Insulin downregulates SIRT1 and AMPK activation and is associated with changes in liver fat, but not in inflammation and mitochondrial oxidative capacity, in streptozotocin-diabetic rat

Clinical Nutrition

Volumn 30, Issue 3, 2011, Pages 384-390

  Barazzoni, Rocco ^a   Zanetti, Michela ^a   Sturnega, Mauro ^b   Stebel, Marco ^a   Semolic, Annamaria ^a   Pirulli, Alessia ^a   Vinci, Pierandrea ^a   Zentilin, Lorena ^b   Giacca, Mauro ^b   Cattin, Luigi ^a   Guarnieri, Gianfranco ^a  

^a UNIVERSITY OF TRIESTE   (Italy)

^b INTERNATIONAL CENTRE FOR GENETIC ENGINEERING AND BIOTECHNOLOGY   (Italy)

Author keywords

Diabetes; Insulin; Liver; SIRT1

Indexed keywords

ACETYL COENZYME A CARBOXYLASE; CARBOHYDRATE RESPONSE ELEMENT BINDING PROTEIN; CITRATE SYNTHASE; CYTOCHROME C OXIDASE; FAT; FATTY ACID; GLUCOSE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; INSULIN; INSULIN ZINC SUSPENSION; INTERLEUKIN 1BETA; INTERLEUKIN 6; NUCLEIC ACID BINDING PROTEIN; SIRTUIN 1; STAT3 PROTEIN; STEROL REGULATORY ELEMENT BINDING PROTEIN; TRANSCRIPTION FACTOR RELA; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; DIABETES MELLITUS; DOWN REGULATION; ENZYME ACTIVATION; FATTY LIVER; FOOD INTAKE; GLUCOSE BLOOD LEVEL; HEPATITIS; INSULIN BLOOD LEVEL; LIPID LIVER LEVEL; MALE; MITOCHONDRIAL RESPIRATION; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN PHOSPHORYLATION; RAT; STREPTOZOCIN DIABETES;

ACETYL-COA CARBOXYLASE; AMP-ACTIVATED PROTEIN KINASES; ANIMALS; DIABETES MELLITUS, EXPERIMENTAL; DOWN-REGULATION; ENZYME ACTIVATION; HYPOGLYCEMIC AGENTS; INFLAMMATION MEDIATORS; INSULIN; LIPID METABOLISM; LIVER; MALE; MITOCHONDRIA, LIVER; OXIDATION-REDUCTION; PHOSPHORYLATION; PROTEIN PROCESSING, POST-TRANSLATIONAL; RANDOM ALLOCATION; RATS; RATS, WISTAR; RNA, MESSENGER; SIRTUIN 1; TRIGLYCERIDES;

EID: 79957569385     PISSN: 02615614     EISSN: 15321983     Source Type: Journal    
DOI: 10.1016/j.clnu.2010.11.001     Document Type: Article

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