Simvastatin disrupts cytoskeleton and decreases cardiac fibroblast adhesion, migration and viability

Toxicology

Volumn 294, Issue 1, 2012, Pages 42-49

  Copaja, Miguel ^a   Venegas, Daniel ^a   Aranguiz, Pablo ^a   Canales, Jimena ^a   Vivar, Raul ^a   Avalos, Yennifer ^a   Garcia, Lorena ^a   Chiong, Mario ^a   Olmedo, Ivonne ^a   Catalán, Mabel ^a   Leyton, Lisette ^a,b   Lavandero, Sergio ^a,b,c   Díaz Araya, Guillermo ^a  

^a UNIVERSITY OF CHILE   (Chile)

^b UNIVERSITY OF CHILE   (Chile)

^c UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

Cardiac fibroblast; Cytoskeleton; Focal adhesion complex; Migration; Simvastatin

Indexed keywords

ANGIOTENSIN II; COLLAGEN; ISOPRENOID; PAXILLIN; SIMVASTATIN; VIMENTIN; VINCULIN;

ACTIN FILAMENT; ANIMAL CELL; ARTICLE; CELL ADHESION; CELL MIGRATION; CELL STRUCTURE; CELL VIABILITY; CELLULAR DISTRIBUTION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOSKELETON; FIBROBLAST; FOCAL ADHESION; HEART MUSCLE CELL; IMMUNOCYTOCHEMISTRY; NONHUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN LOCALIZATION; RAT; STRUCTURE ANALYSIS; WESTERN BLOTTING;

ANIMALS; BLOTTING, WESTERN; CELL ADHESION; CELL MOVEMENT; CELL SURVIVAL; CELLS, CULTURED; CYTOSKELETON; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; MYOFIBROBLASTS; PAXILLIN; RATS; RATS, SPRAGUE-DAWLEY; SIMVASTATIN; TERPENES; VINCULIN;

EID: 84857796500     PISSN: 0300483X     EISSN: 18793185     Source Type: Journal    
DOI: 10.1016/j.tox.2012.01.011     Document Type: Article

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