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Volumn 21, Issue 2, 2011, Pages 316-326

FOXA2 functions as a suppressor of tumor metastasis by inhibition of epithelial-to-mesenchymal transition in human lung cancers

Author keywords

EMT; FOXA2; lung tumors; slug; TGF 1

Indexed keywords

FOXA2 PROTEIN, HUMAN; HEPATOCYTE NUCLEAR FACTOR 3BETA; SMALL INTERFERING RNA; SNAIL FAMILY TRANSCRIPTION FACTORS; TRANSCRIPTION FACTOR; TRANSFORMING GROWTH FACTOR BETA1;

EID: 79651473733     PISSN: 10010602     EISSN: 17487838     Source Type: Journal    
DOI: 10.1038/cr.2010.126     Document Type: Article
Times cited : (130)

References (38)
  • 1
    • 70349729970 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transi-tion and cell cooperativity in metastasis
    • Tsuji T, Ibaragi S, Hu GF. Epithelial-mesenchymal transi-tion and cell cooperativity in metastasis. Cancer Res 2009; 69:7135-7139.
    • (2009) Cancer Res , vol.69 , pp. 7135-7139
    • Tsuji, T.1    Ibaragi, S.2    Hu, G.F.3
  • 2
    • 70450198396 scopus 로고    scopus 로고
    • Epithelial-mes-enchymal transitions in development and disease
    • Thiery JP, Acloque H, Huang RY, Nieto MA. Epithelial-mes-enchymal transitions in development and disease. Cell 2009; 139:871-890.
    • (2009) Cell , vol.139 , pp. 871-890
    • Thiery, J.P.1    Acloque, H.2    Huang, R.Y.3    Nieto, M.A.4
  • 3
    • 77951953778 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition: From molecular mechanisms, redox regulation to implications in human health and disease
    • Cannito S, Novo E, Di Bonzo LV, Busletta C, Colombatto S, Parola M. Epithelial-mesenchymal transition: from molecular mechanisms, redox regulation to implications in human health and disease. Antioxid Redox Signal 2010; 12:1383-1430
    • (2010) Antioxid Redox Signal , vol.12 , pp. 1383-1430
    • Cannito, S.1    Novo, E.2    Di Bonzo, L.V.3    Busletta, C.4    Colombatto, S.5    Parola, M.6
  • 4
    • 33244463813 scopus 로고    scopus 로고
    • Complex networks orchestrate epithelial-mesenchymal transitions
    • DOI 10.1038/nrm1835, PII NRM1835
    • Thiery JP, Sleeman JP. Complex networks orchestrate epithe-lial- mesenchymal transitions. Nat Rev Mol Cell Biol 2006; 7:131-142. (Pubitemid 43278296)
    • (2006) Nature Reviews Molecular Cell Biology , vol.7 , Issue.2 , pp. 131-142
    • Thiery, J.P.1    Sleeman, J.P.2
  • 5
    • 24644480749 scopus 로고    scopus 로고
    • Molecular requirements for epithelial-mesenchymal transition during tumor progression
    • DOI 10.1016/j.ceb.2005.08.001, PII S0955067405001043
    • Huber MA, Kraut N, Beug H. Molecular requirements for epithelial-mesenchymal transition during tumor progression. Curr Opin Cell Biol 2005; 17: 548-558. (Pubitemid 41267170)
    • (2005) Current Opinion in Cell Biology , vol.17 , Issue.5 , pp. 548-558
    • Huber, M.A.1    Kraut, N.2    Beug, H.3
  • 6
    • 63749105896 scopus 로고    scopus 로고
    • Mechanism of TGF-beta signaling to growth arrest, apoptosis, and epithelial-mesenchymal transition
    • Heldin CH, Landstrom M, Moustakas A. Mechanism of TGF-beta signaling to growth arrest, apoptosis, and epithelial-mesenchymal transition. Curr Opin Cell Biol 2009; 21:166-176.
