Vitamin D and metabolic syndrome risk factors: Evidence and mechanisms

Critical Reviews in Food Science and Nutrition

Volumn 52, Issue 2, 2012, Pages 103-112

  Awad, Atif B ^a   Alappat, Lini ^a   Valerio, Michael ^a  

^a UNIVERSITY AT BUFFALO   (United States)

Author keywords

Cytokines; Diabetes; Hypertension; Inflammation; Metabolism; Obesity

Indexed keywords

CYTOKINES; DYSLIPIDEMIAS; ENVIRONMENTAL FACTORS; ESSENTIAL NUTRIENTS; FORTIFICATION LEVEL; HYPERTENSION; INFLAMMATION; METABOLIC SYNDROMES; NORTHERN HEMISPHERES; OBESITY; RISK FACTORS; SCIENTIFIC COMMUNITY; VITAMIN D SYNTHESIS; VITAMIN-D; WESTERN SOCIETIES;

DISEASES; MEDICAL PROBLEMS; METABOLISM; NUTRITION; PATHOLOGY; SOCIETIES AND INSTITUTIONS;

BIOSYNTHESIS;

VITAMIN D;

BLOOD; HUMAN; METABOLIC SYNDROME X; REVIEW; RISK FACTOR; VITAMIN D DEFICIENCY;

HUMANS; METABOLIC SYNDROME X; RISK FACTORS; VITAMIN D; VITAMIN D DEFICIENCY;

EID: 84857434456     PISSN: 10408398     EISSN: 15497852     Source Type: Journal    
DOI: 10.1080/10408391003785458     Document Type: Article

References (114)

