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Volumn 14, Issue 1, 2009, Pages 19-34

DNA microarray technology in the clinical environment: The Amplichip CYP450 test for CYP2D6 and CYP2C19 genotyping

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME P450 2C19; CYTOCHROME P450 2D6; ISOENZYME; CYP2C19 PROTEIN, HUMAN; CYTOCHROME P450; UNSPECIFIC MONOOXYGENASE;

EID: 62449286261     PISSN: 10928529     EISSN: None     Source Type: Journal    
DOI: 10.1017/s1092852900020022     Document Type: Article
Times cited : (80)

References (106)
  • 1
    • 0035861038 scopus 로고    scopus 로고
    • The anatomy of the humane genome: A neo-vesalian basis for medicine in the 21st century
    • McKusick VA. The anatomy of the humane genome: a neo-vesalian basis for medicine in the 21st century. JAMA 2001;286:2289-2295.
    • (2001) JAMA , vol.286 , pp. 2289-2295
    • McKusick, V.A.1
  • 2
    • 0031578605 scopus 로고    scopus 로고
    • Breakthrough of the year
    • Breakthrough of the year. The runners-up. Science. 1997;278:2039-2042.
    • (1997) The Runners-up. Science , vol.278 , pp. 2039-2042
  • 3
    • 0012581599 scopus 로고    scopus 로고
    • Deciphering the code and what might come from it
    • , Nov
    • Lertola J. Deciphering the code and what might come from it. Time. 1999;Nov 8:68-69.
    • (1999) Time , vol.8 , pp. 68-69
    • Lertola, J.1
  • 4
    • 0035819474 scopus 로고    scopus 로고
    • Implications of the human genome project for medical science
    • Collins FS, McKusick VA. Implications of the human genome project for medical science. JAMA. 2001;285:540-544.
    • (2001) JAMA , vol.285 , pp. 540-544
    • Collins, F.S.1    McKusick, V.A.2
  • 5
    • 0030822569 scopus 로고    scopus 로고
    • Massively parallel genomics
    • Fodor SP. Massively parallel genomics. Science 1997;277:393-395.
    • (1997) Science , vol.277 , pp. 393-395
    • Fodor, S.P.1
  • 6
    • 0031975185 scopus 로고
    • Update: Clinically significant cytochrome P-450 drug interactions
    • Michalets EL. Update: clinically significant cytochrome P-450 drug interactions. Pharmacotherapy. 1988;18:84-112.
    • (1988) Pharmacotherapy , vol.18 , pp. 84-112
    • Michalets, E.L.1
  • 7
    • 0037328994 scopus 로고    scopus 로고
    • Pharmacogenetics of the major polymorphic metabolizing enzymes
    • Daly AK. Pharmacogenetics of the major polymorphic metabolizing enzymes. Fund Clin Pharmacol 2003;17:27-41.
    • (2003) Fund Clin Pharmacol , vol.17 , pp. 27-41
    • Daly, A.K.1
  • 8
    • 33745944880 scopus 로고    scopus 로고
    • The AmpliChip CYP450 Test: Personalized medicine has arrived in psychiatry
    • de Leon J. The AmpliChip CYP450 Test: personalized medicine has arrived in psychiatry. Expert Rev Mol Diagn. 2006;6:277-286.
    • (2006) Expert Rev Mol Diagn , vol.6 , pp. 277-286
    • de Leon, J.1
  • 9
    • 29544447266 scopus 로고    scopus 로고
    • The AmpliChip CYP450 Genotyping Test: Integrating a new clinical tool
    • de Leon J, Susce MT, Murray-Carmichael E. The AmpliChip CYP450 Genotyping Test: integrating a new clinical tool. Mol Diagn Ther. 2006;10:135-151.
    • (2006) Mol Diagn Ther , vol.10 , pp. 135-151
    • de Leon, J.1    Susce, M.T.2    Murray-Carmichael, E.3
  • 10
    • 81755184586 scopus 로고    scopus 로고
    • Human Cytochrome P450 (CYP) Allele Nomenclature Committee Web site. Available at, Accessed October 28
    • Human Cytochrome P450 (CYP) Allele Nomenclature Committee Web site. Available at: www.cypalleles.ki.se. Accessed October 28, 2008.
    • (2008)
  • 11
    • 13544249943 scopus 로고    scopus 로고
    • Genetic polymorphisms of cytochrome P450 2D6 (CYP2D6): Clinical consequences, evolutionary aspects and functionary diversity
    • Ingelman-Sundberg M. Genetic polymorphisms of cytochrome P450 2D6 (CYP2D6): clinical consequences, evolutionary aspects and functionary diversity. Pharmacogenomics J 2005;5:6-13.
    • (2005) Pharmacogenomics J , vol.5 , pp. 6-13
    • Ingelman-Sundberg, M.1
  • 12
    • 23044531657 scopus 로고    scopus 로고
    • Cytochrome enzyme genotype and the prediction of therapeutic response to psychotropics
    • Alan DA, Sharma RP. Cytochrome enzyme genotype and the prediction of therapeutic response to psychotropics. Psychiatr Ann. 2001;31:715-722.
    • (2001) Psychiatr Ann , vol.31 , pp. 715-722
    • Alan, D.A.1    Sharma, R.P.2
  • 13
    • 29544449443 scopus 로고    scopus 로고
    • Clinical guidelines for psychiatrists for the use of pharmacogenetic testing for CYP450 2D6 and CYP450 2C19
    • de Leon J, Armstrong SC, Cozza KL. Clinical guidelines for psychiatrists for the use of pharmacogenetic testing for CYP450 2D6 and CYP450 2C19. Psychosomatics 2006;47:75-85.
    • (2006) Psychosomatics , vol.47 , pp. 75-85
    • de Leon, J.1    Armstrong, S.C.2    Cozza, K.L.3
  • 14
    • 0027136288 scopus 로고
    • Inherited amplification of an active gene in the cytochrome P450 CYP2D locus as a cause of ultrarapid metabolism of debrisoquine
    • Johansson I, Lundqvist E, Bertilsson L, Dahl ML, Sjöqvist F, Ingelman-Sundberg M. Inherited amplification of an active gene in the cytochrome P450 CYP2D locus as a cause of ultrarapid metabolism of debrisoquine. Proc Natl Acad Sci U S A 1993;90:11825-11829.
