Hypovitaminosis D: A stealthy epidemic that requires treatment

Geriatrics

Volumn 63, Issue 4, 2008, Pages 24-30

  Cherniack, E Paul ^a,b   Levis, Silvina ^a,c   Troen, Bruce R ^a,c  

^a UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Hypovitaminosis D; Vitamin D insufficiency; Vitamin D supplementation

Indexed keywords

CALCIUM; COLECALCIFEROL; VITAMIN D; 25 HYDROXYVITAMIN D; 25-HYDROXYVITAMIN D; DRUG DERIVATIVE; VITAMIN;

ABSENCE OF SIDE EFFECTS; CANCER RISK; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; DIET THERAPY; DISEASE ASSOCIATION; DISEASE PREDISPOSITION; DISORDERS OF CARBOHYDRATE METABOLISM; DISORDERS OF LIPID AND LIPOPROTEIN METABOLISM; DRUG EFFICACY; ELDERLY CARE; HIP FRACTURE; HUMAN; META ANALYSIS; NUTRITIONAL DEFICIENCY; OSTEOPATHIC MEDICINE; OSTEOPOROSIS; PRACTICE GUIDELINE; PREVALENCE; QUALITY OF LIFE; RECOMMENDED DRUG DOSE; REVIEW; RISK REDUCTION; SYSTEMATIC REVIEW; VITAMIN D DEFICIENCY; VITAMIN DEFICIENCY; VITAMIN SUPPLEMENTATION; AGED; ARTICLE; BIOSYNTHESIS; BLOOD; FALLING; FRACTURE; INFLAMMATION; METABOLIC SYNDROME X; NEOPLASM; ULTRAVIOLET RADIATION;

ACCIDENTAL FALLS; AGED; CHOLECALCIFEROL; FRACTURES, BONE; HUMANS; INFLAMMATION; METABOLIC SYNDROME X; NEOPLASMS; OSTEOPOROSIS; ULTRAVIOLET RAYS; VITAMIN D; VITAMIN D DEFICIENCY; VITAMINS;

EID: 43149099671     PISSN: 0016867X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (63)

