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Volumn 32, Issue 2, 2012, Pages 153-164

Evidence-based medicine versus personalized medicine: Are they enemies?

Author keywords

[No Author keywords available]

Indexed keywords

ANTIDEPRESSANT AGENT; CARBAMAZEPINE; CYTOCHROME P450 2D6; DEXAMETHASONE; LITHIUM; NEUROLEPTIC AGENT; PLACEBO; PRESCRIPTION DRUG; RISPERIDONE; VALPROIC ACID;

EID: 84857852960     PISSN: 02710749     EISSN: 1533712X     Source Type: Journal    
DOI: 10.1097/JCP.0b013e3182491383     Document Type: Review
Times cited : (75)

References (148)
  • 1
    • 8044237061 scopus 로고
    • Clinical biostatistics. I. A new name and some other changes of the guard
    • Feinstein AR. Clinical biostatistics. I. A new name and some other changes of the guard. Clin Pharmacol Ther. 1970;11:135-148.
    • (1970) Clin Pharmacol Ther , vol.11 , pp. 135-148
    • Feinstein, A.R.1
  • 2
    • 67649262125 scopus 로고    scopus 로고
    • Pharmacokinetic drug interaction studies must consider pharmacological heterogeneity, use of repeated dosing, and translation into a message understandable to practicing clinicians
    • de Leon J, Spina E, Diaz FJ. Pharmacokinetic drug interaction studies must consider pharmacological heterogeneity, use of repeated dosing, and translation into a message understandable to practicing clinicians. J Clin Psychopharmacol. 2009;29:201-205.
    • (2009) J Clin Psychopharmacol , vol.29 , pp. 201-205
    • De Leon, J.1    Spina, E.2    Diaz, F.J.3
  • 3
    • 0035709586 scopus 로고    scopus 로고
    • Commentary: 'Medical art' versus 'medical science': J Civiale's statistical research on conditions caused by calculi at the Paris Academy of sciences in 1835
    • Tröhler U. Commentary: 'medical art' versus 'medical science': J Civiale's statistical research on conditions caused by calculi at the Paris Academy of Sciences in 1835. Int J Epidemiol. 2001;30:1252-1253. (Pubitemid 34134267)
    • (2001) International Journal of Epidemiology , vol.30 , Issue.6 , pp. 1252-1253
    • Trohler, U.1
  • 4
    • 0028955811 scopus 로고
    • Evidence based medicine: Socratic dissent
    • Grahame-Smith D. Evidence based medicine: Socratic dissent. BMJ. 1995;310:1126-1127.
    • (1995) BMJ , vol.310 , pp. 1126-1127
    • Grahame-Smith, D.1
  • 5
    • 0030459658 scopus 로고    scopus 로고
    • Evidence-based medicine and "médecine d'observation"
    • Vandenbroucke JP. Evidence-based medicine and "médecine d'observation." J Clin Epidemiol. 1996;49:1335-1338.
    • (1996) J Clin Epidemiol , vol.49 , pp. 1335-1338
    • Vandenbroucke, J.P.1
  • 6
    • 41549117102 scopus 로고    scopus 로고
    • Observational research, randomised trials, and two views of medical science
    • Vandenbroucke JP. Observational research, randomised trials, and two views of medical science. PLoS Med. 2008;5:e67.
    • (2008) PLoS Med , vol.5
    • Vandenbroucke, J.P.1
  • 7
    • 0032480540 scopus 로고    scopus 로고
    • Clinical investigation in the 20th century: The ascendancy of numerical reasoning
    • Vandenbroucke JP. Clinical investigation in the 20th century: the ascendancy of numerical reasoning. Lancet. 1998;352(suppl 2): SII12-SII16. (Pubitemid 128646431)
    • (1998) Lancet , vol.352 , Issue.SUPPL. 2
    • Vandenbroucke, J.P.1
  • 8
    • 55349106945 scopus 로고    scopus 로고
    • Individualized population care: Linking personal care to population care in general practice
    • Buetow S, Getz L, Adams P. Individualized population care: linking personal care to population care in general practice. J Eval Clin Pract. 2008;14:761-766.
    • (2008) J Eval Clin Pract , vol.14 , pp. 761-766
    • Buetow, S.1    Getz, L.2    Adams, P.3
  • 10
    • 0030027092 scopus 로고    scopus 로고
    • Evidence based medicine: What it is and what it isn't
    • Sackett DL, Rosenberg WM, Gray JA, et al. Evidence based medicine: what it is and what it isn't. BMJ. 1996;312:71-72.
    • (1996) BMJ , vol.312 , pp. 71-72
    • Sackett, D.L.1    Rosenberg, W.M.2    Gray, J.A.3
  • 11
    • 0031008748 scopus 로고    scopus 로고
    • Evidence-based medicine: Old French wine with a new Canadian label?
    • Rangachari PK. Evidence-based medicine: old French wine with a new Canadian label? J R Soc Med. 1997;90:280-284. (Pubitemid 27215998)
    • (1997) Journal of the Royal Society of Medicine , vol.90 , Issue.5 , pp. 280-284
    • Rangachari, P.K.1
  • 12
    • 15244352815 scopus 로고    scopus 로고
    • Evidence-based medicine is rooted in Protestant exegesis
    • DOI 10.1016/j.mehy.2004.12.015
    • Gerber A, Lungen M, Lauterbach KW. Evidence-based medicine is rooted in Protestant exegesis. Med Hypotheses. 2005;64:1034-1038. (Pubitemid 40385966)
    • (2005) Medical Hypotheses , vol.64 , Issue.5 , pp. 1034-1038
    • Gerber, A.1    Lungen, M.2    Lauterbach, K.W.3
  • 13
    • 0028860015 scopus 로고
    • Applying overviews and meta-analyses at the bedside
    • Sackett DL. Applying overviews and meta-analyses at the bedside. J Clin Epidemiol. 1995;48:61-66.
    • (1995) J Clin Epidemiol , vol.48 , pp. 61-66
    • Sackett, D.L.1
  • 14
    • 0030040869 scopus 로고    scopus 로고
    • McMaster's pioneer in evidence-based medicine now spreading his message in England
    • Cohen L. McMaster's pioneer in evidence-based medicine now spreading his message in England. CMAJ. 1996;154:388-390. (Pubitemid 26057659)
    • (1996) Canadian Medical Association Journal , vol.154 , Issue.3 , pp. 388-390
    • Cohen, L.1
  • 15
    • 0037542782 scopus 로고    scopus 로고
    • Evidence-based medicine: An introduction for psychiatrists
    • Gray GE. Evidence-based medicine: an introduction for psychiatrists. J Psychiatr Pract. 2002;8:5-13.
    • (2002) J Psychiatr Pract , vol.8 , pp. 5-13
    • Gray, G.E.1
  • 16
    • 0026775637 scopus 로고
    • Evidence-based medicine. A new approach to teaching the practice of medicine
    • Evidence-Based Medicine Working Group
    • Evidence-Based Medicine Working Group. Evidence-based medicine. A new approach to teaching the practice of medicine. JAMA. 1992;268:2420-2425.
