메뉴 건너뛰기




Volumn 23, Issue 1, 2012, Pages 102-108

Clinical relevance of Ephs and ephrins in cancer: Lessons from breast, colorectal, and lung cancer profiling

Author keywords

Cancer; Clinical relevance; Eph; Ephrin; Patient; Profiling

Indexed keywords

EPHRIN; EPHRIN A1; EPHRIN A2; EPHRIN B1; EPHRIN B2; EPHRIN B3; EPHRIN B4; EPHRIN B6; TRASTUZUMAB; UNCLASSIFIED DRUG;

EID: 84857444267     PISSN: 10849521     EISSN: 10963634     Source Type: Journal    
DOI: 10.1016/j.semcdb.2011.10.014     Document Type: Review
Times cited : (44)

References (130)
  • 1
    • 0034614637 scopus 로고    scopus 로고
    • The hallmarks of cancer
    • Hanahan D., Weinberg R.A. The hallmarks of cancer. Cell 2000, 100:57-70.
    • (2000) Cell , vol.100 , pp. 57-70
    • Hanahan, D.1    Weinberg, R.A.2
  • 2
    • 0037079003 scopus 로고    scopus 로고
    • Rules for making human tumor cells
    • Hahn W.C., Weinberg R.A. Rules for making human tumor cells. N Engl J Med 2002, 347:1593-1603.
    • (2002) N Engl J Med , vol.347 , pp. 1593-1603
    • Hahn, W.C.1    Weinberg, R.A.2
  • 3
    • 4043181214 scopus 로고    scopus 로고
    • Cancer genes and the pathways they control
    • Vogelstein B., Kinzler K.W. Cancer genes and the pathways they control. Nat Med 2004, 10:789-799.
    • (2004) Nat Med , vol.10 , pp. 789-799
    • Vogelstein, B.1    Kinzler, K.W.2
  • 4
    • 33646847329 scopus 로고    scopus 로고
    • Cell signalling: growth factors and tyrosine kinase receptors
    • Perona R. Cell signalling: growth factors and tyrosine kinase receptors. Clin Transl Oncol 2006, 8:77-82.
    • (2006) Clin Transl Oncol , vol.8 , pp. 77-82
    • Perona, R.1
  • 5
    • 0035902180 scopus 로고    scopus 로고
    • Oncogenic kinase signalling
    • Blume-Jensen P., Hunter T. Oncogenic kinase signalling. Nature 2001, 411:355-365.
    • (2001) Nature , vol.411 , pp. 355-365
    • Blume-Jensen, P.1    Hunter, T.2
  • 6
    • 57749121465 scopus 로고    scopus 로고
    • The EphA2 receptor and ephrinA1 ligand in solid tumors: function and therapeutic targeting
    • Wykosky J., Debinski W. The EphA2 receptor and ephrinA1 ligand in solid tumors: function and therapeutic targeting. Mol Cancer Res 2008, 6:1795-1806.
    • (2008) Mol Cancer Res , vol.6 , pp. 1795-1806
    • Wykosky, J.1    Debinski, W.2
  • 7
    • 35548948069 scopus 로고    scopus 로고
    • Cell-cell signaling via Eph receptors and ephrins
    • Himanen J.P., Saha N., Nikolov D.B. Cell-cell signaling via Eph receptors and ephrins. Curr Opin Cell Biol 2007, 19:534-542.
    • (2007) Curr Opin Cell Biol , vol.19 , pp. 534-542
    • Himanen, J.P.1    Saha, N.2    Nikolov, D.B.3
  • 8
    • 34249329249 scopus 로고    scopus 로고
    • Paradoxes of the EphB4 receptor in cancer
    • Noren N.K., Pasquale E.B. Paradoxes of the EphB4 receptor in cancer. Cancer Res 2007, 67:3994-3997.
    • (2007) Cancer Res , vol.67 , pp. 3994-3997
    • Noren, N.K.1    Pasquale, E.B.2
  • 9
    • 63849221730 scopus 로고    scopus 로고
    • Eph receptors in breast cancer: roles in tumor promotion and tumor suppression
    • Vaught D., Brantley-Sieders D.M., Chen J. Eph receptors in breast cancer: roles in tumor promotion and tumor suppression. Breast Cancer Res 2008, 10:217.
    • (2008) Breast Cancer Res , vol.10 , pp. 217
    • Vaught, D.1    Brantley-Sieders, D.M.2    Chen, J.3
  • 10
    • 0034619758 scopus 로고    scopus 로고
    • The ephrin-A1 ligand and its receptor, EphA2, are expressed during tumor neovascularization
    • Ogawa K., Pasqualini R., Lindberg R.A., Kain R., Freeman A.L., Pasquale E.B. The ephrin-A1 ligand and its receptor, EphA2, are expressed during tumor neovascularization. Oncogene 2000, 19:6043-6052.
    • (2000) Oncogene , vol.19 , pp. 6043-6052
    • Ogawa, K.1    Pasqualini, R.2    Lindberg, R.A.3    Kain, R.4    Freeman, A.L.5    Pasquale, E.B.6
  • 12
    • 38149028979 scopus 로고    scopus 로고
    • Overexpression of EphA2 gene in invasive human breast cancer and its association with hormone receptor statues [ASCO annual meeting proceedings]
    • Pan M. Overexpression of EphA2 gene in invasive human breast cancer and its association with hormone receptor statues [ASCO annual meeting proceedings]. J Clin Oncol 2005, 23:9583.
    • (2005) J Clin Oncol , vol.23 , pp. 9583
    • Pan, M.1
  • 13
    • 33746894693 scopus 로고    scopus 로고
    • Gene expression signature in organized and growth-arrested mammary acini predicts good outcome in breast cancer
    • Fournier M.V., Martin K.J., Kenny P.A., Xhaja K., Bosch I., Yaswen P., et al. Gene expression signature in organized and growth-arrested mammary acini predicts good outcome in breast cancer. Cancer Res 2006, 66:7095-7102.
    • (2006) Cancer Res , vol.66 , pp. 7095-7102
    • Fournier, M.V.1    Martin, K.J.2    Kenny, P.A.3    Xhaja, K.4    Bosch, I.5    Yaswen, P.6
  • 14
    • 52149124653 scopus 로고    scopus 로고
    • Prognostic breast cancer signature identified from 3D culture model accurately predicts clinical outcome across independent datasets
    • Martin K.J., Patrick D.R., Bissell M.J., Fournier M.V. Prognostic breast cancer signature identified from 3D culture model accurately predicts clinical outcome across independent datasets. PLoS ONE 2008, 3:e2994.
    • (2008) PLoS ONE , vol.3
    • Martin, K.J.1    Patrick, D.R.2    Bissell, M.J.3    Fournier, M.V.4
  • 15
    • 75149129568 scopus 로고    scopus 로고
    • Elevation of receptor tyrosine kinase EphA2 mediates resistance to trastuzumab therapy
    • Zhuang G., Brantley-Sieders D.M., Vaught D., Yu J., Xie L., Wells S., et al. Elevation of receptor tyrosine kinase EphA2 mediates resistance to trastuzumab therapy. Cancer Res 2010, 70:299-308.
    • (2010) Cancer Res , vol.70 , pp. 299-308
    • Zhuang, G.1    Brantley-Sieders, D.M.2    Vaught, D.3    Yu, J.4    Xie, L.5    Wells, S.6
  • 17
    • 38149137411 scopus 로고    scopus 로고
    • The receptor tyrosine kinase EphA2 promotes mammary adenocarcinoma tumorigenesis and metastatic progression in mice by amplifying ErbB2 signaling
    • Brantley-Sieders D.M., Zhuang G., Hicks D., Fang W.B., Hwang Y., Cates J.M., et al. The receptor tyrosine kinase EphA2 promotes mammary adenocarcinoma tumorigenesis and metastatic progression in mice by amplifying ErbB2 signaling. J Clin Invest 2008, 118:64-78.
