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Volumn 28, Issue 10, 2010, Pages 905-913

Comparative effectiveness research and personalized medicine: Catalyzing or colliding?

Author keywords

clinical genetics; decision making; formularies; treatment outcome

Indexed keywords

CLOPIDOGREL; CYTOCHROME P450 2C19; PRASUGREL; WARFARIN;

EID: 77956550527     PISSN: 11707690     EISSN: 11792027     Source Type: Journal    
DOI: 10.2165/11535830-000000000-00000     Document Type: Review
Times cited : (41)

References (39)
  • 1
    • 0141684982 scopus 로고    scopus 로고
    • Practical clinical trials: Increasing the value of clinical research for decision making in clinical and health policy
    • Sep
    • Tunis SR, Stryer DB, Clancy CM. Practical clinical trials: increasing the value of clinical research for decision making in clinical and health policy. JAMA 2003 Sep; 290: 1624-1632
    • (2003) JAMA , vol.290 , pp. 1624-1632
    • Tunis, S.R.1    Stryer, D.B.2    Clancy, C.M.3
  • 2
    • 65649121473 scopus 로고    scopus 로고
    • Does comparative-effectiveness re-search threaten personalized medicine?
    • Garber AM, Tunis SR. Does comparative-effectiveness re-search threaten personalized medicine? N Engl J Med 2009; 360: 1927-1929
    • (2009) N Engl J Med , vol.360 , pp. 1927-1929
    • Garber, A.M.1    Tunis, S.R.2
  • 3
    • 67649538483 scopus 로고    scopus 로고
    • The American Heart Association's principles for comparative effectiveness research
    • on behalf of the American Heart Association Advocacy Coordinating Committee
    • Gibbons RJ, Gardner TJ, Anderson JL, et al., on behalf of the American Heart Association Advocacy Coordinating Committee. The American Heart Association's principles for comparative effectiveness research. Circulation 2009; 119: 2955-2962
    • (2009) Circulation , vol.119 , pp. 2955-2962
    • Gibbons, R.J.1    Gardner, T.J.2    Anderson, J.L.3
  • 4
    • 68249130994 scopus 로고    scopus 로고
    • Rethinking randomized clinical trials for comparative effectiveness research: The need for transformational change
    • Luce BR, Kramer JM, Goodman SN, et al. Rethinking randomized clinical trials for comparative effectiveness research: the need for transformational change. Ann Intern Med 2009; 151: 206-209
    • (2009) Ann Intern Med , vol.151 , pp. 206-209
    • Luce, B.R.1    Kramer, J.M.2    Goodman, S.N.3
  • 5
    • 70350729454 scopus 로고    scopus 로고
    • Comparative effectiveness research and genomic medicine: An evolving partnership for 21st century medicine
    • Oct
    • Khoury MJ, Rich EC, Randhawa G, et al. Comparative effectiveness research and genomic medicine: an evolving partnership for 21st century medicine. Genet Med 2009 Oct; 11: 707-711
    • (2009) Genet Med , vol.11 , pp. 707-711
    • Khoury, M.J.1    Rich, E.C.2    Randhawa, G.3
  • 6
    • 68249103874 scopus 로고    scopus 로고
    • Comparative effectiveness research: A report from the Institute of Medicine
    • Sox HC, Greenfield S. Comparative effectiveness research: a report from the Institute of Medicine. Ann Intern Med 2009; 151: 203-205
    • (2009) Ann Intern Med , vol.151 , pp. 203-205
    • Sox, H.C.1    Greenfield, S.2
  • 7
    • 56649105060 scopus 로고    scopus 로고
    • The human genome and translational re-search: How much evidence is enough?
    • Nov/Dec
    • Woodcock J. The human genome and translational re-search: how much evidence is enough? Health Aff (Millwood) 2008 Nov/Dec; 27: 1616-1618
    • (2008) Health Aff (Millwood) , vol.27 , pp. 1616-1618
    • Woodcock, J.1
  • 8
    • 33750106228 scopus 로고    scopus 로고
    • National surveillance of emergency department visits for outpatient adverse drug events
    • Budnitz DS, Pollock DA, Weidenbach KN, et al. National surveillance of emergency department visits for outpatient adverse drug events. JAMA 2006; 296: 1858-1866
