Synthesis and biological evaluation of 4β-sulphonamido and 4β-[(4′-sulphonamido)benzamide]podophyllotoxins as DNA topoisomerase-IIα and apoptosis inducing agents

Bioorganic and Medicinal Chemistry

Volumn 20, Issue 6, 2012, Pages 2054-2066

  Kamal, Ahmed ^a   Suresh, Paidakula ^a   Ramaiah, M Janaki ^a   Mallareddy, Adla ^a   Imthiajali, Syed ^a   Pushpavalli, S N C V L ^a   Lavanya, A ^a   Pal Bhadra, Manika ^a  

^a INDIAN INSTITUTE OF CHEMICAL TECHNOLOGY   (India)

Author keywords

Anticancer activity; Cell cycle; Comet assay; Etoposide; Topo II enzyme

Indexed keywords

4BETA [(4' SULPHONAMIDO)BENZAMIDE]PODOPHYLLOTOXIN DERIVATIVE; 4BETA [2 ACETAMIDO 4 METHYLTHIAZOLE 5 SULPHONAMIDO]PODOPHYLLOTOXIN; 4BETA [2,5 DICHLOROTHIOPHENE 3 SULPHONAMIDO]PODOPHYLLOTOXIN; 4BETA [4 PHENOXYBENZENE 1 SULPHONAMIDO]PODOPHYLLOTOXIN; 4BETA [4' (5 BROMOTHIOPHENE 2 SULPHONAMIDO)BENZAMIDE]PODOPHYLLOTOXIN; 4BETA [4' (BENZO[C][1,2,5]THIADIAZOLE 4 SULPHONAMIDO)BENZAMIDE]PODOPHYLLOTOXIN; 4BETA [4' (NAPHTHALENE 1 SULPHONAMIDO)BENZAMIDE]PODOPHYLLOTOXIN; 4BETA [5 (PHENYLSULPHONYL)THIOPHENE 2 SULPHONAMIDO]PODOPHYLLOTOXIN; 4BETA [5 BROMOTHIOPHENE 2 SULPHONAMIDO]PODOPHYLLOTOXIN; 4BETA [BENZO[C][1,2,5]THIADIAZOLE 4 SULPHONAMIDO]PODOPHYLLOTOXIN; 4BETA [BIPHENYL 4 SULPHONAMIDO]PODOPHYLLOTOXIN; 4BETA [METHYL 3 (SULPHONAMIDO)THIOPHENE 2 CARBOXYLATE]PODOPHYLLOTOXIN; 4BETA [NAPHTHALENE 1 SULPHONAMIDO]PODOPHYLLOTOXIN; 4BETA [QUINOLINE 8 SULPHONAMIDO]PODOPHYLLOTOXIN; 4BETA SULPHONAMIDO BENZAMIDE PODOPHYLLOTOXIN DERIVATIVE; ANTINEOPLASTIC AGENT; ATM PROTEIN; CASPASE 3; CHECKPOINT KINASE 1; DNA; DOXORUBICIN; ETOPOSIDE; GAMMA HISTONE H2AX; GYRASE INHIBITOR; HISTONE H2AX; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PROTEIN BCL 2; PROTEIN P16; PROTEIN P21; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; COLON CANCER; COMET ASSAY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOUBLE STRANDED DNA BREAK; DRUG CYTOTOXICITY; DRUG EFFICACY; DRUG POTENCY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVATION; ENZYME INHIBITION; FLOW CYTOMETRY; G2 PHASE CELL CYCLE CHECKPOINT; HUMAN; HUMAN CELL; IN VITRO STUDY; SINGLE STRANDED DNA BREAK; WESTERN BLOTTING;

ANTIGENS, NEOPLASM; ANTINEOPLASTIC AGENTS; APOPTOSIS; BENZAMIDES; CELL CYCLE; CELL LINE, TUMOR; COMET ASSAY; DNA BREAKS; DNA TOPOISOMERASES, TYPE II; DNA-BINDING PROTEINS; DRUG SCREENING ASSAYS, ANTITUMOR; ETOPOSIDE; HUMANS; NEOPLASMS; PODOPHYLLOTOXIN; PODOPHYLLUM;

CITRUS MACROPHYLLA;

EID: 84857921837     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2012.01.039     Document Type: Article

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