Dissecting complex phenotypes using the genomics of twins

Functional and Integrative Genomics

Volumn 10, Issue 3, 2010, Pages 321-327

  Tan, Qihua ^a,b   Ohm Kyvik, Kirsten ^a   Kruse, Torben A ^b   Christensen, Kaare ^a  

^a UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

^b ODENSE UNIVERSITY HOSPITAL   (Denmark)

Author keywords

Genetics; Genomics; Twins

Indexed keywords

SEROTONIN RECEPTOR;

COPY NUMBER VARIATION; EPIGENETICS; FUNCTIONAL GENOMICS; GENE CONTROL; GENE DOSAGE; GENE EXPRESSION; GENE MAPPING; GENETIC RISK; GENETIC VARIABILITY; GENOTYPE; HERITABILITY; HUMAN; INSULIN RESISTANCE; OBESITY; PHENOTYPE; PRIORITY JOURNAL; QUANTITATIVE TRAIT LOCUS; REVIEW; RISK FACTOR; SINGLE NUCLEOTIDE POLYMORPHISM; TWINS;

CHROMOSOME MAPPING; DISEASE; EPIGENESIS, GENETIC; GENOMICS; HUMANS; PHENOTYPE; TWINS;

EID: 77955852844     PISSN: 1438793X     EISSN: 14387948     Source Type: Journal    
DOI: 10.1007/s10142-010-0160-9     Document Type: Review

References (43)

