메뉴 건너뛰기




Volumn 55, Issue 1, 2003, Pages 57-103

Pharmacogenetics of anticancer drug sensitivity in non-small cell lung cancer

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; CARBOPLATIN; CETUXIMAB; CISPLATIN; CYCLIN DEPENDENT KINASE 2; CYCLOPHOSPHAMIDE; DNA TOPOISOMERASE INHIBITOR; DOCETAXEL; DOXORUBICIN; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIPODOPHYLLOTOXIN DERIVATIVE; ERLOTINIB; ETOPOSIDE; FOLIC ACID DERIVATIVE; FRAGILE HISTIDINE TRIAD PROTEIN; FTI 2148; FTI 2153; GEFITINIB; GEMCITABINE; HISTONE; IFOSFAMIDE; LONAFARNIB; MULTIDRUG RESISTANCE PROTEIN; NAVELBINE; PACLITAXEL; PEMETREXED; PLATINUM DERIVATIVE; PROTEIN BCL 2; PROTEIN FARNESYLTRANSFERASE INHIBITOR; PROTEIN P16; PROTEIN P53; PROTEOME; RECEPTOR BLOCKING AGENT; TAXANE DERIVATIVE; UNCLASSIFIED DRUG; UNINDEXED DRUG; VINCA ALKALOID;

EID: 0037371443     PISSN: 00316997     EISSN: None     Source Type: Journal    
DOI: 10.1124/pr.55.1.4     Document Type: Review
Times cited : (64)