    • (1993) Proc Natl Acad Sci U S A , vol.90 , pp. 11825-11829
    • Johansson, I.1    Lundqvist, E.2    Bertilsson, L.3    Dahl, M.L.4    Sjöqvist, F.5    Ingelman-Sundberg, M.6
  • 15
    • 0031038038 scopus 로고    scopus 로고
    • Cytochrome P450 2D6 variants in a Caucasian population: Allele frequencies and phenotypic consequences
    • Sachse C, Brockmöller J, Bauer S, Roots I. Cytochrome P450 2D6 variants in a Caucasian population: allele frequencies and phenotypic consequences. Am J Hum Genet 1997;60:284-295.
    • (1997) Am J Hum Genet , vol.60 , pp. 284-295
    • Sachse, C.1    Brockmöller, J.2    Bauer, S.3    Roots, I.4
  • 16
    • 0031884233 scopus 로고    scopus 로고
    • Assessment of the predictive power of genotypes for the in-vivo catalytic function of CYP2D6 in a German population
    • Griese EU, Zanger UM, Brudermanns U, et al. Assessment of the predictive power of genotypes for the in-vivo catalytic function of CYP2D6 in a German population. Pharmacogenetics. 1998;8:15-26.
    • (1998) Pharmacogenetics , vol.8 , pp. 15-26
    • Griese, E.U.1    Zanger, U.M.2    Brudermanns, U.3
  • 17
    • 6344285930 scopus 로고    scopus 로고
    • Genetic variation in eleven phase I drug metabolism genes in an ethnically diverse population
    • Solus J, Arietta B, Harris J, et al. Genetic variation in eleven phase I drug metabolism genes in an ethnically diverse population. Pharmacogenomics 2004;5:895-931.
    • (2004) Pharmacogenomics , vol.5 , pp. 895-931
    • Solus, J.1    Arietta, B.2    Harris, J.3
  • 18
    • 0043014561 scopus 로고    scopus 로고
    • A review and assessment of potential sources of ethnic differences in drug responsiveness
    • Bjornsson TD, Wagner JA, Donahue SR, et al. A review and assessment of potential sources of ethnic differences in drug responsiveness. J Clin Pharmacol 2003;43:943-967.
    • (2003) J Clin Pharmacol , vol.43 , pp. 943-967
    • Bjornsson, T.D.1    Wagner, J.A.2    Donahue, S.R.3
  • 19
    • 0036124107 scopus 로고    scopus 로고
    • Africans and their descendants
    • Bradford LD. CYP2D6 allele frequency in European Caucasians, Asians
    • Bradford LD. CYP2D6 allele frequency in European Caucasians, Asians, Africans and their descendants. Pharmacogenomics 2002;3:229-243.
    • (2002) Pharmacogenomics , vol.3 , pp. 229-243
  • 20
    • 0032954826 scopus 로고    scopus 로고
    • Duplication, multiduplication, and amplification of genes encoding drug-metabolizing enzymes: Evolutionary, toxicological, and clinical pharmacological aspects
    • Ingelman-Sundberg M. Duplication, multiduplication, and amplification of genes encoding drug-metabolizing enzymes: evolutionary, toxicological, and clinical pharmacological aspects. Drug Metabol Rev. 1999;31:449-459.
    • (1999) Drug Metabol Rev , vol.31 , pp. 449-459
    • Ingelman-Sundberg, M.1
  • 21
    • 0033828454 scopus 로고    scopus 로고
    • The CYP2C19 enzyme polymorphism
    • Wedlund PJ. The CYP2C19 enzyme polymorphism. Pharmacology. 2000;6:174-185.
    • (2000) Pharmacology , vol.6 , pp. 174-185
    • Wedlund, P.J.1
  • 22
    • 33750017284 scopus 로고    scopus 로고
    • A poor metabolizer for both cytochrome P450 2D6 and 2C19 (CYP2D6 and CYP2C19): A case report on antidepressant treatment
    • Johnson M, Markham-Abedi C, Susce MT, Murray-Carmichael E, McCollum S, de Leon J. A poor metabolizer for both cytochrome P450 2D6 and 2C19 (CYP2D6 and CYP2C19): a case report on antidepressant treatment. CNS Spectr. 2006;11:757-760.
    • (2006) CNS Spectr , vol.11 , pp. 757-760
    • Johnson, M.1    Markham-Abedi, C.2    Susce, M.T.3    Murray-Carmichael, E.4    McCollum, S.5    de Leon, J.6
  • 23
    • 3142519666 scopus 로고    scopus 로고
    • Pharmacogenetics of antidepressants and antipsychotics: The contribution of allelic variations to the phenotype of drug response
    • Kirchheiner J, Nickchen K, Bauer M, et al. Pharmacogenetics of antidepressants and antipsychotics: the contribution of allelic variations to the phenotype of drug response. Mol Psychiatry. 2004;9:442-473.
    • (2004) Mol Psychiatry , vol.9 , pp. 442-473
    • Kirchheiner, J.1    Nickchen, K.2    Bauer, M.3
  • 24
    • 34548415432 scopus 로고    scopus 로고
    • Incorporating pharmacogenetics into clinical practice: Reality of a new tool in psychiatry. Current issues in clinical implementation
    • de Leon J. Incorporating pharmacogenetics into clinical practice: reality of a new tool in psychiatry. Current issues in clinical implementation. CNS Spectr. 2006;11(suppl 3):8-12.
    • (2006) CNS Spectr , vol.11 , Issue.3 SUPPL. , pp. 8-12
    • de Leon, J.1
  • 25
    • 34248596149 scopus 로고    scopus 로고
    • The crucial role of the therapeutic window in understanding the clinical relevance of the poor versus the ultrarapid metabolizer phenotypes in subjects taking drugs metabolized by CYP2D6 and CYP2C19
    • de Leon J. The crucial role of the therapeutic window in understanding the clinical relevance of the poor versus the ultrarapid metabolizer phenotypes in subjects taking drugs metabolized by CYP2D6 and CYP2C19. J Clin Psychopharmacol 2007;27:241-245.
    • (2007) J Clin Psychopharmacol , vol.27 , pp. 241-245
    • de Leon, J.1
  • 26
    • 13844320650 scopus 로고    scopus 로고
    • CYP2D6 poor metabolizer phenotype may be associated with risperidone adverse drug reactions and discontinuation
    • de Leon J, Susce MT, Pan RM, Fairchild M, Koch W, Wedlund PJ. CYP2D6 poor metabolizer phenotype may be associated with risperidone adverse drug reactions and discontinuation. J Clin Psychiatry. 2005;66:15-27.
    • (2005) J Clin Psychiatry , vol.66 , pp. 15-27
    • de Leon, J.1    Susce, M.T.2    Pan, R.M.3    Fairchild, M.4    Koch, W.5    Wedlund, P.J.6
  • 27
    • 81755184584 scopus 로고    scopus 로고
    • DNA Genotek Inc. Products: Oragene•DNA. Available at, Accessed October 28
    • DNA Genotek Inc. Products: Oragene•DNA. Available at: http://www.dnagenotek.com/products_oragene.htm. Accessed October 28, 2008.