    • (2009) Curr Opin Cell Biol , vol.21 , pp. 166-176
    • Heldin, C.H.1    Landstrom, M.2    Moustakas, A.3
  • 7
    • 33751315728 scopus 로고    scopus 로고
    • Transforming growth factor-1 induces epithelial-to-mesenchymal transition and apoptosis via a cell cycle-dependent mechanism
    • DOI 10.1038/sj.onc.1209712, PII 1209712
    • Yang Y, Pan X, Lei W, Wang J, Song J. Transforming growth factor-beta1 induces epithelial-to-mesenchymal transition and apoptosis via a cell cycle-dependent mechanism. Oncogene 2006; 25:7235-7244. (Pubitemid 44809089)
    • (2006) Oncogene , vol.25 , Issue.55 , pp. 7235-7244
    • Yang, Y.1    Pan, X.2    Lei, W.3    Wang, J.4    Song, J.5
  • 8
    • 16644382513 scopus 로고    scopus 로고
    • Human FOX gene family (Review)
    • Katoh M. Human FOX gene family (Review). Int J Oncol 2004; 25:1495-1500.
    • (2004) Int J Oncol , vol.25 , pp. 1495-1500
    • Katoh, M.1
  • 10
    • 33750438123 scopus 로고    scopus 로고
    • The Foxa family of transcription factors in development and metabolism
    • DOI 10.1007/s00018-006-6095-6
    • Friedman JR, Kaestner KH. The Foxa family of transcription factors in development and metabolism. Cell Mol Life Sci 2006; 63:2317-2328. (Pubitemid 44653042)
    • (2006) Cellular and Molecular Life Sciences , vol.63 , Issue.19-20 , pp. 2317-2328
    • Friedman, J.R.1    Kaestner, K.H.2
  • 11
    • 49149090637 scopus 로고    scopus 로고
    • Hepatocyte-specific ablation of Foxa2 alters bile acid homeostasis and results in endoplasmic reticulum stress
    • Bochkis IM, Rubins NE, White P, Furth EE, Friedman JR, Kaestner KH. Hepatocyte-specific ablation of Foxa2 alters bile acid homeostasis and results in endoplasmic reticulum stress. Nat Med 2008; 14:828-836.
    • (2008) Nat Med , vol.14 , pp. 828-836
    • Bochkis, I.M.1    Rubins, N.E.2    White, P.3    Furth, E.E.4    Friedman, J.R.5    Kaestner, K.H.6
  • 12
    • 32444451567 scopus 로고    scopus 로고
    • Coactivation of Foxa2 through Pgc-1beta promotes liver fatty acid oxidation and triglyceride/VLDL secretion
    • Wolfrum C, Stoffel M. Coactivation of Foxa2 through Pgc-1beta promotes liver fatty acid oxidation and triglyceride/VLDL secretion. Cell Metab 2006; 3:99-110.
    • (2006) Cell Metab , vol.3 , pp. 99-110
    • Wolfrum, C.1    Stoffel, M.2
  • 13
    • 30044452661 scopus 로고    scopus 로고
    • Foxa2, a novel transcriptional regulator of insulin sensitivity
    • DOI 10.1038/nm0106-38
    • Puigserver P, Rodgers JT. Foxa2, a novel transcriptional regu-lator of insulin sensitivity. Nat Med 2006; 12:38-39. (Pubitemid 43050058)
    • (2006) Nature Medicine , vol.12 , Issue.1 , pp. 38-39
    • Puigserver, P.1    Rodgers, J.T.2
  • 14
    • 2442655261 scopus 로고    scopus 로고
    • Forkhead box A2 transcription factor is expressed in all types of neuroendocrine lung tumors
    • DOI 10.1016/j.humpath.2004.01.017
    • Khoor A, Stahlman MT, Johnson JM, Olson SJ, Whitsett JA. Forkhead box A2 transcription factor is expressed in all types of neuroendocrine lung tumors. Hum Pathol 2004; 35:560-564. (Pubitemid 38656939)
    • (2004) Human Pathology , vol.35 , Issue.5 , pp. 560-564
    • Khoor, A.1    Stahlman, M.T.2    Johnson, J.M.3    Olson, S.J.4    Whitsett, J.A.5
  • 15
    • 34247621263 scopus 로고    scopus 로고
    • The hepatocyte nuclear factor 6 (HNF6) and FOXA2 are key regulators in colorectal liver metastases
    • DOI 10.1096/fj.06-6575com
    • Lehner F, Kulik U, Klempnauer J, Borlak J. The hepatocyte nuclear factor 6 (HNF6) and FOXA2 are key regulators in colorectal liver metastases. FASEB J 2007; 21:1445-1462. (Pubitemid 46684847)
    • (2007) FASEB Journal , vol.21 , Issue.7 , pp. 1445-1462
    • Lehner, F.1    Kulik, U.2    Klempnauer, J.3    Borlak, J.4
  • 16
    • 26244458018 scopus 로고    scopus 로고
    • TGF-beta1 induces human alveolar epithelial to mesenchymal cell transition (EMT)
    • Kasai H, Allen JT, Mason RM, Kamimura T, Zhang Z. TGF-beta1 induces human alveolar epithelial to mesenchymal cell transition (EMT). Respir Res 2005; 6:56.
