-
1
-
-
0028807727
-
T lymphocyte-directed gene therapy for ADASCID: Initial trial results after 4 years
-
Blaese RM, Culver KW, Miller AD, Carter CS, Fleisher T, Clerici M et al. T lymphocyte-directed gene therapy for ADASCID: Initial trial results after 4 years. Science 1995; 270: 475-80.
-
(1995)
Science
, vol.270
, pp. 475-480
-
-
Blaese, R.M.1
Culver, K.W.2
Miller, A.D.3
Carter, C.S.4
Fleisher, T.5
Clerici, M.6
-
2
-
-
68849088569
-
Vision 1 year after gene therapy for Leber's congenital amaurosis
-
Cideciyan AV, Hauswirth WW, Aleman TS, Kaushal S, Schwartz SB, Boye SL et al. Vision 1 year after gene therapy for Leber's congenital amaurosis. N Engl J Med 2009; 361: 725-7.
-
(2009)
N Engl J Med
, vol.361
, pp. 725-727
-
-
Cideciyan, A.V.1
Hauswirth, W.W.2
Aleman, T.S.3
Kaushal, S.4
Schwartz, S.B.5
Boye, S.L.6
-
3
-
-
59449098985
-
Gene therapy for immunodeficiency due to adenosine deaminase Deficiency
-
AiutiA, Cattaneo F, Galimberti S, Benninghoff U, Cassani B, Callegaro L et al. Gene therapy for immunodeficiency due to adenosine deaminase Deficiency. N Engl J Med 2009; 360: 447-58.
-
(2009)
N Engl J Med
, vol.360
, pp. 447-458
-
-
Aiuti, A.1
Cattaneo, F.2
Galimberti, S.3
Benninghoff, U.4
Cassani, B.5
Callegaro, L.6
-
4
-
-
84857886668
-
-
US Food and DrugAdministration Homepage [Internet]. Silver Spring: United States Food and DrugAdministration; c2009 [updated cited 2010 Mar 30]. Cellular & Gene Therapy Products; [about 3 screens]Aug 13
-
US Food and DrugAdministration Homepage [Internet]. Silver Spring: United States Food and DrugAdministration; c2009 [updated 2009Aug 13; cited 2010 Mar 30]. Cellular & Gene Therapy Products; [about 3 screens]. Available from: http://www.fda.gov/BiologicsBloodVaccines/CellularGeneTherapyProducts/default.htm
-
(2009)
-
-
-
5
-
-
84857856261
-
-
Gene therapy clinical trials worldwide [Internet]. Chichester: The Journal of Gene Medicine; c2009 [updated Dec; cited 2010 Mar 30]. Vectors used in gene therapy clinical trials; [about 3 screens]
-
Gene therapy clinical trials worldwide [Internet]. Chichester: The Journal of Gene Medicine; c2009 [updated 2009 Dec; cited 2010 Mar 30]. Vectors used in gene therapy clinical trials; [about 3 screens]. Available from: http://www.wiley.co.uk/genmed/clinical/
-
(2009)
-
-
-
6
-
-
34547691354
-
Retroviral integration and human gene therapy
-
Bushman FD. Retroviral integration and human gene therapy. J Clin Invest 2007 117: 2083-6.
-
(2007)
J Clin Invest
, vol.117
, pp. 2083-2086
-
-
Bushman, F.D.1
-
7
-
-
34848904829
-
Adenoviral vectors for gene therapy
-
Douglas JT. Adenoviral vectors for gene therapy. Mol Biotechnol 2007 36: 71-80.
-
(2007)
Mol Biotechnol
, vol.36
, pp. 71-80
-
-
Douglas, J.T.1
-
8
-
-
44049103962
-
Adeno-associated virus integration: virus versus vector
-
Smith RH. Adeno-associated virus integration: virus versus vector. Gene Ther 2008; 15: 817-22.
-
(2008)
Gene Ther
, vol.15
, pp. 817-822
-
-
Smith, R.H.1
-
10
-
-
0036968169
-
Gene delivery using herpes simplex virus vectors
-
Burton EA, Fink DJ, Glorioso JC. Gene delivery using herpes simplex virus vectors. DNA Cell Biol 2002; 21: 915-36.
-
(2002)
DNA Cell Biol
, vol.21
, pp. 915-936
-
-
Burton, E.A.1
Fink, D.J.2
Glorioso, J.C.3
-
11
-
-
72949094624
-
Nonviral Gene Delivery: Principle, Limitations, and Recent Progress
-
Al-Dosari MS, Gao X. Nonviral Gene Delivery: Principle, Limitations, and Recent Progress. AAPS J 2009; 11: 671-81.