    • (2008) J Clin Invest , vol.118 , pp. 64-78
    • Brantley-Sieders, D.M.1    Zhuang, G.2    Hicks, D.3    Fang, W.B.4    Hwang, Y.5    Cates, J.M.6
  • 19
    • 67649234062 scopus 로고    scopus 로고
    • A naturally occurring HER2 carboxy-terminal fragment promotes mammary tumor growth and metastasis
    • Pedersen K., Angelini P.D., Laos S., Bach-Faig A., Cunningham M.P., Ferrer-Ramon C., et al. A naturally occurring HER2 carboxy-terminal fragment promotes mammary tumor growth and metastasis. Mol Cell Biol 2009, 29:3319-3331.
    • (2009) Mol Cell Biol , vol.29 , pp. 3319-3331
    • Pedersen, K.1    Angelini, P.D.2    Laos, S.3    Bach-Faig, A.4    Cunningham, M.P.5    Ferrer-Ramon, C.6
  • 20
    • 79551567742 scopus 로고    scopus 로고
    • Angiocrine factors modulate tumor proliferation and motility through EphA2 repression of Slit2 tumor suppressor function in endothelium
    • Brantley-Sieders D.M., Dunaway C.M., Rao M., Short S., Hwang Y., Gao Y., et al. Angiocrine factors modulate tumor proliferation and motility through EphA2 repression of Slit2 tumor suppressor function in endothelium. Cancer Res 2011, 71:976-987.
    • (2011) Cancer Res , vol.71 , pp. 976-987
    • Brantley-Sieders, D.M.1    Dunaway, C.M.2    Rao, M.3    Short, S.4    Hwang, Y.5    Gao, Y.6
  • 23
    • 0036731242 scopus 로고    scopus 로고
    • Loss of EphB4 receptor tyrosine kinase protein expression during carcinogenesis of the human breast
    • Berclaz G., Flutsch B., Altermatt H.J., Rohrbach V., Djonov V., Ziemiecki A., et al. Loss of EphB4 receptor tyrosine kinase protein expression during carcinogenesis of the human breast. Oncol Rep 2002, 9:985-989.
    • (2002) Oncol Rep , vol.9 , pp. 985-989
    • Berclaz, G.1    Flutsch, B.2    Altermatt, H.J.3    Rohrbach, V.4    Djonov, V.5    Ziemiecki, A.6
  • 24
    • 33746646032 scopus 로고    scopus 로고
    • The EphB4 receptor suppresses breast cancer cell tumorigenicity through an Abl-Crk pathway
    • Noren N.K., Foos G., Hauser C.A., Pasquale E.B. The EphB4 receptor suppresses breast cancer cell tumorigenicity through an Abl-Crk pathway. Nat Cell Biol 2006, 8:815-825.
    • (2006) Nat Cell Biol , vol.8 , pp. 815-825
    • Noren, N.K.1    Foos, G.2    Hauser, C.A.3    Pasquale, E.B.4
  • 25
    • 70349569570 scopus 로고    scopus 로고
    • EphrinB reverse signaling contributes to endothelial and mural cell assembly into vascular structures
    • Salvucci O., Maric D., Economopoulou M., Sakakibara S., Merlin S., Follenzi A., et al. EphrinB reverse signaling contributes to endothelial and mural cell assembly into vascular structures. Blood 2009, 114:1707-1716.
    • (2009) Blood , vol.114 , pp. 1707-1716
    • Salvucci, O.1    Maric, D.2    Economopoulou, M.3    Sakakibara, S.4    Merlin, S.5    Follenzi, A.6
  • 26
    • 71249098177 scopus 로고    scopus 로고
    • Frequent epigenetic inactivation of the receptor tyrosine kinase EphA5 by promoter methylation in human breast cancer
    • Fu D.Y., Wang Z.M., Wang B.L., Chen L., Yang W.T., Shen Z.Z., et al. Frequent epigenetic inactivation of the receptor tyrosine kinase EphA5 by promoter methylation in human breast cancer. Hum Pathol 2010, 41:48-58.
    • (2010) Hum Pathol , vol.41 , pp. 48-58
    • Fu, D.Y.1    Wang, Z.M.2    Wang, B.L.3    Chen, L.4    Yang, W.T.5    Shen, Z.Z.6
  • 27
    • 2442419137 scopus 로고    scopus 로고
    • Invasiveness of breast carcinoma cells and transcript profile: Eph receptors and ephrin ligands as molecular markers of potential diagnostic and prognostic application
    • Fox B.P., Kandpal R.P. Invasiveness of breast carcinoma cells and transcript profile: Eph receptors and ephrin ligands as molecular markers of potential diagnostic and prognostic application. Biochem Biophys Res Commun 2004, 318:882-892.
    • (2004) Biochem Biophys Res Commun , vol.318 , pp. 882-892
    • Fox, B.P.1    Kandpal, R.P.2
  • 28
    • 33644902092 scopus 로고    scopus 로고
    • Potential clinical relevance of Eph receptors and ephrin ligands expressed in prostate carcinoma cell lines
    • Fox B.P., Tabone C.J., Kandpal R.P. Potential clinical relevance of Eph receptors and ephrin ligands expressed in prostate carcinoma cell lines. Biochem Biophys Res Commun 2006, 342:1263-1272.
    • (2006) Biochem Biophys Res Commun , vol.342 , pp. 1263-1272
    • Fox, B.P.1    Tabone, C.J.2    Kandpal, R.P.3
  • 29
    • 64949134648 scopus 로고    scopus 로고
    • EphB6 receptor significantly alters invasiveness and other phenotypic characteristics of human breast carcinoma cells
    • Fox B.P., Kandpal R.P. EphB6 receptor significantly alters invasiveness and other phenotypic characteristics of human breast carcinoma cells. Oncogene 2009, 28:1706-1713.
    • (2009) Oncogene , vol.28 , pp. 1706-1713
    • Fox, B.P.1    Kandpal, R.P.2
  • 30
    • 78149232533 scopus 로고    scopus 로고
    • Tyrosine kinase-deficient EphB6 receptor-dependent alterations in proteomic profiles of invasive breast carcinoma cells as determined by difference gel electrophoresis
    • Kandpal R.P. Tyrosine kinase-deficient EphB6 receptor-dependent alterations in proteomic profiles of invasive breast carcinoma cells as determined by difference gel electrophoresis. Cancer Genomics Proteomics 2010, 7:253-260.
    • (2010) Cancer Genomics Proteomics , vol.7 , pp. 253-260
    • Kandpal, R.P.1
  • 31
    • 76249132650 scopus 로고    scopus 로고
    • The EphB6 receptor cooperates with c-Cbl to regulate the behavior of breast cancer cells
    • Truitt L., Freywald T., DeCoteau J., Sharfe N., Freywald A. The EphB6 receptor cooperates with c-Cbl to regulate the behavior of breast cancer cells. Cancer Res 2010, 70:1141-1153.
    • (2010) Cancer Res , vol.70 , pp. 1141-1153
    • Truitt, L.1    Freywald, T.2    DeCoteau, J.3    Sharfe, N.4    Freywald, A.5
  • 32
  • 33
    • 33746929036 scopus 로고    scopus 로고
    • Disruption of EphA2 receptor tyrosine kinase leads to increased susceptibility to carcinogenesis in mouse skin
    • Guo H., Miao H., Gerber L., Singh J., Denning M., Gilliam A.C., et al. Disruption of EphA2 receptor tyrosine kinase leads to increased susceptibility to carcinogenesis in mouse skin. Cancer Res 2006, 66:7050-7058.
    • (2006) Cancer Res , vol.66 , pp. 7050-7058
    • Guo, H.1    Miao, H.2    Gerber, L.3    Singh, J.4    Denning, M.5    Gilliam, A.C.6
  • 34
    • 57649123443 scopus 로고    scopus 로고
    • Soluble monomeric EphrinA1 is released from tumor cells and is a functional ligand for the EphA2 receptor
    • Wykosky J., Palma E., Gibo D.M., Ringler S., Turner C.P., Debinski W. Soluble monomeric EphrinA1 is released from tumor cells and is a functional ligand for the EphA2 receptor. Oncogene 2008, 27:7260-7273.