    • (2008)
  • 28
    • 0004280149 scopus 로고    scopus 로고
    • Confidence Interval Analysis (CIA) for Windows software package. In: Altman DG, Machin D, Bryant TN, Gardner MJ, eds. 2nd ed. London, UK: BMJ Books
    • Confidence Interval Analysis (CIA) for Windows software package. In: Altman DG, Machin D, Bryant TN, Gardner MJ, eds. Statistics with Confidence 2nd ed. London, UK: BMJ Books; 2000.
    • (2000) Statistics with Confidence
  • 29
    • 33746102723 scopus 로고    scopus 로고
    • CYP2D6 genetic variations in healthy adults in psychiatric African-American subjects: Implications for clinical practice and genetic testing
    • Cai WM, Nikoloff DM, Pan RM, et al. CYP2D6 genetic variations in healthy adults in psychiatric African-American subjects: implications for clinical practice and genetic testing. Pharmacogenomics J. 2006;6:343-350.
    • (2006) Pharmacogenomics J , vol.6 , pp. 343-350
    • Cai, W.M.1    Nikoloff, D.M.2    Pan, R.M.3
  • 30
    • 34249034315 scopus 로고    scopus 로고
    • Identification and characterization of CYP2D6*56B, an allele associated with the poor metabolizer phenotype
    • Gaedigk A, Eklund JD, Pearce RE, et al. Identification and characterization of CYP2D6*56B, an allele associated with the poor metabolizer phenotype. Clin Pharmacol Ther. 2007;81:817-820.
    • (2007) Clin Pharmacol Ther , vol.81 , pp. 817-820
    • Gaedigk, A.1    Eklund, J.D.2    Pearce, R.E.3
  • 31
    • 33847031732 scopus 로고    scopus 로고
    • CYP2D6 worldwide genetic variation shows high frequency of altered activity variants and no continental structure
    • Sistonen J, Sajantila A, Lao O, Corander J, Barbujani G, Fuselli S. CYP2D6 worldwide genetic variation shows high frequency of altered activity variants and no continental structure. Pharmacogenet Genomics. 2007;17:93-101.
    • (2007) Pharmacogenet Genomics , vol.17 , pp. 93-101
    • Sistonen, J.1    Sajantila, A.2    Lao, O.3    Corander, J.4    Barbujani, G.5    Fuselli, S.6
  • 32
    • 14644400494 scopus 로고    scopus 로고
    • The impact of pharmacogenomics on postoperative nausea and vomiting: Do CYP2D6 allele copy number and polymorphisms affect the success or failure of ondansetron prophylaxis?
    • Candiotti KA, Birnbach DJ, Lubarsky DA, et al. The impact of pharmacogenomics on postoperative nausea and vomiting: do CYP2D6 allele copy number and polymorphisms affect the success or failure of ondansetron prophylaxis? Anesthesiology. 2005;102:543-549.
    • (2005) Anesthesiology , vol.102 , pp. 543-549
    • Candiotti, K.A.1    Birnbach, D.J.2    Lubarsky, D.A.3
  • 33
    • 34547644659 scopus 로고    scopus 로고
    • Pharmacokinetics of codeine and its metabolite morphine in ultra-rapid metabolizers due to CYP2D6 duplication
    • Kirchheiner J, Schmidt H, Tzvetkov M, et al. Pharmacokinetics of codeine and its metabolite morphine in ultra-rapid metabolizers due to CYP2D6 duplication. Pharmacogenomics J 2007;7:257-265.
    • (2007) Pharmacogenomics J , vol.7 , pp. 257-265
    • Kirchheiner, J.1    Schmidt, H.2    Tzvetkov, M.3
  • 35
    • 0027965620 scopus 로고
    • Genetic analysis of the Chinese cytochrome P4502D locus: Characterization of variant CYP2D6 genes present in subjects with diminished capacity for debrisoquine hydroxylation
    • Johansson I, Oscarson M, Yue QY, Bertilsson L, Sjöqvist F, Ingelman-Sundberg M. Genetic analysis of the Chinese cytochrome P4502D locus: characterization of variant CYP2D6 genes present in subjects with diminished capacity for debrisoquine hydroxylation. Mol Pharmacol 1994;46:452-459.
    • (1994) Mol Pharmacol , vol.46 , pp. 452-459
    • Johansson, I.1    Oscarson, M.2    Yue, Q.Y.3    Bertilsson, L.4    Sjöqvist, F.5    Ingelman-Sundberg, M.6
  • 36
    • 30344457586 scopus 로고    scopus 로고
    • A common novel CYP2C19 gene variant causes ultrarapid drug metabolism relevant for the drug response to proton pump inhibitors and antidepressants
    • Sim SC, Risinger C, Dahl ML, et al. A common novel CYP2C19 gene variant causes ultrarapid drug metabolism relevant for the drug response to proton pump inhibitors and antidepressants. Clin Pharmacol Ther. 2006;79:103-113.
    • (2006) Clin Pharmacol Ther , vol.79 , pp. 103-113
    • Sim, S.C.1    Risinger, C.2    Dahl, M.L.3
  • 37
    • 36349024762 scopus 로고    scopus 로고
    • Breast cancer treatment outcome with adjuvant tamoxifen relative to patient CYP2D6 and CYP2C19 genotypes
    • Schroth W, Antoniadou L, Fritz P, et al. Breast cancer treatment outcome with adjuvant tamoxifen relative to patient CYP2D6 and CYP2C19 genotypes. J Clin Oncol. 2007;25:5187-5193.
    • (2007) J Clin Oncol , vol.25 , pp. 5187-5193
    • Schroth, W.1    Antoniadou, L.2    Fritz, P.3
  • 38
    • 0035039209 scopus 로고    scopus 로고
    • Genetic polymorphism of CYP2D6 and CYP2C19 in eastand southern African populations including psychiatric patients
    • Dandara C, Masimirembwa CM, Magimba A, et al. Genetic polymorphism of CYP2D6 and CYP2C19 in eastand southern African populations including psychiatric patients. Eur J Clin Pharmacol. 2001;57:11-17.
    • (2001) Eur J Clin Pharmacol , vol.57 , pp. 11-17
    • Dandara, C.1    Masimirembwa, C.M.2    Magimba, A.3
  • 39
    • 0028947973 scopus 로고
    • No association between schizophrenia and polymorphisms within the genes for debrisoquine 4-hydroxylase (CYP2D6) and the dopamine transporter (DAT)
    • Daniels J, Williams J, Asherson P, McGuffin P, Owens M. No association between schizophrenia and polymorphisms within the genes for debrisoquine 4-hydroxylase (CYP2D6) and the dopamine transporter (DAT). Am J Med Genet 1995;60:85-87.