-
(2009)
AAPS J
, vol.11
, pp. 671-681
-
-
Al-Dosari, M.S.1
Gao, X.2
-
12
-
-
0025976935
-
Genetically modified skin fibroblasts persist long after transplantation but gradually inactivate introduced genes
-
Palmer TD, Rosman GJ, Osborne WR, Miller AD. Genetically modified skin fibroblasts persist long after transplantation but gradually inactivate introduced genes. Proc NatlAcad Sci USA1991; 88: 1330-4.
-
(1991)
Proc NatlAcad Sci USA
, vol.88
, pp. 1330-1334
-
-
Palmer, T.D.1
Rosman, G.J.2
Osborne, W.R.3
Miller, A.D.4
-
13
-
-
0034724857
-
Gene therapy of human severe combined immunodeficiency (SCID)-X1 disease
-
Cavazzana-Calvo M, Hacein-Bey S, de Saint Basile G, Gross F, Yvon E, Nusbaum P et al. Gene therapy of human severe combined immunodeficiency (SCID)-X1 disease. Science 2000; 288: 669-72.
-
(2000)
Science
, vol.288
, pp. 669-672
-
-
Cavazzana-Calvo, M.1
Hacein-Bey, S.2
de Saint Basile, G.3
Gross, F.4
Yvon, E.5
Nusbaum, P.6
-
14
-
-
0037129435
-
Sustained correction of X-linked severe combined immunodeficiency by ex vivo gene therapy
-
Hacein-Bey-Abina S, Le Deist F, Carlier F, Bouneaud C, Hue C, De Villartay JP et al. Sustained correction of X-linked severe combined immunodeficiency by ex vivo gene therapy. N Engl J Med 2002; 346: 1185-93.
-
(2002)
N Engl J Med
, vol.346
, pp. 1185-1193
-
-
Hacein-Bey-Abina, S.1
Le Deist, F.2
Carlier, F.3
Bouneaud, C.4
Hue, C.5
De Villartay, J.P.6
-
15
-
-
19944421384
-
Gene therapy of X-linked severe combined immunodeficiency by use of a pseudotyped gammaretroviral vector
-
Gaspar HB, Parsley KL, Howe S, King D, Gilmour KC, Sinclair J et al. Gene therapy of X-linked severe combined immunodeficiency by use of a pseudotyped gammaretroviral vector. Lancet 2004; 364: 2181-7.
-
(2004)
Lancet
, vol.364
, pp. 2181-2187
-
-
Gaspar, H.B.1
Parsley, K.L.2
Howe, S.3
King, D.4
Gilmour, K.C.5
Sinclair, J.6
-
16
-
-
0037189401
-
Correction of ADA-SCID by stem cell gene therapy combined with nonmyeloablative conditioning
-
Aiuti A, Slavin S, Aker M, Ficara F, Deola S, Mortellaro A et al. Correction of ADA-SCID by stem cell gene therapy combined with nonmyeloablative conditioning. Science 2002; 296: 2410-3.
-
(2002)
Science
, vol.296
, pp. 2410-2413
-
-
Aiuti, A.1
Slavin, S.2
Aker, M.3
Ficara, F.4
Deola, S.5
Mortellaro, A.6
-
17
-
-
0142084745
-
LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X1
-
Hacein-Bey-Abina S, Von Kalle C, Schmidt M, McCormack MP, Wulffraat N, Leboulch P et al. LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X1. Science 2003; 17; 302: 415-9.
-
(2003)
Science
, vol.17
, Issue.302
, pp. 415-419
-
-
Hacein-Bey-Abina, S.1
Von Kalle, C.2
Schmidt, M.3
McCormack, M.P.4
Wulffraat, N.5
Leboulch, P.6
-
18
-
-
51349090473
-
Insertional oncogenesis in 4 patients after retrovirus-mediated gene therapy of SCID-X1
-
Hacein-Bey-Abina S, Garrigue A, Wang GP, Soulier J, Lim A, Morillon E et al. Insertional oncogenesis in 4 patients after retrovirus-mediated gene therapy of SCID-X1. J Clin Invest 2008; 118: 3132-42.