    • (1992) JAMA , vol.268 , pp. 2420-2425
  • 18
    • 7944237019 scopus 로고    scopus 로고
    • Evidence based medicine has come a long way
    • Guyatt G, Cook D, Haynes B. Evidence based medicine has come a long way. BMJ. 2004;329:990-991. (Pubitemid 39486247)
    • (2004) British Medical Journal , vol.329 , Issue.7473 , pp. 990-991
    • Guyatt, G.1    Cook, D.2    Haynes, B.3
  • 19
    • 70349283858 scopus 로고    scopus 로고
    • Archie Cochrane and his vision for evidence-based medicine
    • Shah HM, Chung KC. Archie Cochrane and his vision for evidence-based medicine. Plast Reconstr Surg. 2009;124:982-988.
    • (2009) Plast Reconstr Surg , vol.124 , pp. 982-988
    • Shah, H.M.1    Chung, K.C.2
  • 20
    • 85044810260 scopus 로고    scopus 로고
    • The struggle for clinical authority: Shifting ontologies and the politics of evidence
    • Jensen UJ. The struggle for clinical authority: shifting ontologies and the politics of evidence. BioSocieties. 2007;2:101-114.
    • (2007) BioSocieties , vol.2 , pp. 101-114
    • Jensen, U.J.1
  • 21
    • 0028884793 scopus 로고
    • The need for evidence-based medicine
    • Sackett DL, Rosenberg WM. The need for evidence-based medicine. J R Soc Med. 1995;88:620-624.
    • (1995) J R Soc Med , vol.88 , pp. 620-624
    • Sackett, D.L.1    Rosenberg, W.M.2
  • 22
    • 0035233167 scopus 로고    scopus 로고
    • Evidence-based medicine: A historical and international overview
    • Woolf S. Evidence-based medicine: a historical and international overview. Proc R Coll Physicians Edinb. 2001;31(suppl 9):39-41.
    • (2001) Proc R Coll Physicians Edinb , vol.31 , Issue.SUPPL. 9 , pp. 39-41
    • Woolf, S.1
  • 23
    • 3042663701 scopus 로고    scopus 로고
    • A philosophical analysis of the evidence-based medicine debate
    • Sehon SR, Stanley DE. A philosophical analysis of the evidence-based medicine debate. BMC Health Serv Res. 2003;3:14.
    • (2003) BMC Health Serv Res , vol.3 , pp. 14
    • Sehon, S.R.1    Stanley, D.E.2
  • 24
    • 7944222670 scopus 로고    scopus 로고
    • The essence of EBM
    • Reilly BM. The essence of EBM. BMJ. 2004;329:991-992. (Pubitemid 39486248)
    • (2004) British Medical Journal , vol.329 , Issue.7473 , pp. 991-992
    • Reilly, B.M.1
  • 25
    • 13444303884 scopus 로고    scopus 로고
    • Systematic review: The relationship between clinical experience and quality of health care
    • Choudry NK, Fletcher RH, Soumerai SB. Systematic review: the relationship between clinical experience and quality of health care. Ann Intern Med. 2005;142:260-273. (Pubitemid 40216243)
    • (2005) Annals of Internal Medicine , vol.142 , Issue.4 , pp. 260-273
    • Choudhry, N.K.1    Fletcher, R.H.2    Soumerai, S.B.3
  • 26
    • 23944476905 scopus 로고    scopus 로고
    • History and development of evidence-based medicine
    • DOI 10.1007/s00268-005-7910-1
    • Claridge JA, Fabian TC. History and development of evidence-based medicine. World J Surg. 2005;29:547-553. (Pubitemid 41187386)
    • (2005) World Journal of Surgery , vol.29 , Issue.5 , pp. 547-553
    • Claridge, J.A.1    Fabian, T.C.2
  • 27
    • 0031472453 scopus 로고    scopus 로고
    • What can clinicians contribute to mutual challenges in medical statistics
    • Feinstein AR. What can clinicians contribute to mutual challenges in medical statistics. J Clin Epidemiol. 1997;103:529-535.
    • (1997) J Clin Epidemiol , vol.103 , pp. 529-535
    • Feinstein, A.R.1
  • 28
    • 0029384042 scopus 로고
    • Evidence based medicine and ethics
    • Hope T. Evidence based medicine and ethics. J Med Ethics. 1995;21:259-260.
    • (1995) J Med Ethics , vol.21 , pp. 259-260
    • Hope, T.1
  • 29
    • 0141684982 scopus 로고    scopus 로고
    • Practical clinical trials: Increasing the value of clinical research for decision making in clinical and health policy
    • DOI 10.1001/jama.290.12.1624
    • Tunis SR, Stryer DB, Clancy CM. Practical clinical trials: increasing the value of clinical research for decision making in clinical and health policy. JAMA. 2003;290:1624-1632. (Pubitemid 37430387)
    • (2003) Journal of the American Medical Association , vol.290 , Issue.12 , pp. 1624-1632
    • Tunis, S.R.1    Stryer, D.B.2    Clancy, C.M.3
  • 30
    • 84855589229 scopus 로고    scopus 로고
    • Lack of replication of the association of low serum cholesterol and suicide attempts in another country opens more questions
    • de Leon J, Mallory P, Maw L, et al. Lack of replication of the association of low serum cholesterol and suicide attempts in another country opens more questions. Ann Clin Psychiatry. 2011;23:163-170.
    • (2011) Ann Clin Psychiatry , vol.23 , pp. 163-170
    • De Leon, J.1    Mallory, P.2    Maw, L.3
  • 31
    • 0030729014 scopus 로고    scopus 로고
    • Medicine based evidence, a prerequisite for evidence based medicine
    • Knottnerus A, Dinant GJ. Medicine based evidence, a prerequisite for evidence based medicine. BMJ. 1997;315:1109-1110. (Pubitemid 27470305)
    • (1997) British Medical Journal , vol.315 , Issue.7116 , pp. 1109-1110
    • Knottnerus, J.A.1    Dinant, G.J.2
  • 32
    • 14644388106 scopus 로고    scopus 로고
    • Obesity and associated complications in patients with severe mental illnesses: A cross sectional survey
    • Susce MT, Villanueva N, Diaz FJ, et al. Obesity and associated complications in patients with severe mental illnesses: a cross sectional survey. J Clin Psychiatry. 2005;66:167-173.
    • (2005) J Clin Psychiatry , vol.66 , pp. 167-173
    • Susce, M.T.1    Villanueva, N.2    Diaz, F.J.3
  • 33
    • 0031472453 scopus 로고    scopus 로고
    • Problems in the "evidence" of "evidence-based medicine"
    • Feinstein AR, Horwitz RI. Problems in the "evidence" of "evidence-based medicine." Am J Med. 1997;103:529-535.