    • (2005) Respir Res , vol.6 , pp. 56
    • Kasai, H.1    Allen, J.T.2    Mason, R.M.3    Kamimura, T.4    Zhang, Z.5
  • 17
    • 70349750200 scopus 로고    scopus 로고
    • Insulin receptor substrate-1 suppresses transforming growth factor-beta1-mediated epithe-lial-mesenchymal transition
    • Shi J, Wang DM, Wang CM, et al. Insulin receptor substrate-1 suppresses transforming growth factor-beta1-mediated epithe-lial-mesenchymal transition. Cancer Res 2009; 69:7180-7187.
    • (2009) Cancer Res , vol.69 , pp. 7180-7187
    • Shi, J.1    Wang, D.M.2    Wang, C.M.3
  • 18
    • 0028794104 scopus 로고
    • Expression of snail2, a second member of the zebrafish snail family, in cephalic mesendoderm and presumptive neural crest of wild-type and spadetail mutant embryos
    • Thisse C, Thisse B, Postlethwait JH. Expression of snail2, a second member of the zebrafish snail family, in cephalic mesendoderm and presumptive neural crest of wild-type and spadetail mutant embryos. Dev Biol 1995; 172:86-99.
    • (1995) Dev Biol , vol.172 , pp. 86-99
    • Thisse, C.1    Thisse, B.2    Postlethwait, J.H.3
  • 19
    • 0037086277 scopus 로고    scopus 로고
    • The SLUG zinc-finger protein represses E-cadherin in breast cancer
    • Hajra KM, Chen DY, Fearon ER. The SLUG zinc-fnger pro-tein represses E-cadherin in breast cancer. Cancer Res 2002; 62:1613-1618. (Pubitemid 34408479)
    • (2002) Cancer Research , vol.62 , Issue.6 , pp. 1613-1618
    • Hajra, K.M.1    David Y-S. Chen2    Fearon, E.R.3
  • 20
    • 0031005659 scopus 로고    scopus 로고
    • The zinc-finger protein slug causes desmosome dissociation, an initial and necessary step for growth factor-induced epithelial-mesenchymal transition
    • DOI 10.1083/jcb.137.6.1403
    • Savagner P, Yamada KM, Thiery JP. The zinc-fnger protein slug causes desmosome dissociation, an initial and necessary step for growth factor-induced epithelial-mesenchymal transi-tion. J Cell Biol 1997; 137:1403-1419. (Pubitemid 27265951)
    • (1997) Journal of Cell Biology , vol.137 , Issue.6 , pp. 1403-1419
    • Savagner, P.1    Yamada, K.M.2    Thiery, J.P.3
  • 21
    • 58149316623 scopus 로고    scopus 로고
    • Snail and slug promote epithe-lial-mesenchymal transition through beta-catenin-t-cell factor-4-dependent expression of transforming growth factor-beta 3
    • Medici D, Hay ED, Olsen BR. Snail and slug promote epithe-lial- mesenchymal transition through beta-catenin-t-cell factor-4-dependent expression of transforming growth factor-beta 3. Mol Biol Cell 2008; 19:4875-4887.
    • (2008) Mol Biol Cell , vol.19 , pp. 4875-4887
    • Medici, D.1    Hay, E.D.2    Olsen, B.R.3
  • 23
    • 0028920898 scopus 로고
    • Analysis of hepatocyte nuclear factor-3 beta protein domains required for transcriptional activation and nuclear targeting
    • Qian X, Costa RH. Analysis of hepatocyte nuclear factor-3 beta protein domains required for transcriptional activation and nuclear targeting. Nucleic Acids Res 1995; 23:1184-1191.
