Dwarfism in mice lacking collagen-binding integrins α2β1 and α11β1 is caused by severely diminished IGF-1 levels

Journal of Biological Chemistry

Volumn 287, Issue 9, 2012, Pages 6431-6440

  Blumbach, Katrin ^a   Niehoff, Anja ^b   Belgardt, Bengt F ^a,c   Ehlen, Harald W A ^a,d   Schmitz, Markus ^a   Hallinger, Ralf ^a   Schulz, Jan Niklas ^a   Brüning, Jens C ^a,c,e,f   Krieg, Thomas ^a,c   Schubert, Markus ^a,c,e   Gullberg, Donald ^g   Eckesa, Beate ^a  

^a UNIVERSITY OF COLOGNE   (Germany)

^b GERMAN SPORT UNIVERSITY COLOGNE   (Germany)

^c UNIVERSITY OF COLOGNE   (Germany)

^d UNIVERSITY OF DUISBURG ESSEN   (Germany)

^e UNIVERSITY HOSPITAL OF COLOGNE   (Germany)

^f MAX PLANCK INSTITUTE FOR NEUROLOGICAL RESEARCH   (Germany)

^g UNIVERSITY OF BERGEN   (Norway)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL ACTIVITIES; BONE MINERALIZATION; EXTRACELLULAR MATRICES; GROWTH CONTROL; GROWTH HORMONE-RELEASING HORMONES; GROWTH HORMONES; GROWTH PLATE; INSULIN-LIKE GROWTH FACTOR; INTEGRIN RECEPTORS; INTEGRINS; INTERNAL ORGANS; NOVEL CONCEPT; PITUITARY GLAND; SIZE REDUCTIONS;

BIOACTIVITY; BONE; BRAIN; COLLAGEN; ENZYME INHIBITION; GLYCOPROTEINS;

MAMMALS;

ALPHA11BETA1 INTEGRIN; GLYCOPROTEIN; GROWTH HORMONE; GROWTH HORMONE RELEASING FACTOR; SOMATOMEDIN C; UNCLASSIFIED DRUG; VERY LATE ACTIVATION ANTIGEN 2;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE DENSITY; BONE MINERALIZATION; BONE STRENGTH; CONTROLLED STUDY; DWARFISM; ENDOCRINE FUNCTION; EXTRACELLULAR MATRIX; GROWTH REGULATION; HOMEOSTASIS; HORMONAL REGULATION; HORMONE RELEASE; HYPOPHYSIS; HYPOTHALAMUS; LIVER METABOLISM; MOUSE; NEWBORN; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BLOOD LEVEL; PROTEIN DEFICIENCY; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN SYNTHESIS; SIGNAL TRANSDUCTION;

ANIMALS; BONE AND BONES; BONE DENSITY; COLLAGEN; DWARFISM; EXTRACELLULAR MATRIX; FEMALE; GROWTH HORMONE; GROWTH HORMONE-RELEASING HORMONE; HOMEOSTASIS; INSULIN-LIKE GROWTH FACTOR I; INTEGRIN ALPHA2BETA1; INTEGRINS; LIVER; MALE; MICE; MICE, INBRED C57BL; MICE, MUTANT STRAINS; OSTEOBLASTS; RECEPTORS, COLLAGEN; SIGNAL TRANSDUCTION;

MUS;

EID: 84857465368     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.283119     Document Type: Article

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