1. GR Abecasis LR Cardon WO Cookson 2000 A general test of association for quantitative traits in nuclear families Am J Hum Genet 66 1 279 292 10.1086/302698 1:STN:280:DC%2BD3c7gtVKhuw%3D%3D 10631157 (Pubitemid 30481489)
2. D Boomsma A Busjahn L Peltonen 2002 Classical twin studies and beyond Nat Rev Genet 3 11 872 882 10.1038/nrg932 1:CAS:528:DC%2BD38Xotlersbk%3D 12415317 (Pubitemid 35303519)
3. CE Bruder A Piotrowski AA Gijsbers, et al. 2008 Phenotypically concordant and discordant monozygotic twins display different DNA copy-number-variation profiles Am J Hum Genet 82 3 763 771 10.1016/j.ajhg.2007.12.011 1:CAS:528:DC%2BD1cXksVGrurg%3D 18304490
4. VG Cheung RS Spielman KG Ewens TM Weber M Morley JT Burdick 2005 Mapping determinants of human gene expression by regional and genome-wide association Nature 437 7063 1365 1369 10.1038/nature04244 1:CAS:528:DC%2BD2MXhtFCrurrN 16251966 (Pubitemid 41568683)
5. CR Correa VG Cheung 2004 Genetic variation in radiation-induced expression phenotypes Am J Hum Genet 75 5 885 890 10.1086/425221 1:CAS:528:DC%2BD2cXptVSnsLo%3D 15359380 (Pubitemid 39390496)
6. MH De Moor TD Spector LF Cherkas M Falchi JJ Hottenga DI Boomsma EJ De Geus 2007 Genome-wide linkage scan for athlete status in 700 British female DZ twin pairs Twin Res Hum Genet 10 6 812 820 10.1375/twin.10.6.812 18179392 (Pubitemid 350292294)
7. AJ De Smith RG Walters P Froguel AI Blakemore 2008 Human genes involved in copy number variation: mechanisms of origin, functional effects and implications for disease Cytogenet Genome Res 123 1-4 17 26 10.1159/000184688 19287135
8. WJ Ewens M Li RS Spielman 2008 A review of family-based tests for linkage disequilibrium between a quantitative trait and a genetic marker PLoS Genet 4 9 e1000180 10.1371/journal.pgen.1000180 18818728
9. MF Fraga E Ballestar MF Paz, et al. 2005 Epigenetic differences arise during the lifetime of monozygotic twins Proc Natl Acad Sci USA 102 30 10604 10609 10.1073/pnas.0500398102 1:CAS:528:DC%2BD2MXntVSiur0%3D 16009939 (Pubitemid 41061601)
10. G Gibson 2008 The environmental contribution to gene expression profiles Nat Rev Genet 9 575 581 10.1038/nrg2383 1:CAS:528:DC%2BD1cXpsVOku7o%3D 18574472 (Pubitemid 352019756)
11. AM Herskind M McGue NV Holm TI Sorensen B Harvald JW Vaupel 1996 The heritability of human longevity: a population-based study of 2872 Danish twin pairs born 1870-1900 Hum Genet 97 319 323 10.1007/BF02185763 1:STN:280:DyaK287pvVWqug%3D%3D 8786073
12. JB Hjelmborg I Iachine A Skytthe JW Vaupel M McGue M Koskenvuo J Kaprio NL Pedersen K Christensen 2006 Genetic influence on human lifespan and longevity Hum Genet 119 312 321 10.1007/s00439-006-0144-y
13. RC Jansen JP Nap 2001 Genetical genomics: the added value from segregation Trends Genet 17 7 388 391 10.1016/S0168-9525(01)02310-1 1:CAS:528:DC%2BD3MXksVyntLo%3D 11418218 (Pubitemid 32545383)
14. Z Kaminsky A Petronis SC Wang B Levine O Ghaffar D Floden A Feinstein 2008 Epigenetics of personality traits: an illustrative study of identical twins discordant for risk-taking behaviour Twin Res Hum Genet 11 1 1 11 10.1375/twin.11.1.1 18251670 (Pubitemid 351269549)
15. ZA Kaminsky T Tang SC Wang C Ptak GH Oh AH Wong LA Feldcamp C Virtanen J Halfvarson C Tysk AF McRae PM Visscher GW Montgomery II Gottesman NG Martin A Petronis 2009 DNA methylation profiles in monozygotic and dizygotic twins Nat Genet 41 2 240 245 10.1038/ng.286 1:CAS:528:DC%2BD1MXntFGjtQ%3D%3D 19151718
16. Li J, Burmeister M (2005) Genetical genomics: combining genetics with gene expression analysis. Hum Mol Genet 14 Spec No. 2:R163-169.
17. G Livshits BS Kato SG Wilson TD Spector 2007 Linkage of genes to total lean body mass in normal women J Clin Endocrinol Metab 92 8 3171 3176 10.1210/jc.2007-0418 1:CAS:528:DC%2BD2sXptl2htrY%3D 17550956 (Pubitemid 47236387)
18. G Livshits BS Kato G Zhai DJ Hart D Hunter AJ MacGregor FM Williams TD Spector 2007 Genomewide linkage scan of hand osteoarthritis in female twin pairs showing replication of quantitative trait loci on chromosomes 2 and 19 Ann Rheum Dis 66 5 623 627 10.1136/ard.2006.060236 17127684 (Pubitemid 46707130)
19. AJ MacGregor H Snieder NJ Schork TD Spector 2000 Twins. Novel uses to study complex traits and genetic diseases Trends Genet 16 3 131 134 10.1016/S0168-9525(99)01946-0 1:CAS:528:DC%2BD3cXhsFOisLs%3D 10689354 (Pubitemid 30122351)
20. S Maier A Olek 2002 Diabetes: a candidate disease for efficient DNA methylation profiling J Nutr 132 8 Suppl 2440S 2443S 1:CAS:528: DC%2BD38XmtF2qs70%3D 12163708
21. Martin N (2000) Gene-environment interaction and twin studies. In: Spector TD, Snieder H, MacGregor AJ (eds) Advances in twin and sib-pair analysis. Greenwich Medical Media, London, pp 143-150
22. JC Mathers 2008 Session 2: personalised nutrition. Epigenomics: a basis for understanding individual differences? Proc Nutr Soc 67 4 390 394 10.1017/S0029665108008744 18847515
23. SA Monks A Leonardson H Zhu P Cundiff P Pietrusiak S Edwards JW Phillips A Sachs EE Schadt 2004 Genetic inheritance of gene expression in human cell lines Am J Hum Genet 75 6 1094 1105 10.1086/426461 1:CAS:528:DC%2BD2cXhtVegsrbO 15514893 (Pubitemid 39532076)