    • (1997) Am J Med , vol.103 , pp. 529-535
    • Feinstein, A.R.1    Horwitz, R.I.2
  • 34
    • 34548575455 scopus 로고    scopus 로고
    • Limitations of applying summary results of clinical trials to individual patients: The need for risk stratification
    • DOI 10.1001/jama.298.10.1209
    • Kent DM, Hayward RA. Limitations of applying summary results of clinical trials to individual patients: the need for risk stratification. JAMA. 2007;298:1209-1212. (Pubitemid 47403108)
    • (2007) Journal of the American Medical Association , vol.298 , Issue.10 , pp. 1209-1212
    • Kent, D.M.1    Hayward, R.A.2
  • 35
    • 77955382172 scopus 로고    scopus 로고
    • Assessing and reporting heterogeneity in treatment effects in clinical trials: A proposal
    • Kent DM, Rothwell PM, Ioannidis JP, et al. Assessing and reporting heterogeneity in treatment effects in clinical trials: a proposal. Trials. 2010;11:85.
    • (2010) Trials , vol.11 , pp. 85
    • Kent, D.M.1    Rothwell, P.M.2    Ioannidis, J.P.3
  • 36
    • 79952711338 scopus 로고    scopus 로고
    • Pharmacogenetic approach at the serotonin transporter gene as a method of reducing the severity of alcohol drinking
    • Johnson BA, Ait-Daoud N, Seneviratne C, et al. Pharmacogenetic approach at the serotonin transporter gene as a method of reducing the severity of alcohol drinking. Am J Psychiatry. 2011;168:265-275.
    • (2011) Am J Psychiatry , vol.168 , pp. 265-275
    • Johnson, B.A.1    Ait-Daoud, N.2    Seneviratne, C.3
  • 37
    • 0032558244 scopus 로고    scopus 로고
    • Applying results of randomised trials to patients. N of 1 trials are needed
    • Senn SJ. Applying results of randomised trials to patients. N of 1 trials are needed. BMJ. 1998;317:537-538.
    • (1998) BMJ , vol.317 , pp. 537-538
    • Senn, S.J.1
  • 38
    • 0035739148 scopus 로고    scopus 로고
    • Individual therapy: New dawn or false dawn
    • Senn SJ. Individual therapy: new dawn or false dawn. Drug Inform J. 2001;35:1479-1494.
    • (2001) Drug Inform J , vol.35 , pp. 1479-1494
    • Senn, S.J.1
  • 39
    • 7044225065 scopus 로고    scopus 로고
    • Author's reply to Walter and Guyatt
    • Senn SJ. Author's reply to Walter and Guyatt. Drug Inform J. 2003;37:7-10.
    • (2003) Drug Inform J , vol.37 , pp. 7-10
    • Senn, S.J.1
  • 40
    • 6944230023 scopus 로고    scopus 로고
    • Individual response to treatment: Is it a valid assumption?
    • Senn S. Individual response to treatment: is it a valid assumption? BMJ. 2004;329:966-968. (Pubitemid 39422915)
    • (2004) British Medical Journal , vol.329 , Issue.7472 , pp. 966-968
    • Senn, S.1
  • 41
    • 84555192592 scopus 로고    scopus 로고
    • Investigating variability in patient response to treatmentVa case study from a replicate cross-over study
    • Senn S, Rolfe K, Julious SA. Investigating variability in patient response to treatmentVa case study from a replicate cross-over study. Stat Methods Med Res. 2011;20(6):657-666.
    • (2011) Stat Methods Med Res , vol.20 , Issue.6 , pp. 657-666
    • Senn, S.1    Rolfe, K.2    Julious, S.A.3
  • 42
    • 0031826288 scopus 로고    scopus 로고
    • Hypothesis: Comparisons of inter- and intra-individual variations can substitute for twin studies in drug research
    • DOI 10.1097/00008571-199808000-00001
    • KalowW, Tang BK, Endrenyi L. Hypothesis: comparisons of inter- and intra-individual variations can substitute for twin studies in drug research. Pharmacogenetics. 1998;8:283-289. (Pubitemid 28372321)
    • (1998) Pharmacogenetics , vol.8 , Issue.4 , pp. 283-289
    • Kalow, W.1    Tang, B.-K.2    Endrenyi, L.3
  • 43
    • 0033044502 scopus 로고    scopus 로고
    • Repeat administration of drugs as a means to assess the genetic component in pharmacological variability
    • DOI 10.1159/000028292
    • Kalow W, Endrenyi L, Tang BK. Repeat administration of drugs as a means to assess the genetic component in pharmacological variability. Pharmacology. 1999;58:281-284. (Pubitemid 29206182)
    • (1999) Pharmacology , vol.58 , Issue.6 , pp. 281-284
    • Kalow, W.1    Endrenyi, L.2    Tang, B.-K.3
  • 44
    • 27744577933 scopus 로고    scopus 로고
    • Quo vadis personalized medicine
    • Ruano G. Quo vadis personalized medicine. Personalized Med. 2004;1:1-7.
    • (2004) Personalized Med , vol.1 , pp. 1-7
    • Ruano, G.1
  • 45
    • 4344574336 scopus 로고    scopus 로고
    • Pharmacogenetics - Five decades of therapeutic lessons from genetic diversity
    • DOI 10.1038/nrg1428
    • Meyer UA. PharmacogeneticsVfive decades of therapeutic lessons from genetic diversity. Nat Rev Genet. 2004;5:669-676. (Pubitemid 39150124)
    • (2004) Nature Reviews Genetics , vol.5 , Issue.9 , pp. 669-676
    • Meyer, U.A.1
  • 46
    • 30444454824 scopus 로고    scopus 로고
    • Drug metabolism and pharmacogenetics: The British contribution to fields of international significance
    • DOI 10.1038/sj.bjp.0706466, PII 0706466
    • Caldwell J. Drug metabolism and pharmacogenetics: the British contribution fields of international significance. Br J Pharmacol. 2006;147(suppl):S89-S99. (Pubitemid 43077266)
    • (2006) British Journal of Pharmacology , vol.147 , Issue.SUPPL. 1
    • Caldwell, J.1
  • 48
    • 1542708761 scopus 로고    scopus 로고
    • From pharmacogenetics and ecogenetics to pharmacogenomics
    • Motulsky AG. From pharmacogenetics and ecogenetics to pharmacogenomics. Med Secoli. 2002;14:683-705.
    • (2002) Med Secoli , vol.14 , pp. 683-705
    • Motulsky, A.G.1
  • 50
    • 0002150481 scopus 로고
    • Moderne probleme der Humangenetik
    • Vogel F. Moderne probleme der Humangenetik. Ergeb Inn Med Kinderheild. 1959;12:52-125.
    • (1959) Ergeb Inn Med Kinderheild , vol.12 , pp. 52-125
    • Vogel, F.1
  • 51
    • 0030822569 scopus 로고    scopus 로고
    • Massively parallel genomics
    • DOI 10.1126/science.277.5324.393
    • Fodor SP. Massively parallel genomics. Science. 1997;277:393-395. (Pubitemid 27450716)
    • (1997) Science , vol.277 , Issue.5324 , pp. 393-395
    • Fodor, S.P.A.1
  • 52
    • 0034797332 scopus 로고    scopus 로고
    • Pharmacogenetics and pharmacogenomics
    • DOI 10.1046/j.0306-5251.2001.01498.x
    • Pirmohamed M. Pharmacogenetics and pharmacogenomics. J Clin Pharmacol. 2001;52:345-347. (Pubitemid 32939438)
    • (2001) British Journal of Clinical Pharmacology , vol.52 , Issue.4 , pp. 345-347
    • Pirmohamed, M.1
  • 53
    • 0031460022 scopus 로고    scopus 로고
    • New research horizons
    • Science
    • Science. New research horizons. Science. 1997;278:2039.