References (327)
  • 2
    • 0029165313 scopus 로고
    • P-glycoprotein mediated resistance to 5′-noranhydro-vinblastine (Navelbine)
    • Adams DJ and Knick VC (1995) P-glycoprotein mediated resistance to 5′-noranhydro-vinblastine (Navelbine). Invest New Drugs 13:13-21.
    • (1995) Invest New Drugs , vol.13 , pp. 13-21
    • Adams, D.J.1    Knick, V.C.2
  • 3
    • 0034905234 scopus 로고    scopus 로고
    • Synergy of the protein farnesyltransferase inhibitor SCH66336 and cisplatin in human cancer cell lines
    • Adjei AA, Davis JN, Bruzek LM, Erlichman C, and Kaufmann SH (2001) Synergy of the protein farnesyltransferase inhibitor SCH66336 and cisplatin in human cancer cell lines. Clin Cancer Res 7:1438-1445.
    • (2001) Clin Cancer Res , vol.7 , pp. 1438-1445
    • Adjei, A.A.1    Davis, J.N.2    Bruzek, L.M.3    Erlichman, C.4    Kaufmann, S.H.5
  • 5
    • 0000808695 scopus 로고    scopus 로고
    • Cisplatin/gemcitabine (CG) vs. cisplatin/gemcitabine/vinorelbine (CGV) vs. sequential doublets of gemcitabine/vinorelbine followed by ifosfamide/vinorelbine (GV/IV) in advanced non-small cell lung cancer (NSCLC): Results of a Spanish Lung Cancer Group phase III trial (GEPC/98-02)
    • Alberola V, Camps C, Provencia M, Isla D, Rosell R, Vadell C, Bover I, Ruiz Casado A, Azagra P, Jiménez U, González-Larriba J, Cardenal F, Artal A, Carrato A, Morales S and Sanchez J (2001) Cisplatin/gemcitabine (CG) vs. cisplatin/gemcitabine/vinorelbine (CGV) vs. sequential doublets of gemcitabine/vinorelbine followed by ifosfamide/vinorelbine (GV/IV) in advanced non-small cell lung cancer (NSCLC): results of a Spanish Lung Cancer Group phase III trial (GEPC/98-02) (Abstract 1229). Proc Am Soc Clin Oncol 20:308a.
    • (2001) Proc Am Soc Clin Oncol , vol.20
    • Alberola, V.1    Camps, C.2    Provencia, M.3    Isla, D.4    Rosell, R.5    Vadell, C.6    Bover, I.7    Ruiz Casado, A.8    Azagra, P.9    Jiménez, U.10    González-Larriba, J.11    Cardenal, F.12    Artal, A.13    Carrato, A.14    Morales, S.15    Sanchez, J.16
  • 6
    • 0031724520 scopus 로고    scopus 로고
    • Using the National Cancer Institute anticancer drug screen to assess the effect of MRP expression on drug sensitivity profiles
    • Alvarez M, Robey R, Sandor V, Nishiyama K, Matsumoto Y, Paull K, Bates S, and Fojo T (1998) Using the National Cancer Institute anticancer drug screen to assess the effect of MRP expression on drug sensitivity profiles. Mol Pharmacol 54:802-814.
    • (1998) Mol Pharmacol , vol.54 , pp. 802-814
    • Alvarez, M.1    Robey, R.2    Sandor, V.3    Nishiyama, K.4    Matsumoto, Y.5    Paull, K.6    Bates, S.7    Fojo, T.8
  • 7
    • 0035089346 scopus 로고    scopus 로고
    • Function of the c-Myc oncoprotein in chromatin remodeling and transcription
    • Amati B, Frank SR, Donjerkovic D, and Taubert S (2001) Function of the c-Myc oncoprotein in chromatin remodeling and transcription. Biochim Biophys Acta 1471:M135-145.
    • (2001) Biochim Biophys Acta , vol.1471
    • Amati, B.1    Frank, S.R.2    Donjerkovic, D.3    Taubert, S.4
  • 8
    • 0030895921 scopus 로고    scopus 로고
    • A comparison of selected mRNA and protein abundances in human liver
    • Anderson L and Seilhamer J (1997) A comparison of selected mRNA and protein abundances in human liver. Electrophoresis 18:533-537.
    • (1997) Electrophoresis , vol.18 , pp. 533-537
    • Anderson, L.1    Seilhamer, J.2
  • 11
    • 0029086543 scopus 로고
    • The treatment of patients with recurrent brain metastases. A retrospective analysis of 109 patients with non-small cell lung cancer
    • Arbit E, Wronski M, Burt M, and Galicich JH (1995) The treatment of patients with recurrent brain metastases. A retrospective analysis of 109 patients with non-small cell lung cancer. Cancer 76:765-773.
    • (1995) Cancer , vol.76 , pp. 765-773
    • Arbit, E.1    Wronski, M.2    Burt, M.3    Galicich, J.H.4
  • 12
    • 0034819569 scopus 로고    scopus 로고
    • Dose and fractionation concepts in the primary radiotherapy of non-small cell lung cancer
    • Baumann M, Appold S, Petersen C, Zips D, and Herrmann T (2001) Dose and fractionation concepts in the primary radiotherapy of non-small cell lung cancer. Lung Cancer 33 (Suppl 1):S35-S45.
    • (2001) Lung Cancer , vol.33 , Issue.SUPPL. 1
    • Baumann, M.1    Appold, S.2    Petersen, C.3    Zips, D.4    Herrmann, T.5
  • 13
    • 0034176798 scopus 로고    scopus 로고
    • DNA hypermethylation in tumorigenesis: Epigenetics joins genetics
    • Baylin SB and Herman JG (2000) DNA hypermethylation in tumorigenesis: epigenetics joins genetics. Trends Genet 16:168-174.
    • (2000) Trends Genet , vol.16 , pp. 168-174
    • Baylin, S.B.1    Herman, J.G.2
  • 15
    • 0036078423 scopus 로고    scopus 로고
    • Cytotoxic activity of 2′, 2′-difluorodeoxycytidine, 5-aza-2′-deoxycytidine and cytosine arabinoside in cells transduced with deoxycytidine kinase gene