1. Aasheim, E.T., Hofso, D., Hjelmesaeth, J., Birkeland, K.I., and Bohmer, T. (2008). Vitamin status in morbidly obese patients: a cross-sectional study. Am J Clin Nutr. 87: 362-369.
2. Alberti, K.G., Zimmet, P., and Shaw, J. (2005). The metabolic syndrome: A new worldwide definition. Lancet. 366: 1059-1062.
3. Alberti, K.G., Zimmet, P., and Shaw, J. (2006). Metabolic syndrome: A new world-wide definition. A Consensus Statement from the International Diabetes Federation. Diabet Med. 23: 469-480.
4. Alemzadeh, R., Kichler, J., Babar, G., and Calhoun, M. (2008).Hypovitaminosis D in obese children and adolescents: Relationship with adiposity, insulin sensitivity, ethnicity, and season. Metabolism. 57: 183-191.
5. Aloia, J.F., Patel, M., Dimaano, R., Li-Ng, M., Talwar, S.A., Mikhail, M., Pollack, S., and Yeh, J.K. (2008). Vitamin D intake to attain a desired serum 25-hydroxyvitamin D concentration. Am J Clin Nutr. 87: 1952-1958.
6. Armas, L.A., Huerter, C., and Heaney, R.P. (2008). Reply: A responsible approach to maintaining adequate serum vitamin D levels. J Am Acad Dermatol. 58,:516; author reply 516-517.
7. Arunabh, S., Pollack, S., Yeh, J., and Aloia, J.F. (2003). Body fat content and 25-hydroxyvitamin D levels in healthy women. J Clin Endocrinol Metab. 88: 157-161.
8. Atmani, H., Chappard, D., and Basle, M.F. (2003). Proliferation and differentiation of osteoblasts and adipocytes in rat bone marrow stromal cell cultures: Effects of dexamethasone and calcitriol. J Cell Biochem. 89: 364-372.
9. Ayesha, I., Bala, T.S., Reddy, C.V., and Raghuramulu, N. (2001). Vitamin D deficiency reduces insulin secretion and turnover in rats. Diabetes Nutr Metab. 14: 78-84.
10. Beer, T.M., Venner, P.M., Ryan, C.W., Petrylak, D.P., Chatta, G., Dean Ruether, J., Chi, K.N., Curd, J.G., and DeLoughery, T.G. (2006). High dose calcitriol may reduce thrombosis in cancer patients. Br J Haematol. 135: 392-394.
11. Bell, N.H., Epstein, S., Greene, A., Shary, J., Oexmann, M.J., and Shaw, S. (1985). Evidence for alteration of the vitamin D-endocrine system in obese subjects. J Clin Invest. 76: 370-373.
12. Bell, N.H., Shaw, S., and Turner, R.T. (1984). Evidence that 1,25- dihydroxyvitamin D3 inhibits the hepatic production of 25-hydroxyvitamin D in man. J Clin Invest. 74: 1540-1544.
13. Bellows, C.G., Wang, Y.H., Heersche, J.N., and Aubin, J.E. (1994). 1,25- dihydroxyvitamin D3 stimulates adipocyte differentiation in cultures of fetal rat calvaria cells: Comparisonwith the effects of dexamethasone. Endocrinology. 134: 2221-2229.
14. Bhalla, A.K., Amento, E.P., Serog, B., and Glimcher, L.H. (1984). 1,25- Dihydroxyvitamin D3 inhibits antigen-induced T cell activation. J Immunol. 133: 1748-1754.
15. Bolland, M.J., Grey, A.B., Ames, R.W., Horne, A.M., Gamble, G.D., and Reid, I.R. (2006). Fat mass is an important predictor of parathyroid hormone levels in postmenopausal women. Bone. 38: 317-321.
16. Boonstra, A., Barrat, F.J., Crain, C., Heath, V.L., Savelkoul, H.F., and O'Garra, A. (2001). 1alpha,25-Dihydroxyvitamin d3 has a direct effect on naiveCD4(+) T cells to enhance the development of Th2 cells. J Immunol. 167: 4974-4980.
17. Bourlon, P.M., Billaudel, B., and Faure-Dussert, A. (1999). Influence of vitamin D3 deficiency and 1,25 dihydroxyvitamin D3 on de novo insulin biosynthesis in the islets of the rat endocrine pancreas. J Endocrinol. 160: 87-95.
18. Bricker, L.A. and Greydanus, D.E. (2008). The metabolic syndrome: a gathering challenge in a time of abundance. Adolesc Med State Art Rev. 19: 475-497, 9.
