메뉴 건너뛰기




Volumn 13, Issue 4, 2012, Pages 198-205

HIPK2 downregulates vimentin and inhibits breast cancer cell invasion

Author keywords

Breast cancer; HIPK2; Hypoxia; Invasion; Tumor suppressor; Vimentin

Indexed keywords

DOXORUBICIN; HOMEODOMAIN INTERACTING PROTEIN KINASE 2; VIMENTIN;

EID: 84857488842     PISSN: 15384047     EISSN: 15558576     Source Type: Journal    
DOI: 10.4161/cbt.13.4.18694     Document Type: Article
Times cited : (31)

References (46)
  • 1
    • 33846913249 scopus 로고    scopus 로고
    • HIPK2: A versatile switchboard regulating the transcription machinery and cell death
    • PMID:17245128
    • Calzado MA, Renner F, Roscic A, Schmitz ML. HIPK2: a versatile switchboard regulating the transcription machinery and cell death. Cell Cycle 2007; 6:139-43; PMID:17245128; http://dx.doi.org/10.4161/cc.6.2.3788
    • (2007) Cell Cycle , vol.6 , pp. 139-143
    • Calzado, M.A.1    Renner, F.2    Roscic, A.3    Schmitz, M.L.4
  • 2
    • 34948910811 scopus 로고    scopus 로고
    • HIPK2: A multitalented partner for transcription factors in DNA damage response and development
    • PMID:17713576
    • Rinaldo C, Prodosmo A, Siepi F, Soddu S. HIPK2: a multitalented partner for transcription factors in DNA damage response and development. Biochem Cell Biol 2007; 85:411-8; PMID:17713576; http://dx.doi.org/10.1139/O07-071
    • (2007) Biochem Cell Biol , vol.85 , pp. 411-418
    • Rinaldo, C.1    Prodosmo, A.2    Siepi, F.3    Soddu, S.4
  • 3
    • 18244379872 scopus 로고    scopus 로고
    • Homeodomain-interacting protein kinase-2 phosphorylates p53 at Ser46 and mediates apoptosis
    • PMID:11780126
    • D'Orazi G, Cecchinelli B, Bruno T, Manni I, Higashimoto Y, Saito S, et al. Homeodomain-interacting protein kinase-2 phosphorylates p53 at Ser46 and mediates apoptosis. Nat Cell Biol 2002; 4:11-9; PMID:11780126; http://dx.doi.org/10.1038/ncb714
    • (2002) Nat Cell Biol , vol.4 , pp. 11-19
    • D'Orazi, G.1    Cecchinelli, B.2    Bruno, T.3    Manni, I.4    Higashimoto, Y.5    Saito, S.6
  • 4
    • 0142258245 scopus 로고    scopus 로고
    • Homeodomain interacting protein kinase 2 promotes apoptosis by downregulating the transcriptional corepressor CtBP
    • PMID:14567915
    • Zhang Q, Yoshimatsu Y, Hildebrand J, Frisch SM, Goodman RH. Homeodomain interacting protein kinase 2 promotes apoptosis by downregulating the transcriptional corepressor CtBP. Cell 2003; 115:177-86; PMID:14567915; http://dx.doi.org/10.1016/S0092-8674(03)00802-X
    • (2003) Cell , vol.115 , pp. 177-186
    • Zhang, Q.1    Yoshimatsu, Y.2    Hildebrand, J.3    Frisch, S.M.4    Goodman, R.H.5
  • 5
    • 0345734277 scopus 로고    scopus 로고
    • HIPK2 regulates transforming growth factor-beta-induced c-Jun NH(2)-terminal kinase activation and apoptosis in human hepatoma cells
    • PMID:14678985
    • Hofmann TG, Stollberg N, Schmitz ML, Will H. HIPK2 regulates transforming growth factor-beta-induced c-Jun NH(2)-terminal kinase activation and apoptosis in human hepatoma cells. Cancer Res 2003; 63:8271-7; PMID:14678985
    • (2003) Cancer Res , vol.63 , pp. 8271-8277
    • Hofmann, T.G.1    Stollberg, N.2    Schmitz, M.L.3    Will, H.4
  • 6
    • 4644342576 scopus 로고    scopus 로고
    • Homeodomain-interacting protein-2 regulates apoptosis in developing sensory and sympathetic neurons