    • (1995) Am J Med Genet , vol.60 , pp. 85-87
    • Daniels, J.1    Williams, J.2    Asherson, P.3    McGuffin, P.4    Owens, M.5
  • 40
    • 0028596610 scopus 로고
    • An association study of debrisoquine hydroxylase (CYP2D6) polymorphisms in schizophrenia
    • Dawson E, Powell JF, Nöthen MM, et al. An association study of debrisoquine hydroxylase (CYP2D6) polymorphisms in schizophrenia. Psychiatr Genet 1994;4:215-218.
    • (1994) Psychiatr Genet , vol.4 , pp. 215-218
    • Dawson, E.1    Powell, J.F.2    Nöthen, M.M.3
  • 42
    • 0026777590 scopus 로고
    • Debrisoquine 4-hydroxylase (CYP2D) locus and possible susceptibility to schizophrenia [letter]
    • Vallada H, Collier D, Dawson E, et al. Debrisoquine 4-hydroxylase (CYP2D) locus and possible susceptibility to schizophrenia [letter]. Lancet. 1992;340:181-182.
    • (1992) Lancet , vol.340 , pp. 181-182
    • Vallada, H.1    Collier, D.2    Dawson, E.3
  • 44
    • 28444496691 scopus 로고    scopus 로고
    • Identification of CYP2D6 impaired functional alleles in Mexican Americans
    • Luo HR, Gaedigk A, Aloumanis V, Wan YJ. Identification of CYP2D6 impaired functional alleles in Mexican Americans. Eur J Clin Pharmacol. 2005;61:797-802.
    • (2005) Eur J Clin Pharmacol , vol.61 , pp. 797-802
    • Luo, H.R.1    Gaedigk, A.2    Aloumanis, V.3    Wan, Y.J.4
  • 45
    • 0037380942 scopus 로고    scopus 로고
    • Comparison of two CYP2D6 genotyping methods and assessments of genotype-phenotype relationships
    • Chou WH, Yan FX, Robbins-Weilert DK, et al. Comparison of two CYP2D6 genotyping methods and assessments of genotype-phenotype relationships. Clin Chem. 2003;49:542-551.
    • (2003) Clin Chem , vol.49 , pp. 542-551
    • Chou, W.H.1    Yan, F.X.2    Robbins-Weilert, D.K.3
  • 46
    • 34248597277 scopus 로고    scopus 로고
    • A study of genetic (CYP2D6 and ABCB1) and environmental (drug inhibitors and inducers) variables that may influence plasma risperidone levels
    • Leon J, Susce MT, Pan RM, Wedlund PJ, Orrego ML, Diaz FJ. A study of genetic (CYP2D6 and ABCB1) and environmental (drug inhibitors and inducers) variables that may influence plasma risperidone levels. Pharmacopsychiatry. 2007;40:93-102.
    • (2007) Pharmacopsychiatry , vol.40 , pp. 93-102
    • Leon, J.1    Susce, M.T.2    Pan, R.M.3    Wedlund, P.J.4    Orrego, M.L.5    Diaz, F.J.6
  • 47
    • 4344613464 scopus 로고    scopus 로고
    • Allele-specific change of concentration and functional gene dose for the prediction of steady-state serum concentrations of amitriptyline and nortriptyline in CYP2C19 and CYP2D6 extensive and intermediate metabolizers
    • Steimer W, Zopf K, von Amelunxen S, et al. Allele-specific change of concentration and functional gene dose for the prediction of steady-state serum concentrations of amitriptyline and nortriptyline in CYP2C19 and CYP2D6 extensive and intermediate metabolizers. Clin Chem 2004;50:1623-1633.
    • (2004) Clin Chem , vol.50 , pp. 1623-1633
    • Steimer, W.1    Zopf, K.2    von Amelunxen, S.3
  • 48
    • 38349132802 scopus 로고    scopus 로고
    • The CYP2D6 activity score: Translating genotype information into a qualitative measure of phenotype
    • Gaedigk A, Simon SD, Pearce RE, et al. The CYP2D6 activity score: translating genotype information into a qualitative measure of phenotype. Clin Pharmacol Ther. 2008;83:234-242.
    • (2008) Clin Pharmacol Ther , vol.83 , pp. 234-242
    • Gaedigk, A.1    Simon, S.D.2    Pearce, R.E.3
  • 49
    • 38349167330 scopus 로고    scopus 로고
    • The CYP2D6 phenotype prediction from genotype: Which system is best?
    • Kirchheiner J. The CYP2D6 phenotype prediction from genotype: which system is best? Clin Pharmacol Ther. 2008;83:225-227.
    • (2008) Clin Pharmacol Ther , vol.83 , pp. 225-227
    • Kirchheiner, J.1
  • 50
    • 0036339071 scopus 로고    scopus 로고
    • Unique CYP2D6 activity distribution and genotype-phenotype discordance in black Americans
    • Gaedigk A, Bradford LD, Marcucci KA, Leeder JS. Unique CYP2D6 activity distribution and genotype-phenotype discordance in black Americans. Clin Pharmacol Ther. 2002;72:76-89.
    • (2002) Clin Pharmacol Ther , vol.72 , pp. 76-89
    • Gaedigk, A.1    Bradford, L.D.2    Marcucci, K.A.3    Leeder, J.S.4
  • 51
    • 0036007579 scopus 로고    scopus 로고
    • The African-specific CYP2D6*17 allele encodes an enzyme with changed substrate specificity
    • Wennerholm A, Dandara C, Sayi J, et al. The African-specific CYP2D6*17 allele encodes an enzyme with changed substrate specificity. Clin Pharmacol Ther 2002;71:77-88.
    • (2002) Clin Pharmacol Ther , vol.71 , pp. 77-88
    • Wennerholm, A.1    Dandara, C.2    Sayi, J.3
  • 52
    • 19344367709 scopus 로고    scopus 로고
    • Substrate specific metabolism by polymorphic cytochrome P450 2D6 alleles
    • Bogni A, Monshouwer M, Moscone A, et al. Substrate specific metabolism by polymorphic cytochrome P450 2D6 alleles. Toxicol In Vitro. 2005;19:621-629.