24. M Morley CM Molony TM Weber JL Devlin KG Ewens RS Spielman VG Cheung 2004 Genetic analysis of genome-wide variation in human gene expression Nature 430 7001 743 747 10.1038/nature02797 1:CAS:528:DC%2BD2cXmsVGls7k%3D 15269782 (Pubitemid 39071339)
25. DT O'Connor G Zhu F Rao L Taupenot MM Fung M Das SK Mahata M Mahata L Wang K Zhang TA Greenwood PA Shih MG Cockburn MG Ziegler M Stridsberg NG Martin JB Whitfield 2008 Heritability and genome-wide linkage in US and Australian twins identify novel genomic regions controlling chromogranin a: implications for secretion and blood pressure Circulation 118 3 247 257 10.1161/ CIRCULATIONAHA.107.709105 18591442
26. L Pellis 2003 Franssen-van Hal NL, Burema J, Keijer J. The intraclass correlation coefficient applied for evaluation of data correction, labeling methods, and rectal biopsy sampling in DNA microarray experiments Physiol Genomics 16 1 99 106 10.1152/physiolgenomics.00111.2003 1:CAS:528: DC%2BD2cXjslyntbc%3D 14570982
27. L Peltonen VA McKusick 2001 Genomics and medicine. Dissecting human disease in the postgenomic era Science 291 5507 1224 1229 10.1126/science.291. 5507.1224 1:CAS:528:DC%2BD3MXhtlShurY%3D 11233446 (Pubitemid 32173078)
28. M Perola S Sammalisto T Hiekkalinna, et al. 2007 Combined genome scans for body stature in 6,602 European twins: evidence for common Caucasian loci PLoS Genet 3 6 e97 10.1371/journal.pgen.0030097 17559308 (Pubitemid 47015861)
29. A Petronis 2006 Epigenetics and twins: three variations on the theme Trends Genet 22 7 347 350 10.1016/j.tig.2006.04.010 1:CAS:528: DC%2BD28Xmslyks7g%3D 16697072 (Pubitemid 44015966)
30. A Petronis II Gottesman P Kan JL Kennedy VS Basile AD Paterson V Popendikyte 2003 Monozygotic twins exhibit numerous epigenetic differences: clues to twin discordance? Schizophr Bull 29 1 169 178 12908672
31. KH Pietiläinen J Naukkarinen A Rissanen J Saharinen P Ellonen H Keränen A Suomalainen A Götz T Suortti H Yki-Järvinen M Oresic J Kaprio L Peltonen 2008 Global transcript profiles of fat in monozygotic twins discordant for BMI: pathways behind acquired obesity PLoS Med 5 3 e51 10.1371/journal.pmed.0050051 18336063 (Pubitemid 351471696)
32. D Pinkel R Segraves D Sudar S Clark I Poole D Kowbel C Collins WL Kuo C Chen Y Zhai SH Dairkee BM Ljung JW Gray DG Albertson 1998 High resolution analysis of DNA copy number variation using comparative genomic hybridization to microarrays Nat Genet 20 2 207 211 10.1038/2524 9771718 (Pubitemid 28455458)
33. P Poulsen KO Kyvik A Vaag H Beck-Nielsen 1999 Heritability of type 2 (non-insulin-dependent) diabetes mellitus and abnormal glucose tolerance-a population-based twin study Diabetologia 42 139 145 10.1007/s001250051131 1:CAS:528:DyaK1MXhtFajsbk%3D 10064092 (Pubitemid 29064234)
34. P Poulsen M Esteller A Vaag MF Fraga 2007 The epigenetic basis of twin discordance in age-related diseases Pediatr Res 61 5 Pt 2 38R 42R 10.1203/pdr.0b013e31803c7b98 17413848 (Pubitemid 46653066)
35. MV Rockman L Kruglyak 2006 Genetics of global gene expression Nat Rev Genet 7 11 862 872 10.1038/nrg1964 1:CAS:528:DC%2BD28XhtVyktLnP 17047685 (Pubitemid 44607102)
36. D Rodenhiser M Mann 2006 Epigenetics and human disease: translating basic biology into clinical applications CMAJ 174 3 341 348 16446478
37. EE Schadt SA Monks TA Drake AJ Lusis N Che V Colinayo TG Ruff SB Milligan JR Lamb G Cavet PS Linsley M Mao RB Stoughton SH Friend 2003 Genetics of gene expression surveyed in maize, mouse and man Nature 422 297 302 10.1038/nature01434 1:CAS:528:DC%2BD3sXitFKmuro%3D 12646919 (Pubitemid 36378355)
38. TD Spector AJ MacGregor H Snieder 2000 Uses of twins in studying the genetics of complex traits GeneScreen 1 93 95 10.1046/j.1466-9218.2000.00020.x
39. RS Spielman WJ Ewens 1998 A sibship test for linkage in the presence of association: the sib transmission/disequilibrium test Am J Hum Genet 62 2 450 458 10.1086/301714 1:STN:280:DyaK1c7jtVGntQ%3D%3D 9463321 (Pubitemid 28110787)
40. Q Tan K Christensen L Christiansen H Frederiksen L Bathum J Dahlgaard TA Kruse 2005 Genetic dissection of gene expression observed in whole blood samples of elderly Danish twins Hum Genet 117 267 274 10.1007/s00439-005-1308-x 15906095 (Pubitemid 43136804)
41. Q Tan J Zhao S Li L Christiansen TA Kruse K Christensen 2008 Differential and correlation analyses of microarray gene expression data in the CEPH Utah families Genomics. 92 2 94 100 10.1016/j.ygeno.2008.04.001 1:CAS:528: DC%2BD1cXosValurg%3D 18519161
42. NR Wray WL Coventry MR James GW Montgomery LJ Eaves NG Martin 2008 Use of monozygotic twins to investigate the relationship between 5HTTLPR genotype, depression and stressful life events: an application of Item Response Theory Novartis Found Symp 293 48 67 10.1002/9780470696781.ch4 18972745
43. TP York MF Miles KS Kendler C Jackson-Cook ML Bowman LJ Eaves 2005 Epistatic and environmental control of genome-wide gene expression Twin Res Hum Genet 8 1 5 15 10.1375/twin.8.1.5 15836804