19. Calle, C., Maestro, B., and Garcia-Arencibia, M. (2008). Genomic actions of 1,25-dihydroxyvitamin D3 on insulin receptor gene expression, insulin receptor number and insulin activity in the kidney, liver and adipose tissue of streptozotocin-induced diabetic rats. BMC Mol Biol. 9: 65.
20. Cantorna, M.T. (2008). Vitamin D and multiple sclerosis: An update. Nutr Rev. 66: S135-S138.
21. Cherniack, E.P., Levis, S. and Troen, B.R. (2008). Hypovitaminosis D: A widespread epidemic. Geriatrics. 63: 24-30.
22. Chiu, K.C., Chu, A., Go, V.L., and Saad, M.F. (2004). Hypovitaminosis D is associated with insulin resistance and beta cell dysfunction. Am J Clin Nutr. 79: 820-825.
23. Christakos, S., Dhawan, P., Benn, B., Porta, A., Hediger, M., Oh, G.T., Jeung, E.B., Zhong, Y., Ajibade, D., Dhawan, K., and Joshi, S. (2007). Vitamin D: Molecular mechanism of action. Ann N Y Acad Sci. 1116: 340-348.
24. Compston, J.E., Vedi, S., Ledger, J.E., Webb, A., Gazet, J.C., and Pilkington, T.R. (1981). Vitamin D status and bone histomorphometry in gross obesity. Am J Clin Nutr. 34: 2359-2363.
25. Deeb, K.K., Trump, D.L., and Johnson, C.S. (2007). Vitamin D signaling pathways in cancer: Potential for anticancer therapeutics. Nat Rev Cancer. 7: 684-700.
26. Do, J.E., Kwon, S.Y., Park, S., and Lee, E.S. (2008). Effects of vitamin D on expression of Toll-like receptors of monocytes from patients with Behcet's disease. Rheumatology (Oxford). 47: 840-848.
27. Eckel, R.H., Grundy, S.M., and Zimmet, P.Z. (2005). The metabolic syndrome. Lancet. 365: 1415-1428.
28. Fahrleitner, A., Dobnig, H., Obernosterer, A., Pilger, E., Leb, G., Weber, K., Kudlacek, S., and Obermayer-Pietsch, B.M. (2002). Vitamin D deficiency and secondary hyperparathyroidism are common complications in patients with peripheral arterial disease. J Gen Intern Med. 17: 663-669.
29. Ford, E.S., Ajani, U.A., McGuire, L.C., and Liu, S. (2005). Concentrations of serum vitamin D and the metabolic syndrome among U.S. adults. Diabetes Care. 28: 1228-1230.
30. Forman, J.P., Bischoff-Ferrari, H.A., Willett, W.C., Stampfer, M.J., and Curhan, G.C. (2005). Vitamin D intake and risk of incident hypertension: results from three large prospective cohort studies. Hypertension. 46: 676-682.
31. Forouhi, N.G., Luan, J., Cooper, A., Boucher, B.J., and Wareham, N.J. (2008). Baseline serum 25-hydroxy vitamin d is predictive of future glycemic status and insulin resistance: the Medical Research Council Ely Prospective Study 1990-2000. Diabetes. 57: 2619-2625.
32. Foss, Y.J. (2009). Vitamin D deficiency is the cause of common obesity. Med Hypotheses. 72: 314-321.
33. Gedik, O. and Akalin, S. (1986). Effects of vitamin D deficiency and repletion on insulin and glucagon secretion in man. Diabetologia. 29: 142-145.
34. Grundy, S.M., Cleeman, J.I., Daniels, S.R., Donato, K.A., Eckel, R.H., Franklin, B.A., Gordon, D.J., Krauss, R.M., Savage, P.J., Smith, S.C., Jr., Spertus, J.A., and Costa, F. (2005). Diagnosis and management of the metabolic syndrome: An American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement. Circulation. 112: 2735-2752.
35. Harris, S.S. and Dawson-Hughes, B. (2007). Reduced sun exposure does not explain the inverse association of 25-hydroxyvitamin D with percent body fat in older adults. J Clin Endocrinol Metab. 92: 3155-3157.
36. Heaney, R.P. (2008). Vitamin D: Criteria for safety and efficacy. Nutr Rev. 66: S178-181.
37. Hida, Y., Kawada, T., Kayahashi, S., Ishihara, T., and Fushiki, T. (1998). Counteraction of retinoic acid and 1,25-dihydroxyvitamin D3 on up-regulation of adipocyte differentiation with PPARgamma ligand, an antidiabetic thiazolidinedione, in 3T3-L1 cells. Life Sci. 62: PL205-PL211.
