메뉴 건너뛰기




Volumn 418, Issue 4, 2012, Pages 845-850

Cytokine-induced human islet cell death in vitro correlates with a persistently high phosphorylation of STAT-1, but not with NF-κB activation

Author keywords

Apoptosis; Cytokines; Human islets; NF B; Nitric oxide; STAT 1

Indexed keywords

AMINOGUANIDINE; GAMMA INTERFERON; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; NITRIC OXIDE; STAT1 PROTEIN; TRANSCRIPTION FACTOR RELA;

EID: 84857442051     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2012.01.130     Document Type: Article
Times cited : (10)

References (25)
  • 1
    • 0032932324 scopus 로고    scopus 로고
    • Beta-cell destruction in NOD mice correlates with Fas (CD95) expression on beta-cells and proinflammatory cytokine expression in islets
    • Suarez-Pinzon W., Sorensen O., Bleackley R.C., Elliott J.F., Rajotte R.V., Rabinovitch A. Beta-cell destruction in NOD mice correlates with Fas (CD95) expression on beta-cells and proinflammatory cytokine expression in islets. Diabetes 1999, 48:21-28.
    • (1999) Diabetes , vol.48 , pp. 21-28
    • Suarez-Pinzon, W.1    Sorensen, O.2    Bleackley, R.C.3    Elliott, J.F.4    Rajotte, R.V.5    Rabinovitch, A.6
  • 3
    • 0035668779 scopus 로고    scopus 로고
    • A choice of death-the signal-transduction of immune-mediated beta-cell apoptosis
    • Eizirik D., Mandrup-Poulsen T. A choice of death-the signal-transduction of immune-mediated beta-cell apoptosis. Diabetologia 2001, 44:2115-2133.
    • (2001) Diabetologia , vol.44 , pp. 2115-2133
    • Eizirik, D.1    Mandrup-Poulsen, T.2
  • 4
    • 43249096519 scopus 로고    scopus 로고
    • Mediators and mechanisms of pancreatic beta-cell death in type 1 diabetes
    • Pirot P., Cardozo A.K., Eizirik D.L. Mediators and mechanisms of pancreatic beta-cell death in type 1 diabetes. Arq. Bras. Endocrinol. Metab. 2008, 52:156-165.
    • (2008) Arq. Bras. Endocrinol. Metab. , vol.52 , pp. 156-165
    • Pirot, P.1    Cardozo, A.K.2    Eizirik, D.L.3
  • 6
    • 1642553460 scopus 로고    scopus 로고
    • To be or not to be: NF-κB is the answer - role of Rel/NF-κB in the regulation of apoptosis
    • Kucharczak J., Simmons M.J., Fan Y., Gélinas C. To be or not to be: NF-κB is the answer - role of Rel/NF-κB in the regulation of apoptosis. Oncogene 2003, 22:8961-8982.
    • (2003) Oncogene , vol.22 , pp. 8961-8982
    • Kucharczak, J.1    Simmons, M.J.2    Fan, Y.3    Gélinas, C.4
  • 8
    • 0030005411 scopus 로고    scopus 로고
    • The harmony of the spheres: inducible nitric oxide synthase and related genes in pancreatic beta cells
    • Eizirik D.L., Flodström M., Karlsen A.E., Welsh N. The harmony of the spheres: inducible nitric oxide synthase and related genes in pancreatic beta cells. Diabetologia 1996, 39:875-890.
    • (1996) Diabetologia , vol.39 , pp. 875-890
    • Eizirik, D.L.1    Flodström, M.2    Karlsen, A.E.3    Welsh, N.4
  • 10
    • 67349121629 scopus 로고    scopus 로고
    • Cytokine-mediated induction of anti-apoptotic genes that are linked to nuclear factor kappa-B (NF-kappaB) signalling in human islets and in a mouse beta cell line
    • Sarkar S.A., Kutlu B., Velmurugan K., Kizaka-Kondoh S., Lee S.E., Wong R., Valentine A., Davidson H.W., Hutton J.C., Pugazhenthi S. Cytokine-mediated induction of anti-apoptotic genes that are linked to nuclear factor kappa-B (NF-kappaB) signalling in human islets and in a mouse beta cell line. Diabetologia 2009, 52:1092-1101.
    • (2009) Diabetologia , vol.52 , pp. 1092-1101
    • Sarkar, S.A.1    Kutlu, B.2    Velmurugan, K.3    Kizaka-Kondoh, S.4    Lee, S.E.5    Wong, R.6    Valentine, A.7    Davidson, H.W.8    Hutton, J.C.9    Pugazhenthi, S.10
  • 11
    • 70350455734 scopus 로고    scopus 로고
    • Overexpression of the nuclear factor-kB subunit c-Rel protects against human islet cell death in vitro
    • Mokhtari D., Barbu A., Mehmeti I., Vercamer C., Welsh N. Overexpression of the nuclear factor-kB subunit c-Rel protects against human islet cell death in vitro. Am. J. Physiol. Endocrinol. Metab. 2009, 297:E1067-E1077.
    • (2009) Am. J. Physiol. Endocrinol. Metab. , vol.297
    • Mokhtari, D.1    Barbu, A.2    Mehmeti, I.3    Vercamer, C.4    Welsh, N.5
  • 12
    • 0029401861 scopus 로고
    • Differences in the expression of heat-shock proteins and antioxidant enzymes between isolated human and rodent pancreatic islets: implications for the pathogenesis of insulin-dependent diabetes mellitus