    • (2008) Oncogene , vol.27 , pp. 7260-7273
    • Wykosky, J.1    Palma, E.2    Gibo, D.M.3    Ringler, S.4    Turner, C.P.5    Debinski, W.6
  • 36
    • 0032031705 scopus 로고    scopus 로고
    • Eph receptors discriminate specific ligand oligomers to determine alternative signaling complexes, attachment, and assembly responses
    • Stein E., Lane A.A., Cerretti D.P., Schoecklmann H.O., Schroff A.D., Van Etten R.L., et al. Eph receptors discriminate specific ligand oligomers to determine alternative signaling complexes, attachment, and assembly responses. Genes Dev 1998, 12:667-678.
    • (1998) Genes Dev , vol.12 , pp. 667-678
    • Stein, E.1    Lane, A.A.2    Cerretti, D.P.3    Schoecklmann, H.O.4    Schroff, A.D.5    Van Etten, R.L.6
  • 37
    • 36048971979 scopus 로고    scopus 로고
    • Tissue transglutaminase clusters soluble A-type ephrins into functionally active high molecular weight oligomers
    • Alford S.C., Bazowski J., Lorimer H., Elowe S., Howard P.L. Tissue transglutaminase clusters soluble A-type ephrins into functionally active high molecular weight oligomers. Exp Cell Res 2007, 313:4170-4179.
    • (2007) Exp Cell Res , vol.313 , pp. 4170-4179
    • Alford, S.C.1    Bazowski, J.2    Lorimer, H.3    Elowe, S.4    Howard, P.L.5
  • 38
    • 31544433363 scopus 로고    scopus 로고
    • EphB/EphrinB receptors and Wnt signaling in colorectal cancer
    • Clevers H., Batlle E. EphB/EphrinB receptors and Wnt signaling in colorectal cancer. Cancer Res 2006, 66:2-5.
    • (2006) Cancer Res , vol.66 , pp. 2-5
    • Clevers, H.1    Batlle, E.2
  • 39
    • 77949877661 scopus 로고    scopus 로고
    • The role of Eph receptors and ephrin ligands in colorectal cancer
    • Herath N.I., Boyd A.W. The role of Eph receptors and ephrin ligands in colorectal cancer. Int J Cancer 2010, 126:2003-2011.
    • (2010) Int J Cancer , vol.126 , pp. 2003-2011
    • Herath, N.I.1    Boyd, A.W.2
  • 42
    • 0037083623 scopus 로고    scopus 로고
    • Coexpression of ephrin-Bs and their receptors in colon carcinoma
    • Liu W., Ahmad S.A., Jung Y.D., Reinmuth N., Fan F., Bucana C.D., et al. Coexpression of ephrin-Bs and their receptors in colon carcinoma. Cancer 2002, 94:934-939.
    • (2002) Cancer , vol.94 , pp. 934-939
    • Liu, W.1    Ahmad, S.A.2    Jung, Y.D.3    Reinmuth, N.4    Fan, F.5    Bucana, C.D.6
  • 44
    • 33644866330 scopus 로고    scopus 로고
    • Reduced expression of EphB2 that parallels invasion and metastasis in colorectal tumours
    • Guo D.L., Zhang J., Yuen S.T., Tsui W.Y., Chan A.S., Ho C., et al. Reduced expression of EphB2 that parallels invasion and metastasis in colorectal tumours. Carcinogenesis 2006, 27:454-464.
    • (2006) Carcinogenesis , vol.27 , pp. 454-464
    • Guo, D.L.1    Zhang, J.2    Yuen, S.T.3    Tsui, W.Y.4    Chan, A.S.5    Ho, C.6
  • 45
    • 70249128037 scopus 로고    scopus 로고
    • Over-expression of EphB3 enhances cell-cell contacts and suppresses tumor growth in HT-29 human colon cancer cells
    • Chiu S.T., Chang K.J., Ting C.H., Shen H.C., Li H., Hsieh F.J. Over-expression of EphB3 enhances cell-cell contacts and suppresses tumor growth in HT-29 human colon cancer cells. Carcinogenesis 2009, 30:1475-1486.
    • (2009) Carcinogenesis , vol.30 , pp. 1475-1486
    • Chiu, S.T.1    Chang, K.J.2    Ting, C.H.3    Shen, H.C.4    Li, H.5    Hsieh, F.J.6
  • 46
    • 54249146058 scopus 로고    scopus 로고
    • EphB1 is underexpressed in poorly differentiated colorectal cancers
    • Sheng Z., Wang J., Dong Y., Ma H., Zhou H., Sugimura H., et al. EphB1 is underexpressed in poorly differentiated colorectal cancers. Pathobiology 2008, 75:274-280.
    • (2008) Pathobiology , vol.75 , pp. 274-280
    • Sheng, Z.1    Wang, J.2    Dong, Y.3    Ma, H.4    Zhou, H.5    Sugimura, H.6
  • 47
    • 43049139925 scopus 로고    scopus 로고
    • Loss of expression of EphB1 protein in gastric carcinoma associated with invasion and metastasis
    • Wang J.D., Dong Y.C., Sheng Z., Ma H.H., Li G.L., Wang X.L., et al. Loss of expression of EphB1 protein in gastric carcinoma associated with invasion and metastasis. Oncology 2007, 73:238-245.
    • (2007) Oncology , vol.73 , pp. 238-245
    • Wang, J.D.1    Dong, Y.C.2    Sheng, Z.3    Ma, H.H.4    Li, G.L.5    Wang, X.L.6
  • 49
    • 25144470101 scopus 로고    scopus 로고
    • EphB2 expression across 138 human tumor types in a tissue microarray: high levels of expression in gastrointestinal cancers
    • Lugli A., Spichtin H., Maurer R., Mirlacher M., Kiefer J., Huusko P., et al. EphB2 expression across 138 human tumor types in a tissue microarray: high levels of expression in gastrointestinal cancers. Clin Cancer Res 2005, 11:6450-6458.
    • (2005) Clin Cancer Res , vol.11 , pp. 6450-6458
    • Lugli, A.1    Spichtin, H.2    Maurer, R.3    Mirlacher, M.4    Kiefer, J.5    Huusko, P.6
  • 50
    • 78751621909 scopus 로고    scopus 로고
    • Reduced expression of EphB2 is significantly associated with nodal metastasis in Chinese patients with gastric cancer
    • Yu G., Gao Y., Ni C., Chen Y., Pan J., Wang X., et al. Reduced expression of EphB2 is significantly associated with nodal metastasis in Chinese patients with gastric cancer. J Cancer Res Clin Oncol 2011, 137:73-80.
    • (2011) J Cancer Res Clin Oncol , vol.137 , pp. 73-80
    • Yu, G.1    Gao, Y.2    Ni, C.3    Chen, Y.4    Pan, J.5    Wang, X.6
  • 52
    • 31544468441 scopus 로고    scopus 로고
    • Identification of early-stage colorectal cancer patients at risk of relapse post-resection by immunobead reverse transcription-PCR analysis of peritoneal lavage fluid for malignant cells
    • Lloyd J.M., McIver C.M., Stephenson S.A., Hewett P.J., Rieger N., Hardingham J.E. Identification of early-stage colorectal cancer patients at risk of relapse post-resection by immunobead reverse transcription-PCR analysis of peritoneal lavage fluid for malignant cells. Clin Cancer Res 2006, 12:417-423.
    • (2006) Clin Cancer Res , vol.12 , pp. 417-423
    • Lloyd, J.M.1    McIver, C.M.2    Stephenson, S.A.3    Hewett, P.J.4    Rieger, N.5    Hardingham, J.E.6
  • 53
    • 58149174073 scopus 로고    scopus 로고
    • Downregulation of EphA1 in colorectal carcinomas correlates with invasion and metastasis
    • Dong Y., Wang J., Sheng Z., Li G., Ma H., Wang X., et al. Downregulation of EphA1 in colorectal carcinomas correlates with invasion and metastasis. Mod Pathol 2009, 22:151-160.