38. Holick, M.F., Chen, T.C., Lu, Z., and Sauter, E. (2007). Vitamin D and skin physiology: A D-lightful story. J Bone Miner Res. 22 Suppl 2: V28-V33.
39. Holick, M.F., Matsuoka, L.Y., and Wortsman, J. (1989). Age, vitamin D, and solar ultraviolet. Lancet. 2:1104-1105.
40. Hollis, B.W. (2008). Assessment of vitamin D status and definition of a normal circulating range of 25-hydroxyvitamin D. Curr Opin Endocrinol Diabetes Obes. 15: 489-494.
41. Huotari, A. and Herzig, K.-H. (2008). Vitamin D and living in northern latitudes-an endemic risk area for vitamin D deficiency. Int J Circumpolar Health. 67: 164-178.
42. Hypponen, E. and Power, C. (2006). Vitamin D status and glucose homeostasis in the 1958 British birth cohort: The role of obesity. Diabetes Care. 29: 2244-2246.
43. Inomata, S., Kadowaki, S., Yamatani, T., Fukase, M., and Fujita, T. (1986). Effect of 1 alpha (OH)-vitamin D3 on insulin secretion in diabetes mellitus. Bone Miner. 1: 187-192.
44. Isaia, G., Giorgino, R., and Adami, S. (2001). High prevalence of hypovitaminosis D in female type 2 diabetic population. Diabetes Care. 24: 1496.
45. Ismail, A. and Namala, R. (2000). Impaired glucose tolerance in vitamin D deficiency can be corrected by calcium. J Nutr Biochem. 11: 170-175.
46. Jelic, S. and Le Jemtel, T.H. (2008). Inflammation, oxidative stress, and the vascular endothelium in obstructive sleep apnea. Trends Cardiovasc Med. 18: 253-260.
47. Jones, G., Strugnell, S.A., and DeLuca, H.F. (1998). Current understanding of the molecular actions of vitamin D. Physiol Rev. 78: 1193-1231.
48. Jorde, R., Sundsfjord, J., Haug, E., and Bonaa, K.H. (2000). Relation between low calcium intake, parathyroid hormone, and blood pressure. Hypertension. 35: 1154-1159.
49. Jorde, R., Svartberg, J., and Sundsfjord, J. (2005). Serum parathyroid hormone as a predictor of increase in systolic blood pressure in men. J Hypertens. 23: 1639-1644.
50. Kadowaki, S. and Norman, A.W. (1984). Dietary vitamin D is essential for normal insulin secretion from the perfused rat pancreas. J Clin Invest. 73: 759-766.
51. Kamei, Y., Kawada, T., Kazuki, R., Ono, T., Kato, S., and Sugimoto, E. (1993). Vitamin D receptor gene expression is up-regulated by 1, 25- dihydroxyvitamin D3 in 3T3-L1 preadipocytes. Biochem Biophys Res Commun. 193: 948-955.
52. Kamycheva, E., Sundsfjord, J., and Jorde, R. (2004). Serum parathyroid hormone level is associated with body mass index. The 5th Tromso study. Eur J Endocrinol. 151: 167-172.
53. Karin, M. (2008). The IkappaB kinase: A bridge between inflammation and cancer. Cell Res. 18: 334-342.
54. Kendrick, J., Targher, G., Smits, G., and Chonchol, M. (2008). 25- Hydroxyvitamin D deficiency is independently associated with cardiovascular disease in the Third National Health and Nutrition Examination Survey. Atherosclerosis. 205: 255-260.
55. Knekt, P., Laaksonen, M., Mattila, C., Harkanen, T., Marniemi, J., Heliovaara, M., Rissanen, H., Montonen, J., and Reunanen, A. (2008). Serum vitamin D and subsequent occurrence of type 2 diabetes. Epidemiology. 19: 666-671.
56. Kong, J. and Li, Y.C. (2006). Molecular mechanism of 1,25-dihydroxyvitamin D3 inhibition of adipogenesis in 3T3-L1 cells. Am J Physiol Endocrinol Metab. 290: E916-E924.
57. Kong, J., Qiao, G., Zhang, Z., Liu, S.Q., and Li, Y.C. (2008). Targeted vitamin D receptor expression in juxtaglomerular cells suppresses renin expression independent of parathyroid hormone and calcium. Kidney Int. 74: 1577-1581.
58. Lanou, A.J. and Barnard, N.D. (2008). Dairy and weight loss hypothesis: An evaluation of the clinical trials. Nutr Rev. 66: 272-279.
