The orexin receptor OX 1R in colon cancer: A promising therapeutic target and a new paradigm in G protein-coupled receptor signalling through ITIMs

British Journal of Pharmacology

Volumn 165, Issue 6, 2012, Pages 1678-1687

  Laburthe, Marc ^a,b   Voisin, Thierry ^a,b  

^a CENTRE DE RECHERCHE BIOMÉDICALE BICHAT BEAUJON CRB3   (France)

^b UNIVERSITÉ PARIS DESCARTES   (France)

Author keywords

apoptosis; cancer therapy; caspase; colon cancer; G protein coupled receptor; hypocretin; immunoreceptor tyrosine based inhibitory motif; metastases; orexin; protein phosphatase SHP2; tumour; tyrosine based motif

Indexed keywords

ANTINEOPLASTIC AGENT; CASPASE 3; CASPASE 7; G PROTEIN COUPLED RECEPTOR; IMMUNORECEPTOR TYROSINE BASED INHIBITORY MOTIFS; OREXIN; OREXIN 1 RECEPTOR; OREXIN A; OREXIN RECEPTOR ANTAGONIST; PHOSPHOLIPASE C; PROTEIN KINASE P60; PROTEIN TYROSINE PHOSPHATASE SHP 2; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

APOPTOSIS; CANCER CELL; CELL MEMBRANE; COLON CANCER; DOSE RESPONSE; DRUG EFFICACY; ENZYME ACTIVATION; HUMAN; METASTASIS POTENTIAL; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN CONFORMATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN MOTIF; PROTEIN PHOSPHORYLATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; REVIEW; SIGNAL TRANSDUCTION;

ANIMALS; APOPTOSIS; COLONIC NEOPLASMS; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; NEUROPEPTIDES; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, NEUROPEPTIDE;

EID: 84857476810     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2011.01510.x     Document Type: Review

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