Mutation of Glu521or Glu535in cytoplasmic loop 5 causes differential misfolding in multiple domains of multidrug and organic anion transporter MRP1 (ABCC1)

Journal of Biological Chemistry

Volumn 287, Issue 10, 2012, Pages 7543-7555

  Iram, Surtaj H ^a   Cole, Susan P C ^a  

^a QUEEN S UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CELL PROLIFERATION; CONFORMATIONS; NEGATIVE IONS; PROTEINS;

4-PHENYLBUTYRIC ACID; CONFORMATIONAL CHANGE; ENDOPLASMIC RETICULUM; INTER-DOMAIN INTERACTIONS; MULTIDRUG RESISTANCE; SUBSTRATE AFFINITY; TRANSMEMBRANE HELICES; TRANSPORT ACTIVITY;

CELL MEMBRANES;

4 PHENYLBUTYRIC ACID; ALANINE; GLUTAMIC ACID; LYSINE; MEMBRANE PROTEIN; MULTIDRUG RESISTANCE PROTEIN 1; PROTEASOME; 4-PHENYLBUTYRIC ACID; ARYLBUTYRIC ACID DERIVATIVE; CHAPERONE; MULTIDRUG RESISTANCE PROTEIN; MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN 1;

AMINO ACID SUBSTITUTION; ARTICLE; CELL COMPONENT; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CYTOPLASMIC LOOP; DOWN REGULATION; ENDOPLASMIC RETICULUM; MUTATIONAL ANALYSIS; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FOLDING; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; PROTEIN TARGETING; PROTEIN TRANSPORT; RESIDUE ANALYSIS; STABLE EXPRESSION; BIOSYNTHESIS; CELL MEMBRANE; CELL STRAIN HEK293; DRUG EFFECT; GENE EXPRESSION REGULATION; GENETICS; HUMAN; METABOLISM; MISSENSE MUTATION; PROTEIN SECONDARY STRUCTURE; PROTEIN TERTIARY STRUCTURE;

AMINO ACID SUBSTITUTION; CELL MEMBRANE; ENDOPLASMIC RETICULUM; GENE EXPRESSION REGULATION; HEK293 CELLS; HUMANS; MOLECULAR CHAPERONES; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; MUTATION, MISSENSE; PHENYLBUTYRATES; PROTEIN FOLDING; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; PROTEOLYSIS;

EID: 84857723864     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.310409     Document Type: Article

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