of genes converting adrenal androgens to testosterone in androgen-independent prostate cancer
    • Stanbrough M., Bubley G.J., Ross K., Golub T.R., Rubin M.A., Penning T.M., et al. Increased expression of genes converting adrenal androgens to testosterone in androgen-independent prostate cancer. Cancer Res 66 (2006) 2815-2825
    • (2006) Cancer Res , vol.66 , pp. 2815-2825
    • Stanbrough, M.1    Bubley, G.J.2    Ross, K.3    Golub, T.R.4    Rubin, M.A.5    Penning, T.M.6
  • 40
    • 0035652497 scopus 로고    scopus 로고
    • 5alpha-reductase activity in the prostate
    • Steers W.D. 5alpha-reductase activity in the prostate. Urology 58 (2001) 17-24
    • (2001) Urology , vol.58 , pp. 17-24
    • Steers, W.D.1
  • 42
    • 33749235692 scopus 로고    scopus 로고
    • Characterization of brain neurons that express enzymes mediating neurosteroid biosynthesis
    • Agís-Balboa R.C., Pinna G., Zhubi A., Maloku E., Veldic M., Costa E., et al. Characterization of brain neurons that express enzymes mediating neurosteroid biosynthesis. Proc Natl Acad Sci U S A 103 (2006) 14602-14607
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 14602-14607
    • Agís-Balboa, R.C.1    Pinna, G.2    Zhubi, A.3    Maloku, E.4    Veldic, M.5    Costa, E.6
  • 43
    • 0033995108 scopus 로고    scopus 로고
    • Phenotypic variability and origins of mutations in the gene encoding 3beta-hydroxysteroid dehydrogenase type II
    • McCartin S., Russell A.J., Fisher R.A., Wallace A.M., Arnhold I.J., Mason J.I., et al. Phenotypic variability and origins of mutations in the gene encoding 3beta-hydroxysteroid dehydrogenase type II. J Mol Endocrinol 24 (2000) 75-82
    • (2000) J Mol Endocrinol , vol.24 , pp. 75-82
    • McCartin, S.1    Russell, A.J.2    Fisher, R.A.3    Wallace, A.M.4    Arnhold, I.J.5    Mason, J.I.6
  • 44
    • 0029922644 scopus 로고    scopus 로고
    • Differential control of 17 alpha-hydroxylase and 3 beta-hydroxysteroid dehydrogenase expression in human adrenocortical H295R cells
    • Bird I.M., Pasquarette M.M., Rainey W.E., and Mason J.I. Differential control of 17 alpha-hydroxylase and 3 beta-hydroxysteroid dehydrogenase expression in human adrenocortical H295R cells. J Clin Endocrinol Metab 81 (1996) 2171-2178
    • (1996) J Clin Endocrinol Metab , vol.81 , pp. 2171-2178
    • Bird, I.M.1    Pasquarette, M.M.2    Rainey, W.E.3    Mason, J.I.4
  • 45
    • 1642305724 scopus 로고    scopus 로고
    • Human cytosolic 3α-hydroxysteroid dehydrogenases of the aldo-keto reductase superfamily display significant 3β-hydroxysteroid dehydrogenase activity
    • Steckelbroeck S., Jin Y., Gopishetty S., Oyesanmi B., and Penning T.M. Human cytosolic 3α-hydroxysteroid dehydrogenases of the aldo-keto reductase superfamily display significant 3β-hydroxysteroid dehydrogenase activity. J Biol Chem 279 (2004) 10784-10795
    • (2004) J Biol Chem , vol.279 , pp. 10784-10795
    • Steckelbroeck, S.1    Jin, Y.2    Gopishetty, S.3    Oyesanmi, B.4    Penning, T.M.5
  • 46
    • 0032697032 scopus 로고    scopus 로고
    • Regulation of HSD17B1 and SRD5A1 in lymphocytes
    • Zhou Z., and Speiser P.W. Regulation of HSD17B1 and SRD5A1 in lymphocytes. Mol Genet Metab 68 (1999) 410-417