59. Lawson, D.E., Douglas, J., Lean, M., and Sedrani, S. (1986). Estimation of vitamin D3 and 25-hydroxyvitamin D3 in muscle and adipose tissue of rats and man. Clin Chim Acta. 157: 175-181.
60. Lenoir, C., Dace, A., Martin, C., Bonne, J., Teboul, M., Planells, R., and Torresani, J. (1996). Calcitriol down-modulates the 3,5,3_ triiodothyronine (T3) receptors and affects, in a biphasic manner, the T3-dependent adipose differentiation of Ob 17 preadipocytes. Endocrinology. 137: 4268-4276.
61. Li, Y.C., Kong, J., Wei, M., Chen, Z.F., Liu, S.Q., and Cao, L.P. (2002). 1,25-Dihydroxyvitamin D(3) is a negative endocrine regulator of the reninangiotensin system. J Clin Invest. 110: 229-238.
62. Liel, Y., Ulmer, E., Shary, J., Hollis, B.W., and Bell, N.H. (1988). Low circulating vitamin D in obesity. Calcif Tissue Int. 43: 199-201.
63. Lin, S.H., Lin, Y.F., Lu, K.C., Diang, L.K., Chyr, S.H., Liao, W.K., and Shieh, S.D. (1994). Effects of intravenous calcitriol on lipid profiles and glucose tolerance in uraemic patients with secondary hyperparathyroidism. Clin Sci (Lond). 87: 533-538.
64. Liu, S., Song, Y., Ford, E.S., Manson, J.E., Buring, J.E., and Ridker, P.M. (2005). Dietary calcium, vitamin D, and the prevalence of metabolic syndrome in middle-aged and older U.S. women. Diabetes Care. 28: 2926-2932.
65. Looker, A.C. (2007). Do body fat and exercise modulate vitamin D status? Nutr Rev. 65: S124-S126.
66. Looker, A.C., Pfeiffer, C.M., Lacher, D.A., Schleicher, R.L., Picciano, M.F., and Yetley, E.A. (2008). Serum 25-hydroxyvitaminDstatus of the US population: 1988-1994 compared with 2000-2004. Am J Clin Nutr. 88: 1519-1527.
67. Lucas, J.A., Bolland, M.J., Grey, A.B., Ames, R.W., Mason, B.H., Horne, A.M., Gamble, G.D., and Reid, I.R. (2005). Determinants of vitamin D status in older women living in a subtropical climate. Osteoporos Int. 16: 1641-1648.
68. MacLean, H.J. and Freedman, M.S. (2009). Multiple sclerosis: Following clues from cause to cure. Lancet Neurol. 8: 6-8.
69. Maestro, B., Campion, J., Davila, N., and Calle, C. (2000). Stimulation by 1,25-dihydroxyvitamin D3 of insulin receptor expression and insulin responsiveness for glucose transport in U-937 human promonocytic cells. Endocr J. 47: 383-391.
70. Maestro, B., Molero, S., Bajo, S., Davila, N., and Calle, C. (2002). Transcriptional activation of the human insulin receptor gene by 1,25-dihydroxyvitamin D(3). Cell Biochem Funct. 20: 227-232.
71. Martini, L.A. and Wood, R.J. (2006). Vitamin D status and the metabolic syndrome. Nutr Rev. 64: 479-486.
72. Martins, D., Wolf, M., Pan, D., Zadshir, A., Tareen, N., Thadhani, R., Felsenfeld, A., Levine, B., Mehrotra, R., and Norris, K. (2007). Prevalence of cardiovascular risk factors and the serum levels of 25-hydroxyvitamin D in the United States: Data from the Third National Health and Nutrition Examination Survey. Arch Intern Med. 167: 1159-1165.
73. Mathieu, C., Gysemans, C., Giulietti, A., and Bouillon, R. (2005). Vitamin D and diabetes. Diabetologia. 48: 1247-1257.
74. Matsuzawa, Y. (2008). The role of fat topology in the risk of disease. Int J Obes (Lond). 32 Suppl 7: S83-S92.
75. Muller, K., Odum, N., and Bendtzen, K. (1993). 1,25-dihydroxyvitamin D3 selectively reduces interleukin-2 levels and proliferation of human T cell lines in vitro. Immunol Lett. 35: 177-182.
76. Muray, S., Parisi, E., Cardus, A., Craver, L., and Fernandez, E. (2003). Influence of vitamin D receptor gene polymorphisms and 25-hydroxyvitamin D on blood pressure in apparently healthy subjects. J Hypertens. 21: 2069-2075.
77. NCEP (2002). Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) Final Report. Circulation. 106: 3143-3421.