1. Holick MF. The vitamin D epidemic and its health consequences. J Nutr. 2005;135(11):2739S-2748S.
2. Hollis BW. Circulating 25-hydroxyvitamin D levels indicative of vitamin D sufficiency: implications for establishing a new effective dietary intake recommendation for vitamin D. J Nutr. 2005;135(2):317-322.
3. Matsuoka LY, Wortsman J, Hollis BW. Use of topical sunscreen for the evaluation of regional synthesis of vitamin D3. J Am Acad Dermatol. 1990;22(5 Pt 1):772-775.
4. Clemens TL, Adams JS, Henderson SL, Holick MF. Increased skin pigment reduces the capacity of skin to synthesize vitamin D3. Lancet. 1982;1(8263):74-76.
5. Matsuoka LY, Wortsman J, Haddad JG, Kolm P, Hollis BW. Racial pigmentation and the cutaneous synthesis of vitamin D. Arch Dermatol. 1991;127(4):536-538.
6. Holick MF, Siris ES, Binkley N, et al. Prevalence of Vitamin D inadequacy among postmenopausal North American women receiving osteoporosis therapy. J Clin Endocrinol Metab. 2005;90(6):3215-3224.
7. Heaney RP. The vitamin D requirement in health and disease. J Steroid Biochem Mol Biol. 2005;97(1-2):13-19.
8. Chapuy MC, Preziosi P, Maamer M, et al. Prevalence of vitamin D insufficiency in an adult normal population. Osteoporos Int. 1997;7(5):439-443.
9. Levis S, Gomez A, Jimenez C, et al. Vitamin D deficiency and seasonal variation in an adult South Florida population. J Clin Endocrinol Metab. 2005;90(3):1557-1562.
10. Meier C, Woitge HW, Witte K, Lemmer B, Seibel MJ. Supplementation with oral vitamin D3 and calcium during winter prevents seasonal bone loss: a randomized controlled open-label prospective trial. J Bone Miner Res. 2004;19(8):1221-1230.
11. Harris SS. Vitamin D and African Americans. J Nutr. 2006;136(4):1126-1129.
12. Parfitt AM. Osteomalacia and related disorders. In: Avioli LV, Krane SM, eds. METABOLIC BONE DISEASE AND CLINICALLY RELATED DISORDERS. 2nd ed. Philadelphia: WB Saunders; 1990:329-396.
13. Heaney RP. Lessons for nutritional science from vitamin D. Am J Clin Nutr. 1999;69(5):825-826.
14. Bischoff-Ferrari HA, Dawson-Hughes B, Willett WC, et al. Effect of vitamin D on falls: a meta-analysis. JAMA. 2004;291(16):1999-2006.
15. Larsen ER, Mosekilde L, Foldspang A. Vitamin D and calcium supplementation prevents severe falls in elderly community-dwelling women: a pragmatic population-based 3-year intervention study. Aging Clin Exp Res. 2005;17(2):125-132.
16. Wilkins CH, Birge SJ. Prevention of osteoporotic fractures in the elderly. Am J Med. 2005;118(11):1190-1195.
17. Dawson-Hughes B, Harris SS, Krall EA, Dallal GE. Effect of calcium and vitamin D supplementation on bone density in men and women 65 years of age or older. N Engl J Med. 1997;337(10):670-676.
18. Trivedi DP, Doll R, Khaw KT. Effect of four monthly oral vitamin D3 (cholecalciferol) supplementation on fractures and mortality in men and women living in the community: randomised double blind controlled trial. BMJ. 2003;326(7387):469.
19. Chapuy MC, Pamphile R, Paris E, et al. Combined calcium and vitamin D3 supplementation in elderly women: confirmation of reversal of secondary hyperparathyroidism and hip fracture risk: the Decalyos II study. Osteoporos Int. 2002;13(3):257-264.
20. Bischoff-Ferrari HA, Willett WC, Wong JB, Giovannucci E, Dietrich T, Dawson-Hughes B. Fracture prevention with vitamin D supplementation: a meta-analysis of randomized controlled trials. JAMA. 2005;293(18):2257- 2264.
21. Jackson RD, LaCroix AZ, Gass M, et al, for the Women's Health Initiative Investigators. Calcium plus vitamin D supplementation and the risk of fractures. N Engl J Med. 2006;354(7):669-683.
22. Bischoff-Ferrari HA, Dietrich T, Orav EJ, et al. Higher 25-hydroxyvitamin D concentrations are associated with better lower-extremity function in both active and inactive persons aged > or =60 y. Am J Clin Nutr. 2004;80(3):752-758.
23. Bischoff-Ferrari HA, Borchers M, Gudat F, Durmuller U, Stahelin HB, Dick W. Vitamin D receptor expression in human muscle tissue decreases with age. J Bone Miner Res. 2004;19(2):265-269.
24. Pfeifer M, Dobnig H, Begerow B, Suppan K. Effects of vitamin D and calcium supplementation on falls and parameters of muscle function - a prospective, randomized, double-blind, multi-center study. J Bone Miner Res. 2004;19(suppl 1):S58.
25. Kenny AM, Biskup B, Robbins B, Marcella G, Burleson JA. Effects of vitamin D supplementation on strength, physical function, and health perception in older, community-dwelling men. J Am Geriatr Soc. 2003;51(12):1762- 1767.
26. Latham NK, Anderson CS, Lee A, Bennett DA, Moseley A, Cameron ID, for the Fitness Collaborative Group. A randomized, controlled trial of quadriceps resistance exercise and vitamin D in frail older people: the Frailty Interventions Trial in Elderly Subjects (FITNESS). J Am Geriatr Soc. 2003;51(3):291-299.
27. Flicker L, MacInnis RJ, Stein MS, et al. Should older people in residential care receive vitamin D to prevent falls? Results of a randomized trial. J Am Geriatr Soc. 2005;53(11):1881-1888.
28. Dhesi JK, Jackson SH, Bearne LM, et al. Vitamin D supplementation improves neuromuscular function in older people who fall. Age Ageing. 2004;33(6):589-595.
29. Kwon J, Suzuki T, Yoshida H, Kim H, Yoshida Y, Iwasa H. Concomitant lower serum albumin and vitamin D levels are associated with decreased objective physical performance among Japanese community-dwelling elderly. Gerontology. 2007;53(5):322-328.
30. Wicherts IS, van Schoor NM, Boeke AJ, et al. Vitamin D status predicts physical performance and its decline in older persons. J Clin Endocrinol Metab. 2007;92(6):2058-2065.
