Rapid exchange of metal between Zn 7-metallothionein-3 and amyloid-β peptide promotes amyloid-related structural changes

Biochemistry

Volumn 51, Issue 8, 2012, Pages 1697-1706

  Pedersen, Jeppe T ^a,b,c,d   Hureau, Christelle ^b,c   Hemmingsen, Lars ^a   Heegaard, Niels H H ^e   Østergaard, Jesper ^d   Vašák, Milan ^f   Faller, Peter ^b,c  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b LCC LABORATOIRE DE CHIMIE DE COORDINATION   (France)

^c UNIVERSITÉ DE TOULOUSE   (France)

^d UNIVERSITY OF COPENHAGEN   (Denmark)

^e STATENS SERUM INSTITUT   (Denmark)

^f UNIVERSITY OF ZURICH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ALZHEIMER'S DISEASE; DETAILED MODELS; METAL EXCHANGE; METAL ION HOMEOSTASIS; METALLOPROTEIN; METALLOTHIONEIN-3; MORPHOLOGICAL CHANGES; NEUROTOXICITY; REACTIVE OXYGEN SPECIES; SPECIFIC RECOGNITION; STRUCTURAL CHANGE; THERAPEUTIC STRATEGY; THIOFLAVIN T; UNDERLYING CAUSE;

GLYCOPROTEINS; METAL IONS; METALS; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PEPTIDES; TRANSMISSION ELECTRON MICROSCOPY; ZINC;

COPPER;

AMYLOID BETA PROTEIN; AMYLOID BETA PROTEIN[1-16]; AMYLOID BETA PROTEIN[1-40]; COPPER; METALLOTHIONEIN III; UNCLASSIFIED DRUG; ZINC;

ARTICLE; COMPLEX FORMATION; ION EXCHANGE; MOLECULAR MECHANICS; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN STRUCTURE; SPECTROSCOPY;

AMYLOID BETA-PEPTIDES; COPPER; METALLOTHIONEIN; MICROSCOPY, ELECTRON, TRANSMISSION; MODELS, MOLECULAR; PROTEIN CONFORMATION; REACTIVE OXYGEN SPECIES; ZINC;

EID: 84857612193     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi201774z     Document Type: Article

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