Downregulation of the Na/K-ATPase pump by leptospiral glycolipoprotein activates the NLRP3 inflammasome

Journal of Immunology

Volumn 188, Issue 6, 2012, Pages 2805-2814

  Lacroix Lamandé, Sonia ^a,b,c   D'Andon, Martine Fanton ^a,b   Michel, Eric ^a,b,d   Ratet, Gwenn ^a,b   Philpott, Dana J ^e   Girardin, Stephen E ^e   Boneca, Ivo G ^a,b   Vandewalle, Alain ^f,g   Werts, Catherine ^a,b  

^a INSTITUT PASTEUR   (France)

^b INSERM   (France)

^c UR1282   (France)

^d UPMC University Paris 06   (France)

^e UNIVERSITY OF TORONTO   (Canada)

^f CENTRE DE RECHERCHE BIOMÉDICALE BICHAT BEAUJON CRB3   (France)

^g UNIVERSITÉ PARIS DESCARTES   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); BACTERIAL PROTEIN; CRYOPYRIN; GLYCOLIPOPROTEIN; INFLAMMASOME; INTERLEUKIN 1BETA; NUCLEOTIDE BINDING OLIGOMERIZATION DOMAIN PROTEIN; POTASSIUM; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BACTERIAL CELL WALL; BONE MARROW CELL; CELL STIMULATION; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DISEASE DURATION; DOWN REGULATION; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME REGULATION; FEMALE; HYPOKALEMIA; IMMUNOMODULATION; IN VIVO STUDY; LEPTOSPIRA INTERROGANS; LEPTOSPIROSIS; LYSOSOME; MACROPHAGE; MEMBRANE STABILIZATION; MOUSE; NONHUMAN; POTASSIUM TRANSPORT; PRIORITY JOURNAL; PROTEIN DEFICIENCY; PROTEIN EXPRESSION;

ANIMALS; BACTERIAL PROTEINS; BLOTTING, WESTERN; CARRIER PROTEINS; DOWN-REGULATION; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; INFLAMMASOMES; INTERLEUKIN-1BETA; LEPTOSPIRA; LEPTOSPIROSIS; MACROPHAGES; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SODIUM-POTASSIUM-EXCHANGING ATPASE;

EID: 84857819545     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1101987     Document Type: Article

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