    • (2005) Toxicol In Vitro , vol.19 , pp. 621-629
    • Bogni, A.1    Monshouwer, M.2    Moscone, A.3
  • 53
    • 33846619202 scopus 로고    scopus 로고
    • Absorption, metabolism and excretion of a single oral dose of 14C-paliperidone 1 mg in healthy subjects
    • Vermier M, Boom S, Naessens I, et al. Absorption, metabolism and excretion of a single oral dose of 14C-paliperidone 1 mg in healthy subjects. Eur Neuropsychopharmacol. 2005;15:648-649.
    • (2005) Eur Neuropsychopharmacol , vol.15 , pp. 648-649
    • Vermier, M.1    Boom, S.2    Naessens, I.3
  • 54
    • 75849152698 scopus 로고    scopus 로고
    • Impact of the CYP2D6 metabolizer phenotype on the safety profile of paliperidone ER
    • Dunbar F, Chue P, Fu DJ, et al. Impact of the CYP2D6 metabolizer phenotype on the safety profile of paliperidone ER. Biol Psychiatry. 2007;61(suppl):83S.
    • (2007) Biol Psychiatry , vol.61 , Issue.SUPPL.
    • Dunbar, F.1    Chue, P.2    Fu, D.J.3
  • 55
    • 33745068503 scopus 로고    scopus 로고
    • Serum concentrations of risperidone and 9-OH risperidone following intramuscular injection of long-acting risperidone compared with oral risperidone medication
    • Nesvåg R, Hendset M, Refsum H, Tanum L. Serum concentrations of risperidone and 9-OH risperidone following intramuscular injection of long-acting risperidone compared with oral risperidone medication. Acta Psychiatr Scand 2006;114:21-26.
    • (2006) Acta Psychiatr Scand , vol.114 , pp. 21-26
    • Nesvåg, R.1    Hendset, M.2    Refsum, H.3    Tanum, L.4
  • 56
    • 33646812979 scopus 로고    scopus 로고
    • High carrier prevalence of deficient and null alleles of CYP2 genes in a major USA hospital: Implications for personalized drug safety
    • Ruaño G, Makowski G, Windemuth A, et al. High carrier prevalence of deficient and null alleles of CYP2 genes in a major USA hospital: implications for personalized drug safety. Personalized Med. 2006;3:131-137.
    • (2006) Personalized Med , vol.3 , pp. 131-137
    • Ruaño, G.1    Makowski, G.2    Windemuth, A.3
  • 57
    • 0036796048 scopus 로고    scopus 로고
    • The impact of the CYP2D6 polymorphism on haloperidol pharmacokinetics and on the outcome of haloperidol treatment
    • Brockmoller J, Kirchheiner J, Schmider J, et al. The impact of the CYP2D6 polymorphism on haloperidol pharmacokinetics and on the outcome of haloperidol treatment. Clin Pharmacol Ther 2002;72:438-452.
    • (2002) Clin Pharmacol Ther , vol.72 , pp. 438-452
    • Brockmoller, J.1    Kirchheiner, J.2    Schmider, J.3
  • 60
    • 9644275322 scopus 로고    scopus 로고
    • Severe adverse effects in a newborn with two defective CYP2D6 alleles after exposure to paroxetine during late pregnancy
    • Laine K, Kytölä J, Bertilsson L. Severe adverse effects in a newborn with two defective CYP2D6 alleles after exposure to paroxetine during late pregnancy. Ther Drug Monit. 2004;26:685-687.
    • (2004) Ther Drug Monit , vol.26 , pp. 685-687
    • Laine, K.1    Kytölä, J.2    Bertilsson, L.3
  • 61
    • 0034059585 scopus 로고    scopus 로고
    • Fluoxetine-related death in a child with cytochrome P-450 2D6 genetic deficiency
    • Sallee FR, DeVane CL, Ferrell RE. Fluoxetine-related death in a child with cytochrome P-450 2D6 genetic deficiency. J Child Adolesc Psychopharmacol 2000;10:27-34.
    • (2000) J Child Adolesc Psychopharmacol , vol.10 , pp. 27-34
    • Sallee, F.R.1    Devane, C.L.2    Ferrell, R.E.3
  • 62
    • 37349093041 scopus 로고    scopus 로고
    • Testing for cytochrome P450 polymorphisms in adults with nonpsychotics depression treated with selective serotonin reuptake inhibitors
    • Evaluation of Genomic Applications in Practice and Prevention (EGAPP) Working Group Recommendations from the EGAPP Working Group
    • Evaluation of Genomic Applications in Practice and Prevention (EGAPP) Working Group Recommendations from the EGAPP Working Group. Testing for cytochrome P450 polymorphisms in adults with nonpsychotics depression treated with selective serotonin reuptake inhibitors. Genet Med. 2007;9:819-825.
    • (2007) Genet Med , vol.9 , pp. 819-825
  • 63
    • 33748363505 scopus 로고    scopus 로고
    • CYP2D6 polymorphism and clinical effect of the antidepressant venlafaxine
    • Shams ME, Arneth B, Hiemke C, et al. CYP2D6 polymorphism and clinical effect of the antidepressant venlafaxine. J Clin Pharm Ther. 2006;31:493-502.
    • (2006) J Clin Pharm Ther , vol.31 , pp. 493-502
    • Shams, M.E.1    Arneth, B.2    Hiemke, C.3
  • 64
  • 66
    • 0013499111 scopus 로고    scopus 로고
    • Disposition and metabolic fate of atomoxetine hydrochloride: The role of CYP2D6 in human disposition and metabolism
    • Sauer JM, Poinsler GD, Mattiuz EL. Disposition and metabolic fate of atomoxetine hydrochloride: the role of CYP2D6 in human disposition and metabolism. Drug Metab Dispos 2003;31:98-107.
    • (2003) Drug Metab Dispos , vol.31 , pp. 98-107
    • Sauer, J.M.1    Poinsler, G.D.2    Mattiuz, E.L.3
  • 67
    • 0036929584 scopus 로고    scopus 로고
    • Safety profile of atomoxetine in the treatment of children and adolescents with ADHD
    • Wernicke JF, Kratochvil CJ. Safety profile of atomoxetine in the treatment of children and adolescents with ADHD. J Clin Psychiatry 2002;63:50-55.
    • (2002) J Clin Psychiatry , vol.63 , pp. 50-55
    • Wernicke, J.F.1    Kratochvil, C.J.2
  • 68
    • 3543054961 scopus 로고    scopus 로고
    • Safety and efficacy of atomoxetine in pediatric CYP2D6 extensive versus poor metabolizers
    • Presented at, May 16-18, Philadelphia, Penn
    • Allen AJ, Wernicke J, Dunn D, et al. Safety and efficacy of atomoxetine in pediatric CYP2D6 extensive versus poor metabolizers. Presented at: the 57th Annual Meeting of the Society of Biological Psychiatry. May 16-18, 2002; Philadelphia, Penn.