    • (1997) Science , vol.278 , pp. 2039
  • 54
    • 0034600638 scopus 로고    scopus 로고
    • The race is over
    • July 3
    • Golden F, Lemonick MD. The race is over. Time. July 3, 2000:18-23.
    • (2000) Time , pp. 18-23
    • Golden, F.1    Lemonick, M.D.2
  • 55
    • 0012581599 scopus 로고    scopus 로고
    • Deciphering the code and what might come from it
    • November 8
    • Lertola J. Deciphering the code and what might come from it. Time. November 8, 1999:68-69.
    • (1999) Time , pp. 68-69
    • Lertola, J.1
  • 57
    • 43049122356 scopus 로고    scopus 로고
    • From human genetics and genomics to pharmacogenetics and pharmacogenomics: Past lessons, future directions
    • DOI 10.1080/03602530801952864, PII 792810082
    • Nebert DW, Zhang G, Vesell ES. From human genetics and genomics to pharmacogenetics and pharmacogenomics: past lessons, future directions. Drug Metab Rev. 2008;40:187-224. (Pubitemid 352000946)
    • (2008) Drug Metabolism Reviews , vol.40 , Issue.2 , pp. 187-224
    • Nebert, D.W.1    Zhang, G.2    Vesell, E.S.3
  • 58
    • 33745944880 scopus 로고    scopus 로고
    • AmpliChip CYP450 test: Personalized medicine has arrived in psychiatry
    • DOI 10.1586/14737159.6.3.277
    • de Leon J. The AmpliChip CYP450 Test: personalized medicine has arrived in psychiatry. Expert Rev Mol Diagn. 2006;6:277-286. (Pubitemid 44174334)
    • (2006) Expert Review of Molecular Diagnostics , vol.6 , Issue.3 , pp. 277-286
    • De Leon, J.1
  • 59
    • 57149135263 scopus 로고    scopus 로고
    • Products for pharmacogenetic testing in psychiatry: A review of features and clinical realities
    • de Leon J, Arranz MJ, Ruaño G. Products for pharmacogenetic testing in psychiatry: a review of features and clinical realities. Clin Lab Med. 2008;28:599-617.
    • (2008) Clin Lab Med , vol.28 , pp. 599-617
    • De Leon, J.1    Arranz, M.J.2    Ruaño, G.3
  • 60
    • 77955657343 scopus 로고    scopus 로고
    • Expectations, validity, and reality in omics
    • Ioannidis JP. Expectations, validity, and reality in omics. J Clin Epidemiol. 2010;63:945-949.
    • (2010) J Clin Epidemiol , vol.63 , pp. 945-949
    • Ioannidis, J.P.1
  • 61
    • 57649139354 scopus 로고    scopus 로고
    • Pharmacogenomics: The promise of personalized medicine for CNS disorders
    • de Leon J. Pharmacogenomics: the promise of personalized medicine for CNS disorders. Neuropsychopharmacol. 2009;34: 159-172.
    • (2009) Neuropsychopharmacol , vol.34 , pp. 159-172
    • De Leon, J.1
  • 62
    • 58749115733 scopus 로고    scopus 로고
    • The future (or lack of future) of personalized prescription in psychiatry
    • de Leon J. The future (or lack of future) of personalized prescription in psychiatry. Pharmacol Res. 2009;59:81-89.
    • (2009) Pharmacol Res , vol.59 , pp. 81-89
    • De Leon, J.1
  • 65
    • 49449098790 scopus 로고    scopus 로고
    • The potential of genotyping [letter]
    • de Leon J. The potential of genotyping [letter]. Science. 2008;321:769.
    • (2008) Science , vol.321 , pp. 769
    • De Leon, J.1
  • 66
    • 0014425524 scopus 로고
    • Life's irreducible structure
    • Polanyi M. Life's irreducible structure. Science. 1968;160:1308-1312.
    • (1968) Science , vol.160 , pp. 1308-1312
    • Polanyi, M.1
  • 67
    • 84865852711 scopus 로고    scopus 로고
    • Future of personalized prescription in psychiatry
    • Schwab M, Kaschka WP, Spina E, eds., Basel, Switzerland: Karger
    • de Leon J. Future of personalized prescription in psychiatry. In: Schwab M, Kaschka WP, Spina E, eds. Pharmacogenomics in Psychiatry. Advances in Biological Psychiatry 25. Basel, Switzerland: Karger; 2010:118-134.
    • (2010) Pharmacogenomics in Psychiatry. Advances in Biological Psychiatry 25 , pp. 118-134
    • De Leon, J.1
  • 68
    • 79961065476 scopus 로고    scopus 로고
    • Paying attention to pharmacokinetic and pharmacodynamic mechanisms to progress in the area of anticholinergic use in geriatric patients
    • de Leon J. Paying attention to pharmacokinetic and pharmacodynamic mechanisms to progress in the area of anticholinergic use in geriatric patients. Curr Drug Met. 2011;12:635-646.
    • (2011) Curr Drug Met , vol.12 , pp. 635-646
    • De Leon, J.1
  • 69
    • 62449286261 scopus 로고    scopus 로고
    • DNA microarray technology in the clinical environment: The AmpliChip CYP 450 Test for CYP2D6 and CYP2C19 genotyping
    • de Leon J, Susce MT, Johnson M, et al. DNA microarray technology in the clinical environment: the AmpliChip CYP 450 Test for CYP2D6 and CYP2C19 genotyping. CNS Spectr. 2009;14:19-34.
    • (2009) CNS Spectr , vol.14 , pp. 19-34
    • De Leon, J.1    Susce, M.T.2    Johnson, M.3
  • 71
    • 0034006802 scopus 로고    scopus 로고
    • History and evolution of the monoamine hypothesis of depression
    • Hirschfeld RM. History and evolution of the monoamine hypothesis of depression. J Clin Psychiatry. 2000;6(suppl 6):4-6. (Pubitemid 30217404)
    • (2000) Journal of Clinical Psychiatry , vol.61 , Issue.SUPPL. 6 , pp. 4-6
    • Hirschfeld, R.M.A.1
  • 72
    • 0016280259 scopus 로고
    • Differential effect of chlorimipramine and nortriptyline on cerebrospinal fluid metabolites of serotonin and noradrenaline in depression
    • Bertilsson L, Asberg M, Thorén P. Differential effect of chlorimipramine and nortriptyline on cerebrospinal fluid metabolites of serotonin and noradrenaline in depression. Eur J Clin Pharmacol. 1974;7:365-368.