    • (2009) Mod Pathol , vol.22 , pp. 151-160
    • Dong, Y.1    Wang, J.2    Sheng, Z.3    Li, G.4    Ma, H.5    Wang, X.6
  • 54
    • 24644498612 scopus 로고    scopus 로고
    • Downregulation of EphA7 by hypermethylation in colorectal cancer
    • Wang J., Kataoka H., Suzuki M., Sato N., Nakamura R., Tao H., et al. Downregulation of EphA7 by hypermethylation in colorectal cancer. Oncogene 2005, 24:5637-5647.
    • (2005) Oncogene , vol.24 , pp. 5637-5647
    • Wang, J.1    Kataoka, H.2    Suzuki, M.3    Sato, N.4    Nakamura, R.5    Tao, H.6
  • 55
    • 63949086165 scopus 로고    scopus 로고
    • Epigenetic silencing of EphA1 expression in colorectal cancer is correlated with poor survival
    • Herath N.I., Doecke J., Spanevello M.D., Leggett B.A., Boyd A.W. Epigenetic silencing of EphA1 expression in colorectal cancer is correlated with poor survival. Br J Cancer 2009, 100:1095-1102.
    • (2009) Br J Cancer , vol.100 , pp. 1095-1102
    • Herath, N.I.1    Doecke, J.2    Spanevello, M.D.3    Leggett, B.A.4    Boyd, A.W.5
  • 56
    • 1542358915 scopus 로고    scopus 로고
    • Differential gene expression of Eph receptors and ephrins in benign human tissues and cancers
    • Hafner C., Schmitz G., Meyer S., Bataille F., Hau P., Langmann T., et al. Differential gene expression of Eph receptors and ephrins in benign human tissues and cancers. Clin Chem 2004, 50:490-499.
    • (2004) Clin Chem , vol.50 , pp. 490-499
    • Hafner, C.1    Schmitz, G.2    Meyer, S.3    Bataille, F.4    Hau, P.5    Langmann, T.6
  • 57
    • 4644307189 scopus 로고    scopus 로고
    • Expression of EphA2 and E-cadherin in colorectal cancer: correlation with cancer metastasis
    • Saito T., Masuda N., Miyazaki T., Kanoh K., Suzuki H., Shimura T., et al. Expression of EphA2 and E-cadherin in colorectal cancer: correlation with cancer metastasis. Oncol Rep 2004, 11:605-611.
    • (2004) Oncol Rep , vol.11 , pp. 605-611
    • Saito, T.1    Masuda, N.2    Miyazaki, T.3    Kanoh, K.4    Suzuki, H.5    Shimura, T.6
  • 58
    • 70350247569 scopus 로고    scopus 로고
    • Over-expression of EphA2 and EphrinA-1 in human gastric adenocarcinoma and its prognostic value for postoperative patients
    • Yuan W.J., Ge J., Chen Z.K., Wu S.B., Shen H., Yang P., et al. Over-expression of EphA2 and EphrinA-1 in human gastric adenocarcinoma and its prognostic value for postoperative patients. Dig Dis Sci 2009, 54:2410-2417.
    • (2009) Dig Dis Sci , vol.54 , pp. 2410-2417
    • Yuan, W.J.1    Ge, J.2    Chen, Z.K.3    Wu, S.B.4    Shen, H.5    Yang, P.6
  • 59
    • 73449147672 scopus 로고    scopus 로고
    • Expression of EphA2 and E-cadherin in gastric cancer: correlated with tumor progression and lymphogenous metastasis
    • Yuan W., Chen Z., Wu S., Ge J., Chang S., Wang X., et al. Expression of EphA2 and E-cadherin in gastric cancer: correlated with tumor progression and lymphogenous metastasis. Pathol Oncol Res 2009, 15:473-478.
    • (2009) Pathol Oncol Res , vol.15 , pp. 473-478
    • Yuan, W.1    Chen, Z.2    Wu, S.3    Ge, J.4    Chang, S.5    Wang, X.6
  • 60
    • 12144291332 scopus 로고    scopus 로고
    • Correlation of EPHA2 overexpression with high microvessel count in human primary colorectal cancer
    • Kataoka H., Igarashi H., Kanamori M., Ihara M., Wang J.D., Wang Y.J., et al. Correlation of EPHA2 overexpression with high microvessel count in human primary colorectal cancer. Cancer Sci 2004, 95:136-141.
    • (2004) Cancer Sci , vol.95 , pp. 136-141
    • Kataoka, H.1    Igarashi, H.2    Kanamori, M.3    Ihara, M.4    Wang, J.D.5    Wang, Y.J.6
  • 61
    • 0037168958 scopus 로고    scopus 로고
    • Reduced expression of EphrinA1 (EFNA1) inhibits three-dimensional growth of HT29 colon carcinoma cells
    • Potla L., Boghaert E.R., Armellino D., Frost P., Damle N.K. Reduced expression of EphrinA1 (EFNA1) inhibits three-dimensional growth of HT29 colon carcinoma cells. Cancer Lett 2002, 175:187-195.
    • (2002) Cancer Lett , vol.175 , pp. 187-195
    • Potla, L.1    Boghaert, E.R.2    Armellino, D.3    Frost, P.4    Damle, N.K.5
  • 62
    • 0348108204 scopus 로고    scopus 로고
    • EphA2 up-regulation induced by deoxycholic acid in human colon carcinoma cells, an involvement of extracellular signal-regulated kinase and p53-independence
    • Li Z., Tanaka M., Kataoka H., Nakamura R., Sanjar R., Shinmura K., et al. EphA2 up-regulation induced by deoxycholic acid in human colon carcinoma cells, an involvement of extracellular signal-regulated kinase and p53-independence. J Cancer Res Clin Oncol 2003, 129:703-708.
    • (2003) J Cancer Res Clin Oncol , vol.129 , pp. 703-708
    • Li, Z.1    Tanaka, M.2    Kataoka, H.3    Nakamura, R.4    Sanjar, R.5    Shinmura, K.6
  • 63
    • 60549086460 scopus 로고    scopus 로고
    • Loss of EphA2 receptor tyrosine kinase reduces ApcMin/+ tumorigenesis
    • Bogan C., Chen J., O'Sullivan M.G., Cormier R.T. Loss of EphA2 receptor tyrosine kinase reduces ApcMin/+ tumorigenesis. Int J Cancer 2009, 124:1366-1371.
    • (2009) Int J Cancer , vol.124 , pp. 1366-1371
    • Bogan, C.1    Chen, J.2    O'Sullivan, M.G.3    Cormier, R.T.4
  • 64
    • 54849186500 scopus 로고    scopus 로고
    • Overexpression of EphA4 gene and reduced expression of EphB2 gene correlates with liver metastasis in colorectal cancer
    • Oshima T., Akaike M., Yoshihara K., Shiozawa M., Yamamoto N., Sato T., et al. Overexpression of EphA4 gene and reduced expression of EphB2 gene correlates with liver metastasis in colorectal cancer. Int J Oncol 2008, 33:573-577.
    • (2008) Int J Oncol , vol.33 , pp. 573-577
    • Oshima, T.1    Akaike, M.2    Yoshihara, K.3    Shiozawa, M.4    Yamamoto, N.5    Sato, T.6
  • 65
    • 77649114060 scopus 로고    scopus 로고
    • Eph receptors and ephrins in cancer: bidirectional signalling and beyond
    • Pasquale E.B. Eph receptors and ephrins in cancer: bidirectional signalling and beyond. Nat Rev Cancer 2010, 10:165-180.
    • (2010) Nat Rev Cancer , vol.10 , pp. 165-180
    • Pasquale, E.B.1
  • 66
    • 0037314612 scopus 로고    scopus 로고
    • Predictive value of the EphA2 receptor tyrosine kinase in lung cancer recurrence and survival
    • Kinch M.S., Moore M.B., Harpole D.H. Predictive value of the EphA2 receptor tyrosine kinase in lung cancer recurrence and survival. Clin Cancer Res 2003, 9:613-618.