-
(2008)
J Clin Invest
, vol.118
, pp. 3132-3142
-
-
Hacein-Bey-Abina, S.1
Garrigue, A.2
Wang, G.P.3
Soulier, J.4
Lim, A.5
Morillon, E.6
-
19
-
-
51349158298
-
Insertional mutagenesis combined with acquiredsomatic mutations causes leukemogenesis following gene therapy of SCID-X1 patients
-
Howe SJ, Mansour MR, Schwarzwaelder K, Bartholomae C, Hubank M, Kempski H et al. Insertional mutagenesis combined with acquiredsomatic mutations causes leukemogenesis following gene therapy of SCID-X1 patients. J Clin Invest 2008; 118: 3143-50.
-
(2008)
J Clin Invest
, vol.118
, pp. 3143-3150
-
-
Howe, S.J.1
Mansour, M.R.2
Schwarzwaelder, K.3
Bartholomae, C.4
Hubank, M.5
Kempski, H.6
-
20
-
-
33750624015
-
Cell-culture assays reveal the importance of retroviral vector design for insertional genotoxicity
-
Modlich U, Bohne J, Schmidt M, Von Kalle C, Knoss S, Schambach A et al. Cell-culture assays reveal the importance of retroviral vector design for insertional genotoxicity. Blood 2006; 108: 2545-53.
-
(2006)
Blood
, vol.108
, pp. 2545-2553
-
-
Modlich, U.1
Bohne, J.2
Schmidt, M.3
Von Kalle, C.4
Knoss, S.5
Schambach, A.6
-
21
-
-
33745108790
-
Hematopoietic stem cell gene transfer in a tumour-prone mouse model uncovers low genotoxicity of lentiviral vector integration
-
Montini E, Cesana D, Schmidt M, Sanvito F, Ponzoni M, Bartholomae C et al. Hematopoietic stem cell gene transfer in a tumour-prone mouse model uncovers low genotoxicity of lentiviral vector integration. Nat Biotechnol 2006; 24: 687-96.
-
(2006)
Nat Biotechnol
, vol.24
, pp. 687-696
-
-
Montini, E.1
Cesana, D.2
Schmidt, M.3
Sanvito, F.4
Ponzoni, M.5
Bartholomae, C.6
-
22
-
-
36448992228
-
Efficient transplantation via antibody-based clearance of hematopoietic stem cell niches
-
Czechowicz A, Kraft D, Weissman IL, Bhattacharya D. Efficient transplantation via antibody-based clearance of hematopoietic stem cell niches. Science 2007; 318: 1296-9.
-
(2007)
Science
, vol.318
, pp. 1296-1299
-
-
Czechowicz, A.1
Kraft, D.2
Weissman, I.L.3
Bhattacharya, D.4
-
23
-
-
41149133413
-
Physiological promoters reduce the genotoxic risk of integrating gene vectors
-
Zychlinski D, Schambach A, Modlich U, Maetzig T, Meyer J, Grassman E et al. Physiological promoters reduce the genotoxic risk of integrating gene vectors. Mol Ther 2008; 16: 718-25.
-
(2008)
Mol Ther
, vol.16
, pp. 718-725
-
-
Zychlinski, D.1
Schambach, A.2
Modlich, U.3
Maetzig, T.4
Meyer, J.5
Grassman, E.6
-
24
-
-
0027254748
-
A 5' element of the chicken betaglobin domain serves as an insulator in human erythroid cells and protects against position effect in Drosophila
-
Chung JH, Whiteley M, Felsenfeld G. A 5' element of the chicken betaglobin domain serves as an insulator in human erythroid cells and protects against position effect in Drosophila. Cell 1993; 74: 505-14.
-
(1993)
Cell
, vol.74
, pp. 505-514
-
-
Chung, J.H.1
Whiteley, M.2
Felsenfeld, G.3
-
25
-
-
54949104686
-
Treatment of Leber congenital amaurosis due to RPE65 mutations by ocular subretinal injection of adeno-associated virus gene vector: short-term results of a phase I trial
-
Hauswirth WW, Aleman TS, Kaushal S, Cideciyan AV, Schwartz SB, Wang L et al. Treatment of Leber congenital amaurosis due to RPE65 mutations by ocular subretinal injection of adeno-associated virus gene vector: short-term results of a phase I trial. Hum Gene Ther 2008; 19: 979-90.