    • (1995) Nucleic Acids Res , vol.23 , pp. 1184-1191
    • Qian, X.1    Costa, R.H.2
  • 24
    • 0028353904 scopus 로고
    • The DNA-binding specificity of the hepatocyte nuclear factor 3/forkhead domain is influenced by amino acid residues adjacent to the recognition helix
    • Overdier DG, Porcella A, Costa RH. The DNA-binding speci-fcity of the hepatocyte nuclear factor 3/forkhead domain is infuenced by amino-acid-residues adjacent to the recognition helix. Mol Cell Biol 1994; 14:2755-2766. (Pubitemid 24108256)
    • (1994) Molecular and Cellular Biology , vol.14 , Issue.4 , pp. 2755-2766
    • Overdier, D.G.1    Porcella, A.2    Costa, R.H.3
  • 25
    • 0026672433 scopus 로고
    • Hepatocyte nuclear factor 3 beta contains two transcriptional activation domains, one of which is novel and conserved with the Drosophila fork head protein
    • Pani L, Overdier DG, Porcella A, Qian X, Lai E, Costa RH. Hepatocyte nuclear factor 3 beta contains two transcriptional activation domains, one of which is novel and conserved with the Drosophila fork head protein. Mol Cell Biol 1992; 12:3723-3732.
    • (1992) Mol Cell Biol , vol.12 , pp. 3723-3732
    • Pani, L.1    Overdier, D.G.2    Porcella, A.3    Qian, X.4    Lai, E.5    Costa, R.H.6
  • 26
    • 0028920898 scopus 로고
    • Analysis of hepatocyte nuclear factor-3-beta protein domains required for transcriptional activation and nuclear targeting
    • Qian XB, Costa RH. Analysis of hepatocyte nuclear factor-3-beta protein domains required for transcriptional activation and nuclear targeting. Nucleic Acids Res 1995; 23:1184-1191.
    • (1995) Nucleic Acids Res , vol.23 , pp. 1184-1191
    • Qian, X.B.1    Costa, R.H.2
  • 27
    • 0035467993 scopus 로고    scopus 로고
    • Global cancer statistics in the year 2000
    • DOI 10.1016/S1470-2045(01)00486-7, PII S1470204501004867
    • Parkin DM. Global cancer statistics in the year 2000. Lancet Oncol 2001; 2:533-543. (Pubitemid 33586866)
    • (2001) Lancet Oncology , vol.2 , Issue.9 , pp. 533-543
    • Parkin, D.M.1
  • 28
    • 0034282535 scopus 로고    scopus 로고
    • Genome-wide allelotyping of lung cancer identifes new regions of allelic loss, differences between small cell lung cancer and non-small cell lung cancer, and loci cluster-ing
    • Girard L, Zochbauer-Muller S, Virmani AK, Gazdar AF, Minna JD. Genome-wide allelotyping of lung cancer identifes new regions of allelic loss, differences between small cell lung cancer and non-small cell lung cancer, and loci cluster-ing. Cancer Res 2000; 60:4894-4906.
    • (2000) Cancer Res , vol.60 , pp. 4894-4906
    • Girard, L.1    Zochbauer-Muller, S.2    Virmani, A.K.3    Gazdar, A.F.4    Minna, J.D.5
  • 29
    • 64349088929 scopus 로고    scopus 로고
    • Nucleosome-binding affnity as a primary determinant of the nuclear mobility of the pioneer transcription factor FoxA
    • Sekiya T, Muthurajan UM, Luger K, Tulin AV, Zaret KS. Nucleosome-binding affnity as a primary determinant of the nuclear mobility of the pioneer transcription factor FoxA. Genes Dev 2009; 23:804-809.
    • (2009) Genes Dev , vol.23 , pp. 804-809
    • Sekiya, T.1    Muthurajan, U.M.2    Luger, K.3    Tulin, A.V.4    Zaret, K.S.5
  • 30
    • 36849053911 scopus 로고    scopus 로고
    • Dual roles of myocardin-related transcription factors in epithelial-mesenchymal transition via slug induction and actin remodeling
    • DOI 10.1083/jcb.200708174
    • Morita T, Mayanagi T, Sobue K. Dual roles of myocardin-related transcription factors in epithelial mesenchymal transi-tion via slug induction and actin remodeling. J Cell Biol 2007; 179:1027-1042. (Pubitemid 350223496)
    • (2007) Journal of Cell Biology , vol.179 , Issue.5 , pp. 1027-1042
    • Morita, T.1    Mayanagi, T.2    Sobue, K.3
  • 32
    • 65649118799 scopus 로고    scopus 로고
    • Foxa2 regulates polarity and epithe-lialization in the endoderm germ layer of the mouse embryo
    • Burtscher I, Lickert H. Foxa2 regulates polarity and epithe-lialization in the endoderm germ layer of the mouse embryo. Development 2009; 136:1029-1038.