    • (2006) JAMA , vol.296 , pp. 1858-1866
    • Budnitz, D.S.1    Pollock, D.A.2    Weidenbach, K.N.3
  • 9
    • 38449106799 scopus 로고    scopus 로고
    • Medication use leading to emergency department visits for adverse drug events in older adults
    • Budniz DS, Shehab N, Kegler SR, et al. Medication use leading to emergency department visits for adverse drug events in older adults. Ann Intern Med 2007; 147: 755-765
    • (2007) Ann Intern Med , vol.147 , pp. 755-765
    • Budniz, D.S.1    Shehab, N.2    Kegler, S.R.3
  • 10
    • 23644437525 scopus 로고    scopus 로고
    • Common VKORCI and GGCX polymorphisms associated with warfarin dose
    • Wadelius M, Chen LY, Downes K, et al. Common VKORCI and GGCX polymorphisms associated with warfarin dose. Pharmacogenomics J 2005; 5: 262-270
    • (2005) Pharmacogenomics J , vol.5 , pp. 262-270
    • Wadelius, M.1    Chen, L.Y.2    Downes, K.3
  • 11
    • 22044433685 scopus 로고    scopus 로고
    • Cytochrome P450 2C9 (CYP2C9) and vitamin K reductase (VKORC1) genotypes as determinants of acenocoumarol sensitivity
    • Jul
    • Bodin L, Verstuyft C, Tregouet D-A, et al. Cytochrome P450 2C9 (CYP2C9) and vitamin K reductase (VKORC1) genotypes as determinants of acenocoumarol sensitivity. Blood 2005 Jul; 106: 135-140
    • (2005) Blood , vol.106 , pp. 135-140
    • Bodin, L.1    Verstuyft, C.2    Tregouet, D.-A.3
  • 12
    • 47949086046 scopus 로고    scopus 로고
    • Use of pharmacoge-netic and clinical factors to predict the therapeutic dose of warfarin
    • Sep
    • Gage BF, Johnson JA, Deych E, et al. Use of pharmacoge-netic and clinical factors to predict the therapeutic dose of warfarin. Clin Pharmacol Ther 2008 Sep; 84: 326-331
    • (2008) Clin Pharmacol Ther , vol.84 , pp. 326-331
    • Gage, B.F.1    Johnson, J.A.2    Deych, E.3
  • 13
    • 39449086981 scopus 로고    scopus 로고
    • CYP2C9 gentoype-guided warfarin prescribing enhances the efficacy and safety of anticoagulation: A prospective randomized controlled study
    • Mar
    • Caraco Y, Blotnick S, Muszkat M. CYP2C9 gentoype-guided warfarin prescribing enhances the efficacy and safety of anticoagulation: a prospective randomized controlled study. Clin Pharmacol Ther 2008 Mar; 83: 460-470
    • (2008) Clin Pharmacol Ther , vol.83 , pp. 460-470
    • Caraco, Y.1    Blotnick, S.2    Muszkat, M.3
  • 14
    • 38349126516 scopus 로고    scopus 로고
    • Influence of CYP2C9 and VKORC1 1173C/T genotype on the risk of hemorrhagic complications in African-American and European-American patients on warfarin
    • Feb
    • Limdi NA, McGwin G, Goldstein JA, et al. Influence of CYP2C9 and VKORC1 1173C/T genotype on the risk of hemorrhagic complications in African-American and European-American patients on warfarin. Clin Pharmacol Ther 2008 Feb; 83: 312-321
    • (2008) Clin Pharmacol Ther , vol.83 , pp. 312-321
    • Limdi, N.A.1    McGwin, G.2    Goldstein, J.A.3
  • 15
    • 0037012465 scopus 로고    scopus 로고
    • Association between CYP2C9 genetic variants and anticoagulation-related outcomes during warfarin therapy
    • Apr
    • Higashi MK, Veenstra DL, Kondo LM, et al. Association between CYP2C9 genetic variants and anticoagulation-related outcomes during warfarin therapy. JAMA 2002 Apr; 287: 1690-1698
    • (2002) JAMA , vol.287 , pp. 1690-1698
    • Higashi, M.K.1    Veenstra, D.L.2    Kondo, L.M.3
  • 16
    • 38049092618 scopus 로고    scopus 로고
    • CYP2C9 genotypes and the quality of anticoagulation control with warfarin therapy among Brazilian patients
    • Jan
    • Lima MV, Ribeiro GS, Mesquita ET, et al. CYP2C9 genotypes and the quality of anticoagulation control with warfarin therapy among Brazilian patients. Eur J Clin Pharmacol 2008 Jan; 64: 9-15
    • (2008) Eur J Clin Pharmacol , vol.64 , pp. 9-15
    • Lima, M.V.1    Ribeiro, G.S.2    Mesquita, E.T.3
  • 18
