Non-combinatorial library screening reveals subsite cooperativity and identifies new high-efficiency substrates for kallikrein-related peptidase 14

Biological Chemistry

Volumn 393, Issue 5, 2012, Pages 331-341

  De Veer, Simon J ^a   Swedberg, Joakim E ^b   Parker, Edward A ^a   Harris, Jonathan M ^a  

^a QUEENSLAND UNIVERSITY OF TECHNOLOGY   (Australia)

^b UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

Phage display; Positional scanning synthetic combinatorial library; Serine protease; Sparse matrix library; Substrate specificity

Indexed keywords

KALLIKREIN 5; KALLIKREIN RELATED PEPTIDASE 14; KALLIKREIN RELATED PEPTIDASE 4; PEPTIDASE; UNCLASSIFIED DRUG;

BINDING SITE; COMBINATORIAL LIBRARY; CONFERENCE PAPER; COOPERATION; ENZYME BINDING; ENZYME KINETICS; ENZYME SPECIFICITY; ENZYME STRUCTURE; MICHAELIS CONSTANT; MOLECULAR DYNAMICS; NONCOMBINATORIAL LIBRARY; PEPTIDE SYNTHESIS; PHAGE DISPLAY; PRIORITY JOURNAL; PROTEIN CLEAVAGE; SIMULATION;

AMINO ACID SEQUENCE; BINDING SITES; BIOCATALYSIS; COMBINATORIAL CHEMISTRY TECHNIQUES; DRUG EVALUATION, PRECLINICAL; HUMANS; KALLIKREINS; MOLECULAR DYNAMICS SIMULATION; MOLECULAR SEQUENCE DATA; PROTEIN BINDING; PROTEIN CONFORMATION; SEQUENCE HOMOLOGY, AMINO ACID; SUBSTRATE SPECIFICITY;

EID: 84857560905     PISSN: 14316730     EISSN: 14374315     Source Type: Journal    
DOI: 10.1515/BC-2011-250     Document Type: Conference Paper

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