    • (1974) Eur J Clin Pharmacol , vol.7 , pp. 365-368
    • Bertilsson, L.1    Asberg, M.2    Thorén, P.3
  • 75
    • 0017108978 scopus 로고
    • Neuroendocrine regulation in depression. I. Limbic system-adrenocortical dysfunction
    • Carroll BJ, Curtis GC, Mendels J. Neuroendocrine regulation in depression. I. Limbic system-adrenocortical dysfunction. Arch Gen Psychiatry. 1976;33:1039-1044.
    • (1976) Arch Gen Psychiatry , vol.33 , pp. 1039-1044
    • Carroll, B.J.1    Curtis, G.C.2    Mendels, J.3
  • 76
    • 0017151345 scopus 로고
    • Neuroendocrine regulation in depression. II. Discrimination of depressed from nondepressed patients
    • Carroll BJ, Curtis GC, Mendels J. Neuroendocrine regulation in depression. II. Discrimination of depressed from nondepressed patients. Arch Gen Psychiatry. 1976;33:1051-1058.
    • (1976) Arch Gen Psychiatry , vol.33 , pp. 1051-1058
    • Carroll, B.J.1    Curtis, G.C.2    Mendels, J.3
  • 77
    • 0023232461 scopus 로고
    • The dexamethasone suppression test: An overview of its current status in psychiatry
    • The APA Task Force on Laboratory Tests in Psychiatry
    • The APA Task Force on Laboratory Tests in Psychiatry. The dexamethasone suppression test: an overview of its current status in psychiatry. Am J Psychiatry. 1987;144:1253-1262.
    • (1987) Am J Psychiatry , vol.144 , pp. 1253-1262
  • 79
    • 84857802819 scopus 로고    scopus 로고
    • American Psychiatric Association, Available at, Accessed August 15, 2011
    • American Psychiatric Association. Appendix. Practice guideline development process. American Psychiatric Association, 2006. Available at: http://www.psych.org/Departments/QIPS/Downloads/appendix-development%20process- 04-28-06.aspx. Accessed August 15, 2011.
    • (2006) Appendix. Practice Guideline Development Process
  • 81
    • 23844516328 scopus 로고    scopus 로고
    • Pharmacogenetics-based therapeutic recommendations - Ready for clinical practice?
    • DOI 10.1038/nrd1801
    • Kirchheiner J, Fuhr U, Brockmöller J. Pharmacogenetics-based therapeutic recommendationsVready for clinical practice? Nat Rev Drug Discov. 2005;4:639-647. (Pubitemid 41149757)
    • (2005) Nature Reviews Drug Discovery , vol.4 , Issue.8 , pp. 639-647
    • Kirchheiner, J.1    Fuhr, U.2    Brockmoller, J.3
  • 82
    • 78951495386 scopus 로고    scopus 로고
    • Why, when, and how should pharmacogenetics be applied in clinical studies? Current and future approaches to study designs
    • Stingl JC, Brockmö ller J. Why, when, and how should pharmacogenetics be applied in clinical studies? Current and future approaches to study designs. Clin Pharmacol Ther. 2011;89:198-209.
    • (2011) Clin Pharmacol Ther , vol.89 , pp. 198-209
    • Stingl, J.C.1    Brockmö Ller, J.2
  • 84
    • 33749027737 scopus 로고    scopus 로고
    • Can pharmacogenetics help rescue drugs withdrawn from the market?
    • DOI 10.2217/14622416.7.6.889
    • Shah RR. Can pharmacogenetics help rescue drugs withdrawn from the market? Pharmacogenomics. 2006;7:889-908. (Pubitemid 44446737)
    • (2006) Pharmacogenomics , vol.7 , Issue.6 , pp. 889-908
    • Shah, R.R.1
  • 85
    • 77949721082 scopus 로고    scopus 로고
    • Classical twin design in modern pharmacogenomics studies
    • Rahmio?lu N, Ahmadi KR. Classical twin design in modern pharmacogenomics studies. Pharmacogenomics. 2010;11:215-226.
    • (2010) Pharmacogenomics , vol.11 , pp. 215-226
    • Rahmiolu, N.1    Ahmadi, K.R.2
  • 86
    • 77955852844 scopus 로고    scopus 로고
    • Dissecting complex phenotypes using the genomics of twins
    • Tan Q, Ohm Kyvik K, Kruse TA, et al. Dissecting complex phenotypes using the genomics of twins. Funct Integr Genomics. 2010;10: 321-327.
    • (2010) Funct Integr Genomics , vol.10 , pp. 321-327
    • Tan, Q.1    Ohm Kyvik, K.2    Kruse, T.A.3
  • 87
    • 0024523831 scopus 로고
    • Pharmacogenetic perspectives gained from twin and family studies
    • DOI 10.1016/0163-7258(89)90130-7
    • Vesell ES. Pharmacogenetic perspectives gained from twin and family studies. Pharmacol Ther. 1989;41:535-552. (Pubitemid 19102462)
    • (1989) Pharmacology and Therapeutics , vol.41 , Issue.3 , pp. 535-552
    • Vesell, E.S.1
  • 88
    • 77958085098 scopus 로고    scopus 로고
    • Opioid pharmacogenomics using a twin study paradigm: Methods and procedures for determining familial aggregation and heritability
    • Angst MS, Phillips NG, Drover DR, et al. Opioid pharmacogenomics using a twin study paradigm: methods and procedures for determining familial aggregation and heritability. Twin Res Hum Genet. 2010;13:412-425.
    • (2010) Twin Res Hum Genet , vol.13 , pp. 412-425
    • Angst, M.S.1    Phillips, N.G.2    Drover, D.R.3
  • 89
    • 70450253101 scopus 로고    scopus 로고
    • Genetic influences on the pharmacokinetics of orally and intravenously administered digoxin as exhibited by monozygotic twins
    • Birkenfeld AL, Jordan J, Hofmann U, et al. Genetic influences on the pharmacokinetics of orally and intravenously administered digoxin as exhibited by monozygotic twins. Clin Pharmacol Ther. 2009;86:605-608.
    • (2009) Clin Pharmacol Ther , vol.86 , pp. 605-608
    • Birkenfeld, A.L.1    Jordan, J.2    Hofmann, U.3
  • 90
    • 14844343485 scopus 로고    scopus 로고
    • Multigenic control of drug response and regulatory decision-making in pharmacogenomics: The need for an upper-bound estimate of genetic contributions
    • DOI 10.2174/1570160053175027
    • Ozdemir V, Kalow W, Tothfalusi L, et al. Multigenic control of drug response and regulatory decision-making in pharmacogenomics: the need for an upper-bound estimate of genetic contributions. Curr Pharmacogenomics Person Med. 2005;3:53-71. (Pubitemid 40352699)
    • (2005) Current Pharmacogenomics , vol.3 , Issue.1 , pp. 53-71
    • Ozdemir, V.1    Kalow, W.2    Tothfalusi, L.3    Bertilsson, L.4    Endrenyi, L.5    Graham, J.E.6
  • 91
    • 9444279003 scopus 로고    scopus 로고
    • Impact of inter-individual differences in drug metabolism and pharmacokinetics on safety evaluation
    • DOI 10.1111/j.1472-8206.2004.00292.x
    • Dorne JL. Impact of inter-individual differences in drug metabolism and pharmacokinetics on safety evaluation. Fundam Clin Pharmacol. 2004;18:609-620. (Pubitemid 39564260)
    • (2004) Fundamental and Clinical Pharmacology , vol.18 , Issue.6 , pp. 609-620
    • Dorne, J.L.C.M.1
  • 92
    • 0033608471 scopus 로고    scopus 로고
    • Can randomised trials inform clinical decisions about individual patients?