-
(2008)
Hum Gene Ther
, vol.19
, pp. 979-990
-
-
Hauswirth, W.W.1
Aleman, T.S.2
Kaushal, S.3
Cideciyan, A.V.4
Schwartz, S.B.5
Wang, L.6
-
26
-
-
44249085878
-
Safety and efficacy of gene transfer for Leber's congenital amaurosis
-
Maguire AM, Simonelli F, Pierce EA, Pugh EN Jr, Mingozzi F, Bennicelli J et al. Safety and efficacy of gene transfer for Leber's congenital amaurosis. N Engl J Med 2008; 358: 2240-8.
-
(2008)
N Engl J Med
, vol.358
, pp. 2240-2248
-
-
Maguire, A.M.1
Simonelli, F.2
Pierce, E.A.3
Pugh Jr., E.N.4
Mingozzi, F.5
Bennicelli, J.6
-
27
-
-
32944481724
-
Adenoviral vector-delivered pigment epithelium-derived factor for neovascular age-related macular degeneration: results of Single gene disorders: results of a phase I clinical trial
-
Campochiaro PA, Nguyen QD, Shah SM, Klein ML, Holz E, Frank RN et al. Adenoviral vector-delivered pigment epithelium-derived factor for neovascular age-related macular degeneration: results of Single gene disorders: results of a phase I clinical trial. Hum Gene Ther 2006; 17: 167-76.
-
(2006)
Hum Gene Ther
, vol.17
, pp. 167-176
-
-
Campochiaro, P.A.1
Nguyen, Q.D.2
Shah, S.M.3
Klein, M.L.4
Holz, E.5
Frank, R.N.6
-
28
-
-
70349971731
-
Gene therapy for red-green colour blindness in adult primates
-
Mancuso K, Hauswirth WW, Li Q, Connor TB, Kuchenbecker JA, Mauck MC et al. Gene therapy for red-green colour blindness in adult primates. Nature 2009; 8: 784-7.
-
(2009)
Nature
, vol.8
, pp. 784-787
-
-
Mancuso, K.1
Hauswirth, W.W.2
Li, Q.3
Connor, T.B.4
Kuchenbecker, J.A.5
Mauck, M.C.6
-
29
-
-
0034689207
-
Phase I clinical trial utilizing gene therapy for limb girdle muscular dystrophy: alpha-, beta-, gamma-, or delta-sarcoglycan gene delivered with intramuscular instillations of adeno-associated vectors
-
Stedman H, Wilson JM, Finke R, Kleckner AL, Mendell J. Phase I clinical trial utilizing gene therapy for limb girdle muscular dystrophy: alpha-, beta-, gamma-, or delta-sarcoglycan gene delivered with intramuscular instillations of adeno-associated vectors. J Hum Gene Ther 2000; 11: 777-90.
-
(2000)
J Hum Gene Ther
, vol.11
, pp. 777-790
-
-
Stedman, H.1
Wilson, J.M.2
Finke, R.3
Kleckner, A.L.4
Mendell, J.5
-
30
-
-
10744227749
-
Repeated adeno-associated virus serotype 2 aerosolmediated cystic fibrosis transmembrane regulator gene transfer to the lungs of patients with cystic fibrosis: a multicenter, double-blind, placebo-controlled trial
-
Moss RB, Rodman D, Spencer LT, Aitken ML, Zeitlin PL, Waltz D et al. Repeated adeno-associated virus serotype 2 aerosolmediated cystic fibrosis transmembrane regulator gene transfer to the lungs of patients with cystic fibrosis: a multicenter, double-blind, placebo-controlled trial. Chest 2004; 125: 509-21.
-
(2004)
Chest
, vol.125
, pp. 509-521
-
-
Moss, R.B.1
Rodman, D.2
Spencer, L.T.3
Aitken, M.L.4
Zeitlin, P.L.5
Waltz, D.6
-
31
-
-
33845807816
-
Phase I trial of intramuscular injection of a recombinant adeno-associated virus serotype 2 alpha(1)-antitrypsin (AAT) vector in AAT-deficient adults
-
Brantly ML, Spencer LT, Humphries M, Conlon TJ, Spencer CT, PoirrierA et al. Phase I trial of intramuscular injection of a recombinant adeno-associated virus serotype 2 alpha(1)-antitrypsin (AAT) vector in AAT-deficient adults. Hum Gene Ther 2006; 17: 1177-86.