    • (2003) Clin Cancer Res , vol.9 , pp. 613-618
    • Kinch, M.S.1    Moore, M.B.2    Harpole, D.H.3
  • 68
    • 67650403368 scopus 로고    scopus 로고
    • Expression of the receptor tyrosine kinase EphA2 is increased in smokers and predicts poor survival in non-small cell lung cancer
    • Brannan J.M., Dong W., Prudkin L., Behrens C., Lotan R., Bekele B.N., et al. Expression of the receptor tyrosine kinase EphA2 is increased in smokers and predicts poor survival in non-small cell lung cancer. Clin Cancer Res 2009, 15:4423-4430.
    • (2009) Clin Cancer Res , vol.15 , pp. 4423-4430
    • Brannan, J.M.1    Dong, W.2    Prudkin, L.3    Behrens, C.4    Lotan, R.5    Bekele, B.N.6
  • 69
    • 43249083693 scopus 로고    scopus 로고
    • Transcriptional profiling of non-small cell lung cancer cells with activating EGFR somatic mutations
    • Choi K., Creighton C.J., Stivers D., Fujimoto N., Kurie J.M. Transcriptional profiling of non-small cell lung cancer cells with activating EGFR somatic mutations. PLoS ONE 2007, 2:e1226.
    • (2007) PLoS ONE , vol.2
    • Choi, K.1    Creighton, C.J.2    Stivers, D.3    Fujimoto, N.4    Kurie, J.M.5
  • 70
    • 77953304209 scopus 로고    scopus 로고
    • EphA2 mutation in lung squamous cell carcinoma promotes increased cell survival, cell invasion, focal adhesions, and mammalian target of rapamycin activation
    • Faoro L., Singleton P.A., Cervantes G.M., Lennon F.E., Choong N.W., Kanteti R., et al. EphA2 mutation in lung squamous cell carcinoma promotes increased cell survival, cell invasion, focal adhesions, and mammalian target of rapamycin activation. J Biol Chem 2010, 285:18575-18585.
    • (2010) J Biol Chem , vol.285 , pp. 18575-18585
    • Faoro, L.1    Singleton, P.A.2    Cervantes, G.M.3    Lennon, F.E.4    Choong, N.W.5    Kanteti, R.6
  • 71
    • 24744453982 scopus 로고    scopus 로고
    • Somatic mutations of the protein kinase gene family in human lung cancer
    • Davies H., Hunter C., Smith R., Stephens P., Greenman C., Bignell G., et al. Somatic mutations of the protein kinase gene family in human lung cancer. Cancer Res 2005, 65:7591-7595.
    • (2005) Cancer Res , vol.65 , pp. 7591-7595
    • Davies, H.1    Hunter, C.2    Smith, R.3    Stephens, P.4    Greenman, C.5    Bignell, G.6
  • 73
    • 39449101440 scopus 로고    scopus 로고
    • Coexpression of EphB4 and ephrinB2 in tumour advancement of ovarian cancers
    • Alam S.M., Fujimoto J., Jahan I., Sato E., Tamaya T. Coexpression of EphB4 and ephrinB2 in tumour advancement of ovarian cancers. Br J Cancer 2008, 98:845-851.
    • (2008) Br J Cancer , vol.98 , pp. 845-851
    • Alam, S.M.1    Fujimoto, J.2    Jahan, I.3    Sato, E.4    Tamaya, T.5
  • 74
    • 78049458678 scopus 로고    scopus 로고
    • EphA3 functions are regulated by collaborating phosphotyrosine residues
    • Shi G., Yue G., Zhou R. EphA3 functions are regulated by collaborating phosphotyrosine residues. Cell Res 2010, 20:1263-1275.
    • (2010) Cell Res , vol.20 , pp. 1263-1275
    • Shi, G.1    Yue, G.2    Zhou, R.3
  • 75
    • 79551542878 scopus 로고    scopus 로고
    • EphB3 is overexpressed in non-small-cell lung cancer and promotes tumor metastasis by enhancing cell survival and migration
    • Ji X.D., Li G., Feng Y.X., Zhao J.S., Li J.J., Sun Z.J., et al. EphB3 is overexpressed in non-small-cell lung cancer and promotes tumor metastasis by enhancing cell survival and migration. Cancer Res 2011, 71:1156-1166.
    • (2011) Cancer Res , vol.71 , pp. 1156-1166
    • Ji, X.D.1    Li, G.2    Feng, Y.X.3    Zhao, J.S.4    Li, J.J.5    Sun, Z.J.6
  • 76
    • 79955852758 scopus 로고    scopus 로고
    • Phosphoproteomic profiling of NSCLC cells reveals that ephrin B3 regulates pro-survival signaling through Akt1-mediated phosphorylation of the EphA2 receptor
    • Stahl S., Mm Branca R., Efazat G., Ruzzene M., Zhivotovsky B., Lewensohn R., et al. Phosphoproteomic profiling of NSCLC cells reveals that ephrin B3 regulates pro-survival signaling through Akt1-mediated phosphorylation of the EphA2 receptor. J Proteome Res 2011, 10:2566-2578.
    • (2011) J Proteome Res , vol.10 , pp. 2566-2578
    • Stahl, S.1    Mm Branca, R.2    Efazat, G.3    Ruzzene, M.4    Zhivotovsky, B.5    Lewensohn, R.6
  • 77
    • 33745938939 scopus 로고    scopus 로고
    • Over-expression of Eph and ephrin genes in advanced ovarian cancer: ephrin gene expression correlates with shortened survival
    • Herath N.I., Spanevello M.D., Sabesan S., Newton T., Cummings M., Duffy S., et al. Over-expression of Eph and ephrin genes in advanced ovarian cancer: ephrin gene expression correlates with shortened survival. BMC Cancer 2006, 6:144.
    • (2006) BMC Cancer , vol.6 , pp. 144
    • Herath, N.I.1    Spanevello, M.D.2    Sabesan, S.3    Newton, T.4    Cummings, M.5    Duffy, S.6
  • 78
    • 1642453727 scopus 로고    scopus 로고
    • Identification of necrosis-associated genes in glioblastoma by cDNA microarray analysis
    • Raza S.M., Fuller G.N., Rhee C.H., Huang S., Hess K., Zhang W., et al. Identification of necrosis-associated genes in glioblastoma by cDNA microarray analysis. Clin Cancer Res 2004, 10:212-221.
    • (2004) Clin Cancer Res , vol.10 , pp. 212-221
    • Raza, S.M.1    Fuller, G.N.2    Rhee, C.H.3    Huang, S.4    Hess, K.5    Zhang, W.6
  • 79
    • 78649402747 scopus 로고    scopus 로고
    • Expression of EphA1 in gastric carcinomas is associated with metastasis and survival
    • Wang J., Dong Y., Wang X., Ma H., Sheng Z., Li G., et al. Expression of EphA1 in gastric carcinomas is associated with metastasis and survival. Oncol Rep 2010, 24:1577-1584.
    • (2010) Oncol Rep , vol.24 , pp. 1577-1584
    • Wang, J.1    Dong, Y.2    Wang, X.3    Ma, H.4    Sheng, Z.5    Li, G.6
  • 80
    • 0027977939 scopus 로고
    • Overexpression of ERK, an EPH family receptor protein tyrosine kinase, in various human tumors
    • Kiyokawa E., Takai S., Tanaka M., Iwase T., Suzuki M., Xiang Y.Y., et al. Overexpression of ERK, an EPH family receptor protein tyrosine kinase, in various human tumors. Cancer Res 1994, 54:3645-3650.
    • (1994) Cancer Res , vol.54 , pp. 3645-3650
    • Kiyokawa, E.1    Takai, S.2    Tanaka, M.3    Iwase, T.4    Suzuki, M.5    Xiang, Y.Y.6
  • 82
    • 0023741167 scopus 로고
    • Evolution, expression, and chromosomal location of a novel receptor tyrosine kinase gene
    • Maru Y., Hirai H., Yoshida M.C., Takaku F., Evolution, expression, and chromosomal location of a novel receptor tyrosine kinase gene, eph Mol Cell Biol 1988, 8:3770-3776.