    • 20144387370 scopus 로고    scopus 로고
    • Prospective dosing of warfarin based on cytochrome P-450 2C9 genotype
    • Apr
    • Voora D, Eby C, Linder MW, et al. Prospective dosing of warfarin based on cytochrome P-450 2C9 genotype. Thromb Haemost 2005 Apr; 93: 700-705
    • (2005) Thromb Haemost , vol.93 , pp. 700-705
    • Voora, D.1    Eby, C.2    Linder, M.W.3
  • 19
    • 3042575861 scopus 로고    scopus 로고
    • Warfarin dosing and cytochrome P450 2C9 polymorphisms
    • Jun
    • Joffe HV, Xu R, Johnson FB, et al. Warfarin dosing and cytochrome P450 2C9 polymorphisms. Thromb Haemost 2004 Jun; 91: 1123-1128
    • (2004) Thromb Haemost , vol.91 , pp. 1123-1128
    • Joffe, H.V.1    Xu, R.2    Johnson, F.B.3
  • 20
    • 48249098212 scopus 로고    scopus 로고
    • Delivery of optimized anticoagulant therapy: Consensus statement from the An-ticoagulation Forum
    • Jul/Aug
    • Garcia DA, Witt DM, Hylek E, et al. Delivery of optimized anticoagulant therapy: consensus statement from the An-ticoagulation Forum. Ann Pharmacother 2008 Jul/Aug; 42: 979-988
    • (2008) Ann Pharmacother , vol.42 , pp. 979-988
    • Garcia, D.A.1    Witt, D.M.2    Hylek, E.3
  • 21
    • 45949103309 scopus 로고    scopus 로고
    • Pharmacology and management of the vitamin K antagonists: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines
    • 8th ed
    • Ansell J, Hirsh J, Hylek E. Pharmacology and management of the vitamin K antagonists: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. 8th ed. Chest 2008; 133 (6 Suppl.): 160S-98S
    • (2008) Chest , vol.133 , Issue.6 SUPPL.
    • Ansell, J.1    Hirsh, J.2    Hylek, E.3
  • 23
    • 39449137238 scopus 로고    scopus 로고
    • Pharmaco-genetic testing of CYP2C9 and VKORC1 alleles for warfarin
    • Feb
    • Flockhart DA, O'Kane D, Williams MS, et al. Pharmaco-genetic testing of CYP2C9 and VKORC1 alleles for warfarin. Genet Med 2008 Feb; 10: 139-150
    • (2008) Genet Med , vol.10 , pp. 139-150
    • Flockhart, D.A.1    O'Kane, D.2    Williams, M.S.3
  • 24
    • 77956546038 scopus 로고    scopus 로고
    • [online]. Available from URL [Accessed 2010 Jun 10]
    • Aetna. Clinical policy bulletin: pharmacogenetic testing [online]. Available from URL: http://www.aetna.com/cpb/medical/data/700-799/0715.html [Accessed 2010 Jun 10].
    • Clinical Policy Bulletin: Pharmacogenetic Testing
  • 25
    • 77956511503 scopus 로고    scopus 로고
    • Department of Health and Human Services, Centers for Medicare and Medicaid Services [Pub 100-103 Medicare national coverage determinations; online]. Available from URL [Accessed 2010 Jun 10]
    • Department of Health and Human Services, Centers for Medicare and Medicaid Services. Pharmacogenomic testing for warfarin response [Pub 100-103 Medicare national coverage determinations; online]. Available from URL: http://www.cms.hhs.gov/Transmittals/Downloads/R111NCD.pdf [Accessed 2010 Jun 10]
    • Pharmacogenomic Testing for Warfarin Response
  • 27
    • 39449086981 scopus 로고    scopus 로고
    • CYP2C9 genotype-guided warfarin prescribing enhances the efficacy and safety of anticoagulation: A prospective randomized controlled study
    • Caraco Y, Blotnick S, Muszkat M. CYP2C9 genotype-guided warfarin prescribing enhances the efficacy and safety of anticoagulation: a prospective randomized controlled study. Clin Pharmacol Ther 2008; 83 (3): 460-470
    • (2008) Clin Pharmacol Ther , vol.83 , Issue.3 , pp. 460-470
    • Caraco, Y.1    Blotnick, S.2    Muszkat, M.3
  • 28
    • 40449120615 scopus 로고    scopus 로고
    • Genetic de-terminants of response to warfarin during initial antic-oagulation
    • Schwartz UI, Ritchie MD, Bradford Y, et al. Genetic de-terminants of response to warfarin during initial antic-oagulation. N Engl J Med 2008; 358 (10): 999-1008
    • (2008) N Engl J Med , vol.358 , Issue.10 , pp. 999-1008
    • Schwartz, U.I.1    Ritchie, M.D.2    Bradford, Y.3
