High-throughput library screening identifies two novel NQO1 inducers in human lung cells

American Journal of Respiratory Cell and Molecular Biology

Volumn 46, Issue 3, 2012, Pages 365-371

  Tan, Xiang Lin ^a,b,c   Marquardt, Gaby ^a   Massimi, Aldo B ^a   Shi, Miao ^a   Han, Weiguo ^a   Spivack, Simon D ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b MAYO GRADUATE SCHOOL   (United States)

^c MAYO CLINIC   (United States)

Author keywords

Gene expression; GSTP1; High throughput screening; NQO1; Phytochemicals

Indexed keywords

2,3 DIHYDROXY 4 METHOXY 4' ETHOXYBENZOPHENONE; ANTINEOPLASTIC AGENT; DAUNORUBICIN; GLUTATHIONE; GLUTATHIONE TRANSFERASE P1; HYDROGEN PEROXIDE; IVERMECTIN; MESSENGER RNA; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE); TRANSCRIPTION FACTOR NRF2; TRIACETYLRESVERATROL; UNCLASSIFIED DRUG;

ANTIOXIDANT ACTIVITY; ARTICLE; BRONCHUS MUCOSA; CELL IMMORTALIZATION; DRUG IDENTIFICATION; ENZYME INDUCTION; GENE EXPRESSION; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; IN VITRO STUDY; LUNG ALVEOLUS CELL; MOLECULAR LIBRARY; PROTEIN EXPRESSION;

ANTICARCINOGENIC AGENTS; ANTIOXIDANTS; BENZOPHENONES; BLOTTING, WESTERN; BRONCHI; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INDUCTION; EPITHELIAL CELLS; GLUTATHIONE; GLUTATHIONE S-TRANSFERASE PI; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; NAD(P)H DEHYDROGENASE (QUINONE); POLYMERASE CHAIN REACTION; REACTIVE OXYGEN SPECIES; REPRODUCIBILITY OF RESULTS; RNA, MESSENGER; STILBENES;

EID: 84857696377     PISSN: 10441549     EISSN: None     Source Type: Journal    
DOI: 10.1165/rcmb.2011-0301OC     Document Type: Article

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