    • (1988) eph Mol Cell Biol , vol.8 , pp. 3770-3776
    • Maru, Y.1    Hirai, H.2    Yoshida, M.C.3    Takaku, F.4
  • 83
    • 76649136182 scopus 로고    scopus 로고
    • EphA1 receptor silencing by small interfering RNA has antiangiogenic and antitumor efficacy in hepatocellular carcinoma
    • Chen G., Wang Y., Zhou M., Shi H., Yu Z., Zhu Y., et al. EphA1 receptor silencing by small interfering RNA has antiangiogenic and antitumor efficacy in hepatocellular carcinoma. Oncol Rep 2010, 23:563-570.
    • (2010) Oncol Rep , vol.23 , pp. 563-570
    • Chen, G.1    Wang, Y.2    Zhou, M.3    Shi, H.4    Yu, Z.5    Zhu, Y.6
  • 84
    • 33750520933 scopus 로고    scopus 로고
    • Transcriptome profiling in clinical breast cancer: from 3D culture models to prognostic signatures
    • Fournier M.V., Martin K.J. Transcriptome profiling in clinical breast cancer: from 3D culture models to prognostic signatures. J Cell Physiol 2006, 209:625-630.
    • (2006) J Cell Physiol , vol.209 , pp. 625-630
    • Fournier, M.V.1    Martin, K.J.2
  • 85
    • 33846212673 scopus 로고    scopus 로고
    • EphA2 overexpression is associated with angiogenesis in ovarian cancer
    • Lin Y.G., Han L.Y., Kamat A.A., Merritt W.M., Landen C.N., Deavers M.T., et al. EphA2 overexpression is associated with angiogenesis in ovarian cancer. Cancer 2007, 109:332-340.
    • (2007) Cancer , vol.109 , pp. 332-340
    • Lin, Y.G.1    Han, L.Y.2    Kamat, A.A.3    Merritt, W.M.4    Landen, C.N.5    Deavers, M.T.6
  • 87
    • 22944462687 scopus 로고    scopus 로고
    • Predictive value of EphA2 and EphrinA-1 expression in oesophageal squamous cell carcinoma
    • Xu F., Zhong W., Li J., Shanshen Z., Cui J., Nesland J.M., et al. Predictive value of EphA2 and EphrinA-1 expression in oesophageal squamous cell carcinoma. Anticancer Res 2005, 25:2943-2950.
    • (2005) Anticancer Res , vol.25 , pp. 2943-2950
    • Xu, F.1    Zhong, W.2    Li, J.3    Shanshen, Z.4    Cui, J.5    Nesland, J.M.6
  • 88
    • 0037455813 scopus 로고    scopus 로고
    • EphA2 overexpression correlates with poor prognosis in esophageal squamous cell carcinoma
    • Miyazaki T., Kato H., Fukuchi M., Nakajima M., Kuwano H. EphA2 overexpression correlates with poor prognosis in esophageal squamous cell carcinoma. Int J Cancer 2003, 103:657-663.
    • (2003) Int J Cancer , vol.103 , pp. 657-663
    • Miyazaki, T.1    Kato, H.2    Fukuchi, M.3    Nakajima, M.4    Kuwano, H.5
  • 89
    • 27644466229 scopus 로고    scopus 로고
    • EphA2 as a novel molecular marker and target in glioblastoma multiforme
    • Wykosky J., Gibo D.M., Stanton C., Debinski W. EphA2 as a novel molecular marker and target in glioblastoma multiforme. Mol Cancer Res 2005, 3:541-551.
    • (2005) Mol Cancer Res , vol.3 , pp. 541-551
    • Wykosky, J.1    Gibo, D.M.2    Stanton, C.3    Debinski, W.4
  • 90
    • 67649361516 scopus 로고    scopus 로고
    • EphA2 mediates ligand-dependent inhibition and ligand-independent promotion of cell migration and invasion via a reciprocal regulatory loop with Akt
    • Miao H., Li D.Q., Mukherjee A., Guo H., Petty A., Cutter J., et al. EphA2 mediates ligand-dependent inhibition and ligand-independent promotion of cell migration and invasion via a reciprocal regulatory loop with Akt. Cancer Cell 2009, 16:9-20.
    • (2009) Cancer Cell , vol.16 , pp. 9-20
    • Miao, H.1    Li, D.Q.2    Mukherjee, A.3    Guo, H.4    Petty, A.5    Cutter, J.6
  • 91
    • 78049494241 scopus 로고    scopus 로고
    • Up-regulation of EphA2 and down-regulation of EphrinA1 are associated with the aggressive phenotype and poor prognosis of malignant glioma
    • Li X., Wang L., Gu J.W., Li B., Liu W.P., Wang Y.G., et al. Up-regulation of EphA2 and down-regulation of EphrinA1 are associated with the aggressive phenotype and poor prognosis of malignant glioma. Tumour Biol 2010, 31:477-488.
    • (2010) Tumour Biol , vol.31 , pp. 477-488
    • Li, X.1    Wang, L.2    Gu, J.W.3    Li, B.4    Liu, W.P.5    Wang, Y.G.6
  • 92
    • 33846651832 scopus 로고    scopus 로고
    • Patterns of EphA2 protein expression in primary and metastatic pancreatic carcinoma and correlation with genetic status
    • Mudali S.V., Fu B., Lakkur S.S., Luo M., Embuscado E.E., Iacobuzio-Donahue C.A. Patterns of EphA2 protein expression in primary and metastatic pancreatic carcinoma and correlation with genetic status. Clin Exp Metastasis 2006, 23:357-365.
    • (2006) Clin Exp Metastasis , vol.23 , pp. 357-365
    • Mudali, S.V.1    Fu, B.2    Lakkur, S.S.3    Luo, M.4    Embuscado, E.E.5    Iacobuzio-Donahue, C.A.6
  • 93
    • 73849147321 scopus 로고    scopus 로고
    • Overexpression of EphA2, MMP-9, and MVD-CD34 in hepatocellular carcinoma: Implications for tumor progression and prognosis
    • Yang P., Yuan W., He J., Wang J., Yu L., Jin X., et al. Overexpression of EphA2, MMP-9, and MVD-CD34 in hepatocellular carcinoma: Implications for tumor progression and prognosis. Hepatol Res 2009, 39:1169-1177.
    • (2009) Hepatol Res , vol.39 , pp. 1169-1177
    • Yang, P.1    Yuan, W.2    He, J.3    Wang, J.4    Yu, L.5    Jin, X.6
  • 98
    • 68149142724 scopus 로고    scopus 로고
    • Low frequency mutation of the Ephrin receptor A3 gene in hepatocellular carcinoma
    • Bae H.J., Song J.H., Noh J.H., Kim J.K., Jung K.H., Eun J.W., et al. Low frequency mutation of the Ephrin receptor A3 gene in hepatocellular carcinoma. Neoplasma 2009, 56:331-334.
    • (2009) Neoplasma , vol.56 , pp. 331-334
    • Bae, H.J.1    Song, J.H.2    Noh, J.H.3    Kim, J.K.4    Jung, K.H.5    Eun, J.W.6
  • 99
    • 34248547564 scopus 로고    scopus 로고
    • Novel somatic and germline mutations in cancer candidate genes in glioblastoma, melanoma, and pancreatic carcinoma
    • Balakrishnan A., Bleeker F.E., Lamba S., Rodolfo M., Daniotti M., Scarpa A., et al. Novel somatic and germline mutations in cancer candidate genes in glioblastoma, melanoma, and pancreatic carcinoma. Cancer Res 2007, 67:3545-3550.
    • (2007) Cancer Res , vol.67 , pp. 3545-3550
    • Balakrishnan, A.1    Bleeker, F.E.2    Lamba, S.3    Rodolfo, M.4    Daniotti, M.5    Scarpa, A.6
  • 100
    • 54049153684 scopus 로고    scopus 로고
    • EphA4 promotes cell proliferation and migration through a novel EphA4-FGFR1 signaling pathway in the human glioma U251 cell line
    • Fukai J., Yokote H., Yamanaka R., Arao T., Nishio K., Itakura T. EphA4 promotes cell proliferation and migration through a novel EphA4-FGFR1 signaling pathway in the human glioma U251 cell line. Mol Cancer Ther 2008, 7:2768-2778.
