GATA6 promotes angiogenic function and survival in endothelial cells by suppression of autocrine transforming growth factor β/activin receptor-like kinase 5 signaling

Journal of Biological Chemistry

Volumn 286, Issue 7, 2011, Pages 5680-5690

  Froese, Natali ^a   Kattih, Badder ^a   Breitbart, Astrid ^a   Grund, Andrea ^a   Geffers, Robert ^b   Molkentin, Jeffery D ^c   Kispert, Andreas ^a   Wollert, Kai C ^a   Drexler, Helmut ^a   Heineke, Joerg ^a  

^a HANNOVER MEDICAL SCHOOL   (Germany)

^b HELMHOLTZ CENTRE FOR INFECTION RESEARCH   (Germany)

^c UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOGENESIS; APOPTOSIS; DOWN-REGULATION; GROWTH FACTOR; IN-VIVO; MICROVASCULAR; MICROVASCULAR ENDOTHELIAL CELLS; NEUTRALIZING ANTIBODIES; NUCLEAR TRANSLOCATIONS; OVER-EXPRESSION; PROMOTER ACTIVITIES; RECEPTOR-LIKE KINASE; THERAPEUTIC TARGETS; TRANSCRIPTIONAL ACTIVATIONS; TRANSCRIPTIONAL REGULATION; TRANSFORMING GROWTH FACTORS; VASCULAR ENDOTHELIAL CELLS;

BLOOD VESSELS; CELL DEATH; ENZYMES; GLYCOPROTEINS; PEPTIDES; SELF ASSEMBLY; SIGNALING; TRANSCRIPTION FACTORS;

ENDOTHELIAL CELLS;

NEUTRALIZING ANTIBODY; SMAD2 PROTEIN; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR GATA 6; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 1; TRANSFORMING GROWTH FACTOR BETA1; TRANSFORMING GROWTH FACTOR BETA2;

ANGIOGENESIS; ARTICLE; AUTOCRINE EFFECT; CELL ACTIVATION; CELL FUNCTION; CELL MIGRATION; CELL NUCLEUS; CELL PROLIFERATION; CELL STRUCTURE; CELL SURVIVAL; CHROMATIN ASSEMBLY AND DISASSEMBLY; CONTROLLED STUDY; DOWN REGULATION; ENDOTHELIUM CELL; ENZYME REPRESSION; GENE OVEREXPRESSION; HEART MUSCLE CELL; HUMAN; HUMAN CELL; IN VIVO STUDY; MICROVASCULARIZATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN SECRETION; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION;

ANIMALS; APOPTOSIS; AUTOCRINE COMMUNICATION; CELLS, CULTURED; ENDOTHELIAL CELLS; GATA6 TRANSCRIPTION FACTOR; GENE EXPRESSION REGULATION; HUMANS; MICE; NEOVASCULARIZATION, PHYSIOLOGIC; PROTEIN-SERINE-THREONINE KINASES; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; SIGNAL TRANSDUCTION; SMAD2 PROTEIN; TRANSFORMING GROWTH FACTOR BETA1; TRANSFORMING GROWTH FACTOR BETA2;

MUS;

EID: 79953137084     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.176925     Document Type: Article

References (38)