    • (2002) The 57th Annual Meeting of the Society of Biological Psychiatry
    • Allen, A.J.1    Wernicke, J.2    Dunn, D.3
  • 69
    • 0034758620 scopus 로고    scopus 로고
    • Pharmacokinetic and pharmacodynamic drug interaction in the treatment of attention-deficit hyperactivity disorder
    • Markowitz JS, Patrick KS. Pharmacokinetic and pharmacodynamic drug interaction in the treatment of attention-deficit hyperactivity disorder. Clin Pharmacokinet. 2001;40:753-772.
    • (2001) Clin Pharmacokinet , vol.40 , pp. 753-772
    • Markowitz, J.S.1    Patrick, K.S.2
  • 71
    • 11144221180 scopus 로고    scopus 로고
    • Codeine intoxication associated with ultrarapid CYP2D6 metabolism
    • Gasche Y, Daali Y, Fathi M, et al. Codeine intoxication associated with ultrarapid CYP2D6 metabolism. N Eng J Med. 2004;351:2827-2831.
    • (2004) N Eng J Med , vol.351 , pp. 2827-2831
    • Gasche, Y.1    Daali, Y.2    Fathi, M.3
  • 72
    • 33747134323 scopus 로고    scopus 로고
    • Pharmacogenetics of morphine poisoning in a breastfed neonate of a codeine-prescribed mother
    • Koren G, Cairns J, Chitayat D, Gaedigk A, Leeder SJ. Pharmacogenetics of morphine poisoning in a breastfed neonate of a codeine-prescribed mother. Lancet 2006;368:704.
    • (2006) Lancet , vol.368 , pp. 704
    • Koren, G.1    Cairns, J.2    Chitayat, D.3    Gaedigk, A.4    Leeder, S.J.5
  • 73
    • 10044297116 scopus 로고    scopus 로고
    • Genetic predictors of the clinical response to opioid analgesics: Clinical utility and future perspectives
    • Lötsch J, Skarke C, Liefhold J, Geisslinger G. Genetic predictors of the clinical response to opioid analgesics: clinical utility and future perspectives. Clin Pharmacokinet. 2004;43:983-1013.
    • (2004) Clin Pharmacokinet , vol.43 , pp. 983-1013
    • Lötsch, J.1    Skarke, C.2    Liefhold, J.3    Geisslinger, G.4
  • 74
    • 0042634370 scopus 로고    scopus 로고
    • Adverse drug reactions to oxycodone and hydrocodone in CYP2D6 ultrarapid metabolizers [letter]
    • de Leon J, Dinsmore L, Wedlund PJ. Adverse drug reactions to oxycodone and hydrocodone in CYP2D6 ultrarapid metabolizers [letter]. J Clin Psychopharmacol 2003;23:420-421.
    • (2003) J Clin Psychopharmacol , vol.23 , pp. 420-421
    • de Leon, J.1    Dinsmore, L.2    Wedlund, P.J.3
  • 75
    • 42249096010 scopus 로고    scopus 로고
    • Paradoxical excitation on diphenhydramine may be associated with being a CYP2D6 ultrarapid metabolizer: Three case reports
    • de Leon J, Nikoloff DM. Paradoxical excitation on diphenhydramine may be associated with being a CYP2D6 ultrarapid metabolizer: three case reports. CNS Spectr. 2008;13:133-135.
    • (2008) CNS Spectr , vol.13 , pp. 133-135
    • de Leon, J.1    Nikoloff, D.M.2
  • 76
    • 81755183502 scopus 로고    scopus 로고
    • FDA Executive Summary on Tamoxifen and CYP2D6. Available at, Accessed October 28
    • FDA Executive Summary on Tamoxifen and CYP2D6. Available at: http://www.fda.gov/ohrms/dockets/ac/06/briefing/2006-4248B1-01-FDA-Tamoxifen%20Background%20Summary%20Final.pdf. Accessed October 28, 2008.
    • (2008)
  • 77
    • 34548650021 scopus 로고    scopus 로고
    • CYP2D6 polymorphisms and the mpact on tamoxifen therapy
    • Beverage JN, Sissung TM, Sion AM, et al. CYP2D6 polymorphisms and the mpact on tamoxifen therapy. J Pharm Sci 2007;96:2224-2231.
    • (2007) J Pharm Sci , vol.96 , pp. 2224-2231
    • Beverage, J.N.1    Sissung, T.M.2    Sion, A.M.3
  • 78
    • 33847034287 scopus 로고    scopus 로고
    • The impact of cytochrome P450 2D6 metabolism in women receiving adjuvant tamoxifen therapy
    • Goetz M, Knox S, Suman V, et al. The impact of cytochrome P450 2D6 metabolism in women receiving adjuvant tamoxifen therapy. Breast Cancer Res Treat 2007;101:113-121.
    • (2007) Breast Cancer Res Treat , vol.101 , pp. 113-121
    • Goetz, M.1    Knox, S.2    Suman, V.3
  • 79
    • 34548532227 scopus 로고    scopus 로고
    • Clinical implications of CYP2D6 genotypes predictive of tamoxifen pharmacokinetics in metastatic breast
    • Lim HS, Ju Lee H, Seok Lee K, Sook Lee E, Jang IJ, Ro J. Clinical implications of CYP2D6 genotypes predictive of tamoxifen pharmacokinetics in metastatic breast. J Clin Oncol 2007;25:3837-3845.
    • (2007) J Clin Oncol , vol.25 , pp. 3837-3845
    • Lim, H.S.1    Ju, L.H.2    Seok, L.K.3    Sook, L.E.4    Jang, I.J.5    Ro, J.6
  • 80
    • 43649090742 scopus 로고    scopus 로고
    • Impact of CYP2D6*10 on recurrence-free survival in breast cancer patients receiving adjuvant tamoxifen therapy
    • Kiyotani K, Mushiroda T, Sasa M, et al. Impact of CYP2D6*10 on recurrence-free survival in breast cancer patients receiving adjuvant tamoxifen therapy. Cancer Sci. 2008;99:885-999.
    • (2008) Cancer Sci , vol.99 , pp. 885-999
    • Kiyotani, K.1    Mushiroda, T.2    Sasa, M.3
  • 81
    • 47749105202 scopus 로고    scopus 로고
    • Association between CYP2D6 *10 genotype and survival of breast cancer patients receiving tamoxifen treatment
    • Xu Y, Sun Y, Yao L, et al. Association between CYP2D6 *10 genotype and survival of breast cancer patients receiving tamoxifen treatment. Ann Oncol 2008;19:1423-1429.
