Deletion of growth hormone receptor gene but not visceral fat removal decreases expression of apoptosis-related genes in the kidney - Potential mechanism of lifespan extension

Age

Volumn 34, Issue 2, 2012, Pages 295-304

  Gesing, Adam ^a,b   Masternak, Michal M ^a,c   Wang, Feiya ^a   Karbownik Lewinska, Malgorzata ^b,d   Bartke, Andrzej ^a  

^a SOUTHERN ILLINOIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b MEDICAL UNIVERSITY OF LODZ   (Poland)

^c INSTITUTE OF HUMAN GENETICS   (Poland)

^d POLISH MOTHER S MEMORIAL HOSPITAL RESEARCH INSTITUTE   (Poland)

Author keywords

Apoptosis; Caspases; Gene expression; GHRKO mice; Kidney; Visceral fat removal

Indexed keywords

APOPTOTIC PROTEASE ACTIVATING FACTOR 1; CASPASE 3; CASPASE 8; CASPASE 9; CYTOCHROME C1; GROWTH HORMONE RECEPTOR; PROTEIN BAD; PROTEIN BAX; PROTEIN BCL 2; PROTEIN P53; SECOND MITOCHONDRIAL ACTIVATOR OF CASPASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CONTROLLED STUDY; ENDOCRINE DISEASE; FEMALE; GENE DELETION; GENE EXPRESSION REGULATION; INTRAABDOMINAL FAT; KIDNEY; LIFE EXTENSION; MALE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE;

AGING; ANIMALS; APOPTOSIS; APOPTOTIC PROTEASE-ACTIVATING FACTOR 1; CALORIC RESTRICTION; FEMALE; GENE DELETION; GENE EXPRESSION; INTRA-ABDOMINAL FAT; KIDNEY; LONGEVITY; MALE; MICE; MICE, KNOCKOUT; RATS; REAL-TIME POLYMERASE CHAIN REACTION; RECEPTORS, SOMATOTROPIN; RNA; SIGNAL TRANSDUCTION;

EID: 84857920047     PISSN: 01619152     EISSN: 15744647     Source Type: Journal    
DOI: 10.1007/s11357-011-9232-6     Document Type: Article

References (46)