    • PMID:15458648
    • Doxakis E, Huang EJ, Davies AM. Homeodomain-interacting protein-2 regulates apoptosis in developing sensory and sympathetic neurons. Curr Biol 2004; 14:1761-5; PMID:15458648; http://dx.doi.org/10.1016/j.cub.2004.09.050
    • (2004) Curr Biol , vol.14 , pp. 1761-1765
    • Doxakis, E.1    Huang, E.J.2    Davies, A.M.3
  • 7
    • 61349121467 scopus 로고    scopus 로고
    • Inhibition of HIF-1alpha activity by homeodomain-interacting protein kinase-2 correlates with sensitization of chemoresistant cells to undergo apoptosis
    • PMID:19128456
    • Nardinocchi L, Puca R, Sacchi A, D'Orazi G. Inhibition of HIF-1alpha activity by homeodomain-interacting protein kinase-2 correlates with sensitization of chemoresistant cells to undergo apoptosis. Mol Cancer 2009; 8:1-9; PMID:19128456; http://dx.doi.org/10.1186/1476-4598-8-1
    • (2009) Mol Cancer , vol.8 , pp. 1-9
    • Nardinocchi, L.1    Puca, R.2    Sacchi, A.3    D'Orazi, G.4
  • 8
    • 69949108875 scopus 로고    scopus 로고
    • Targeting hypoxia in cancer cells by restoring homeodomain interacting protein kinase 2 and p53 activity and suppressing HIF-1alpha
    • PMID:19714248
    • Nardinocchi L, Puca R, Sacchi A, Rechavi G, Givol D, D'Orazi G. Targeting hypoxia in cancer cells by restoring homeodomain interacting protein kinase 2 and p53 activity and suppressing HIF-1alpha. PLoS ONE 2009; 4:e6819; PMID:19714248; http://dx.doi.org/10.1371/journal.pone.0006819
    • (2009) PLoS ONE , vol.4
    • Nardinocchi, L.1    Puca, R.2    Sacchi, A.3    Rechavi, G.4    Givol, D.5    D'Orazi, G.6
  • 9
    • 0023951297 scopus 로고
    • Molecular and cellular biology of intermediate filaments
    • PMID:3052284
    • Steinert PM, Roop DR. Molecular and cellular biology of intermediate filaments. Annu Rev Biochem 1988; 57:593-625; PMID:3052284; http://dx.doi.org/ 10.1146/annurev.bi.57.070188.003113
    • (1988) Annu Rev Biochem , vol.57 , pp. 593-625
    • Steinert, P.M.1    Roop, D.R.2
  • 10
    • 79960315948 scopus 로고    scopus 로고
    • Vimentin: Central hub in EMT induction?
    • PMID:21686283
    • Ivaska J. Vimentin: Central hub in EMT induction? Small GTPases 2011; 2:51-3; PMID:21686283; http:// dx.doi.org/10.4161/sgtp.2.1.15114
    • (2011) Small GTPases , vol.2 , pp. 51-53
    • Ivaska, J.1
  • 11
    • 0036595629 scopus 로고    scopus 로고
    • Epithelial-mesenchimal transition in tumor progression
    • PMID: 12189386
    • Thiery JP. Epithelial-mesenchimal transition in tumor progression. Nat Rev Cancer 2002; 2:442-54; PMID: 12189386; http://dx.doi.org/10.1038/nrc822
    • (2002) Nat Rev Cancer , vol.2 , pp. 442-454
    • Thiery, J.P.1
  • 12
    • 3042618951 scopus 로고    scopus 로고
    • N-cadherin expression and epithelial-mesenchymal transition in pancreatic carcinoma
    • PMID:15217949
    • Nakajima S, Doi R, Toyoda E, Tsuji S, Wada M, Koizumi M, et al. N-cadherin expression and epithelial-mesenchymal transition in pancreatic carcinoma. Clin Cancer Res 2004; 10:4125-33; PMID:15217949; http://dx.doi.org/ 10.1158/1078-0432.CCR-0578-03
    • (2004) Clin Cancer Res , vol.10 , pp. 4125-4133
    • Nakajima, S.1    Doi, R.2    Toyoda, E.3    Tsuji, S.4    Wada, M.5    Koizumi, M.6
  • 13
    • 48249128425 scopus 로고    scopus 로고
    • Vimentin affects the mobility and invasiveness of prostate cancer cells