    • (1999) Mol Genet Metab , vol.68 , pp. 410-417
    • Zhou, Z.1    Speiser, P.W.2
  • 47
    • 13844262629 scopus 로고    scopus 로고
    • Comparative effects of DHEA vs. testosterone, dihydrotestosterone, and estradiol on proliferation and gene expression in human LNCaP prostate cancer cells
    • Arnold J.T., Le H., McFann K.K., and Blackman M.R. Comparative effects of DHEA vs. testosterone, dihydrotestosterone, and estradiol on proliferation and gene expression in human LNCaP prostate cancer cells. Am J Physiol Endocrinol Metab 288 (2005) E573-E584
    • (2005) Am J Physiol Endocrinol Metab , vol.288
    • Arnold, J.T.1    Le, H.2    McFann, K.K.3    Blackman, M.R.4
  • 48
    • 29344465951 scopus 로고    scopus 로고
    • Effect of increasing ratio of estrogen:androgen on proliferation of normal human prostate stromal and epithelial cells, and the malignant cell line LNCaP
    • King K.J., Nicholson H.D., and Assinder S.J. Effect of increasing ratio of estrogen:androgen on proliferation of normal human prostate stromal and epithelial cells, and the malignant cell line LNCaP. Prostate 66 (2006) 105-114
    • (2006) Prostate , vol.66 , pp. 105-114
    • King, K.J.1    Nicholson, H.D.2    Assinder, S.J.3
  • 49
    • 1842668004 scopus 로고    scopus 로고
    • Interleukin-6 promotes androgen-independent growth in LNCaP human prostate cancer cells
    • Lee S.O., Lou W., Hou M., de Miguel F., Gerber L., and Gao A.C. Interleukin-6 promotes androgen-independent growth in LNCaP human prostate cancer cells. Clin Cancer Res 9 (2003) 370-376
    • (2003) Clin Cancer Res , vol.9 , pp. 370-376
    • Lee, S.O.1    Lou, W.2    Hou, M.3    de Miguel, F.4    Gerber, L.5    Gao, A.C.6
  • 50
    • 85047675514 scopus 로고    scopus 로고
    • 3 actions in LNCaP human prostate cancer cells are androgen-dependent
    • 3 actions in LNCaP human prostate cancer cells are androgen-dependent. Endocrinology 138 (1997) 3290-3298
    • (1997) Endocrinology , vol.138 , pp. 3290-3298
    • Zhao, X.Y.1    Ly, L.H.2    Peehl, D.M.3    Feldman, D.4
  • 51
    • 33645243020 scopus 로고    scopus 로고
    • Prostate cancer prevention through pomegranate fruit
    • Malik A., and Mukhtar H. Prostate cancer prevention through pomegranate fruit. Cell Cycle 5 (2006) 371-373
    • (2006) Cell Cycle , vol.5 , pp. 371-373
    • Malik, A.1    Mukhtar, H.2
  • 52
    • 20144381777 scopus 로고    scopus 로고
    • In vitro antiproliferative, apoptotic and antioxidant activities of punicalagin, ellagic acid and a total pomegranate tannin extract are enhanced in combination with other polyphenols as found in pomegranate juice
    • Seeram N.P., Adams L.S., Henning S.M., Niu Y., Zhang Y., Nair M.G., et al. In vitro antiproliferative, apoptotic and antioxidant activities of punicalagin, ellagic acid and a total pomegranate tannin extract are enhanced in combination with other polyphenols as found in pomegranate juice. J Nutr Biochem 16 (2005) 360-367
    • (2005) J Nutr Biochem , vol.16 , pp. 360-367
    • Seeram, N.P.1    Adams, L.S.2    Henning, S.M.3    Niu, Y.4    Zhang, Y.5    Nair, M.G.6


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