Expression of EphA2 and E-cadherin in gastric cancer: Correlated with tumor progression and lymphogenous metastasis

Pathology and Oncology Research

Volumn 15, Issue 3, 2009, Pages 473-478

  Yuan, Weijie ^a   Chen, Zhikang ^a   Wu, Shaobin ^a   Ge, Jie ^a   Chang, Shi ^a   Wang, Xianwei ^a   Chen, Jingxiang ^a   Chen, Zihua ^a  

^a CENTRAL SOUTH UNIVERSITY   (China)

Author keywords

E cadherin; EphA2; Gastric cancer; Immunohistochemistry

Indexed keywords

EPHRIN RECEPTOR A2; UVOMORULIN;

ADULT; AGED; ARTICLE; CANCER GROWTH; CANCER INVASION; CANCER STAGING; CONTROLLED STUDY; CORRELATION ANALYSIS; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MALE; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; STOMACH CANCER; TUMOR DIFFERENTIATION;

EID: 73449147672     PISSN: 12194956     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12253-008-9132-y     Document Type: Article

References (38)

1. V Catalano R Labianca GD Beretta, et al. 2005 Gastric cancer Crit Rev Oncol Hematol 54 209 241 10.1016/j.critrevonc.2005.01.002 15890270 (Pubitemid 40703920)
2. BJ Dicken DL Bigam C Cass, et al. 2005 Gastric adenocarcinoma: review and considerations for future directions Ann Surg 241 27 39 15621988
3. EP Sulman XX Tang C Allen, et al. 1997 ECK, a human EPH-related gene, maps to 1p36.1, a common region of alteration in human cancers Genomics 40 371 374 10.1006/geno.1996.4569 1:CAS:528:DyaK2sXhvVOrtLo%3D 9119409 (Pubitemid 27124104)
4. J Walker-Daniels AR Hess MJC Hendrix, et al. 2003 Differential regulation of EphA2 in normal and malignant cells Am J Pathol 162 1037 1042 1:CAS:528:DC%2BD3sXjtVemt70%3D 12651595
5. T Miyazaki H Kato M Fukuchi, et al. 2003 EphA2 overexpression correlates with poor prognosis in esophageal squamous cell carcinoma Int J Cancer 103 657 663 10.1002/ijc.10860 1:CAS:528:DC%2BD3sXmtFKntg%3D%3D 12494475 (Pubitemid 36091471)
6. G Zeng Z Hu MS Kinch, et al. 2003 High-level expression of EphA2 receptor tyrosine kinase in prostatic intraepithelial neoplasia Am J Pathol 163 2271 2276 1:CAS:528:DC%2BD2cXkslGm 14633601
7. MS Kinch MB Moore DH Harpole, et al. 2003 Predictive value of the EphA2 receptor tyrosine kinase in lung cancer recurrence and survival Clin Cancer Res 9 613 618 1:CAS:528:DC%2BD3sXhtVKks78%3D 12576426
8. L Han Z Dong Y Qiao, et al. 2005 The clinical significance of EphA2 and Ephrin A-1 in epithelial ovarian carcinomas Gynecol Oncol 99 278 286 10.1016/j.ygyno.2005.06.036 1:CAS:528:DC%2BD2MXhtFKhsrfN 16061279 (Pubitemid 41502831)
9. S Abraham DW Knapp L Cheng, et al. 2006 Expression of EphA2 and Ephrin A-1 in carcinoma of the urinary bladder Clin Cancer Res 12 353 360 10.1158/1078-0432.CCR-05-1505 1:CAS:528:DC%2BD28XmtlGqug%3D%3D 16428472 (Pubitemid 43166121)
10. MJ Bussemakers A van Bokhoven SG Mees, et al. 1993 Molecular cloning and characterization of the human E-cadherin cDNA Mol Biol Rep 17 123 128 10.1007/BF00996219 1:CAS:528:DyaK3sXktVegur4%3D 8459805