31. Houston DK, Cesari M, Ferrucci L, et al. Association between vitamin D status and physical performance: the InCHIANTI study. J Gerontol A Biol Sci Med Sci. 2007;62(4):440-446.
32. Grant WB, Garland CF. The association of solar ultraviolet B (UVB) with reducing risk of cancer: multifactorial ecologic analysis of geographic variation in age-adjusted cancer mortality rates. Anticancer Res. 2006;26(4A):2687-2699.
33. Grant WB, Holick MF. Benefits and requirements of vitamin D for optimal health: a review. Altern Med Rev. 2005;10(2):94-111.
34. Garland CF, Garland FC, Gorham ED, et al. The role of vitamin D in cancer prevention. Am J Public Health. 2006;96(2):252-261.
35. Giovannucci E, Liu Y, Rimm EB, et al. Prospective study of predictors of vitamin D status and cancer incidence and mortality in men. J Natl Cancer Inst. 2006;98(7):451-459.
36. Lappe JM, Travers-Gustafson D, Davies KM, Recker RR, Heaney RP. Vitamin D and calcium supplementation reduces cancer risk: results of a randomized trial. Am J Clin Nutr. 2007;85(6):1586-1591.
37. Ford ES, Ajani UA, McGuire LC, Liu S. Concentrations of serum vitamin D and the metabolic syndrome among U.S. adults. Diabetes Care. 2005;28(5):1228-1230.
38. Mathieu C, Gysemans C, Giulietti A, Bouillon R. Vitamin D and diabetes. Diabetologia. 2005;48(7):1247-1257.
39. Chiu KC, Chu A, Go VL, Saad MF. Hypovitaminosis D is associated with insulin resistance and beta cell dysfunction. Am J Clin Nutr. 2004;79(5):820-825.
40. Wortsman J, Matsuoka LY, Chen TC, Lu Z, Holick MF. Decreased bioavailability of vitamin D in obesity. Am J Clin Nutr. 2000;72(3):690-693.
41. Snijder MB, van Dam RM, Visser M, et al. Adiposity in relation to vitamin D status and parathyroid hormone levels: a population-based study in older men and women. J Clin Endocrinol Metab. 2005;90(7):4119-4123.
42. Luong KV, Nguyen LT. Vitamin D and cardiovascular disease. Curr Med Chem. 2006;13(20):2443-2447.
43. Harris SS. Vitamin D in type 1 diabetes prevention. J Nutr. 2005;135(2):323-325.
44. Visser M, Deeg DJ, Lips P. Low vitamin D and high parathyroid hormone levels as determinants of loss of muscle strength and muscle mass (sarcopenia): the Longitudinal Aging Study Amsterdam. J Clin Endocrinol Metab. 2003;88(12):5766-5772.
45. Visser M, Deeg DJ, Puts MT, Seidell JC, Lips P. Low serum concentrations of 25-hydroxyvitamin D in older persons and the risk of nursing home admission. Am J Clin Nutr. 2006;84(3):616-622.
46. Hayes CE, Nashold FE, Spach KM, Pedersen LB. The immunological functions of the vitamin D endocrine system. Cell Mol Biol (Noisy-le-grand). 2003;49(2):277-300.
47. Gombart AF, Borregaard N, Koeffler HP. Human cathelicidin antimicrobial peptide (CAMP) gene is a direct target of the vitamin D receptor and is strongly up-regulated in myeloid cells by 1,25-dihydroxyvitamin D3. Faseb J. 2005;19(9):1067-1077.
48. van Etten E, Mathieu C. Immunoregulation by 1,25-dihydroxyvitamin D3: basic concepts. J Steroid Biochem Mol Biol. 2005;97(1-2):93-101.
49. Cantorna MT. Vitamin D and its role in immunology: multiple sclerosis, and inflammatory bowel disease. Prog Biophys Mol Biol. 2006;92(1):60-64.
50. Grant WB, Gorham ED. Commentary: time for public health action on vitamin D for cancer risk reduction. Int J Epidemiol. 2006;35(2):224-225.
51. Agrawal S, Krueger DC, Engelke JA, et al. Between-meal risedronate does not alter bone turnover in nursing home residents. J Am Geriatr Soc. 2006;54(5):790-795.
52. Dawson-Hughes B, Heaney RP, Holick MF, Lips P, Meunier PJ, Vieth R. Estimates of optimal vitamin D status. Osteoporos Int. 2005;16(7):713-716.
53. Vieth R. Vitamin D supplementation, 25-hydroxyvitamin D concentrations, and safety. Am J Clin Nutr. 1999;69(5):842-856.
54. Bischoff-Ferrari HA, Dietrich T, Orav EJ, Dawson-Hughes B. Positive association between 25-hydroxy vitamin D levels and bone mineral density: a population-based study of younger and older adults. Am J Med. 2004;116(9):634-639.
55. Haddad JG, Chyu KJ. Competitive protein-binding radioassay for 25-hydroxycholecaliferol. J Clin Endocrinol Metab. 1971;33(6):992-995.
56. Ishijima M, Yamanaka M, Sakamoto Y, et al. Vitamin D insufficiency impairs the effect of alendronate for the treatment of osteoporosis in postmenopausal women. J Bone Miner Res. 2005;20(suppl 1):S296.
57. Ish-Shalom S, Salganik T, Segal E, Raz B, Bromberg I, Vieth R. Daily, weekly or monthly protocols to reach the desired serum 25-hydroxyvitamin D concentration for the elderly. J Bone Miner Res. 2005;20(suppl 1):S288.
58. Mocanu V, Stitt PA, Costan A, Zbranca E, Luca V, Vieth R. Safety and bone mineral density effects of bread fortified with 125 mcg vitamin D3/day in Romanian nursing-home residents. J Bone Miner Res. 2005;20(suppl 1):S288.
59. Florez HJ, Cherniack EP, Gómez-Marín O, Roos BA, Levis S, Troen BR. Age modifies the impact of vitamin D3 supplementation on the 25-OH vitamin D/ parathyroid hormone ratio. J Bone Miner Res. 2007;22(suppl 1):S208.
60. Armas LA, Hollis BW, Heaney RP. Vitamin D2 is much less effective than vitamin D3 in humans. J Clin Endocrinol Metab. 2004;89(11):5387-5391.
61. Houghton LA, Vieth R. The case against ergocalciferol (vitamin D2) as a vitamin supplement. Am J Clin Nutr. 2006;84(4):694-697.
62. Autier P, Gandini S. Vitamin D supplementation and total mortality: a meta-analysis of randomized controlled trials. Arch Intern Med. 2007;167(16):1730-1737.
63. Giovannucci E. Can vitamin D reduce total mortality? Arch Intern Med. 2007;167(16):1709-1710.