-
(2006)
Hum Gene Ther
, vol.17
, pp. 1177-1186
-
-
Brantly, M.L.1
Spencer, L.T.2
Humphries, M.3
Conlon, T.J.4
Spencer, C.T.5
Poirrier, A.6
-
32
-
-
5644295321
-
Neuroprotective gene therapy for Huntington's disease using polymer encapsulated cells engineered to secrete human CNTF: results of a phase I study
-
Bloch J, Bachoud-Lévi AC, Déglon N, Lefaucheur JP, Winkel L, Palfi S et al. Neuroprotective gene therapy for Huntington's disease using polymer encapsulated cells engineered to secrete human CNTF: results of a phase I study. Hum Gene Ther 2004; 15: 968-75.
-
(2004)
Hum Gene Ther
, vol.15
, pp. 968-975
-
-
Bloch, J.1
Bachoud-Lévi, A.C.2
Déglon, N.3
Lefaucheur, J.P.4
Winkel, L.5
Palfi, S.6
-
33
-
-
33645861655
-
Gene therapy for lysosomal storage diseases
-
Sands MS, Davidson BL. Gene therapy for lysosomal storage diseases. Mol Ther 2006; 13: 839-49.
-
(2006)
Mol Ther
, vol.13
, pp. 839-849
-
-
Sands, M.S.1
Davidson, B.L.2
-
34
-
-
33645734405
-
Correction of X-linked chronic granulomatous disease by gene therapy, augmented by insertional activation of MDS/EVI1 PRDM16 or SETBP1
-
Ott MG, Schmidt M, Schwarzwaelder K, Stein S, Siler U, Koehl U et al. Correction of X-linked chronic granulomatous disease by gene therapy, augmented by insertional activation of MDS/EVI1, PRDM16 or SETBP1. Nat Med 2006; 12: 401-9.
-
(2006)
Nat Med
, vol.12
, pp. 401-409
-
-
Ott, M.G.1
Schmidt, M.2
Schwarzwaelder, K.3
Stein, S.4
Siler, U.5
Koehl, U.6
-
35
-
-
0036145350
-
A pilot study of in vivo liver-directed gene transfer with an adenoviral vector in partial ornithine transcarbamylase deficiency
-
Raper SE, Yudkoff M, Chirmule N, Gao GP, Nunes F, Haskal ZJ et al. A pilot study of in vivo liver-directed gene transfer with an adenoviral vector in partial ornithine transcarbamylase deficiency. Hum Gene Ther 2002; 13: 163-75.
-
(2002)
Hum Gene Ther
, vol.13
, pp. 163-175
-
-
Raper, S.E.1
Yudkoff, M.2
Chirmule, N.3
Gao, G.P.4
Nunes, F.5
Haskal, Z.J.6
-
36
-
-
33845524625
-
Correction of junctional epidermolysis bullosa by transplantation of genetically modified epidermal stem cells
-
Mavilio F, Pellegrini G, Ferrari S, Di Nunzio F, Di Iorio E, Recchia A et al. Correction of junctional epidermolysis bullosa by transplantation of genetically modified epidermal stem cells. Nat Med 2006; 12: 1397-402.
-
(2006)
Nat Med
, vol.12
, pp. 1397-1402
-
-
Mavilio, F.1
Pellegrini, G.2
Ferrari, S.3
Di Nunzio, F.4
Di Iorio, E.5
Recchia, A.6
-
37
-
-
33644820684
-
Successful transduction of liver in hemophilia by AAVFactor IX and limitations imposed by the host immune response
-
Manno CS, Pierce GF, Arruda VR, Glader B, Ragni M, Rasko JJ et al. Successful transduction of liver in hemophilia by AAVFactor IX and limitations imposed by the host immune response. Nat Med 2006; 12: 342-7.
-
(2006)
Nat Med
, vol.12
, pp. 342-347
-
-
Manno, C.S.1
Pierce, G.F.2
Arruda, V.R.3
Glader, B.4
Ragni, M.5
Rasko, J.J.6
-
38
-
-
84857886670
-
-
Gene therapy clinical trials worldwide [Internet]. Chichester: The Journal of Gene Medicine; c2009 [updated 2009 Dec; cited Mar 30]. Indications addressed by gene therapy clinical trials; [about 2 screens]
-
Gene therapy clinical trials worldwide [Internet]. Chichester: The Journal of Gene Medicine; c2009 [updated 2009 Dec; cited 2010 Mar 30]. Indications addressed by gene therapy clinical trials; [about 2 screens]. Available from: http://www.wiley.co.uk/genmed/clinical/.