    • DOI 10.1016/S0140-6736(98)09102-8
    • Mant D. Can randomised trials inform clinical decisions about individual patients? Lancet. 1999;353:743-746. (Pubitemid 29103819)
    • (1999) Lancet , vol.353 , Issue.9154 , pp. 743-746
    • Mant, D.1
  • 93
    • 0036431808 scopus 로고    scopus 로고
    • Evidence-based medicine, opinion-based medicine, and real-world medicine
    • Hampton JR. Evidence-based medicine, opinion-based medicine, and real-world medicine. Perspect Biol Med. 2002;45:549-568. (Pubitemid 35346232)
    • (2002) Perspectives in Biology and Medicine , vol.45 , Issue.4 , pp. 549-568
    • Hampton, J.R.1
  • 94
    • 0031979947 scopus 로고    scopus 로고
    • Incommunicable knowledge? Interpreting and applying the results of clinical trials and meta-analyses
    • DOI 10.1016/S0895-4356(97)00293-X, PII S089543569700293X
    • Smith GD, Egger M. Incommunicable knowledge? Interpreting and applying the results of clinical trials and meta-analyses. J Clin Epidemiol. 1998;51:289-295. (Pubitemid 28156044)
    • (1998) Journal of Clinical Epidemiology , vol.51 , Issue.4 , pp. 289-295
    • Davey Smith, G.1    Egger, M.2
  • 95
    • 0037317783 scopus 로고    scopus 로고
    • Mood stabilisers plus risperidone or placebo in the treatment of acute mania: International, double-blind, randomised controlled trial
    • DOI 10.1192/bjp.182.2.141
    • Yatham LN, Grossman F, Augustyns I, et al. Mood stabilisers plus risperidone or placebo in the treatment of acute mania. International, double-blind, randomised controlled trial. Br J Psychiatry. 2003;182:141-147. (Pubitemid 36177237)
    • (2003) British Journal of Psychiatry , vol.182 , Issue.FEB. , pp. 141-147
    • Yatham, L.N.1    Grossman, F.2    Augustyns, I.3    Vieta, E.4    Ravindran, A.5
  • 96
    • 0030724345 scopus 로고    scopus 로고
    • Risperidone and the cytochrome P4503A [letter]
    • de Leon J, Bork JA. Risperidone and the cytochrome P4503A [letter]. J Clin Psychiatry. 1997;58:450.
    • (1997) J Clin Psychiatry , vol.58 , pp. 450
    • De Leon, J.1    Bork, J.A.2
  • 97
    • 0032776927 scopus 로고    scopus 로고
    • A pilot study on risperidone metabolism: The role of cytochromes P450 2D6 and 3A
    • Bork J, Rogers T, Wedlund P, et al. A pilot study of risperidone metabolism: the role of cytochrome P450 2D6 and 3A. J Clin Psychiatry. 1999;60:469-476. (Pubitemid 29369803)
    • (1999) Journal of Clinical Psychiatry , vol.60 , Issue.7 , pp. 469-476
    • Bork, J.A.1    Rogers, T.2    Wedlund, P.J.3    De Leon, J.4
  • 99
    • 0033063442 scopus 로고    scopus 로고
    • Metabolism of risperidone to 9-hydroxyrisperidone by human cytochromes P450 2D6 and 3A4
    • Fang J, Bourin M, Baker GB. Metabolism of risperidone to 9-hydroxyrisperidone by human cytochromes P450 2D6 and 3A4. Naunyn Schmiedebergs Arch Pharmacol. 1999;359:147-151. (Pubitemid 29142884)
    • (1999) Naunyn-Schmiedeberg's Archives of Pharmacology , vol.359 , Issue.2 , pp. 147-151
    • Fang, J.1    Bourin, M.2    Baker, G.B.3
  • 101
    • 2042458387 scopus 로고    scopus 로고
    • Strength of recommendation taxonomy (SORT): A patient-centered approach to grading evidence in the medical literature
    • Ebell MH, Siwek J, Weiss BD, et al. Strength of recommendation taxonomy (SORT): a patient-centered approach to grading evidence in the medical literature. J Am Board Fam Pract. 2004;17:59-67.
    • (2004) J Am Board Fam Pract , vol.17 , pp. 59-67
    • Ebell, M.H.1    Siwek, J.2    Weiss, B.D.3
  • 102
    • 3142519666 scopus 로고    scopus 로고
    • Pharmacogenetics of antidepressants and antipsychotics: The contribution of allelic variations to the phenotype of drug response
    • DOI 10.1038/sj.mp.4001494
    • Kirchheiner J, Nickchen K, Bauer M, et al. Pharmacogenetics of antidepressants and antipsychotics: the contribution of allelic variations to the phenotype of drug response. Mol Psychiatry. 2004;9:442-473. (Pubitemid 38903502)
    • (2004) Molecular Psychiatry , vol.9 , Issue.5 , pp. 442-473
    • Kirchheiner, J.1    Nickchen, K.2    Bauer, M.3    Wong, M.-L.4    Licinio, J.5    Roots, I.6    Brockmoller, J.7
  • 104
    • 79955463893 scopus 로고    scopus 로고
    • Pharmacogenetics: From bench to byteVan update of guidelines
    • Swen JJ, Nijenhuis M, de Boer A, et al. Pharmacogenetics: from bench to byteVan update of guidelines. Clin Pharmacol Ther. 2011;89:662-673.
    • (2011) Clin Pharmacol Ther , vol.89 , pp. 662-673
    • Swen, J.J.1    Nijenhuis, M.2    De Boer, A.3
  • 105
    • 38349144995 scopus 로고    scopus 로고
    • A prototypical process for creating evidentiary standards for biomarkers and diagnostics
    • Altar CA, Amakye D, Bounos D, et al. A prototypical process for creating evidentiary standards for biomarkers and diagnostics. Clin Pharmacol Ther. 2008;83:368-371.
    • (2008) Clin Pharmacol Ther , vol.83 , pp. 368-371
    • Altar, C.A.1    Amakye, D.2    Bounos, D.3
  • 106
    • 41549117102 scopus 로고    scopus 로고
    • Observational research, randomised trials and two views of medical science
    • Vandenbroucke JP. Observational research, randomised trials and two views of medical science. PLoS Med. 2008;5:339-343.
    • (2008) PLoS Med , vol.5 , pp. 339-343
    • Vandenbroucke, J.P.1
  • 107
    • 33644763919 scopus 로고    scopus 로고
    • What is the best evidence for determining harms of medical treatment?
