Synthesis of 4β-N-polyaromatic substituted podophyllotoxins: DNA topoisomerase inhibition, anticancer and apoptosis-inducing activities

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 24, 2010, Pages 8493-8500

  Kamal, Ahmed ^a   Kumar, B Ashwini ^a   Suresh, Paidakula ^a   Agrawal, Satyam Kumar ^b   Chashoo, Gousia ^b   Singh, Shashank K ^b   Saxena, A K ^b  

^a INDIAN INSTITUTE OF CHEMICAL TECHNOLOGY   (India)

^b CSIR INDIAN INSTITUTE OF INTEGRATIVE MEDICINE   (India)

Author keywords

Anticancer activity; Apoptosis; DNA topoisomerase inhibition; Etoposide; Podophyllotoxin; Polyarylamines

Indexed keywords

4' O DEMETHYL 4BETA (1'' ANTHRYLAMINO) 4 DESOXYPODOPHYLLOTOXIN; 4' O DEMETHYL 4BETA (1'' CHRYCENYLAMINO) 4 DESOXYPODOPHYLLOTOXIN; 4' O DEMETHYL 4BETA (1'' FLUORENYLAMINO) 4 DESOXYPODOPHYLLOTOXIN; 4' O DEMETHYL 4BETA (1'' PYRENYLAMINO) 4 DESOXYPODOPHYLLOTOXIN; 4' O DEMETHYL 4BETA [4'' (4'' FLUOROBENZOYL)ANILINO] 4 DESOXYPODOPHYLLOTOXIN; 4' O DEMETHYL 4BETA [4'' [4'' [DI(2'' CHLOROETHYL)AMINO]BENZOYL]ANILINO] 4 DESOXY PODOPHYLLOTOXIN; 4BETA (1'' FLUORENYLAMINO) 4 DESOXYPODOPHYLLOTOXIN; 4BETA (1'' PYRENYLAMINO) 4 DESOXYPODOPHYLLOTOXIN; 4BETA (1''ANTHRYLAMINO) 4 DESOXYPODOPHYLLOTOXIN; 4BETA (6'' CHRYCENYLAMINO) 4 DESOXYPODOPHYLLOTOXIN; 4BETA [4'' (4'' FLUOROBENZOYL)ANILINO] 4 DESOXYPODOPHYLLOTOXIN; 4BETA [4'' [4'' [DI(2'' CHLOROETHYL)AMINO]BENZOYL]ANILINO] 4 DESOXYPODOPHYLLOTOXIN; ANTINEOPLASTIC AGENT; CAMPTOTHECIN; DNA TOPOISOMERASE INHIBITOR; ETOPOSIDE; FLUOROURACIL; PODOPHYLLOTOXIN DERIVATIVE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL LINE, TUMOR; DNA TOPOISOMERASES, TYPE II; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; PODOPHYLLOTOXIN; TOPOISOMERASE II INHIBITORS;

EID: 78649448073     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2010.10.042     Document Type: Article

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