-
(2010)
-
-
-
39
-
-
39849099798
-
A phase I trial of intratumoural administration of reovirus in patients with histologically confirmed recurrent malignant gliomas
-
Forsyth P, Roldán G, George D, Wallace C, Palmer CA, Morris D et al. A phase I trial of intratumoural administration of reovirus in patients with histologically confirmed recurrent malignant gliomas. Mol Ther 2008; 16: 627-32.
-
(2008)
Mol Ther
, vol.16
, pp. 627-632
-
-
Forsyth, P.1
Roldán, G.2
George, D.3
Wallace, C.4
Palmer, C.A.5
Morris, D.6
-
40
-
-
54949090721
-
Recombinant oncolytic poliovirus eliminates glioma in vivo without genetic adaptation to a pathogenic phenotype
-
Dobrikova EY, Broadt T, Poiley-Nelson J, Yang X, Soman G, Giardina S et al. Recombinant oncolytic poliovirus eliminates glioma in vivo without genetic adaptation to a pathogenic phenotype. Mol Ther 2008; 16: 1865-72.
-
(2008)
Mol Ther
, vol.16
, pp. 1865-1872
-
-
Dobrikova, E.Y.1
Broadt, T.2
Poiley-Nelson, J.3
Yang, X.4
Soman, G.5
Giardina, S.6
-
41
-
-
24944454988
-
Current status of gendicine in China: recombinant human Adp53 agent for treatment of cancers
-
Peng Z. Current status of gendicine in China: recombinant human Adp53 agent for treatment of cancers. Hum Gene Ther 2005; 16: 1016-27.
-
(2005)
Hum Gene Ther
, vol.16
, pp. 1016-1027
-
-
Peng, Z.1
-
43
-
-
0034694011
-
A phase III clinical evaluation of herpes simplex virus type 1 thymidine kinase and ganciclovir gene therapy as an adjuvant to surgical resection and radiation in adults with previously untreated glioblastoma multiforme
-
Rainov NG. A phase III clinical evaluation of herpes simplex virus type 1 thymidine kinase and ganciclovir gene therapy as an adjuvant to surgical resection and radiation in adults with previously untreated glioblastoma multiforme. Hum Gene Ther 2000; 11: 2389-401.
-
(2000)
Hum Gene Ther
, vol.11
, pp. 2389-2401
-
-
Rainov, N.G.1
-
44
-
-
20044363101
-
Phase I study of MetXia-P450 gene therapy and oral cyclophosphamide for patients with advanced breast cancer or melanoma
-
Braybrooke JP, Slade A, Deplanque G, Harrop R, Madhusudan S, Forster MD et al. Phase I study of MetXia-P450 gene therapy and oral cyclophosphamide for patients with advanced breast cancer or melanoma. Clin Cancer Res 2005; 11: 1512-20.
-
(2005)
Clin Cancer Res
, vol.11
, pp. 1512-1520
-
-
Braybrooke, J.P.1
Slade, A.2
Deplanque, G.3
Harrop, R.4
Madhusudan, S.5
Forster, M.D.6
-
45
-
-
14844331400
-
Dendritic-cell-based therapeutic vaccination against cancer
-
Nestle FO, Farkas A, Conrad C. Dendritic-cell-based therapeutic vaccination against cancer. Curr Opin Immunol 2005; 17: 163-9.
-
(2005)
Curr Opin Immunol
, vol.17
, pp. 163-169
-
-
Nestle, F.O.1
Farkas, A.2
Conrad, C.3
-
46
-
-
32844465516
-
Fusion hybrid of dendritic cells and engineered tumour cells expressing interleukin-12 induces type 1 immune responses against tumour
-
Shi M, Su L, Hao S, Guo X, Xiang J. Fusion hybrid of dendritic cells and engineered tumour cells expressing interleukin-12 induces type 1 immune responses against tumour. Tumouri 2005; 91: 531-8.
-
(2005)
Tumouri
, vol.91
, pp. 531-538
-
-
Shi, M.1
Su, L.2
Hao, S.3
Guo, X.4
Xiang, J.5
-
47
-
-
33749624177
-
Cancer regression in patients after transfer of genetically engineered lymphocytes
-
Morgan RA, Dudley ME, Wunderlich JR, Hughes MS, Yang JC, Sherry RM et al. Cancer regression in patients after transfer of genetically engineered lymphocytes. Science 2006; 314: 126-9.