    • DOI 10.1503/cmaj.051484
    • Vandenbroucke JP. What is the best evidence for determining harms of medical treatment? CMAJ. 2006;174:645-646. (Pubitemid 43341875)
    • (2006) Canadian Medical Association Journal , vol.174 , Issue.5 , pp. 645-646
    • Vandenbroucke, J.P.1
  • 108
    • 57049133083 scopus 로고    scopus 로고
    • Benefits and risks of drug treatments: How to combine the best evidence on benefits with the best data about adverse effects
    • Vandenbroucke JP, Psaty BM. Benefits and risks of drug treatments: how to combine the best evidence on benefits with the best data about adverse effects. JAMA. 2008;300:2417-2419.
    • (2008) JAMA , vol.300 , pp. 2417-2419
    • Vandenbroucke, J.P.1    Psaty, B.M.2
  • 109
    • 0035916288 scopus 로고    scopus 로고
    • In defense of case reports and case series
    • Vandenbroucke JP. In defense of case reports and case series. Ann Intern Med. 2001;134:330-334. (Pubitemid 32163956)
    • (2001) Annals of Internal Medicine , vol.134 , Issue.4 , pp. 330-334
    • Vandenbroucke, J.P.1
  • 110
    • 70350517166 scopus 로고    scopus 로고
    • Adverse events in randomized trials: Neglected, restricted, distorted, and silenced
    • Ioannidis JP. Adverse events in randomized trials: neglected, restricted, distorted, and silenced. Arch Intern Med. 2009;169:1737-1739.
    • (2009) Arch Intern Med , vol.169 , pp. 1737-1739
    • Ioannidis, J.P.1
  • 112
    • 12444289440 scopus 로고    scopus 로고
    • Evidence-based medicine, heterogeneity of treatment effects, and the trouble with averages
    • DOI 10.1111/j.0887-378X.2004.00327.x
    • Kravitz RL, Duan N, Braslow J. Evidence-based medicine, heterogeneity of treatment effects, and the trouble with averages. Milbank Q. 2004;82:661-687. (Pubitemid 40143102)
    • (2004) Milbank Quarterly , vol.82 , Issue.4 , pp. 661-687
    • Kravitz, R.L.1    Duan, N.2    Braslow, J.3
  • 113
    • 85044911913 scopus 로고    scopus 로고
    • Are RCTs the gold standard
    • Cartwright N. Are RCTs the gold standard. BioSocieties. 2007;2:11-20.
    • (2007) BioSocieties , vol.2 , pp. 11-20
    • Cartwright, N.1
  • 114
    • 33846563409 scopus 로고    scopus 로고
    • Why most published research findings are false
    • Ioannidis JP. Why most published research findings are false. PLoS Med. 2005;2:e124.
    • (2005) PLoS Med , vol.2
    • Ioannidis, J.P.1
  • 115
    • 22144431885 scopus 로고    scopus 로고
    • Contradicted and initially stronger effects in highly cited clinical research
    • DOI 10.1001/jama.294.2.218
    • Ioannidis JP. Contradicted and initially stronger effects in highly cited clinical research. JAMA. 2005;294:218-228. (Pubitemid 41043792)
    • (2005) Journal of the American Medical Association , vol.294 , Issue.2 , pp. 218-228
    • Ioannidis, J.P.A.1
  • 116
    • 55949084294 scopus 로고    scopus 로고
    • Why current publication practices may distort science
    • Young NS, Ioannidis JP, Al-Ubaydli O. Why current publication practices may distort science. PLoS Med. 2008;5:e201.
    • (2008) PLoS Med , vol.5
    • Young, N.S.1    Ioannidis, J.P.2    Al-Ubaydli, O.3
  • 117
    • 0035797930 scopus 로고    scopus 로고
    • Alternative medicine: A "mirror image" for scientific reasoning in conventional medicine
    • Vandenbroucke JP, de Craen AJM. Alternative medicine: a "mirror image" for scientific reasoning in conventional medicine. Ann Intern Med. 2001;135:507-513. (Pubitemid 32923568)
    • (2001) Annals of Internal Medicine , vol.135 , Issue.7 , pp. 507-513
    • Vandenbroucke, J.P.1    De Craen, A.J.M.2
  • 118
    • 62249094521 scopus 로고    scopus 로고
    • Overstating the evidence: Double counting in meta-analysis and related problems
    • Senn SJ. Overstating the evidence: double counting in meta-analysis and related problems. BMC Med Res Methodol. 2009;9:10.
    • (2009) BMC Med Res Methodol , vol.9 , pp. 10
    • Senn, S.J.1
  • 121
    • 37349093041 scopus 로고    scopus 로고
    • Recommendations from the EGAPP Working Group: Testing for cytochrome P450 polymorphisms in adults with nonpsychotic depression treated with selective serotonin reuptake inhibitors
    • Evaluation of Genomic Applications in Practice and Prevention (EGAPP) Working Group
    • Evaluation of Genomic Applications in Practice and Prevention (EGAPP) Working Group. Recommendations from the EGAPP Working Group: testing for cytochrome P450 polymorphisms in adults with nonpsychotic depression treated with selective serotonin reuptake inhibitors. Genet Med. 2007;9:819-825.
    • (2007) Genet Med , vol.9 , pp. 819-825
  • 122
    • 62549117737 scopus 로고    scopus 로고
    • Warfarin and pharmacogenomic testing: What would Pascal do?
    • Teagarden JR. Warfarin and pharmacogenomic testing: what would Pascal do? Pharmacotherapy. 2009;29:245-247.
    • (2009) Pharmacotherapy , vol.29 , pp. 245-247
    • Teagarden, J.R.1
  • 124
    • 22744432216 scopus 로고    scopus 로고
    • Trial and error: The Supreme Court's philosophy of science
    • DOI 10.2105/AJPH.2004.044529
    • Haack S. Trial and error: the Supreme Court's philosophy of science. Am J Public Health. 2005;95:S66-S73. (Pubitemid 41033421)
    • (2005) American Journal of Public Health , vol.95 , Issue.SUPPL. 1
    • Haack, S.1
  • 126
    • 34547912839 scopus 로고    scopus 로고
    • The cha-cha-cha theory of scientific discovery
    • Koshland DE. The cha-cha-cha theory of scientific discovery. Science. 2007;317:761-762.
    • (2007) Science , vol.317 , pp. 761-762
    • Koshland, D.E.1
  • 127
    • 33847640214 scopus 로고    scopus 로고
    • Most published research findings are false-but a little replication goes a long way
    • Moonesinghe R, Khoury MJ, Janssens AC. Most published research findings are false-but a little replication goes a long way. PLoS Med. 2007;4:e28.
    • (2007) PLoS Med , vol.4
    • Moonesinghe, R.1    Khoury, M.J.2    Janssens, A.C.3
  • 128
    • 0028923154 scopus 로고
    • Grey zones of clinical practice: Some limits to evidence-based medicine
    • Naylor CD. Grey zones of clinical practice: some limits to evidence-based medicine. Lancet. 1995;345:840-842.