    • (2009) Development , vol.136 , pp. 1029-1038
    • Burtscher, I.1    Lickert, H.2
  • 33
    • 77950293595 scopus 로고    scopus 로고
    • Loss of FOXA1/2 is essential for the epithelial-to-mesenchymal transition in pan-creatic cancer
    • Song Y Washington MK, Crawford HC. Loss of FOXA1/2 is essential for the epithelial-to-mesenchymal transition in pan-creatic cancer. Cancer Res 2010; 70:2115-2125.
    • (2010) Cancer Res , vol.70 , pp. 2115-2125
    • Song, Y.1    Washington, M.K.2    Crawford, H.C.3
  • 34
    • 67650456885 scopus 로고    scopus 로고
    • Ferritin heavy chain-mediated iron homeostasis and subsequent increased reactive oxygen species production are essential for epithelial-mesen-chymal transition
    • Zhang KH, Tian HY, Gao X, et al. Ferritin heavy chain-mediated iron homeostasis and subsequent increased reactive oxygen species production are essential for epithelial-mesen-chymal transition. Cancer Res 2009; 69:5340-5348.
    • (2009) Cancer Res , vol.69 , pp. 5340-5348
    • Zhang, K.H.1    Tian, H.Y.2    Gao, X.3
  • 35
    • 0038485575 scopus 로고    scopus 로고
    • TGF-1 suppresses apoptosis via differential regulation of MAP kinases and ceramide production
    • DOI 10.1038/sj.cdd.4401171
    • Chen HH, Zhao S, Song JG. TGF-beta1 suppresses apoptosis via differential regulation of MAP kinases and ceramide pro-duction. Cell Death Differ 2003; 10:516-527. (Pubitemid 36656641)
    • (2003) Cell Death and Differentiation , vol.10 , Issue.5 , pp. 516-527
    • Chen, H.-H.1    Zhao, S.2    Song, J.-G.3
  • 36
    • 40749094918 scopus 로고    scopus 로고
    • SATB1 reprogrammes gene expression to promote breast tumour growth and metastasis
    • DOI 10.1038/nature06781, PII NATURE06781
    • Han HJ, Russo J, Kohwi Y, Kohwi-Shigematsu T. SATB1 reprogrammes gene expression to promote breast tumour growth and metastasis. Nature 2008; 452:187-193. (Pubitemid 351380252)
    • (2008) Nature , vol.452 , Issue.7184 , pp. 187-193
    • Han, H.-J.1    Russo, J.2    Kohwi, Y.3    Kohwi-Shigematsu, T.4
  • 37
    • 41149157649 scopus 로고    scopus 로고
    • TGF Primes Breast Tumors for Lung Metastasis Seeding through Angiopoietin-like 4
    • DOI 10.1016/j.cell.2008.01.046, PII S0092867408002110
    • Padua D, Zhang XH, Wang Q, et al. TGFbeta primes breast tumors for lung metastasis seeding through angiopoietin-like 4. Cell 2008; 133:66-77. (Pubitemid 351442989)
    • (2008) Cell , vol.133 , Issue.1 , pp. 66-77
    • Padua, D.1    Zhang, X.H.-F.2    Wang, Q.3    Nadal, C.4    Gerald, W.L.5    Gomis, R.R.6    Massague, J.7
  • 38
    • 34548175512 scopus 로고    scopus 로고
    • Signaling networks guiding epithelial-mesenchymal transitions during embryogenesis and cancer progression
    • Moustakas A, Heldin CH. Signaling networks guiding epithelial-mesenchymal transitions during embryogenesis and cancer progression. Cancer Sci 2007; 98:1512-1520.
    • (2007) Cancer Sci , vol.98 , pp. 1512-1520
    • Moustakas, A.1    Heldin, C.H.2


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