    • (2008) Mol Cancer Ther , vol.7 , pp. 2768-2778
    • Fukai, J.1    Yokote, H.2    Yamanaka, R.3    Arao, T.4    Nishio, K.5    Itakura, T.6
  • 101
    • 33748936707 scopus 로고    scopus 로고
    • EphA4 receptor, overexpressed in pancreatic ductal adenocarcinoma, promotes cancer cell growth
    • Iiizumi M., Hosokawa M., Takehara A., Chung S., Nakamura T., Katagiri T., et al. EphA4 receptor, overexpressed in pancreatic ductal adenocarcinoma, promotes cancer cell growth. Cancer Sci 2006, 97:1211-1216.
    • (2006) Cancer Sci , vol.97 , pp. 1211-1216
    • Iiizumi, M.1    Hosokawa, M.2    Takehara, A.3    Chung, S.4    Nakamura, T.5    Katagiri, T.6
  • 102
    • 42249088607 scopus 로고    scopus 로고
    • Increased expression of EphA7 correlates with adverse outcome in primary and recurrent glioblastoma multiforme patients
    • Wang L.F., Fokas E., Juricko J., You A., Rose F., Pagenstecher A., et al. Increased expression of EphA7 correlates with adverse outcome in primary and recurrent glioblastoma multiforme patients. BMC Cancer 2008, 8:79.
    • (2008) BMC Cancer , vol.8 , pp. 79
    • Wang, L.F.1    Fokas, E.2    Juricko, J.3    You, A.4    Rose, F.5    Pagenstecher, A.6
  • 103
    • 58149402919 scopus 로고    scopus 로고
    • Aberrant methylation of EphA7 in human prostate cancer and its relation to clinicopathologic features
    • Guan M., Xu C., Zhang F., Ye C. Aberrant methylation of EphA7 in human prostate cancer and its relation to clinicopathologic features. Int J Cancer 2009, 124:88-94.
    • (2009) Int J Cancer , vol.124 , pp. 88-94
    • Guan, M.1    Xu, C.2    Zhang, F.3    Ye, C.4
  • 105
    • 75449087524 scopus 로고    scopus 로고
    • Liver cancer: EphrinA2 promotes tumorigenicity through Rac1/Akt/NF-kappaB signaling pathway 120
    • Feng Y.X., Zhao J.S., Li J.J., Wang T., Cheng S.Q., Yuan Y., et al. Liver cancer: EphrinA2 promotes tumorigenicity through Rac1/Akt/NF-kappaB signaling pathway 120. Hepatology 2010, 51:535-544.
    • (2010) Hepatology , vol.51 , pp. 535-544
    • Feng, Y.X.1    Zhao, J.S.2    Li, J.J.3    Wang, T.4    Cheng, S.Q.5    Yuan, Y.6
  • 106
    • 65049090992 scopus 로고    scopus 로고
    • EphrinA5 acts as a tumor suppressor in glioma by negative regulation of epidermal growth factor receptor
    • Li J.J., Liu D.P., Liu G.T., Xie D. EphrinA5 acts as a tumor suppressor in glioma by negative regulation of epidermal growth factor receptor. Oncogene 2009, 28:1759-1768.
    • (2009) Oncogene , vol.28 , pp. 1759-1768
    • Li, J.J.1    Liu, D.P.2    Liu, G.T.3    Xie, D.4
  • 107
    • 25144492370 scopus 로고    scopus 로고
    • EphB2/R-Ras signaling regulates glioma cell adhesion, growth, and invasion
    • Nakada M., Niska J.A., Tran N.L., McDonough W.S., Berens M.E. EphB2/R-Ras signaling regulates glioma cell adhesion, growth, and invasion. Am J Pathol 2005, 167:565-576.
    • (2005) Am J Pathol , vol.167 , pp. 565-576
    • Nakada, M.1    Niska, J.A.2    Tran, N.L.3    McDonough, W.S.4    Berens, M.E.5
  • 109
    • 33846239002 scopus 로고    scopus 로고
    • Expression of EphB4 and Ephrin B2 in cervical cancer tissues and angiogenesis
    • Zhang S., Jiang T., Liang M. Expression of EphB4 and Ephrin B2 in cervical cancer tissues and angiogenesis. Int J Gynaecol Obstet 2007, 96:46-47.
    • (2007) Int J Gynaecol Obstet , vol.96 , pp. 46-47
    • Zhang, S.1    Jiang, T.2    Liang, M.3
  • 110
    • 67349089517 scopus 로고    scopus 로고
    • Coexpression of EphB4 and ephrinB2 in tumor advancement of uterine cervical cancers
    • Alam S.M., Fujimoto J., Jahan I., Sato E., Tamaya T. Coexpression of EphB4 and ephrinB2 in tumor advancement of uterine cervical cancers. Gynecol Oncol 2009, 114:84-88.
    • (2009) Gynecol Oncol , vol.114 , pp. 84-88
    • Alam, S.M.1    Fujimoto, J.2    Jahan, I.3    Sato, E.4    Tamaya, T.5
  • 111
    • 0035345024 scopus 로고    scopus 로고
    • Expression of receptor tyrosine kinase EphB4 and its ligand ephrin-B2 is associated with malignant potential in endometrial cancer
    • Takai N., Miyazaki T., Fujisawa K., Nasu K., Miyakawa I. Expression of receptor tyrosine kinase EphB4 and its ligand ephrin-B2 is associated with malignant potential in endometrial cancer. Oncol Rep 2001, 8:567-573.
    • (2001) Oncol Rep , vol.8 , pp. 567-573
    • Takai, N.1    Miyazaki, T.2    Fujisawa, K.3    Nasu, K.4    Miyakawa, I.5
  • 112
    • 0344406286 scopus 로고    scopus 로고
    • Activation of the receptor protein tyrosine kinase EphB4 in endometrial hyperplasia and endometrial carcinoma
    • Berclaz G., Karamitopoulou E., Mazzucchelli L., Rohrbach V., Dreher E., Ziemiecki A., et al. Activation of the receptor protein tyrosine kinase EphB4 in endometrial hyperplasia and endometrial carcinoma. Ann Oncol 2003, 14:220-226.
    • (2003) Ann Oncol , vol.14 , pp. 220-226
    • Berclaz, G.1    Karamitopoulou, E.2    Mazzucchelli, L.3    Rohrbach, V.4    Dreher, E.5    Ziemiecki, A.6
  • 113
    • 26844478267 scopus 로고    scopus 로고
    • Investigation of the expression of the EphB4 receptor tyrosine kinase in prostate carcinoma
    • Lee Y.C., Perren J.R., Douglas E.L., Raynor M.P., Bartley M.A., Bardy P.G., et al. Investigation of the expression of the EphB4 receptor tyrosine kinase in prostate carcinoma. BMC Cancer 2005, 5:119.
    • (2005) BMC Cancer , vol.5 , pp. 119
    • Lee, Y.C.1    Perren, J.R.2    Douglas, E.L.3    Raynor, M.P.4    Bartley, M.A.5    Bardy, P.G.6
  • 114
    • 47549091383 scopus 로고    scopus 로고
    • Identification of EphB6 variant-derived epitope peptides recognized by cytotoxic T-lymphocytes from HLA-A24+ malignant glioma patients
    • Jin M., Komohara Y., Shichijo S., Harada M., Yamanaka R., Miyamoto S., et al. Identification of EphB6 variant-derived epitope peptides recognized by cytotoxic T-lymphocytes from HLA-A24+ malignant glioma patients. Oncol Rep 2008, 19:1277-1283.
    • (2008) Oncol Rep , vol.19 , pp. 1277-1283
    • Jin, M.1    Komohara, Y.2    Shichijo, S.3    Harada, M.4    Yamanaka, R.5    Miyamoto, S.6
  • 115
    • 49749109122 scopus 로고    scopus 로고
    • Erythropoietin-producing hepatocyte B6 variant-derived peptides with the ability to induce glioma-reactive cytotoxic T lymphocytes in human leukocyte antigen-A2+ glioma patients
    • Jin M., Komohara Y., Shichijo S., Yamanaka R., Nikawa J., Itoh K., et al. Erythropoietin-producing hepatocyte B6 variant-derived peptides with the ability to induce glioma-reactive cytotoxic T lymphocytes in human leukocyte antigen-A2+ glioma patients. Cancer Sci 2008, 99:1656-1662.