    • (1995) Lancet , vol.345 , pp. 840-842
    • Naylor, C.D.1
  • 131
    • 78650373804 scopus 로고    scopus 로고
    • Network medicine: A network-based approach to human disease
    • Barabási AL, Gulbahce N, Loscalzo J. Network medicine: a network-based approach to human disease. Nat Rev Genet. 2011;12:56-68.
    • (2011) Nat Rev Genet , vol.12 , pp. 56-68
    • Barabási, A.L.1    Gulbahce, N.2    Loscalzo, J.3
  • 132
    • 76949104315 scopus 로고    scopus 로고
    • Modeling complex genetic and environmental influences on comorbid bipolar disorder with tobacco use disorder
    • McEachin RC, Saccone NL, Saccone SF, et al. Modeling complex genetic and environmental influences on comorbid bipolar disorder with tobacco use disorder. BMC Med Genet. 2010;11:14.
    • (2010) BMC Med Genet , vol.11 , pp. 14
    • McEachin, R.C.1    Saccone, N.L.2    Saccone, S.F.3
  • 133
    • 73649105806 scopus 로고    scopus 로고
    • Defining statistical race and phenotypic race and their implications for health disparities
    • Lee SSJ. Defining statistical race and phenotypic race and their implications for health disparities. Curr Pharmacogenomics Person Med. 2009;7:238-242.
    • (2009) Curr Pharmacogenomics Person Med , vol.7 , pp. 238-242
    • Lee, S.S.J.1
  • 134
    • 80054025178 scopus 로고    scopus 로고
    • Inter-chromosomal variation in the pattern of human population genetic structure
    • Baye TM. Inter-chromosomal variation in the pattern of human population genetic structure. Hum Genomics. 2011;5:220-240.
    • (2011) Hum Genomics , vol.5 , pp. 220-240
    • Baye, T.M.1
  • 135
    • 33847708321 scopus 로고    scopus 로고
    • Scientific contribution. Some causal limitations of pharmacogenetic concepts
    • Badcott D. Scientific contribution. Some causal limitations of pharmacogenetic concepts. Med Health Care Philos. 2006;9:307-316.
    • (2006) Med Health Care Philos , vol.9 , pp. 307-316
    • Badcott, D.1
  • 136
    • 78650878764 scopus 로고    scopus 로고
    • Dynamic treatment regimes for managing chronic health conditions: A statistical perspective
    • Chakraborty B. Dynamic treatment regimes for managing chronic health conditions: a statistical perspective. Am J Public Health. 2011;101:40-45.
    • (2011) Am J Public Health , vol.101 , pp. 40-45
    • Chakraborty, B.1
  • 138
    • 14944385711 scopus 로고    scopus 로고
    • Conceptual issues
    • D'haenen H, den Boer JA, Willner P, eds., Chichester, UK: John Wiley & Sons, Ltd
    • Berrios GE, Markova IS. Conceptual issues. In: D'haenen H, den Boer JA, Willner P, eds. Biological Psychiatry. Chichester, UK: John Wiley & Sons, Ltd; 2002:1-24.
    • (2002) Biological Psychiatry , pp. 1-24
    • Berrios, G.E.1    Markova, I.S.2
  • 141
    • 77956550527 scopus 로고    scopus 로고
    • Comparative effectiveness research and personalized medicine: Catalyzing or colliding?
    • Epstein RS, Teagarden JR. Comparative effectiveness research and personalized medicine: catalyzing or colliding? Pharmacoeconomics. 2010;28:905-913.
    • (2010) Pharmacoeconomics , vol.28 , pp. 905-913
    • Epstein, R.S.1    Teagarden, J.R.2
  • 142
    • 60849099314 scopus 로고    scopus 로고
    • Practical guidelines for the use of new generation antipsychotic drugs (except clozapine) in adult individuals with intellectual disabilities
    • de Leon J, Greenlee B, Barber J, et al. Practical guidelines for the use of new generation antipsychotic drugs (except clozapine) in adult individuals with intellectual disabilities. Res Dev Disabil. 2009;30:613-669.
    • (2009) Res Dev Disabil , vol.30 , pp. 613-669
    • De Leon, J.1    Greenlee, B.2    Barber, J.3
  • 143
    • 65649121473 scopus 로고    scopus 로고
    • Does comparative-effectiveness research threaten PM?
    • Garber AM, Tunis SR. Does comparative-effectiveness research threaten PM? N Engl J Med. 2009;360:1925-1927.
    • (2009) N Engl J Med , vol.360 , pp. 1925-1927
    • Garber, A.M.1    Tunis, S.R.2
  • 144
    • 70449513464 scopus 로고    scopus 로고
    • Back to the future: Why randomized controlled trials cannot be the answer to pharmacogenomics and personalized medicine
    • Frueh FW. Back to the future: why randomized controlled trials cannot be the answer to pharmacogenomics and personalized medicine. Pharmacogenomics. 2009;10:1077-1081.
    • (2009) Pharmacogenomics , vol.10 , pp. 1077-1081
    • Frueh, F.W.1
  • 145
    • 70350729454 scopus 로고    scopus 로고
    • Comparative effectiveness research and genomic medicine: An evolving partnership for 21st century medicine
    • Khoury MJ, Rich EC, Randhawa G, et al. Comparative effectiveness research and genomic medicine: an evolving partnership for 21st century medicine. Genet Med. 2009;11:707-711.
    • (2009) Genet Med , vol.11 , pp. 707-711
    • Khoury, M.J.1    Rich, E.C.2    Randhawa, G.3
  • 146
    • 56649105060 scopus 로고    scopus 로고
    • The human genome and translational research: How much evidence is enough?
    • Woodcock J. The human genome and translational research: how much evidence is enough? Health Aff. 2008;27:1616-1618.
    • (2008) Health Aff , vol.27 , pp. 1616-1618
    • Woodcock, J.1
  • 147
    • 55349143224 scopus 로고    scopus 로고
    • Evidence-based healthcare, clinical knowledge and the rise of personalised medicine
    • Miles A, Loughlin M, Polychronis A. Evidence-based healthcare, clinical knowledge and the rise of personalised medicine. J Eval Clin Pract. 2008;14:621-649.
    • (2008) J Eval Clin Pract , vol.14 , pp. 621-649
    • Miles, A.1    Loughlin, M.2    Polychronis, A.3
  • 148
    • 78649817107 scopus 로고    scopus 로고
    • ACP Journal Club. Editorial: New and underutilized features of ACP Journal Club PLUS and ACPJC.org: Stellar articles, searches, and succinct synopses of the principles and practice of "personalized" evidence-based medicine
    • Haynes B. ACP Journal Club. Editorial: new and underutilized features of ACP Journal Club PLUS and ACPJC.org: stellar articles, searches, and succinct synopses of the principles and practice of "personalized" evidence-based medicine. Ann Intern Med. 2009;151:JC6-2-JC6-3.
    • (2009) Ann Intern Med , vol.151
    • Haynes, B.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.