    • PMID: 18464297
    • Zhao Y, Yan Q, Long X, Chen X, Wang Y. Vimentin affects the mobility and invasiveness of prostate cancer cells. Cell Biochem Funct 2008; 26:571-7; PMID: 18464297; http://dx.doi.org/10.1002/cbf.1478
    • (2008) Cell Biochem Funct , vol.26 , pp. 571-577
    • Zhao, Y.1    Yan, Q.2    Long, X.3    Chen, X.4    Wang, Y.5
  • 14
    • 0024371489 scopus 로고
    • Vimentin rather than keratin expression in some hormone-independent breast cancer cell lines and in oncogenes-transformed mammary epithelial cells
    • PMID:2472876
    • Sommers CL, Walker-Jones D, Heckford SE, Worland P, Valverius E, Clark R, et al. Vimentin rather than keratin expression in some hormone-independent breast cancer cell lines and in oncogenes-transformed mammary epithelial cells. Cancer Res 1989; 49:4258-63; PMID:2472876
    • (1989) Cancer Res , vol.49 , pp. 4258-4263
    • Sommers, C.L.1    Walker-Jones, D.2    Heckford, S.E.3    Worland, P.4    Valverius, E.5    Clark, R.6
  • 15
    • 0026781976 scopus 로고
    • Loss of epithelial markers and acquisition of vimentin expression in adriamycin- and vinblastine-resistant human breast cancer cell lines
    • PMID: 1382837
    • Sommers CL, Heckford SE, Skerker JM, Worland P, Torri JA, Thompson EW, et al. Loss of epithelial markers and acquisition of vimentin expression in adriamycin- and vinblastine-resistant human breast cancer cell lines. Cancer Res 1992; 52:5190-7; PMID: 1382837
    • (1992) Cancer Res , vol.52 , pp. 5190-5197
    • Sommers, C.L.1    Heckford, S.E.2    Skerker, J.M.3    Worland, P.4    Torri, J.A.5    Thompson, E.W.6
  • 16
    • 0029804487 scopus 로고    scopus 로고
    • Vimentin expression in cervical carcinomas: Association with invasive and migratory potential
    • PMID:8976877
    • Gilles C, Polette M, Piette J, Delvigne AC, Thompson EW, Foidart JM, et al. Vimentin expression in cervical carcinomas: association with invasive and migratory potential. J Pathol 1996; 180:175-80; PMID:8976877; http://dx.doi.org/10.1002/(SICI)1096-9896(199610) 180:2〈175::AID- PATH630〉3.0.CO;2-G
    • (1996) J Pathol , vol.180 , pp. 175-180
    • Gilles, C.1    Polette, M.2    Piette, J.3    Delvigne, A.C.4    Thompson, E.W.5    Foidart, J.M.6
  • 17
    • 0025136699 scopus 로고
    • Vimentin is preferentially expressed in human breast carcinomas with low estrogen receptor and high Ki-67 growth fraction
    • PMID:2153347
    • Domagala W, Lasota J, Bartkowiak J, Weber K, Osborn M. Vimentin is preferentially expressed in human breast carcinomas with low estrogen receptor and high Ki-67 growth fraction. Am J Pathol 1990; 136:219-27; PMID:2153347
    • (1990) Am J Pathol , vol.136 , pp. 219-227
    • Domagala, W.1    Lasota, J.2    Bartkowiak, J.3    Weber, K.4    Osborn, M.5
  • 18
    • 0032724043 scopus 로고    scopus 로고
    • Association between keratin and vimentin expression, malignant phenotype, and survival in postmenopausal breast cancer patients
    • PMID:10537332
    • Thomas PA, Kirschmann DA, Cerhan JR, Folberg R, Seftor EA, Sellers TA, et al. Association between keratin and vimentin expression, malignant phenotype, and survival in postmenopausal breast cancer patients. Clin Cancer Res 1999; 5:2698-703; PMID:10537332
    • (1999) Clin Cancer Res , vol.5 , pp. 2698-2703
