The novel indole compound SK228 induces apoptosis and FAK/Paxillin disruption in tumor cell lines and inhibits growth of tumor graft in the nude mouse

International Journal of Cancer

Volumn 131, Issue 3, 2012, Pages 722-732

  Huang, Sin Ming ^a,b   Hsu, Pei Chun ^b   Chen, Mei Yu ^b   Li, Wen Shan ^c   More, Shivaji V ^c   Lu, Kwok Tung ^a   Wang, Yi Ching ^b  

^a NATIONAL TAIWAN NORMAL UNIVERSITY   (Taiwan)

^b NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

^c INSTITUTE OF CHEMISTRY   (Taiwan)

Author keywords

apoptosis; DNA damage; indole; invasion; xenograft

Indexed keywords

1,4 BIS[DI(5 HYDROXY 1H INDOL 3 YL)METHYL]BENZENE; ANTINEOPLASTIC AGENT; CASPASE 3; CASPASE 8; CASPASE 9; CYTOCHROME C; DOXORUBICIN; FOCAL ADHESION KINASE; INDOLE DERIVATIVE; PAXILLIN; PROTEIN BCL 2; REACTIVE OXYGEN METABOLITE; SK 228; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CANCER INHIBITION; CANCER INVASION; CONTROLLED STUDY; CYTOSOL; DNA DAMAGE; DRUG CYTOTOXICITY; DRUG EFFICACY; DRUG MECHANISM; ENZYME ACTIVITY; ESOPHAGUS CARCINOMA; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; LUNG NON SMALL CELL CANCER; MITOCHONDRIAL MEMBRANE POTENTIAL; MOUSE; NICK END LABELING; NONHUMAN; NUDE MOUSE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN SECRETION; SIGNAL TRANSDUCTION; TUMOR CELL LINE; TUMOR XENOGRAFT; WESTERN BLOTTING;

ACTIN CYTOSKELETON; ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CASPASE 3; CASPASE 8; CASPASE 9; CELL LINE, TUMOR; CELL PROLIFERATION; CYTOCHROMES C; DNA DAMAGE; ESOPHAGEAL NEOPLASMS; FOCAL ADHESION PROTEIN-TYROSINE KINASES; HUMANS; INDOLES; LUNG NEOPLASMS; MICE; MICE, INBRED BALB C; MICE, NUDE; MITOCHONDRIA; NEOPLASM INVASIVENESS; NEOPLASMS, EXPERIMENTAL; PAXILLIN; PROTO-ONCOGENE PROTEINS C-BCL-2; REACTIVE OXYGEN SPECIES; RHOA GTP-BINDING PROTEIN; SIGNAL TRANSDUCTION; XENOGRAFT MODEL ANTITUMOR ASSAYS; XYLENES;

EID: 84857425346     PISSN: 00207136     EISSN: 10970215     Source Type: Journal    
DOI: 10.1002/ijc.26401     Document Type: Article

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