11. M Takeichi 1993 Cadherins in cancer: implications for invasion and metastasis Curr Opin Cell Biol 5 806 811 10.1016/0955-0674(93)90029-P 1:CAS:528:DyaK2cXltFWmsQ%3D%3D 8240824
12. H Chen NE Paradies M Fedor-Chaiken, et al. 1997 E-cadherin mediates adhesion and suppresses cell motility via distinct mechanisms J Cell Sci 110 345 356 1:CAS:528:DyaK2sXhsFantbs%3D 9057087
13. RB Hazan R Qiao R Keren, et al. 2004 Cadherin switch in tumor progression Ann NY Acad Sci 1014 155 163 10.1196/annals.1294.016 1:CAS:528: DC%2BD2cXkvVehsbY%3D 15153430 (Pubitemid 38594801)
14. ND Zantek M Azimi M Fedor-Chaiken, et al. 1999 E-cadherin regulates the function of the EphA2 receptor tyrosine kinase Cell Growth Differ 10 629 638 1:CAS:528:DyaK1MXmtl2gs7g%3D 10511313
15. PH Thaker M Deavers J Celestino, et al. 2004 EphA2 expression is associated with aggressive features in ovarian carcinoma Clin Cancer Res 10 5145 5150 10.1158/1078-0432.CCR-03-0589 1:CAS:528:DC%2BD2cXmtlSitb0%3D 15297418 (Pubitemid 39099789)
16. YG Lin LY Han AA Kamat, et al. 2007 EphA2 overexpression is associated with angiogenesis in ovarian cancer Cancer 109 332 340 10.1002/cncr.22415 1:CAS:528:DC%2BD2sXhs1yrsLY%3D 17154180 (Pubitemid 46106248)
17. H Shiozaki H Tahara H Oka, et al. 1991 Expression of immunoreactive E-cadherin adhesion molecule in human cancer Am J Pathol 139 17 23 1:STN:280:DyaK3Mzgs12ktA%3D%3D 1713020
18. A Jawhari S Jordan S Poole, et al. 1997 Abnormal immunoreactivity of the E-cadherin-catenin complex in gastric carcinoma: relationship with patient survival Gastroenterology 112 46 54 10.1016/S0016-5085(97)70218-X 1:STN:280:DyaK2s7jt12rsQ%3D%3D 8978342
19. Y Zhou J Ran C Tang 2007 Effect of celecoxib on E-cadherin, VEGF, Microvessel density and apoptosis in gastric cancer Cancer Biol Ther 6 269 275 10.1158/1535-7163.MCT-06-0560 17224647 (Pubitemid 46206691)
20. Sobin LH, Wittekind CH (eds) (1997) TNM Classification of Malignant Tumors, 5th edn. Wiley, New York
21. K Ogawa R Pasqualini RA Lindberg, et al. 2000 The ephrin-A1 ligand and its receptor, EphA2, are expressed during tumor neovascularization Oncogene 19 6043 6052 10.1038/sj.onc.1204004 1:CAS:528:DC%2BD3MXhsFCrsw%3D%3D 11146556 (Pubitemid 32039378)
22. DP Zelinski ND Zantek JC Stewart, et al. 2001 EphA2 overexpression causes tumorigenesis of mammary epithelial cells Cancer Res 61 2301 2306 1:CAS:528:DC%2BD3MXit1Ogt7k%3D 11280802
23. WB Fang DM Brantley-Sieders MA Parker, et al. 2005 A kinase-dependent role for EphA2 receptor in promoting tumor growth and metastasis Oncogene 24 7859 7868 10.1038/sj.onc.1208937 1:CAS:528:DC%2BD2MXht1GisLrL 16103880 (Pubitemid 41715192)
24. C Lu MM Shahzad H Wang, et al. 2008 EphA2 overexpression promotes ovarian cancer growth Cancer Biol Ther 7 1 6 10.1158/1535-7163.MCT-07-0573
25. ND Zantek J Walker-Daniels J Stewart, et al. 2001 MCF-10A-NeoST: a new cell system for studying cell-ECM and cell-cell interactions in breast cancer Clin Cancer Res 7 3640 3648 1:CAS:528:DC%2BD3MXptFaisbo%3D 11705887