1. Carmeliet, P. (2000) Nat. Med. 6, 389-395
2. Simons, M. (2005) Circulation 111, 1556-1566
3. Carmeliet, P. (2003) Nat. Med. 9, 653-660
4. Kessler, T., Bayer, M., Schwöppe, C., Liersch, R., Mesters, R. M., and Berdel, W. E. (2010) Recent Results Cancer Res. 180, 137-163
5. Ylä-Herttuala, S., and Alitalo, K. (2003) Nat. Med. 9, 694-701
6. De Val, S., and Black, B. L. (2009) Dev. Cell 16, 180-195
7. Molkentin, J. D. (2000) J. Biol. Chem. 275, 38949-38952
8. Koutsourakis, M., Langeveld, A., Patient, R., Beddington, R., and Grosveld, F. (1999) Development 126, 723-732
9. Morrisey, E. E., Tang, Z., Sigrist, K., Lu, M. M., Jiang, F., Ip, H. S., and Parmacek, M. S. (1998) Genes Dev. 12, 3579-3590
10. Zhao, R., Watt, A. J., Li, J., Luebke-Wheeler, J., Morrisey, E. E., and Duncan, S. A. (2005) Mol. Cell. Biol. 25, 2622-2631
11. Lepore, J. J., Mericko, P. A., Cheng, L., Lu, M. M., Morrisey, E. E., and Parmacek, M. S. (2006) J. Clin. Invest. 116, 929-939
12. Morrisey, E. E., Ip, H. S., Lu, M. M., and Parmacek, M. S. (1996) Dev. Biol. 177, 309-322
13. Zhang, Y., Goss, A. M., Cohen, E. D., Kadzik, R., Lepore, J. J., Muthuku- maraswamy, K., Yang, J., DeMayo, F. J., Whitsett, J. A., Parmacek, M. S., and Morrisey, E. E. (2008) Nat. Genet. 40, 862-870
14. Lepore, J. J., Cappola, T. P., Mericko, P. A., Morrisey, E. E., and Parmacek, M. S. (2005) Arterioscler. Thromb. Vasc. Biol. 25, 309-314
15. Mano, T., Luo, Z., Malendowicz, S. L., Evans, T., and Walsh, K. (1999) Circ. Res. 84, 647-654
16. Umetani, M., Mataki, C., Minegishi, N., Yamamoto, M., Hamakubo, T., and Kodama, T. (2001) Arterioscler. Thromb. Vasc. Biol. 21, 917-922
17. German, Z., Chambliss, K. L., Pace, M. C., Arnet, U. A., Lowenstein, C. J., and Shaul, P. W. (2000) J. Biol. Chem. 275, 8183-8189
18. Gumina, R. J., Kirschbaum, N. E., Piotrowski, K., and Newman, P. J. (1997) Blood 89, 1260-1269
19. Yamashita, K., Discher, D. J., Hu, J., Bishopric, N. H., and Webster, K. A. (2001) J. Biol. Chem. 276, 12645-12653
20. Dorfman, D. M., Wilson, D. B., Bruns, G. A., and Orkin, S. H. (1992) J. Biol. Chem. 267, 1279-1285
21. Moorman, A. F., Houweling, A. C., de Boer, P. A., and Christoffels, V. M. (2001) J. Histochem. Cytochem. 49, 1-8
22. Liang, Q., De Windt, L. J., Witt, S. A., Kimball, T. R., Markham, B. E., and Molkentin, J. D. (2001) J. Biol. Chem. 276, 30245-30253
23. Ochiai, N., Uchida, R., Fuchida, S., Okano, A., Okamoto, M., Ashihara, E., Inaba, T., Fujita, N., Matsubara, H., and Shimazaki, C. (2003) Blood 102, 3349-3353
24. Nakano, N., Hosokawa, H., Kohyama, M., and Hozumi, N. (2007) J. Immunol. 178, 3067-3075
25. Heineke, J., Auger-Messier, M., Xu, J., Oka, T., Sargent, M. A., York, A., Klevitsky, R., Vaikunth, S., Duncan, S. A., Aronow, B. J., Robbins, J., Crombleholme, T. M., and Molkentin, J. D. (2007) J. Clin. Invest. 117, 3198-3210
26. Collavin, L., Gostissa, M., Avolio, F., Secco, P., Ronchi, A., Santoro, C., and Del Sal, G. (2004) Proc. Natl. Acad. Sci. U.S.A. 101, 8870-8875
27. Fuchshofer, R., Stephan, D. A., Russell, P., and Tamm, E. R. (2009) Exp. Eye Res. 88, 1020-1032
28. Goumans, M. J., Valdimarsdottir, G., Itoh, S., Rosendahl, A., Sideras, P., and ten Dijke, P. (2002) EMBO J. 21, 1743-1753
29. Pepper, M. S. (1997) Cytokine Growth Factor Rev. 8, 21-43
30. Lebrin, F., Deckers, M., Bertolino, P., and Ten Dijke, P. (2005) Cardiovasc. Res. 65, 599-608
31. Lugus, J. J., Chung, Y. S., Mills, J. C., Kim, S. I., Grass, J., Kyba, M., Doherty, J. M., Bresnick, E. H., and Choi, K. (2007) Development 134, 393-405
32. Song, H., Suehiro, J., Kanki, Y., Kawai, Y., Inoue, K., Daida, H., Yano, K., Ohhashi, T., Oettgen, P., Aird, W. C., Kodama, T., and Minami, T. (2009) J. Biol. Chem. 284, 29109-29124
33. Mammoto, A., Connor, K. M., Mammoto, T., Yung, C. W., Huh, D., Aderman, C. M., Mostoslavsky, G., Smith, L. E., and Ingber, D. E. (2009) Nature 457, 1103-1108
34. Zhou, B., Ma, Q., Kong, S. W., Hu, Y., Campbell, P. H., McGowan, F. X., Ackerman, K. G., Wu, B., Zhou, B., Tevosian, S. G., and Pu, W. T. (2009) J. Clin. Invest. 119, 1462-1476
35. Yamagata, T., Nishida, J., Sakai, R., Tanaka, T., Honda, H., Hirano, N., Mano, H., Yazaki, Y., and Hirai, H. (1995) Mol. Cell. Biol. 15, 3830-3839
36. Pepper, M. S., Vassalli, J. D., Orci, L., and Montesano, R. (1993) Exp. Cell Res. 204, 356-363
37. Vernon, R. B., and Sage, E. H. (1999) Microvasc. Res. 57, 118-133
38. Ota, T., Fujii, M., Sugizaki, T., Ishii, M., Miyazawa, K., Aburatani, H., and Miyazono, K. (2002) J. Cell. Physiol. 193, 299-318