1. Ali SM, Wong VY, Kikly K, Fredrickson TA, Keller PM, DeWolf WE Jr, Lee D, Brooks DP (2000) Apoptosis in polycystic kidney disease: involvement of caspases. Am J Physiol Regul Integr Comp Physiol 278:R763-R769 (Pubitemid 30158139)
2. Bartke A, Brown-Borg H (2004) Life extension in the dwarf mouse. Curr Top Dev Biol 63:189-225. doi:10.1016/S0070-2153(04)63006-7 (Pubitemid 39752388)
3. Bartke A, Chandrashekar V, Bailey B, Zaczek D, Turyn D (2002) Consequences of growth hormone (GH) overexpression and GH resistance. Neuropeptides 36:201-208. doi:10.1054/npep.2002.0889
4. Barton M, Lattmann T, d'Uscio LV, Luscher TF, Shaw S (2000) Inverse regulation of endothelin-1 and nitric oxide metabolites in tissue with aging: implications for the age-dependent increase of cardiorenal disease. J Cardiovasc Pharmacol 36(5 Suppl 1):S153-S156
5. Barzilai N, She L, Liu B-Q, Vuguin P, Cohen P,Wang J, Rossetti L (1999) Surgical removal of visceral fat reverses hepatic insulin resistance. Diabetes 48:94-98. doi:10.2337/diabetes.48.1.94 (Pubitemid 29019357)
6. Berryman DE, List EO, Coschigano KT, Behar K, Kim JK, Kopchick JJ (2004) Comparing adiposity profiles in three mouse models with altered GH signaling. Growth Horm IGF Res 14:309-318. doi:10.1016/j.ghir.2004.02.005 (Pubitemid 38878057)
7. Boatright KM, Salvesen GS (2003) Mechanisms of caspase activation. Curr Opin Cell Biol 15:725-731. doi:10.1016/j.ceb.2003.10.009 (Pubitemid 37492933)
8. Budihardjo I, Oliver H, Lutter M, Luo X, Wang X (1999) Biochemical pathways of caspase activation during apoptosis. Annu Rev Cell Dev Biol 15:269-290. doi:10.1146/annurev.cellbio.15.1.269 (Pubitemid 32250377)
9. Chomczynski P, Sacchi N (1987) Single-step method of RNA isolation by acid guanidinium thiocyanate-phenolchloroform extraction. Anal Biochem 162:156-159. doi:10.1016/0003-2697(87)90021-2 (Pubitemid 17064313)
10. Coschigano KT (2006) Aging-related characteristics of growth hormone receptor/binding protein gene-disrupted mice. AGE 28:191-200. doi:10.1007/s11357-006-9004-x
11. Coschigano KT, Clemmons D, Bellush LL, Kopchick JJ (2000) Assessment of growth parameters and life span of GHR/BP gene disrupted mice. Endocrinology 141:2608-2613 (Pubitemid 32269083)
12. Coschigano KT, Holland AN, Riders ME, List EO, Flyvbjerg A, Kopchick JJ (2003) Deletion, but not antagonism, of the mouse growth hormone receptor results in severely decreased body weights, insulin, and insulin-like growth factor I levels and increased lifespan. Endocrinology 144:3799-3810. doi:10.1210/en.2003-0374 (Pubitemid 37088732)
13. Doi T, Striker LJ, Quaife C, Conti FG, Palmiter R, Behringer R, Brinster R, Striker GE (1988) Progressive glomerulosclerosis develops in transgenic mice chronically expressing growth hormone and growth hormone releasing factor but not in those expressing insulinlike growth factor-1. Am J Pathol 131:398-403
14. Fasshauer M, Paschke R (2003) Regulation of adipocytokines and insulin resistance. Diabetologia 46:1594-1603. doi:10.1007/s00125-003-1228-z (Pubitemid 38005321)
15. Faubel S, Edelstein CL (2005) Caspases as drug targets in ischemic organ injury. Curr Drug Targets Immune Endocr Metabol Disord 5:269-287. doi:10.2174/1568008054863754 (Pubitemid 41131706)
16. Gesing A, Masternak MM, Wang F, Lewinski A, Karbownik-Lewinska M, Bartke A (2011) Decreased expression level of apoptosis-related genes and/or proteins in skeletal muscles, but not in hearts, of growth hormone receptor knockout mice. Exp Biol Med 236:156-168. doi:10.1258/ebm.2010.010202