-
(2006)
Science
, vol.314
, pp. 126-129
-
-
Morgan, R.A.1
Dudley, M.E.2
Wunderlich, J.R.3
Hughes, M.S.4
Yang, J.C.5
Sherry, R.M.6
-
48
-
-
20144386684
-
Direct intramyocardial plasmid vascular endothelial growth factor-A165 gene therapy in patients with stable severe angina pectoris A randomized double-blind placebo-controlled study: the Euroinject One trial
-
Kastrup J, Jorgensen E, Ruck A, Tagil K, Glogar D, Ruzyllo W et al. Direct intramyocardial plasmid vascular endothelial growth factor-A165 gene therapy in patients with stable severe angina pectoris A randomized double-blind placebo-controlled study: the Euroinject One trial. J Am Coll Cardiol 2005; 45: 982-8.
-
(2005)
J Am Coll Cardiol
, vol.45
, pp. 982-988
-
-
Kastrup, J.1
Jorgensen, E.2
Ruck, A.3
Tagil, K.4
Glogar, D.5
Ruzyllo, W.6
-
49
-
-
33748155036
-
Angiogenic gene therapy in patients with nonrevascularizable ischemic heart disease: a phase 2 randomized, controlled trial of AdVEGF(121) (AdVEGF121) versus maximum medical treatment
-
Stewart DJ, Hilton JD, Arnold JM, Gregoire J, Rivard A, Archer SL et al. Angiogenic gene therapy in patients with nonrevascularizable ischemic heart disease: a phase 2 randomized, controlled trial of AdVEGF(121) (AdVEGF121) versus maximum medical treatment. Gene Therapy 2006; 13: 1503-11.
-
(2006)
Gene Therapy
, vol.13
, pp. 1503-1511
-
-
Stewart, D.J.1
Hilton, J.D.2
Arnold, J.M.3
Gregoire, J.4
Rivard, A.5
Archer, S.L.6
-
50
-
-
0036665610
-
Increased vascularity detected by digital subtraction angiography after VEGF gene transfer to human lower limb artery: a randomized, placebo-controlled, doubleblinded phase II study
-
Mäkinen K, Manninen H, Hedman M, Matsi P, Mussalo H, Alhava E et al. Increased vascularity detected by digital subtraction angiography after VEGF gene transfer to human lower limb artery: a randomized, placebo-controlled, doubleblinded phase II study. Mol Ther 2002; 6: 127-33.
-
(2002)
Mol Ther
, vol.6
, pp. 127-133
-
-
Mäkinen, K.1
Manninen, H.2
Hedman, M.3
Matsi, P.4
Mussalo, H.5
Alhava, E.6
-
51
-
-
0142023866
-
Regional angiogenesis with vascular endothelial growth factor in peripheral arterial disease: a phase II randomized, double-blind, controlled study of adenoviral delivery of vascular endothelial growth factor 121 in patients with disabling intermittent claudication
-
Rajagopalan S, Mohler III ER, Lederman RJ, Mendelsohn FO, Saucedo JF, Goldman CK et al. Regional angiogenesis with vascular endothelial growth factor in peripheral arterial disease: a phase II randomized, double-blind, controlled study of adenoviral delivery of vascular endothelial growth factor 121 in patients with disabling intermittent claudication. Circulation 2003; 108: 1933-8.
-
(2003)
Circulation
, vol.108
, pp. 1933-1938
-
-
Rajagopalan, S.1
Mohler 3rd, E.R.2
Lederman, R.J.3
Mendelsohn, F.O.4
Saucedo, J.F.5
Goldman, C.K.6
-
52
-
-
34250683023
-
Safety and tolerability of AAV-GAD gene therapy for Parkinson's disease: an open-label, phase I trial
-
Kaplitt MG, Feigin A, Tang C, Fitzsimons HL, Mattis P, Lawlor PA et al. Safety and tolerability of AAV-GAD gene therapy for Parkinson's disease: an open-label, phase I trial. Lancet. 2007; 369: 2097-105.
-
(2007)
Lancet
, vol.369
, pp. 2097-2105
-
-
Kaplitt, M.G.1
Feigin, A.2
Tang, C.3
Fitzsimons, H.L.4
Mattis, P.5
Lawlor, P.A.6
-
53
-
-
33845993229
-
Delivery of neurturin by AAV2 (CERE-120)-mediated gene transfer provides structural and functional neuroprotection and neurorestoration in MPTP-treated monkeys
-
Kordower JH, Herzog CD, Dass B, Bakay RA, Stansell III J, Gasmi M et al. Delivery of neurturin by AAV2 (CERE-120)-mediated gene transfer provides structural and functional neuroprotection and neurorestoration in MPTP-treated monkeys. Ann Neurol 2006; 60: 706-15.
