Direct intramyocardial plasmid vascular endothelial growth factor-A 165 gene therapy in patients with stable severe angina pectoris: A randomized double-blind placebo-controlled study: The Euroinject One trial

Journal of the American College of Cardiology

Volumn 45, Issue 7, 2005, Pages 982-988

  Kastrup, Jens ^a   Jørgensen, Erik ^a   Rück, Andreas ^g   Tägil, Kristina ^f   Glogar, Dietmar ^c   Ruzyllo, Witold ^d   Bøtker, Hans Erik ^b   Dudek, Dariusz ^e   Drvota, Viktor ^g   Hesse, Birger ^a   Thuesen, Leif ^b   Blomberg, Pontus ^g   Gyöngyösi, Mariann ^c   Sylvén, Christer ^g  

^a Rigshospitalet   (Denmark)

^b AARHUS UNIVERSITY HOSPITAL   (Denmark)

^c UNIVERSITY OF VIENNA   (Austria)

^d INSTITUTE OF CARDIOLOGY   (Poland)

^e JAGIELLONIAN UNIVERSITY   (Poland)

^f Karolinska Institutet ^*  (Sweden)

^g KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

HERPESVIRUS VECTOR; METHOXY ISOBUTYL ISONITRILE TECHNETIUM TC 99M; PLACEBO; PLASMID VECTOR; TETROFOSMIN TC 99M; VASCULOTROPIN A;

ACUTE HEART INFARCTION; ADULT; ANGIOGENESIS; ARTICLE; ARTIFICIAL HEART PACEMAKER; ATRIOVENTRICULAR BLOCK; CANCER; CARDIOGENIC SHOCK; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORONARY ARTERY OBSTRUCTION; DISEASE CLASSIFICATION; DISEASE SEVERITY; DOUBLE BLIND PROCEDURE; DRUG EFFECT; DRUG EFFICACY; DRUG SAFETY; FEMALE; GENE OVEREXPRESSION; GENE TRANSFER; GENERAL CONDITION IMPROVEMENT; HEART FAILURE; HEART LEFT VENTRICLE FUNCTION; HEART LEFT VENTRICLE WALL MOTION; HEART MUSCLE PERFUSION; HEART STRESS; HEART TAMPONADE; HEART VENTRICULOGRAPHY; HUMAN; MALE; MEDICAL ASSESSMENT; MEDICAL SOCIETY; OBSERVATION; PERCUTANEOUS CORONARY INTERVENTION; PHASE 2 CLINICAL TRIAL; POSTOPERATIVE COMPLICATION; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; RANDOMIZATION; RANDOMIZED CONTROLLED TRIAL; RECORDING; RETINOPATHY; SEPSIS; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; STABLE ANGINA PECTORIS; SYMPTOM; UNSTABLE ANGINA PECTORIS; VIRAL GENE THERAPY; VISUAL IMPAIRMENT;

EID: 20144386684     PISSN: 07351097     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jacc.2004.12.068     Document Type: Article

References (14)

1. S. Ylä-Herttuala, K. Alitalo Gene transfer as a tool to induce therapeutic vascular growth Nat Med 9 2003 694 701
2. M. Hedman, J. Hartikainen, M. Syvänne Safety and feasibility of catheter-based local intracoronary vascular endothelial growth factor gene transfer in the prevention of postangioplasty and in-stent restenosis and in the treatment of chronic myocardial ischemia Phase II results of the Kuopio Angiogenesis Trial (KAT) Circulation 107 2003 2677 2683
3. C.L. Grines, M.W. Watkins, J.J. Mahmarian A randomized, double-blind, placebo-controlled trial of Ad5FGF-4 gene therapy and its effect on myocardial perfusion in patients with stable angina J Am Coll Cardiol 42 2003 1339 1347
4. C.L. Grines, M.W. Watkins, G. Helmer Angiogenic Gene Therapy (AGENT) trial in patients with stable angina pectoris Circulation 105 2002 1291 1297
5. P.R. Vale, D.W. Losordo, C.E. Milliken Randomized, single-blind, placebo-controlled pilot study of catheter-based myocardial gene transfer for therapeutic angiogenesis using left ventricular electromechanical mapping in patients with chronic myocardial ischemia Circulation 103 2001 2138 2143
6. D.W. Losordo, P.R. Vale, R.C. Hendel Phase 1/2 placebo-controlled, double-blind, dose-escalating trial of myocardial vascular endothelial growth factor 2 gene transfer by catheter delivery in patients with chronic myocardial ischemia Circulation 105 2002 2012 2018
7. D. Lindahl, J. Lanke, A. Lundin Computer-based decision support system with improved classifications of myocardial bulls-eye scintigrams J Nucl Med 40 1999 1 7
8. H.E. Bøtker, J.F. Lassen, F. Hermansen Electromechanical mapping for detection of myocardial viability in patients with ischemic cardiomyopathy Circulation 103 2001 1631 1637
9. M. Gyongyosi, H. Sochor, A. Khorsand Online myocardial viability assessment in the catheterization laboratory via NOGA electroanatomic mapping Quantitative comparison with thallium-201 uptake Circulation 104 2001 1005 1011
10. H. Wiggers, H.E. Bøtker, P. Søgaard Electromechanical mapping versus position emission tomography and single photon emission computed tomography for the detection of myocardial viability in patients with ischemic cardiomyopathy J Am Coll Cardiol 41 2003 843 848
11. F.H. Sheehan, E.L. Bolson, H.A.T. Dodge Advantages and applications of the centerline method for characterizing regional ventricular function Circulation 74 1986 293 305
12. N. Sarkar, A. Rück, G. Källner Effects of intramyocardial injections of phVEGF-A165 as sole therapy in patients with refractory coronary artery disease--12 months' follow-up J Intern Med 250 2001 1 9
13. C. Sylvén, N. Sarkar, P. Insulander Catheter-based transcutaneous transendocardial myocardial gene transfer J Intervent Cardiol 15 2002 7 13
14. S.B. Freedman, P. Vale, C. Kalka Plasma vascular endothelial growth factor (VEGF) levels after intramuscular and intramyocardial gene transfer of VEGF-1 plasmid DNA Hum Gene Ther 13 2002 1595 1603