    • Thomas, P.A.1    Kirschmann, D.A.2    Cerhan, J.R.3    Folberg, R.4    Seftor, E.A.5    Sellers, T.A.6
  • 19
    • 79953060389 scopus 로고    scopus 로고
    • Vimentin regulates EMT induction by Slug and oncogenes H-Ras and migration by governing Axl expression in breast cancer
    • PMID:21057535
    • Vuoriluoto K, Haugen H, Kiviluoto S, Mpindi J-P, Nevo J, Gjerdrum C, et al. Vimentin regulates EMT induction by Slug and oncogenes H-Ras and migration by governing Axl expression in breast cancer. Oncogene 2011; 30:1436-8; PMID:21057535; http://dx.doi.org/ 10.1038/onc.2010.509
    • (2011) Oncogene , vol.30 , pp. 1436-1438
    • Vuoriluoto, K.1    Haugen, H.2    Kiviluoto, S.3    Mpindi, J.-P.4    Nevo, J.5    Gjerdrum, C.6
  • 20
    • 80052267874 scopus 로고    scopus 로고
    • Vimentin in cancer and its potential as molecular target for cancer therapy
    • PMID:21637948
    • Satelli A, Li S. Vimentin in cancer and its potential as molecular target for cancer therapy. Cell Mol Life Sci 2011; 68:3033-46; PMID:21637948; http://dx.doi. org/10.1007/s00018-011-0735-1
    • (2011) Cell Mol Life Sci , vol.68 , pp. 3033-3046
    • Satelli, A.1    Li, S.2
  • 21
    • 0028138771 scopus 로고
    • Differentiation state and invasiveness of human breast cancer cell lines
    • PMID:7881109
    • Sommers CL, Byers SW, Thompson EW, Torri JA, Gelmann EP. Differentiation state and invasiveness of human breast cancer cell lines. Breast Cancer Res Treat 1994; 31:325-35; PMID:7881109; http://dx.doi.org/ 10.1007/BF00666165
    • (1994) Breast Cancer Res Treat , vol.31 , pp. 325-335
    • Sommers, C.L.1    Byers, S.W.2    Thompson, E.W.3    Torri, J.A.4    Gelmann, E.P.5
  • 22
    • 33751087736 scopus 로고    scopus 로고
    • Raf plus TGFbeta-dependent EMT is initiated by endocytosis and lysosomal degradation of E-cadherin
    • PMID: 16751808
    • Janda E, Nevolo M, Lehmann K, Downward J, Beung H, Grieco M. Raf plus TGFbeta-dependent EMT is initiated by endocytosis and lysosomal degradation of E-cadherin. Oncogene 2006; 25:7117-30; PMID: 16751808; http://dx.doi.org/10. 1038/sj.onc.1209701
    • (2006) Oncogene , vol.25 , pp. 7117-7130
    • Janda, E.1    Nevolo, M.2    Lehmann, K.3    Downward, J.4    Beung, H.5    Grieco, M.6
  • 25
    • 34547872344 scopus 로고    scopus 로고
    • The zinc finger repressor, ZBP-89, recruits histone deacetylase 1 to repress vimentin gene expression
    • PMID:17663720
    • Wu Y, Zhang X, Salmon M, Zehner ZE. The zinc finger repressor, ZBP-89, recruits histone deacetylase 1 to repress vimentin gene expression. Genes Cells 2007; 12:905-18; PMID:17663720; http://dx.doi.org/10.1111/j.1365-2443.2007. 01104.x
    • (2007) Genes Cells , vol.12 , pp. 905-918
    • Wu, Y.1    Zhang, X.2    Salmon, M.3    Zehner, Z.E.4
  • 26
    • 77955470408 scopus 로고    scopus 로고
    • Regulation of p53 activity by HIPK2: Molecular mechanisms and therapeutical implications in cancer cells
    • PMID:20514025
    • Puca R, Nardinocchi L, Givol D, D'Orazi G. Regulation of p53 activity by HIPK2: molecular mechanisms and therapeutical implications in cancer cells. Oncogene 2010; 29:4378-87; PMID:20514025; http://dx.doi.org/10.1038/onc.2010.183
    • (2010) Oncogene , vol.29 , pp. 4378-4387
    • Puca, R.1    Nardinocchi, L.2    Givol, D.3    D'Orazi, G.4
  • 27