26. MS Kinch K Carles-Kinch 2003 Overexpression and functional alterations of the EphA2 tyrosine kinase in cancer Clin Exp Metastasis 20 59 68 10.1023/A:1022546620495 1:CAS:528:DC%2BD3sXhsVWitbw%3D 12650608 (Pubitemid 36308137)
27. KD Kikawa DR Vidale RL Van Etten, et al. 2002 Regulation of the EphA2 kinase by the low molecular weight tyrosine phosphatase induces transformation J Biol Chem 277 39274 39279 10.1074/jbc.M207127200 1:CAS:528:DC%2BD38XnvVeisbk%3D 12167657 (Pubitemid 35190898)
28. M Parri F Buricchi ML Taddei, et al. 2005 EphrinA1 repulsive response is regulated by an EphA2 tyrosine phosphatase J Biol Chem 280 34008 34018 10.1074/jbc.M502879200 1:CAS:528:DC%2BD2MXhtVKisbbJ 16051609 (Pubitemid 41443122)
29. HC Chen RY Chu PN Hsu, et al. 2003 Loss of E-cadherin expression correlates with poor differentiation and invasion into adjacent organs in gastric adenocarcinomas Cancer Lett 201 97 106 10.1016/j.canlet.2003.07.007 1:CAS:528:DC%2BD3sXot1OksLY%3D 14580691 (Pubitemid 37298002)
30. KH Lee SJ Shin KO Kim, et al. 2006 Relationship between E-cadherin, matrix metalloproteinase-7 gene expression and clinicopathological features in gastric carcinoma Oncol Rep 16 823 830 1:CAS:528:DC%2BD28XhtFSisr3F 16969501
31. PJ Guilford JB Hopkins WM Grady, et al. 1999 E-cadherin germline mutations define an inherited cancer syndrome dominated by diffuse gastric cancer Hum Mutat 14 249 255 10.1002/(SICI)1098-1004(1999)14:3<249::AID- HUMU8>3.0.CO;2-9 1:CAS:528:DyaK1MXmtFartbk%3D 10477433 (Pubitemid 29407266)
32. G Tamura J Yin S Wang, et al. 2000 E-Cadherin gene promoter hypermethylation in primary human gastric carcinomas J Natl Cancer Inst 92 569 573 10.1093/jnci/92.7.569 1:CAS:528:DC%2BD3cXivFWqtrw%3D 10749913
33. S Koizume K Tachibana T Sekiya, et al. 2002 Heterogeneity in the modification and involvement of chromatin components of the CpG island of the silenced human CDH1 gene in cancer cells Nucleic Acids Res 30 4770 4780 10.1093/nar/gkf593 1:CAS:528:DC%2BD38XosVSqsbk%3D 12409468
34. B Catimel M Layton N Church, et al. 2006 In situ phosphorylation of immobilized receptors on biosensor surfaces: application to E-cadherin/beta- catenin interactions Anal Biochem 357 277 288 10.1016/j.ab.2006.07.034 1:CAS:528:DC%2BD28XpvFemu70%3D 16945320 (Pubitemid 44415703)
35. V Noë B Fingleton K Jacobs, et al. 2001 Release of an invasion promoter E-cadherin fragment by matrilysin and stromelysin-1 J Cell Sci 114 111 118 11112695
36. J Rios-Doria KC Day R Kuefer, et al. 2003 The role of calpain in the proteolytic cleavage of E-cadherin in prostate and mammary epithelial cells J Biol Chem 278 1372 1379 10.1074/jbc.M208772200 1:CAS:528:DC%2BD3sXnvVal 12393869 (Pubitemid 36790823)
37. T Saito N Masuda T Miyazaki, et al. 2004 Expression of EphA2 and E-cadherin in colorectal cancer: correlation with cancer metastasis Oncol Rep 11 605 611 1:CAS:528:DC%2BD2cXitVartLk%3D 14767510
38. S Orsulic R Kemler 2000 Expression of Eph receptors and ephrins is differentially regulated by E-cadherin J Cell Sci 113 1793 1802 1:CAS:528:DC%2BD3cXjvFGlsLY%3D 10769210