The emerging role of the TGFβ tumor suppressor pathway in pancreatic cancer

Cell Cycle

Volumn 11, Issue 4, 2012, Pages 683-686

  Birnbaum, David J ^a   Mamessier, Emilie ^a   Birnbaum, Daniel ^a  

^a INSTITUT PAOLI CALMETTES   (France)

Author keywords

ARID1A; GATA6; Gene mutation; Pancreatic cancer; Signaling pathway; SWI SNF; TGF

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR 2A; HEPATOCYTE NUCLEAR FACTOR 3BETA; K RAS PROTEIN; NOTCH RECEPTOR; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN MDM2; PROTEIN P53; SMAD4 PROTEIN; TRANSCRIPTION FACTOR GATA 6; TRANSFORMING GROWTH FACTOR BETA; WNT PROTEIN;

CARCINOGENESIS; CELL PROLIFERATION; EPITHELIAL MESENCHYMAL TRANSITION; GENE EXPRESSION; GENE MUTATION; GENETIC TRANSCRIPTION; HISTONE MODIFICATION; HUMAN; NONHUMAN; PANCREAS CANCER; REVIEW; SIGNAL TRANSDUCTION;

EID: 84857490311     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.11.4.19130     Document Type: Review

References (27)

1. Vincent A, Herman J, Schulick R, Hruban RH, Goggins M. Pancreatic cancer. Lancet 2011; 378:607- 20; PMID:21620466; http://dx.doi.org/10.1016/ S0140-6736(10)62307-0.
2. Harada T, Chelala C, Crnogorac-Jurcevic T, Lemoine NR. Genome-wide analysis of pancreatic cancer using microarray-based techniques. Pancreatology 2009; 9:13-24; PMID:19077451; http://dx.doi. org/10.1159/000178871.
3. Birnbaum DJ, Adélaïde J, Mamessier E, Finetti P, Lagarde A, Monges G, et al. Genome profiling of pancreatic adenocarcinoma. Genes Chromosomes Cancer 2011; 50:456-65; PMID:21412932; http:// dx.doi.org/10.1002/ gcc.20870.
4. Jones S, Zhang X, Parsons DW, Lin JC, Leary RJ, Angenendt P, et al. Core signaling pathways in human pancreatic cancers revealed by global genomic analyses. Science 2008; 321:1801-6; PMID:18772397; http://dx.doi.org/10.1126/ science.1164368.
5. Campbell PJ, Yachida S, Mudie LJ, Stephens PJ, Pleasance ED, Stebbings LA, et al. The patterns and dynamics of genomic instability in metastatic pancreatic cancer. Nature 2010; 467:1109-13; PMID:20981101; http://dx.doi.org/ 10.1038/ nature09460.
6. Jones S, Li M, Parsons DW, Zhang X, Wesseling J, Kristel P, et al. Somatic mutations in the chromatin remodeling gene ARID1A occur in several tumor types. Hum Mutat 2012; 33:100-3; PMID:22009941; http://dx.doi.org/10.1002/ humu.21633.
7. Yachida S, Jones S, Bozic I, Antal T, Leary R, Fu B, et al. Distant metastasis occurs late during the genetic evolution of pancreatic cancer. Nature 2010; 467:1114-7; PMID:20981102; http://dx.doi. org/10.1038/nature09515.
8. Qiu W, Sahin F, Iacobuzio-Donahue CA, Garcia- Carracedo D, Wang WM, Kuo CY, et al. Disruption of p16 and Activation of Kras in Pancreas Increase Ductal Adenocarcinoma Formation and Metastasis in vivo. Oncotarget 2:862-73.
9. Kwei KA, Bashyam MD, Kao J, Ratheesh R, Reddy EC, Kim YH, et al. Genomic profiling identifies GATA6 as a candidate oncogene amplified in pancreatobiliary cancer. PLoS Genet 2008; 4:1000081; PMID:18535672; http://dx.doi.org/10.1371/ journal. pgen.1000081.
10. Wiegand KC, Shah SP, Al-Agha OM, Zhao Y, Tse K, Zeng T, et al. ARID1A mutations in endometriosis-associated ovarian carcinomas. N Engl J Med 2010; 363:1532-43; PMID:20942669; http://dx.doi. org/10.1056/NEJMoa1008433.
11. Collisson EA, Sadanandam A, Olson P, Gibb WJ, Truitt M, Gu S, et al. Subtypes of pancreatic ductal adenocarcinoma and their differing responses to therapy. Nat Med 2011; 17:500-3; PMID:21460848; http://dx.doi.org/10.1038/nm. 2344.
12. Yamaguchi H, Kuboki Y, Hatori T, Yamamoto M, Shiratori K, Kawamura S, et al. Somatic mutations in PIK3CA and activation of AKT in intraductal tubulopapillary neoplasms of the pancreas. Am J Surg Pathol 2011; 35:1812-7; PMID:21945955; http:// dx.doi.org/10.1097/PAS.0b013e31822769a0.
13. Kwei KA, Shain AH, Bair R, Montgomery K, Karikari CA, van de Rijn M, et al. SMURF1 amplification promotes invasiveness in pancreatic cancer. PLoS ONE 2011; 6:23924; PMID:21887346; http://dx.doi.org/10.1371/journal.pone.0023924.