    • 33748370779 scopus 로고    scopus 로고
    • The analysis of doxorubicin resistance in human breast cancer cells using antibody microarrays
    • PMID:16928833
    • Smith L, Watson MB, O'Kane SL, Drew PL, Lind MJ, Cawkwell L. The analysis of doxorubicin resistance in human breast cancer cells using antibody microarrays. Mol Cancer Ther 2006; 5:2115-20; PMID:16928833; http://dx.doi.org/10.1158/1535-7163.MCT-06-0190
    • (2006) Mol Cancer Ther , vol.5 , pp. 2115-2120
    • Smith, L.1    Watson, M.B.2    O'Kane, S.L.3    Drew, P.L.4    Lind, M.J.5    Cawkwell, L.6
  • 28
    • 40249113328 scopus 로고    scopus 로고
    • Direct regulation of TWIST by HIF-1a promotes metastasis
    • PMID:18297062
    • Yang M-H, Wu M-Z, Chiou S-H, Chen P-M, Chang S-Y, Liu C-J, et al. Direct regulation of TWIST by HIF-1a promotes metastasis. Nat Cell Biol 2008; 10:295-305; PMID:18297062; http://dx.doi.org/10.1038/ncb1691
    • (2008) Nat Cell Biol , vol.10 , pp. 295-305
    • Yang, M.-H.1    Wu, M.-Z.2    Chiou, S.-H.3    Chen, P.-M.4    Chang, S.-Y.5    Liu, C.-J.6
  • 29
    • 58549105909 scopus 로고    scopus 로고
    • Transcriptional regulation of hypoxia-inducible factor 1alpha by HIPK2 suggests a novel mechanism to restrain tumor growth
    • PMID:19046997
    • Nardinocchi L, Puca R, Guidolin D, Belloni AS, Bossi G, Michiels C, et al. Transcriptional regulation of hypoxia-inducible factor 1alpha by HIPK2 suggests a novel mechanism to restrain tumor growth. Biochim Biophys Acta 2009; 1793:368-77; PMID:19046997; http://dx.doi.org/10.1016/j.bbamcr.2008.10.013
    • (2009) Biochim Biophys Acta , vol.1793 , pp. 368-377
    • Nardinocchi, L.1    Puca, R.2    Guidolin, D.3    Belloni, A.S.4    Bossi, G.5    Michiels, C.6
  • 30
    • 0029051439 scopus 로고
    • Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension
    • PMID:7539918
    • Wang GL, Jiang H, Rue EA, Semenza GL. Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension. Proc Natl Acad Sci USA 1995; 92:5510-4; PMID:7539918; http://dx.doi.org/10.1073/pnas. 92.12.5510
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 5510-5514
    • Wang, G.L.1    Jiang, H.2    Rue, E.A.3    Semenza, G.L.4
  • 31
    • 52949128032 scopus 로고    scopus 로고
    • Regulation of vascular endothelial growth factor expression by homeodomain-interacting protein kinase-2
    • PMID:18644116
    • Puca R, Nardinocchi L, D'Orazi G. Regulation of vascular endothelial growth factor expression by homeodomain-interacting protein kinase-2. J Exp Clin Cancer Res 2008; 27:22; PMID:18644116; http://dx.doi.org/10.1186/1756-9966-27- 22
    • (2008) J Exp Clin Cancer Res , vol.27 , pp. 22
    • Puca, R.1    Nardinocchi, L.2    D'Orazi, G.3
  • 32
    • 0000782017 scopus 로고    scopus 로고
    • The Homeodomain protein NK-3 recruits Groucho and histone deacetylase complex to repress transcription
    • PMID:10559189
    • Choi CY, Kim YH, Kwon HJ, Kim Y. The Homeodomain protein NK-3 recruits Groucho and histone deacetylase complex to repress transcription. J Biol Chem 1999; 274:33194-7; PMID:10559189; http://dx.doi.org/10.1074/jbc.274.47.33194
    • (1999) J Biol Chem , vol.274 , pp. 33194-33197
    • Choi, C.Y.1    Kim, Y.H.2    Kwon, H.J.3    Kim, Y.4
  • 33
    • 0031016323 scopus 로고    scopus 로고