-
(2006)
Ann Neurol
, vol.60
, pp. 706-715
-
-
Kordower, J.H.1
Herzog, C.D.2
Dass, B.3
Bakay, R.A.4
Stansell 3rd, J.5
Gasmi, M.6
-
54
-
-
33748083041
-
Long-term clinical improvement in MPTPlesioned primates after gene therapy with AAV-hAADC
-
Bankiewicz KS, Forsayeth J, Eberling JL, Sanchez-Pernaute R, Pivirotto P, Bringas J et al. Long-term clinical improvement in MPTPlesioned primates after gene therapy with AAV-hAADC. Mol Ther 2006; 14: 564-70.
-
(2006)
Mol Ther
, vol.14
, pp. 564-570
-
-
Bankiewicz, K.S.1
Forsayeth, J.2
Eberling, J.L.3
Sanchez-Pernaute, R.4
Pivirotto, P.5
Bringas, J.6
-
55
-
-
0035852680
-
Nontropic actions of neurotrophins: subcortical nerve growth factor gene delivery reversesage-related degeneration of primate cortical cholinergic innervation
-
Conner JM, Darracq MA, Roberts J, Tuszynski MH. Nontropic actions of neurotrophins: subcortical nerve growth factor gene delivery reversesage-related degeneration of primate cortical cholinergic innervation. Proc Natl Acad Sci USA 2001; 98: 1941-6.
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 1941-1946
-
-
Conner, J.M.1
Darracq, M.A.2
Roberts, J.3
Tuszynski, M.H.4
-
56
-
-
84857818995
-
Interim data from a phase 1 clinical trial of AAV-NGF (CERE-110) gene delivery in Alzheimers disease
-
Arvanitakis Z, Tuszynski MH, Bakay R, Arends D, Potkin S, Bartus R et al. Interim data from a phase 1 clinical trial of AAV-NGF (CERE-110) gene delivery in Alzheimers disease. Abstr Amer Acad Neurol 2007; 05. 071
-
(2007)
Abstr Amer Acad Neurol
, vol.5
, pp. 071
-
-
Arvanitakis, Z.1
Tuszynski, M.H.2
Bakay, R.3
Arends, D.4
Potkin, S.5
Bartus, R.6
-
57
-
-
57649105262
-
Long-term reversal of cholinergic neuronal decline in aged non-human primates by lentiviral NGF gene delivery
-
Nagahara AH, Bernot T, Moseanko R, Brignolo L, Blesch A, Conner JM et al. Long-term reversal of cholinergic neuronal decline in aged non-human primates by lentiviral NGF gene delivery. Exp Neurol 2009; 215: 153-9.
-
(2009)
Exp Neurol
, vol.215
, pp. 153-159
-
-
Nagahara, A.H.1
Bernot, T.2
Moseanko, R.3
Brignolo, L.4
Blesch, A.5
Conner, J.M.6
-
58
-
-
0033168686
-
A clinical trial of retroviral-mediated transfer of a Rev-responsive element decoy gene into CD34 cells from the bone marrow of human immunodeficiency virus-1-infected children
-
Kohn DB, Bauer G, Rice CR, Rothschild JC, Carbonaro DA, Valdez P et al. A clinical trial of retroviral-mediated transfer of a Rev-responsive element decoy gene into CD34 cells from the bone marrow of human immunodeficiency virus-1-infected children. Blood 1999; 94: 279-87.
-
(1999)
Blood
, vol.94
, pp. 279-287
-
-
Kohn, D.B.1
Bauer, G.2
Rice, C.R.3
Rothschild, J.C.4
Carbonaro, D.A.5
Valdez, P.6
-
59
-
-
33751251058
-
Gene transfer in humans using a conditionally replicating lentiviral vector
-
Levine BL, Humeau LM, Boyer J, MacGregor RR, Rebello T, Lu X et al. Gene transfer in humans using a conditionally replicating lentiviral vector. PNAS. 2006; 103: 17372-7.
-
(2006)
PNAS
, vol.103
, pp. 17372-17377
-
-
Levine, B.L.1
Humeau, L.M.2
Boyer, J.3
MacGregor, R.R.4
Rebello, T.5
Lu, X.6
|