    • (2008) Ann Oncol , vol.19 , pp. 1423-1429
    • Xu, Y.1    Sun, Y.2    Yao, L.3
  • 82
    • 33747045564 scopus 로고    scopus 로고
    • Polymorphism in the CYP2D6 tamoxifen-metabolizing gene influences clinical effect but not hot flashes: Data from the Italian tamoxifen trial
    • Bonanni B, Macis D, Maisonneuve P, et al. Polymorphism in the CYP2D6 tamoxifen-metabolizing gene influences clinical effect but not hot flashes: data from the Italian tamoxifen trial. J Clin Oncol 2006;24:3708-3709.
    • (2006) J Clin Oncol , vol.24 , pp. 3708-3709
    • Bonanni, B.1    Macis, D.2    Maisonneuve, P.3
  • 83
    • 0034923234 scopus 로고    scopus 로고
    • Pharmacokinetics of sertraline in relation to genetic polymorphism of CYP2C19
    • Wang JH, Liu ZQ, Wang W, et al. Pharmacokinetics of sertraline in relation to genetic polymorphism of CYP2C19. Clin Pharmacol Ther 2001;70:42-47.
    • (2001) Clin Pharmacol Ther , vol.70 , pp. 42-47
    • Wang, J.H.1    Liu, Z.Q.2    Wang, W.3
  • 84
    • 13444278490 scopus 로고    scopus 로고
    • Sertraline is metabolized by multiple cytochrome P450 enzymes, monoamine oxidases, and glucuronyl transferases in human: An in vitro study
    • Obach RS, Cox LM, Tremaine LM. Sertraline is metabolized by multiple cytochrome P450 enzymes, monoamine oxidases, and glucuronyl transferases in human: an in vitro study. Drug Metab Dispos 2005;33:262-270.
    • (2005) Drug Metab Dispos , vol.33 , pp. 262-270
    • Obach, R.S.1    Cox, L.M.2    Tremaine, L.M.3
  • 85
    • 34248566810 scopus 로고    scopus 로고
    • Are the 5HT transporter and/or the P450 isonezyme genes associated with response/remission to citalopram
    • Mrazek DA. Are the 5HT transporter and/or the P450 isonezyme genes associated with response/remission to citalopram. Biol Psychiatry. 2006;59(suppl):105S.
    • (2006) Biol Psychiatry , vol.59 , Issue.SUPPL.
    • Mrazek, D.A.1
  • 86
    • 38349110295 scopus 로고    scopus 로고
    • Impact of the ultrarapid CYP2C19*17 allele on serum concentration of escitalopram in psychiatric patients
    • Rudberg I, Mohebi B, Hermann M, Refsum H, Molden E. Impact of the ultrarapid CYP2C19*17 allele on serum concentration of escitalopram in psychiatric patients. Clin Pharmacol Ther. 2008;83:322-327.
    • (2008) Clin Pharmacol Ther , vol.83 , pp. 322-327
    • Rudberg, I.1    Mohebi, B.2    Hermann, M.3    Refsum, H.4    Molden, E.5
  • 87
    • 0036394942 scopus 로고    scopus 로고
    • Clinical significance of the cytochrome P450 2C19 genetic polymorphism
    • Desta Z, Zhao X, Shin J, Flockhart D. Clinical significance of the cytochrome P450 2C19 genetic polymorphism. Clin Pharmacokinet. 2002;41:913-958.
    • (2002) Clin Pharmacokinet , vol.41 , pp. 913-958
    • Desta, Z.1    Zhao, X.2    Shin, J.3    Flockhart, D.4
  • 88
    • 28844431530 scopus 로고    scopus 로고
    • CYP2C19 genotype affects diazepam pharmacokinetics and emergence from general anesthesia
    • Inomata S, Nagashima A, Itagaki F, et al. CYP2C19 genotype affects diazepam pharmacokinetics and emergence from general anesthesia. Clin Pharmacol Ther 2005;78:647-655.
    • (2005) Clin Pharmacol Ther , vol.78 , pp. 647-655
    • Inomata, S.1    Nagashima, A.2    Itagaki, F.3
  • 89
    • 49449098790 scopus 로고    scopus 로고
    • The potential of genotyping [letter]
    • de Leon J. The potential of genotyping [letter]. Science 2008;321:769.
    • (2008) Science , vol.321 , pp. 769
    • de Leon, J.1
  • 90
    • 57149135263 scopus 로고    scopus 로고
    • Products for pharmacogenetic testing in psychiatry: A review of features and clinical realities
    • de Leon J, Arranz MJ, Ruaño G. Products for pharmacogenetic testing in psychiatry: a review of features and clinical realities. Clin Lab Med. 2008;28:599-617.
    • (2008) Clin Lab Med , vol.28 , pp. 599-617
    • de Leon, J.1    Arranz, M.J.2    Ruaño, G.3
  • 91
    • 57649139354 scopus 로고    scopus 로고
    • Pharmacogenomics: The promise of personalized medicine for CNS disorders
    • de Leon J. Pharmacogenomics: the promise of personalized medicine for CNS disorders. Neuropsychopharmacology 2009;34:159-172.
    • (2009) Neuropsychopharmacology , vol.34 , pp. 159-172
    • de Leon, J.1
  • 92
    • 34547469943 scopus 로고    scopus 로고
    • Pharmacogenetics and pharmacogenomics of schizophrenia: A review of the last decade of research
    • Arranz MJ, de Leon J. Pharmacogenetics and pharmacogenomics of schizophrenia: a review of the last decade of research. Mol Psychiatry. 2007;12:707-747.
    • (2007) Mol Psychiatry , vol.12 , pp. 707-747
    • Arranz, M.J.1    de Leon, J.2
  • 94
    • 11144262726 scopus 로고    scopus 로고
    • Do new prescription drugs pay for themselves? The case of secondgeneration antipsychotics
    • Duggan M. Do new prescription drugs pay for themselves? The case of secondgeneration antipsychotics. J Health Econ. 2005;24:1-31.
    • (2005) J Health Econ , vol.24 , pp. 1-31
    • Duggan, M.1
  • 95
    • 49749099137 scopus 로고    scopus 로고
    • Second-generation antipsychotics: Costeffectiveness, policy options, and political decision making
    • Rosenheck RA, Leslie DL, Doshi JA. Second-generation antipsychotics: costeffectiveness, policy options, and political decision making. Psychiatr Serv 2008;59:515-520.