    • Welsh N., Margulis B., Borg L.A.H., Jernberg-Wiklund H., Saldeèn J., Andersson A., Pipeleers D.G., Hellerström C., Eizirik D.L. Differences in the expression of heat-shock proteins and antioxidant enzymes between isolated human and rodent pancreatic islets: implications for the pathogenesis of insulin-dependent diabetes mellitus. Mol. Med. 1995, 1:806-820.
    • (1995) Mol. Med. , vol.1 , pp. 806-820
    • Welsh, N.1    Margulis, B.2    Borg, L.A.H.3    Jernberg-Wiklund, H.4    Saldeèn, J.5    Andersson, A.6    Pipeleers, D.G.7    Hellerström, C.8    Eizirik, D.L.9
  • 14
    • 0025833992 scopus 로고
    • Interleukin-1b induced nitric oxide production in isolated rat pancreatic islets requires gene transcription and may lead to inhibition of the Krebs cycle enzyme aconitase
    • Welsh N., Eizirik D.L., Bendtzen K., Sandler S. Interleukin-1b induced nitric oxide production in isolated rat pancreatic islets requires gene transcription and may lead to inhibition of the Krebs cycle enzyme aconitase. Endocrinology 1991, 129:3167-3173.
    • (1991) Endocrinology , vol.129 , pp. 3167-3173
    • Welsh, N.1    Eizirik, D.L.2    Bendtzen, K.3    Sandler, S.4
  • 16
    • 33749992682 scopus 로고    scopus 로고
    • Cell cycle-dependent expression of cIAP2 at G2/M phase contributes to survival during mitotic cell cycle arrest
    • Jin H-S., Lee T.H. Cell cycle-dependent expression of cIAP2 at G2/M phase contributes to survival during mitotic cell cycle arrest. Biochem. J. 2006, 399:335-342.
    • (2006) Biochem. J. , vol.399 , pp. 335-342
    • Jin, H.-S.1    Lee, T.H.2
  • 17
    • 0028167680 scopus 로고
    • Interleukin-1b induced activation of NF-kB in insulin producing RINm5F cells is prevented by the protease inhibitor tosyl-lysine chloromethyl ketone
    • Saldeen J., Welsh N. Interleukin-1b induced activation of NF-kB in insulin producing RINm5F cells is prevented by the protease inhibitor tosyl-lysine chloromethyl ketone. Biochem. Biophys. Res. Commun. 1994, 203:149-155.
    • (1994) Biochem. Biophys. Res. Commun. , vol.203 , pp. 149-155
    • Saldeen, J.1    Welsh, N.2
  • 19
    • 0034070569 scopus 로고    scopus 로고
    • Selection of insulinoma cell lines with resistance to interleukin-1beta- and gamma-interferon-induced cytotoxicity
    • Chen G., Hohmeier H.E., Gasa R., Tran V.V., Newgard C.B. Selection of insulinoma cell lines with resistance to interleukin-1beta- and gamma-interferon-induced cytotoxicity. Diabetes 2000, 49:562-570.
    • (2000) Diabetes , vol.49 , pp. 562-570
    • Chen, G.1    Hohmeier, H.E.2    Gasa, R.3    Tran, V.V.4    Newgard, C.B.5
  • 20
    • 80052492726 scopus 로고    scopus 로고
    • Cytokine toxicity in insulin-producing cells is mediated by nitro-oxidative stress-induced hydroxyl radical formation in mitochondria
    • Gurgul-Convey E., Mehmeti I., Lortz S., Lenzen S. Cytokine toxicity in insulin-producing cells is mediated by nitro-oxidative stress-induced hydroxyl radical formation in mitochondria. J. Mol. Med. (Berl.) 2011, 89:785-798.
    • (2011) J. Mol. Med. (Berl.) , vol.89 , pp. 785-798
    • Gurgul-Convey, E.1    Mehmeti, I.2    Lortz, S.3    Lenzen, S.4
  • 22
    • 35648958721 scopus 로고    scopus 로고
    • IkappaB kinase beta phosphorylates the K63 deubiquitinase A20 to cause feedback inhibition of the NF-kappaB pathway
    • Hutti J.E., Turk B.E., Asara J.M., Ma A., Cantley L.C., Abbott D.W. IkappaB kinase beta phosphorylates the K63 deubiquitinase A20 to cause feedback inhibition of the NF-kappaB pathway. Mol. Cell. Biol. 2007, 27:7451-7461.
    • (2007) Mol. Cell. Biol. , vol.27 , pp. 7451-7461
    • Hutti, J.E.1    Turk, B.E.2    Asara, J.M.3    Ma, A.4    Cantley, L.C.5    Abbott, D.W.6
  • 24
    • 34547561721 scopus 로고    scopus 로고
    • Deletion of STAT-1 pancreatic islets protects against streptozotocin-induced diabetes and early graft failure but not against late rejection
    • Callewaert H.I., Gysemans C.A., Ladrière L., D'Hertog W., Hagenbrock J., Overbergh L., Eizirik D.L., Mathieu C. Deletion of STAT-1 pancreatic islets protects against streptozotocin-induced diabetes and early graft failure but not against late rejection. Diabetes 2007, 56:2169-2173.
    • (2007) Diabetes , vol.56 , pp. 2169-2173
    • Callewaert, H.I.1    Gysemans, C.A.2    Ladrière, L.3    D'Hertog, W.4    Hagenbrock, J.5    Overbergh, L.6    Eizirik, D.L.7    Mathieu, C.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.