14. Shain AH, Giacomini CP, Matsukuma K, Karikari CA, Bashyam MD, Hidalgo M, et al. Convergent structural alterations define Switch/Sucrose NonFermentable (SWI/SNF) chromatin remodeler as a central tumor suppressive complex in pancreatic cancer. Proc Natl Acad Sci USA 2012; In press, http://dx.doi.org/10. 1073/pnas.1114817109
15. Guan B, Wang TL, Shih IeM. ARID1A, a factor that promotes formation of SWI/SNF-mediated chromatin remodeling, is a tumor suppressor in gynecologic cancers. Cancer Res 2011; 71:6718-27; PMID:21900401; http://dx.doi.org/10.1158/ 0008-5472.CAN-11-1562.
16. Ross S, Cheung E, Petrakis TG, Howell M, Kraus WL, Hill CS. Smads orchestrate specific histone modifications and chromatin remodeling to activate transcription. EMBO J 2006; 25:4490-502; PMID:16990801; http://dx.doi.org/10. 1038/ sj.emboj.7601332.
17. Froese N, Kattih B, Breitbart A, Grund A, Geffers R, Molkentin JD, et al. GATA6 promotes angiogenic function and survival in endothelial cells by suppression of autocrine transforming growth factor beta/ activin receptor-like kinase 5 signaling. J Biol Chem 2011; 286:5680-90; PMID:21127043; http://dx.doi. org/10.1074/jbc.M110.176925.
18. Liu Z, Lin X, Cai Z, Zhang Z, Han C, Jia S, et al. Global identification of SMAD2 target genes reveals a role for multiple co-regulatory factors in zebrafish early gastrulas. J Biol Chem 2011; 286:28520-32; PMID:21669877; http://dx.doi.org/10.1074/jbc. M111.236307.
19. Afouda BA, Ciau-Uitz A, Patient R. GATA4, 5 and 6 mediate TGFbeta maintenance of endodermal gene expression in Xenopus embryos. Development 2005; 132:763-74; PMID:15659482; http://dx.doi. org/10.1242/dev.01647.
20. Tang Y, Shu G, Yuan X, Jing N, Song J. FOXA2 functions as a suppressor of tumor metastasis by inhibition of epithelial-to-mesenchymal transition in human lung cancers. Cell Res 2011; 21:316- 26; PMID:20820189; http://dx.doi.org/10. 1038/ cr.2010.126.
21. Zhong Y, Wang Z, Fu B, Pan F, Yachida S, Dhara M, et al. GATA6 activates Wnt signaling in pancreatic cancer by negatively regulating the Wnt antagonist Dickkopf-1. PLoS ONE 2011; 6:22129; PMID:21811562; http://dx.doi.org/10.1371/ journal. pone.0022129.
22. Nolan-Stevaux O, Lau J, Truitt ML, Chu GC, Hebrok M, Fernández- Zapico ME, et al. GLI1 is regulated through Smoothened-independent mechanisms in neoplastic pancreatic ducts and mediates PDAC cell survival and transformation. Genes Dev 2009; 23:24-36; PMID:19136624; http://dx.doi. org/10.1101/gad. 1753809.
23. Bardeesy N, Cheng KH, Berger JH, Chu GC, Pahler J, Olson P, et al. Smad4 is dispensable for normal pancreas development yet critical in progression and tumor biology of pancreas cancer. Genes Dev 2006; 20:3130-46; PMID:17114584; http://dx.doi. org/10.1101/gad.1478706.
24. Bianchi A, Gervasi ME, Bakin A. Role of β5-integrin in epithelial-mesenchymal transition in response to TGFβ. Cell Cycle 2010; 9:1647- 59; PMID:20404485; http://dx.doi.org/10.4161/ cc.9.8.11517.
25. Fuxe J, Vincent T, Garcia de Herreros A. Transcriptional crosstalk between TGFβ and stem cell pathways in tumor cell invasion: role of EMT promoting Smad complexes. Cell Cycle 2010; 9:2363-74; PMID:20519943; http://dx.doi. org/10.4161/cc.9.12.12050.
26. Salem AF, Bonuccelli G, Bevilacqua G, Arafat H, Pestell RG, Sotgia F, et al. Caveolin-1 promotes pancreatic cancer cell differentiation and restores membranous E-cadherin via suppression of the epithelialmesenchymal transition. Cell Cycle 2011; 10:3692- 700; PMID:22041584; http://dx.doi.org/10.4161/ cc.10.21.17895.
27. Taylor MA, Parvani JG, Schiemann WP. The pathophysiology of epithelial-mesenchymal transition induced by transforming growth factor-beta in normal and malignant mammary epithelial cells. J Mammary Gland Biol Neoplasia 2010; 15:169- 90; PMID:20467795; http://dx.doi.org/10.1007/ s10911-010-9181-1.