    • (2008) Psychiatr Serv , vol.59 , pp. 515-520
    • Rosenheck, R.A.1    Leslie, D.L.2    Doshi, J.A.3
  • 96
    • 34047139907 scopus 로고    scopus 로고
    • Effectiveness of olanzapine, quetiapine, and risperidone in patients with chronic schizophrenia after discontinuing perphenazine: A CATIE study
    • Stroup TS, Lieberman JA, McEvoy JP, et al. Effectiveness of olanzapine, quetiapine, and risperidone in patients with chronic schizophrenia after discontinuing perphenazine: a CATIE study. Am J Psychiatry. 2007;164:415-427.
    • (2007) Am J Psychiatry , vol.164 , pp. 415-427
    • Stroup, T.S.1    Lieberman, J.A.2    McEvoy, J.P.3
  • 97
    • 55749083565 scopus 로고    scopus 로고
    • Double-blind comparison of firstand secondgeneration antipsychotics in early-onset schizophrenia and schizo-affective disorder: Findings from the Treatment of Early-Onset Schizophrenia Spectrum Disorders (TEOSS) study
    • Sept 15, [Epub ahead of print]
    • Sikich L, Frazier JA, McClellan J, et al. Double-blind comparison of firstand secondgeneration antipsychotics in early-onset schizophrenia and schizo-affective disorder: findings from the Treatment of Early-Onset Schizophrenia Spectrum Disorders (TEOSS) study. Am J Psychiatry. 2008 Sept 15. [Epub ahead of print].
    • (2008) Am J Psychiatry
    • Sikich, L.1    Frazier, J.A.2    McClellan, J.3
  • 98
    • 34848889545 scopus 로고    scopus 로고
    • Planning for the optimal design of studies to personalize antipsychotic prescriptions in the post-CATIE era: The clinical and pharmacoepidemiological data suggest that pursuing the pharmacogenetics of metabolic syndrome complications (hypertension, diabetes mellitus and hyperlipidemia) may be a reasonable strategy
    • de Leon J, Diaz FJ. Planning for the optimal design of studies to personalize antipsychotic prescriptions in the post-CATIE era: the clinical and pharmacoepidemiological data suggest that pursuing the pharmacogenetics of metabolic syndrome complications (hypertension, diabetes mellitus and hyperlipidemia) may be a reasonable strategy. Schizophr Res. 2007;96:185-197.
    • (2007) Schizophr Res , vol.96 , pp. 185-197
    • de Leon, J.1    Diaz, F.J.2
  • 99
    • 36849095003 scopus 로고    scopus 로고
    • Exploring genetic variations that may be associated with the direct effects of some antipsychotics on lipid levels
    • de Leon J, Correa JC, Ruaño G, Windemuth A, Arranz MJ, Diaz FJ. Exploring genetic variations that may be associated with the direct effects of some antipsychotics on lipid levels. Schizophr Res 2008;98:40-46.
    • (2008) Schizophr Res , vol.98 , pp. 40-46
    • de Leon, J.1    Correa, J.C.2    Ruaño, G.3    Windemuth, A.4    Arranz, M.J.5    Diaz, F.J.6
  • 100
    • 40949134281 scopus 로고    scopus 로고
    • Beyond the "hype" on the association between metabolic syndrome and atypical antipsychotics: The confounding effects of cohort, typical antipsychotics, severe mental illness, and co-morbid substance use [editorial]
    • de Leon J. Beyond the "hype" on the association between metabolic syndrome and atypical antipsychotics: the confounding effects of cohort, typical antipsychotics, severe mental illness, and co-morbid substance use [editorial]. J Clin Psychopharmacol 2008;28:125-131.
    • (2008) J Clin Psychopharmacol , vol.28 , pp. 125-131
    • de Leon, J.1
  • 101
    • 33144468024 scopus 로고    scopus 로고
    • Pharmacogenetics for off-patent antipsychotcs: Reframing the risk for tardive dyskinesia and access to essential medicines
    • Ozdemir V, Aklillu E, Mee S, et al. Pharmacogenetics for off-patent antipsychotcs: reframing the risk for tardive dyskinesia and access to essential medicines. Expert Opin Pharmacother 2006;7:119-133.
    • (2006) Expert Opin Pharmacother , vol.7 , pp. 119-133
    • Ozdemir, V.1    Aklillu, E.2    Mee, S.3
  • 102
    • 25444490459 scopus 로고    scopus 로고
    • Polymorphic variations n GSTM1, GSTT1, PgP, CYP2D6, CYP3A5, and dopamine D2 and D3 receptors and their association with tardive dyskinesia in severe mental illness
    • de Leon J, Susce MT, Pan RM, Koch W, Wedlund PJ. Polymorphic variations n GSTM1, GSTT1, PgP, CYP2D6, CYP3A5, and dopamine D2 and D3 receptors and their association with tardive dyskinesia in severe mental illness. J Clin Psychopharmacol 2005;25:448-456.
    • (2005) J Clin Psychopharmacol , vol.25 , pp. 448-456
    • de Leon, J.1    Susce, M.T.2    Pan, R.M.3    Koch, W.4    Wedlund, P.J.5
  • 103
    • 34247481499 scopus 로고    scopus 로고
    • Physiogenomic comparison of weight profiles of olanzapineand risperidone-treated patients
    • Ruaño G, Goethe JW, Caley C, et al. Physiogenomic comparison of weight profiles of olanzapineand risperidone-treated patients. Mol Psychiatry 2007;12:474-482.
    • (2007) Mol Psychiatry , vol.12 , pp. 474-482
    • Ruaño, G.1    Goethe, J.W.2    Caley, C.3
  • 104
    • 81755179077 scopus 로고    scopus 로고
    • The future (or lack of future) of personalized prescription in psychiatry
    • Oct 17, [Epub ahead of print]
    • de Leon J. The future (or lack of future) of personalized prescription in psychiatry. Pharmacol Res. 2008 Oct 17. [Epub ahead of print].
    • (2008) Pharmacol Res
    • de Leon, J.1
  • 105
    • 46149124547 scopus 로고    scopus 로고
    • A preliminary attempt to personalize risperidone dosing using drug-drug interactions and genetics: Part II
    • de Leon J, Sandson NB, Cozza KL. A preliminary attempt to personalize risperidone dosing using drug-drug interactions and genetics: part II. Psychosomatics 2008;49:347-361.
    • (2008) Psychosomatics , vol.49 , pp. 347-361
    • de Leon, J.1    Sandson, N.B.2    Cozza, K.L.3
  • 106
    • 0034621009 scopus 로고    scopus 로고
    • Science, medicine, and the future: Pharmacogenetcs
    • Wolf CR, Smith G, Smith RL. Science, medicine, and the future: pharmacogenetcs. BMJ 2000;320:987-990.
    • (2000) BMJ , vol.320 , pp. 987-990
    • Wolf, C.R.1    Smith, G.2    Smith, R.L.3


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