    • Experimental co-expression of vimentin and keratin intermediate filaments in human breast cancer cells results in phenotypic interconversion and increased invasive behaviour
    • PMID:9033265
    • Hendrix MJ, Seftor EA, Seftor RE, Trevor KT. Experimental co-expression of vimentin and keratin intermediate filaments in human breast cancer cells results in phenotypic interconversion and increased invasive behaviour. Am J Pathol 1997; 150:483-95; PMID:9033265
    • (1997) Am J Pathol , vol.150 , pp. 483-495
    • Hendrix, M.J.1    Seftor, E.A.2    Seftor, R.E.3    Trevor, K.T.4
  • 35
    • 0037699018 scopus 로고    scopus 로고
    • Overexpression of vimentin: Role in the invasive phenotype in an androgen-independent model of prostate cancer
    • PMID:12727854
    • Singh S, Sadacharan S, Su S, Belldegrun A, Persad S, Singh G. Overexpression of vimentin: role in the invasive phenotype in an androgen-independent model of prostate cancer. Cancer Res 2003; 63:2306-11; PMID:12727854
    • (2003) Cancer Res , vol.63 , pp. 2306-2311
    • Singh, S.1    Sadacharan, S.2    Su, S.3    Belldegrun, A.4    Persad, S.5    Singh, G.6
  • 36
    • 34250901825 scopus 로고    scopus 로고
    • Down-regulation of vimentin expression inhibits carcinoma cell migration and adhesion
    • PMID:17585878
    • McInroy L, Maatta A. Down-regulation of vimentin expression inhibits carcinoma cell migration and adhesion. Biochem Biophys Res Commun 2007; 360: 109-14; PMID:17585878; http://dx.doi.org/10.1016/j.bbrc.2007.06.036
    • (2007) Biochem Biophys Res Commun , vol.360 , pp. 109-114
    • McInroy, L.1    Maatta, A.2
  • 37
    • 58149354210 scopus 로고    scopus 로고
    • An inducible autoregulatory loop between HIPK2 and Siah2 at the apex of the hypoxic response
    • PMID:19043406
    • Calzado MA, de la Vega L, Moller A, Bowtell DD, Schmitz ML. An inducible autoregulatory loop between HIPK2 and Siah2 at the apex of the hypoxic response. Nat Cell Biol 2009; 11:85-91; PMID:19043406; http://dx.doi.org/10.1038/ncb1816
    • (2009) Nat Cell Biol , vol.11 , pp. 85-91
    • Calzado, M.A.1    De La Vega, L.2    Moller, A.3    Bowtell, D.D.4    Schmitz, M.L.5
  • 38
    • 70350244837 scopus 로고    scopus 로고
    • Hypoxia, angiogenesis and cancer therapy
    • PMID:19770588
    • Michieli P. Hypoxia, angiogenesis and cancer therapy. Cell Cycle 2009; 8:3291; PMID:19770588; http://dx.doi.org/10.4161/cc.8.20.9741
    • (2009) Cell Cycle , vol.8 , pp. 3291
    • Michieli, P.1
  • 39
    • 76349095132 scopus 로고    scopus 로고
    • Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics
    • PMID:19946328
    • Semenza GL. Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics. Oncogene 2010; 29:625-34; PMID:19946328; http://dx.doi.org/10.1038/onc.2009.441
    • (2010) Oncogene , vol.29 , pp. 625-634
    • Semenza, G.L.1
  • 40
    • 77951937457 scopus 로고    scopus 로고
    • HIPK2: A therapeutical target to be (re)activated for tumor suppression. Role in p53 activation and HIF-1a inhibition
    • PMID:20016263
    • Nardinocchi L, Puca R, Givol D, D'Orazi G. HIPK2: A therapeutical target to be (re)activated for tumor suppression. Role in p53 activation and HIF-1a inhibition. Cell Cycle 2010; 9:1-2; PMID:20016263; http://dx.doi.org/10.4161/cc. 9.7.11125
    • (2010) Cell Cycle , vol.9 , pp. 1-2
    • Nardinocchi, L.1    Puca, R.2    Givol, D.3    D'Orazi, G.4