78. Norman, A.W., Frankel, J.B., Heldt, A.M., and Grodsky, G.M. (1980). Vitamin D deficiency inhibits pancreatic secretion of insulin. Science. 209: 823-825.
79. O'Rourke, R.W. (2009). Inflammation in obesity-related diseases. Surgery. 145: 255-259.
80. Obregon, M.J. (2008). Thyroid hormone and adipocyte differentiation. Thyroid. 18: 185-195.
81. Orwoll, E., Riddle, M., and Prince, M. (1994). Effects of vitamin D on insulin and glucagon secretion in non-insulin-dependent diabetes mellitus. Am J Clin Nutr. 59: 1083-1087.
82. Patel, S., Farragher, T., Berry, J., Bunn, D., Silman, A., and Symmons, D. (2007). Association between serum vitamin D metabolite levels and disease activity in patients with early inflammatory polyarthritis. Arthritis Rheum. 56: 2143-2149.
83. Pereira, M.A., Jacobs, D.R., Jr., Van Horn, L., Slattery, M.L., Kartashov, A.I., and Ludwig, D.S. (2002). Dairy consumption, obesity, and the insulin resistance syndrome in young adults: the CARDIA Study. JAMA. 287: 2081-2089.
84. Pittas, A.G., Lau, J., Hu, F.B., and Dawson-Hughes, B. (2007). The role of vitamin D and calcium in type 2 diabetes: A systematic review and metaanalysis. J Clin Endocrinol Metab. 92: 2017-2029.
85. Querfeld, U., Hoffmann, M.M., Klaus, G., Eifinger, F., Ackerschott, M., Michalk, D., and Kern, P.A. (1999). Antagonistic effects of vitamin D and parathyroid hormone on lipoprotein lipase in cultured adipocytes. J Am Soc Nephrol. 10: 2158-2164.
86. Rangwala, S.M. and Lazar, M.A. (2000). Transcriptional control of adipogenesis. Annu Rev Nutr. 0: 535-559.
87. Reis, J.P., von Muhlen, D., Kritz-Silverstein, D., Wingard, D.L., and Barrett- Connor, E. (2007).Vitamin D, parathyroid hormone levels, and the prevalence of metabolic syndrome in community-dwelling older adults. Diabetes Care. 30: 1549-1555.
88. Rigby, W.F., Stacy, T., and Fanger, M.W. (1984) Inhibition of T lymphocyte mitogenesis by 1,25-dihydroxyvitamin D3 (calcitriol). J Clin Invest. 74: 1451-1455.
89. Rosen, E.D. and Spiegelman, B.M. (2000). Molecular regulation of adipogenesis. Annu Rev Cell Dev Biol. 16: 145-171.
90. Rostand, S.G. (1997). Ultraviolet light may contribute to geographic and racial blood pressure differences. Hypertension. 30: 150-156.
91. Sato, M. and Hiragun, A. (1988). Demonstration of 1 alpha,25-dihydroxyvitamin D3 receptor-like molecule in ST 13 and 3T3 L1 preadipocytes and its inhibitory effects on preadipocyte differentiation. J Cell Physiol. 135: 545-550.
92. Scragg, R., Holdaway, I., Jackson, R., and Lim, T. (1992). Plasma 25-hydroxyvitamin D3 and its relation to physical activity and other heart disease risk factors in the general population. Ann Epidemiol. 2: 697-703.
93. Sneve, M., Figenschau, Y., and Jorde, R. (2008). Supplementation with cholecalciferol does not result in weight reduction in overweight and obese subjects. Eur J Endocrinol. 159: 675-684.
94. Snijder, M.B., Lips, P., Seidell, J.C., Visser, M., Deeg, D.J., Dekker, J.M., and van Dam, R.M. (2007). Vitamin D status and parathyroid hormone levels in relation to blood pressure: a population-based study in oldermen and women. J Intern Med. 261: 558-565.
95. Snijder, M.B., van Dam, R.M., Visser, M., Deeg, D.J., Dekker, J.M., Bouter, L.M., Seidell, J.C., and Lips, P. (2005). Adiposity in relation to vitamin D status and parathyroid hormone levels: A population-based study in older men and women. J Clin Endocrinol Metab. 90: 4119-4123.
96. Subramanian, S. and Chait, A. (2009). The effect of dietary cholesterol on macrophage accumulation in adipose tissue: Implications for systemic inflammation and atherosclerosis. Curr Opin Lipidol. 20: 39-44.