17. Ghosh S, Khazaei M, Moien-Afshari F, Ang LS, Granville DJ, Verchere CB, Dunn SR, McCue P, Mizisin A, Sharma K, Laher I (2009) Moderate exercise attenuates caspase-3 activity, oxidative stress, and inhibits progression of diabetic renal disease in db/db mice. Am J Physiol Renal Physiol 296:F700-F708. doi:10.1152/ajprenal.90548.2008
18. Gross A, McDonnell JM, Korsmeyer SJ (1999) BCL-2 family members and the mitochondria in apoptosis. Genes Dev 13:1899-1911 (Pubitemid 29407357)
19. Harper JM, Salmon AB, Chang Y, Bonkowski M, Bartke A, Miller RA (2006) Stress resistance and aging: influence of genes and nutrition. Mech Ageing Dev 127:687-694. doi:10.1016/j.mad.2006.04.002
20. Hickman ES, Helin K (2002) The regulation of APAF1 expression during development and tumourigenesis. Apoptosis 7:167-171. doi:10.1023/A:1014370616864 (Pubitemid 34273132)
21. Holland WL, Miller RA, Wang ZV, Sun K, Barth BM, Bui HH, Davis KE, Bikman BT, Halberg N, Rutkowski JM, Wade MR, Tenorio VM, Kuo M-S, Brozinick JT, Zhang BB, Birnbaum MJ, Summers SA, Scherer PE (2011) Receptor-mediated activation of ceramidase activity initiates the pleiotropic actions of adiponectin. Nat Med 17:55-63. doi:10.1038/nm.2277
22. Ikeno Y, Hubbard GB, Lee S, Cortez LA, Lew CM, Webb CR, Berryman DE, List EO, Kopchick JJ, Bartke A (2009) Reduced incidence and delayed occurrence of fatal neoplastic diseases in growth hormone receptor/binding protein knockout mice. J Gerontol A Biol Sci Med Sci 64:522-529. doi:10.1093/gerona/glp017
23. Jin Z, El-Deiry WS (2005) Overview of cell death signaling pathways. Cancer Biol Ther 4:139-163 (Pubitemid 41351311)
24. Kopchick JJ, Laron Z (1999) Is the Laron mouse an accurate model of Laron syndrome ? Mol Genet Metab 68:232-236. doi:10.1006/mgme.1999.2890 (Pubitemid 29501095)
25. Lagathu C, Bastard JP, Auclair M, Maachi M, Capeau J, Caron M (2003) Chronic interleukin-6 (IL-6) treatment increased IL-6 secretion and induced insulin resistance in adipocyte: prevention by rosiglitazone. Biochem Biophys Res Commun 311:372-379. doi:10.1016/j.bbrc.2003.10.013 (Pubitemid 37340087)
26. Liu JL, Coschigano KT, Robertson K, Lipsett M, Guo Y, Kopchick JJ, Kumar U, Liu YL (2004) Disruption of growth hormone receptor gene causes diminished pancreatic islet size and increased insulin sensitivity in mice. Am J Physiol Endocrinol Metab 287:E405-E413. doi:10.1152/ajpendo.00423.2003 (Pubitemid 39095873)
27. Masternak MM, Al-Regaiey KA, Del Rosario Lim MM, Jimenez-Ortega V, Panici JA, Bonkowski MS, Kopchick JJ, Wang Z, Bartke A (2006) Caloric restriction and growth hormone receptor knockout: effects on expression of genes involved in insulin action in the heart. Exp Gerontol 41:417-429. doi:10.1016/j.exger.2006. 01.009
28. Mishra R, Emancipator SN, Kern T, Simonson MS (2005) High glucose evokes an intrinsic proapoptotic signaling pathway in mesangial cells. Kidney Int 67:82-93. doi:10.1111/j.1523-1755.2005.00058.x (Pubitemid 40019229)
29. -) on physiological aging in C57BL/6J mice. J Radiat Res 50:73-82. doi:10.1269/jrr.08097
30. Moien-Afshari F, Ghosh S, Khazaei M, Kieffer TJ, Brownsey RW, Laher I (2008) Exercise restores endothelial function independently of weight loss or hyperglycemic status in db/db mice. Diabetologia 51:1327-1337. doi:10.1007/s00125-008-0996-x
31. Murata Y, Rydevik B, Nannmark U, Larsson K, Takahashi K, Kato Y, Olmarker K (2010) Local application of interleukin-6 to the dorsal root ganglion induces tumor necrosis factor-alpha in the dorsal root ganglion and results in apoptosis of the dorsal root ganglion cells. Spine. doi:10.1097/BRS. 0b013e3181e7f4a9
32. Muzumdar R, Allison DB, Huffman DM, Ma X, Atzmon G, Einstein FH, Fishman S, Poduval AD, McVei T, Keith S, Barzilai N (2008) Visceral adipose tissue modulates mammalian longevity. Aging Cell 7:438-440. doi:10.1111/j.1474-9726. 2008.00391.x (Pubitemid 351663912)