  • 41
    • 44549085662 scopus 로고    scopus 로고
    • Overexpression of HIPK2 circumvents the blockade of apoptosis in chemoresistant ovarian cancer cells
    • PMID:18395248
    • Puca R, Nardinocchi L, Pistritto G, D'Orazi G. Overexpression of HIPK2 circumvents the blockade of apoptosis in chemoresistant ovarian cancer cells. Gynecol Oncol 2008; 109:403-10; PMID:18395248; http://dx.doi.org/10.1016/j. ygyno.2008.02.018
    • (2008) Gynecol Oncol , vol.109 , pp. 403-410
    • Puca, R.1    Nardinocchi, L.2    Pistritto, G.3    D'Orazi, G.4
  • 42
    • 67651005198 scopus 로고    scopus 로고
    • Negative regulation of b4 integrin transcription by homeodomain- interacting protein kinase 2 and p53 inpmairs tumor progression
    • PMID:19567674
    • Bon G, Di Carlo S, Folgiero V, Avetrani P, Lazzari C, D'Orazi G, et al. Negative regulation of b4 integrin transcription by homeodomain-interacting protein kinase 2 and p53 inpmairs tumor progression. Cancer Res 2009; 69:5978-86; PMID:19567674; http://dx.doi.org/10.1158/0008-5472.CAN-09-0244
    • (2009) Cancer Res , vol.69 , pp. 5978-5986
    • Bon, G.1    Di Carlo, S.2    Folgiero, V.3    Avetrani, P.4    Lazzari, C.5    D'Orazi, G.6
  • 43
    • 8844271685 scopus 로고    scopus 로고
    • Faster cyclic loess: Normalizing RNA arrays via linear models
    • PMID:15166021
    • Ballman KV, Grill DE, Oberg AL, Therneau TM. Faster cyclic loess: normalizing RNA arrays via linear models. Bioinformatics 2004; 20:2778-86; PMID:15166021; http://dx.doi.org/10.1093/bioinformatics/bth327
    • (2004) Bioinformatics , vol.20 , pp. 2778-2786
    • Ballman, K.V.1    Grill, D.E.2    Oberg, A.L.3    Therneau, T.M.4
  • 44
    • 77954871394 scopus 로고    scopus 로고
    • Intensity dependent estimation of noise in microarrays improves detection of differentially expressed genes
    • PMID:20663218
    • Zeisel A, Amir A, Kostler WJ, Domany E. Intensity dependent estimation of noise in microarrays improves detection of differentially expressed genes. BMC Bioinformatics 2010; 11:400; PMID:20663218; http://dx.doi.org/10.1186/1471-2105- 11-400
    • (2010) BMC Bioinformatics , vol.11 , pp. 400
    • Zeisel, A.1    Amir, A.2    Kostler, W.J.3    Domany, E.4
  • 45
    • 0345830383 scopus 로고    scopus 로고
    • Homeodomain-interacting protein kinase-2 activity and p53 phosphorylation are critical events for cisplatin-mediated apoptosis
    • PMID:14729469
    • Di Stefano V, Rinaldo C, Sacchi A, Soddu S, D'Orazi G. Homeodomain-interacting protein kinase-2 activity and p53 phosphorylation are critical events for cisplatin-mediated apoptosis. Exp Cell Res 2004; 293: 311-20; PMID:14729469; http://dx.doi.org/10.1016/j.yexcr.2003.09.032
    • (2004) Exp Cell Res , vol.293 , pp. 311-320
    • Di Stefano, V.1    Rinaldo, C.2    Sacchi, A.3    Soddu, S.4    D'Orazi, G.5
  • 46
    • 0018885287 scopus 로고
    • A 48-well micro chemotaxis assembly for rapid and accurate measurement of leukocyte results
    • PMID:6966301
    • Falk W, Goodwin RH, Jr., Leonard EJ. A 48-well micro chemotaxis assembly for rapid and accurate measurement of leukocyte results. J Immunol Methods 1980; 33:201-12; PMID:6966301
    • (1980) J Immunol Methods , vol.33 , pp. 201-212
    • Falk, W.1    Goodwin Jr., R.H.2    Leonard, E.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.