    • (2008) Cancer Sci , vol.99 , pp. 1656-1662
    • Jin, M.1    Komohara, Y.2    Shichijo, S.3    Yamanaka, R.4    Nikawa, J.5    Itoh, K.6
  • 116
    • 0032979215 scopus 로고    scopus 로고
    • High-level expression of EPHB6, EFNB2, and EFNB3 is associated with low tumor stage and high TrkA expression in human neuroblastomas
    • Tang X.X., Evans A.E., Zhao H., Cnaan A., London W., Cohn S.L., et al. High-level expression of EPHB6, EFNB2, and EFNB3 is associated with low tumor stage and high TrkA expression in human neuroblastomas. Clin Cancer Res 1999, 5:1491-1496.
    • (1999) Clin Cancer Res , vol.5 , pp. 1491-1496
    • Tang, X.X.1    Evans, A.E.2    Zhao, H.3    Cnaan, A.4    London, W.5    Cohn, S.L.6
  • 118
    • 0033659369 scopus 로고    scopus 로고
    • Prognostic significance of EPHB6, EFNB2, and EFNB3 expressions in neuroblastoma
    • Tang X.X., Zhao H., Robinson M.E., Cnaan A., London W., Cohn S.L., et al. Prognostic significance of EPHB6, EFNB2, and EFNB3 expressions in neuroblastoma. Med Pediatr Oncol 2000, 35:656-658.
    • (2000) Med Pediatr Oncol , vol.35 , pp. 656-658
    • Tang, X.X.1    Zhao, H.2    Robinson, M.E.3    Cnaan, A.4    London, W.5    Cohn, S.L.6
  • 120
    • 33745148925 scopus 로고    scopus 로고
    • Ephrin B expression in epithelial ovarian neoplasms correlates with tumor differentiation and angiogenesis
    • Castellvi J., Garcia A., de la Torre J., Hernandez J., Gil A., Xercavins J., et al. Ephrin B expression in epithelial ovarian neoplasms correlates with tumor differentiation and angiogenesis. Hum Pathol 2006, 37:883-889.
    • (2006) Hum Pathol , vol.37 , pp. 883-889
    • Castellvi, J.1    Garcia, A.2    de la Torre, J.3    Hernandez, J.4    Gil, A.5    Xercavins, J.6
  • 121
    • 74049111863 scopus 로고    scopus 로고
    • The phosphorylation of ephrin-B2 ligand promotes glioma cell migration and invasion
    • Nakada M., Anderson E.M., Demuth T., Nakada S., Reavie L.B., Drake K.L., et al. The phosphorylation of ephrin-B2 ligand promotes glioma cell migration and invasion. Int J Cancer 2010, 126:1155-1165.
    • (2010) Int J Cancer , vol.126 , pp. 1155-1165
    • Nakada, M.1    Anderson, E.M.2    Demuth, T.3    Nakada, S.4    Reavie, L.B.5    Drake, K.L.6
  • 122
    • 0347504715 scopus 로고    scopus 로고
    • Expression of ephrin-B1 in hepatocellular carcinoma: possible involvement in neovascularization
    • Sawai Y., Tamura S., Fukui K., Ito N., Imanaka K., Saeki A., et al. Expression of ephrin-B1 in hepatocellular carcinoma: possible involvement in neovascularization. J Hepatol 2003, 39:991-996.
    • (2003) J Hepatol , vol.39 , pp. 991-996
    • Sawai, Y.1    Tamura, S.2    Fukui, K.3    Ito, N.4    Imanaka, K.5    Saeki, A.6
  • 123
    • 34447284784 scopus 로고    scopus 로고
    • Expression and prognostic significance of EFNB2 and EphB4 genes in patients with oesophageal squamous cell carcinoma
    • Tachibana M., Tonomoto Y., Hyakudomi R., Hyakudomi M., Hattori S., Ueda S., et al. Expression and prognostic significance of EFNB2 and EphB4 genes in patients with oesophageal squamous cell carcinoma. Dig Liver Dis 2007, 39:725-732.
    • (2007) Dig Liver Dis , vol.39 , pp. 725-732
    • Tachibana, M.1    Tonomoto, Y.2    Hyakudomi, R.3    Hyakudomi, M.4    Hattori, S.5    Ueda, S.6
  • 124
    • 0031946730 scopus 로고    scopus 로고
    • Overexpression of Lerk-5/Eplg5 messenger RNA: a novel marker for increased tumorigenicity and metastatic potential in human malignant melanomas
    • Vogt T., Stolz W., Welsh J., Jung B., Kerbel R.S., Kobayashi H., et al. Overexpression of Lerk-5/Eplg5 messenger RNA: a novel marker for increased tumorigenicity and metastatic potential in human malignant melanomas. Clin Cancer Res 1998, 4:791-797.
    • (1998) Clin Cancer Res , vol.4 , pp. 791-797
    • Vogt, T.1    Stolz, W.2    Welsh, J.3    Jung, B.4    Kerbel, R.S.5    Kobayashi, H.6
  • 125
    • 13444294190 scopus 로고    scopus 로고
    • Gene expression profile of glioblastoma multiforme invasive phenotype points to new therapeutic targets
    • Hoelzinger D.B., Mariani L., Weis J., Woyke T., Berens T.J., McDonough W.S., et al. Gene expression profile of glioblastoma multiforme invasive phenotype points to new therapeutic targets. Neoplasia 2005, 7:7-16.
    • (2005) Neoplasia , vol.7 , pp. 7-16
    • Hoelzinger, D.B.1    Mariani, L.2    Weis, J.3    Woyke, T.4    Berens, T.J.5    McDonough, W.S.6
  • 126
    • 33748997415 scopus 로고    scopus 로고
    • Ephrin-B3 ligand promotes glioma invasion through activation of Rac1
    • Nakada M., Drake K.L., Nakada S., Niska J.A., Berens M.E. Ephrin-B3 ligand promotes glioma invasion through activation of Rac1. Cancer Res 2006, 66:8492-8500.
    • (2006) Cancer Res , vol.66 , pp. 8492-8500
    • Nakada, M.1    Drake, K.L.2    Nakada, S.3    Niska, J.A.4    Berens, M.E.5
  • 127
    • 80052851917 scopus 로고    scopus 로고
    • Eph/ephrin profiling in human breast cancer reveals significant associations between expression level and clinical outcome
    • Brantley-Sieders D.M., Jiang A., Sarma K., Badu-Nkansah A., Walter D.L., Shyr Y., Chen J. Eph/ephrin profiling in human breast cancer reveals significant associations between expression level and clinical outcome. PLoS One 2011, 6:e24426.
    • (2011) PLoS One , vol.6
    • Brantley-Sieders, D.M.1    Jiang, A.2    Sarma, K.3    Badu-Nkansah, A.4    Walter, D.L.5    Shyr, Y.6    Chen, J.7
  • 129
    • 4344679183 scopus 로고    scopus 로고
    • Eph receptor tyrosine kinases in angiogenesis: from development to disease
    • Brantley-Sieders D.M., Chen J. Eph receptor tyrosine kinases in angiogenesis: from development to disease. Angiogenesis 2004, 7:17-28.
    • (2004) Angiogenesis , vol.7 , pp. 17-28
    • Brantley-Sieders, D.M.1    Chen, J.2
  • 130
    • 77649114060 scopus 로고    scopus 로고
    • Eph receptors and ephrins in cancer: bidirectional signaling and beyond
    • Pasquale E.B. Eph receptors and ephrins in cancer: bidirectional signaling and beyond. Nat Rev Cancer 2010, 10:165-180.
    • (2010) Nat Rev Cancer , vol.10 , pp. 165-180
    • Pasquale, E.B.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.