97. Tai, K., Need, A.G., Horowitz, M., and Chapman, I.M. (2008). Vitamin D, glucose, insulin, and insulin sensitivity. Nutrition. 24: 279-285.
98. Talmor, Y., Golan, E., Benchetrit, S., Bernheim, J., Klein, O., Green, J., and Rashid, G. (2008). Calcitriol blunts the deleterious impact of advanced glycation end products on endothelial cells. Am J Physiol Renal Physiol 294: F1059-F1064.
99. Talwar, S.A., Aloia, J.F., Pollack, S., and Yeh, J.K. (2007). Dose response to vitamin D supplementation among postmenopausal African American women. Am J Clin Nutr 86:1657-1662.
100. Trowman, R., Dumville, J.C., Hahn, S., and Torgerson, D.J. (2006).Asystematic review of the effects of calcium supplementation on body weight. Br J Nutr. 95: 1033-1038.
101. Tuohimaa, P., Tenkanen, L., Syvälä, H., Lumme, S., Hakulinen, T., Dillner, J., and Hakama, M. (2007). Interaction of factors related to the metabolic syndrome and vitaminDon risk of prostate cancer. Cancer Epidemiol Biomarkers Prev. 16: 302-307.
102. van Etten, E. and Mathieu, C. (2005). Immunoregulation by 1,25- dihydroxyvitamin D3: Basic concepts. J Steroid Biochem Mol Biol. 97: 93-101.
103. Vieth, R., Bischoff-Ferrari, H., Boucher, B.J., Dawson-Hughes, B., Garland, C.F., Heaney, R.P., Holick, M.F., Hollis, B.W., Lamberg-Allardt, C., McGrath, J.J., Norman, A.W., Scragg, R., Whiting, S.J., Willett, W.C., and Zittermann, A. (2007). The urgent need to recommend an intake of vitamin D that is effective. Am J Clin Nutr. 85: 649-650.
104. Vu, D., Ong, J.M., Clemens, T.L., and Kern, P.A. (1996). 1,25-Dihydroxyvitamin D induces lipoprotein lipase expression in 3T3-L1 cells in association with adipocyte differentiation. Endocrinology. 137: 1540-1544.
105. Wang, T.J., Pencina, M.J., Booth, S.L., Jacques, P.F., Ingelsson, E., Lanier, K., Benjamin, E.J., D'Agostino, R.B., Wolf, M. and Vasan, R.S. (2008). Vitamin D deficiency and risk of cardiovascular disease. Circulation. 117: 503-511.
106. Wolf, M., Shah, A., Gutierrez, O., Ankers, E., Monroy, M., Tamez, H., Steele, D., Chang, Y., Camargo, C.A., Jr., Tonelli, M., and Thadhani, R. (2007). Vitamin D levels and early mortality among incident hemodialysis patients. Kidney Int. 72: 1004-1013.
107. Wortsman, J., Matsuoka, L.Y., Chen, T.C., Lu, Z., and Holick, M.F. (2000). Decreased bioavailability of vitamin D in obesity. Am J Clin Nutr. 72: 690-693.
108. Yanoff, L.B., Parikh, S.J., Spitalnik, A., Denkinger, B., Sebring, N.G., Slaughter, P., McHugh, T., Remaley, A.T., and Yanovski, J.A. (2006). The prevalence of hypovitaminosis D and secondary hyperparathyroidism in obese Black Americans. Clin Endocrinol (Oxf). 64: 523-529.
109. Yetley, E. A. (2008). Assessing the vitamin D status of the US population. Am J Clin Nutr. 88: 558S-564S.
110. Zemel, M.B. (2004). Role of calcium and dairy products in energy partitioning and weight management. Am J Clin Nutr. 79: 907S-912S.
111. Zemel, M.B. and Miller, S.L. (2004). Dietary calcium and dairy modulation of adiposity and obesity risk. Nutr Rev. 62: 125-131.
112. Zhang, X., Li, Z., Liu, D., Xu, X., Shen, W., and Mei, Z. (2009). Effects of probucol on hepatic tumor necrosis factor-alpha, interleukin-6 and adiponectin receptor-2 expression in diabetic rats. J Gastroenterol Hepatol. 24: 1058-1063.
113. Zhou, C., Lu, F., Cao, K., Xu, D., Goltzman, D., and Miao, D. (2008). Calciumindependent and 1,25(OH)2D3-dependent regulation of the renin-angiotensin system in 1alpha-hydroxylase knockout mice. Kidney Int. 74: 170-179.
114. Zhuang, H., Lin, Y., and Yang, G. (2007). Effects of 1,25-dihydroxyvitamin D3 on proliferation and differentiation of porcine preadipocyte in vitro. Chem Biol Interact. 170: 114-123.