33. Ortiz A, Ziyadeh FN, Neilson EG (1997) Expression of apoptosis-regulatory genes in renal proximal tubular epithelial cells exposed to high ambient glucose and in diabetic kidneys. J Investig Med 45:50-56 (Pubitemid 127453337)
34. Percy CJ, Power D, Gobe GC (2008) Renal ageing: changes in the cellular mechanisms of energy metabolism and oxidant handling. Nephrology 13:147-152. doi:10.1111/j.1440-1797.2008.00924.x (Pubitemid 351229633)
35. Salmon AB, Murakami S, Bartke A, Kopchick JJ, Yasumura K, Miller RA (2005) Fibroblast cell lines from young adult mice of long-lived mutant strains are resistant to multiple forms of stress. Am J Physiol Endocrinol Metab 289:E23-E29. doi:10.1152/ajpendo.00575.2004 (Pubitemid 40874930)
36. Shi H, Strader AD, Woods SC, Seeley RJ (2007) The effect of fat removal on glucose tolerance is depot specific in male and female mice. Am J Physiol Endocrinol Metab 293: E1012-E1020. doi:10.1152/ajpendo.00649.2006 (Pubitemid 47535832)
37. Sishi BJN, Engelbrecht A-M (2011) Tumor necrosis factor alpha (TNF-α) inactivates the PI3-kinase/PKB pathway and induces atrophy and apoptosis in L6 myotubes. Cytokine. doi:10.1016/j.cyto.2011.01.009
38. Sun LY, Steinbaugh MJ, Masternak MM, Bartke A, Miller RA (2009) Fibroblasts from long-lived mutant mice showdiminished ERK1/2 phosphorylation but exaggerated induction of immediate early genes. Free Radic Biol Med 47:1753-1761. doi:10.1016/j.freeradbiomed.2009.09.021
39. Tao Y, Kim J, Faubel S, Wu JC, Falk SA, Schrier RW, Edelstein CL (2005) Caspase inhibition reduces tubular apoptosis and proliferation and slows disease progression in polycystic kidney disease. Proc Natl Acad Sci USA 102:6954-6959. doi:10.1073/pnas.0408518102 (Pubitemid 40675423)
40. Tao Y, Zafar I, Kim J, Schrier RW, Edelstein CL (2008) Caspase-3 gene deletion prolongs survival in polycystic kidney disease. J Am Soc Nephrol 19:749-755. doi:10.1681/ASN.2006121378
41. Wang Z, Havasi A, Gall JM, Mao H, Schwartz JH, Borkan SC (2009) β-catenin promotes survival of renal epithelial cells by inhibiting bax. J Am Soc Nephrol 20:1919-1928. doi:10.1681/ASN.2009030253
42. Yang H, Fogo AB (2010) Cell senescence in the aging kidney. JAm Soc Nephrol 21:1436-1439. doi:10.1681/ASN.2010020205
43. Zhang HH, Kumar S, Barnett AH, Eggo MC (2001) Dexamethasone inhibits tumor necrosis factor-alpha-induced apoptosis and interleukin-1 beta release in human subcutaneous adipocytes and preadipocytes. J Clin Endocrinol Metab 86:2817-2825. doi:10.1210/jc.86.6.2817 (Pubitemid 32545745)
44. Zhang X, Zheng X, Sun H, Feng B, Chen G, Vladau C, Li M, Chen D, Suzuki M, Min L, Liu W, Garcia B, Zhong R, Min WP (2006) Prevention of renal ischemic injury by silencing the expression of renal caspase 3 and caspase 8. Transplantation 82:1728-1732. doi:10.1097/01.tp.0000250764.17636.ba (Pubitemid 46035659)
45. Zheng F, Cheng Q-L, Plati A-R, Ye SQ, Berho M, Banerjee A, Potier M, Jaimes EA, Yu H, Guan Y-F, Hao C-M, Striker LJ, Striker GE (2004) The glomerulosclerosis of aging in females: contribution of the proinflammatory mesangial cell phenotype to macrophage infiltration. Am J Pathol 165:1789-1798 (Pubitemid 39435176)
46. Zhou Y, Xu BC, Maheshwari HG, He L, Reed M, Lozykowski M, Okada S, Cataldo L, Coschigano K, Wagner TE, Baumann G, Kopchick JJ (1997) A mammalian model for Laron syndrome produced by targeted disruption of the mouse growth hormone receptor/binding protein gene (the Laron mouse). Proc Natl Acad Sci USA 94:13215-13220 (Pubitemid 27518502)