  • 29
    • 77953304931 scopus 로고    scopus 로고
    • Warfarin geno-typing reduces hospitalization rates: Results from the MM-WES (Medco-Mayo Warfarin Effectiveness) study
    • Epub 2010 Apr 7
    • Epstein RS, Moyer TP, Aubert RE, et al. Warfarin geno-typing reduces hospitalization rates: results from the MM-WES (Medco-Mayo Warfarin Effectiveness) study. J Am Coll Cardiol. Epub 2010 Apr 7
    • J Am Coll Cardiol
    • Epstein, R.S.1    Moyer, T.P.2    Aubert, R.E.3
  • 30
    • 0033678468 scopus 로고    scopus 로고
    • Identification and biological activity of the active metabolite of clopidogrel
    • Savi P, Pereillo JM, Uzabiaga MF, et al. Identification and biological activity of the active metabolite of clopidogrel. Thromb Haemost 2000; 84: 891-896
    • (2000) Thromb Haemost , vol.84 , pp. 891-896
    • Savi, P.1    Pereillo, J.M.2    Uzabiaga, M.F.3
  • 32
    • 58749094444 scopus 로고    scopus 로고
    • Cytochrome P-450 polymorphisms and response to clopidogrel
    • Mega JL, Close SL, Wiviott SD, et al. Cytochrome P-450 polymorphisms and response to clopidogrel. N Engl J Med 2009; 360: 354-362
    • (2009) N Engl J Med , vol.360 , pp. 354-362
    • Mega, J.L.1    Close, S.L.2    Wiviott, S.D.3
  • 34
    • 78650063012 scopus 로고    scopus 로고
    • US Department of Health and Human Services; US FDA [online]. Available from URL [Accessed 2010 Jun 10]
    • US Department of Health and Human Services; US FDA. Plavix (clopidogrel): reduced effectiveness in patients who are poor metabolizers of the drug [online]. Available from URL: http://www.fda.gov/Safety/MedWatch/ SafetyInformation/SafetyAlertsforHumanMedicalProducts/ucm 204256.htm [Accessed 2010 Jun 10].
    • Plavix (Clopidogrel): Reduced Effectiveness in Patients Who Are Poor Metabolizers of the Drug
  • 35
    • 36148983750 scopus 로고    scopus 로고
    • Prasugrel versus clopidogrel in patients with acute coronary syndromes
    • Wiviott SD, Braunwald E, McCabe CH, et al. Prasugrel ver-sus clopidogrel in patients with acute coronary syndromes. N Engl J Med 2007; 357: 2001-2015
    • (2007) N Engl J Med , vol.357 , pp. 2001-2015
    • Wiviott, S.D.1    Braunwald, E.2    McCabe, C.H.3
  • 36
    • 77955082077 scopus 로고    scopus 로고
    • Genetic variation in metabolizing enzyme and transporter genes: Comprehensive assessment in 3 major east Asian subpopulations with comparison to Caucasians and Africans
    • Epub 2010 Feb 19
    • Man M, Farmen M, Dumaual C, et al. Genetic variation in metabolizing enzyme and transporter genes: comprehensive assessment in 3 major east Asian subpopulations with comparison to Caucasians and Africans. J Clin Pharmacol. Epub 2010 Feb 19
    • J Clin Pharmacol.
    • Man, M.1    Farmen, M.2    Dumaual, C.3
  • 37
    • 0036394942 scopus 로고    scopus 로고
    • Clinical significance of the cytochrome P450 2C19 genetic polymorphism
    • Desta Z, Zhao X, Shin JG, et al. Clinical significance of the cytochrome P450 2C19 genetic polymorphism. Clin Pharmacokinet 2002; 41 (12): 913-958
    • (2002) Clin Pharmacokinet , vol.41 , Issue.12 , pp. 913-958
    • Desta, Z.1    Zhao, X.2    Shin, J.G.3
  • 38
    • 56649120420 scopus 로고    scopus 로고
    • The health benefits of genomics: Out with the old, in with the new
    • Nov/Dec
    • Hudson K. The health benefits of genomics: out with the old, in with the new. Health Aff (Millwood) 2008 Nov/Dec; 27: 1612-1615
    • (2008) Health Aff (Millwood) , vol.27 , pp. 1612-1615
    • Hudson, K.1
  • 39
    • 60849115571 scopus 로고    scopus 로고
    • Pharmacogenetics: Tailoring treat-ment for the outliers
    • Woodcock J, Lesko LJ. Pharmacogenetics: tailoring treat-ment for the outliers. N Engl J Med 2009; 360: 811-3
    • (2009) N Engl J Med , vol.360 , pp. 811-3
    • Woodcock, J.1    Lesko, L.J.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.