    • Beausejour CM, Gagnon J, Primeau M, and Momparler RL (2002) Cytotoxic activity of 2′, 2′-difluorodeoxycytidine, 5-aza-2′-deoxycytidine and cytosine arabinoside in cells transduced with deoxycytidine kinase gene. Biochem Biophys Res Commun 293:1478-484.
    • (2002) Biochem Biophys Res Commun , vol.293 , pp. 1478-1484
    • Beausejour, C.M.1    Gagnon, J.2    Primeau, M.3    Momparler, R.L.4
  • 17
    • 0030802692 scopus 로고    scopus 로고
    • Expression of the multidrug resistance-associated protein (MRP) and chemoresistance of human non-small-cell lung cancer cells
    • Berger W, Elbling L, Hauptmann E, and Micksche M (1997) Expression of the multidrug resistance-associated protein (MRP) and chemoresistance of human non-small-cell lung cancer cells. Int J Cancer 73:84-93.
    • (1997) Int J Cancer , vol.73 , pp. 84-93
    • Berger, W.1    Elbling, L.2    Hauptmann, E.3    Micksche, M.4
  • 18
    • 0033809069 scopus 로고    scopus 로고
    • Expression of the major vault protein LRP in human non-small-cell lung cancer cells: Activation by short-term exposure to antineoplastic drugs
    • Berger W, Elbling L, and Micksche M (2000) Expression of the major vault protein LRP in human non-small-cell lung cancer cells: activation by short-term exposure to antineoplastic drugs. Int J Cancer 88:293-300.
    • (2000) Int J Cancer , vol.88 , pp. 293-300
    • Berger, W.1    Elbling, L.2    Micksche, M.3
  • 19
    • 0035370527 scopus 로고    scopus 로고
    • Collateral sensitivity to gemcitabine (2′, 2′-difluorodeoxycytidine) and cytosine arabinoside of daunorubicin- and VM-26-resistant variants of human small cell lung cancer cell lines
    • Bergman AM, Munch-Petersen B, Jensen PB, Sehested M, Veerman G, Voorn DA, Smid K, Pinedo HM, and Peters GJ (2001a) Collateral sensitivity to gemcitabine (2′, 2′-difluorodeoxycytidine) and cytosine arabinoside of daunorubicin- and VM-26-resistant variants of human small cell lung cancer cell lines. Biochem Pharmacol 61:1401-1408.
    • (2001) Biochem Pharmacol , vol.61 , pp. 1401-1408
    • Bergman, A.M.1    Munch-Petersen, B.2    Jensen, P.B.3    Sehested, M.4    Veerman, G.5    Voorn, D.A.6    Smid, K.7    Pinedo, H.M.8    Peters, G.J.9
  • 20
    • 0035937555 scopus 로고    scopus 로고
    • Steroids affect collateral sensitivity to gemcitabine of multidrug-resistant human lung cancer cells
    • Bergman AM, Pinedo HM, and Peters GJ (2001b) Steroids affect collateral sensitivity to gemcitabine of multidrug-resistant human lung cancer cells. Eur J Pharmacol 416:19-24.
    • (2001) Eur J Pharmacol , vol.416 , pp. 19-24
    • Bergman, A.M.1    Pinedo, H.M.2    Peters, G.J.3
  • 21
    • 0013358535 scopus 로고    scopus 로고
    • Tumour suppressor genes and inheritance of cancer
    • Peters G and Vousden KH eds, IRL Press, Oxford
    • Black DM (1997) Tumour suppressor genes and inheritance of cancer, in Oncogenes and tumour suppressors (Peters G and Vousden KH eds) pp 293-313, IRL Press, Oxford.
    • (1997) Oncogenes and Tumour Suppressors , pp. 293-313
    • Black, D.M.1
  • 22
    • 0030785819 scopus 로고    scopus 로고
    • The extracellular fluid of solid carcinomas contains immunosuppressive concentrations of adenosine
    • Blay J, White TD, and Hoskin DW (1997) The extracellular fluid of solid carcinomas contains immunosuppressive concentrations of adenosine. Cancer Res 57:2602-2605.
    • (1997) Cancer Res , vol.57 , pp. 2602-2605
    • Blay, J.1    White, T.D.2    Hoskin, D.W.3
  • 23
    • 0033915743 scopus 로고    scopus 로고
    • Tumour necrosis factor-alpha and transforming growth factor-beta are significantly associated with better prognosis in non-small cell lung carcinoma: Putative relation with BCL-2-mediated neovascularization
    • Boldrini L, Calcinai A, Samaritani E, Pistolesi F, Mussi A, Lucchi M, Angeletti CA, Basolo F and Fontanini G (2000) Tumour necrosis factor-alpha and transforming growth factor-beta are significantly associated with better prognosis in non-small cell lung carcinoma: putative relation with BCL-2-mediated neovascularization. Br J Cancer 83:480-486.
    • (2000) Br J Cancer , vol.83 , pp. 480-486
    • Boldrini, L.1    Calcinai, A.2    Samaritani, E.3    Pistolesi, F.4    Mussi, A.5    Lucchi, M.6    Angeletti, C.A.7    Basolo, F.8    Fontanini, G.9
  • 24
    • 0035687676 scopus 로고    scopus 로고
    • Effects of proton and combined proton/photon beam radiation on pulmonary function in patients with resectable but medically inoperable non-small cell lung cancer
    • Bonnet RB, Bush D, Cheek GA, Slater JD, Panossian D, Franke C, and Slater JM (2001) Effects of proton and combined proton/photon beam radiation on pulmonary function in patients with resectable but medically inoperable non-small cell lung cancer. Chest 120:1803-1810.
    • (2001) Chest , vol.120 , pp. 1803-1810
    • Bonnet, R.B.1    Bush, D.2    Cheek, G.A.3    Slater, J.D.4    Panossian, D.5    Franke, C.6    Slater, J.M.7
  • 27
    • 0033781847 scopus 로고    scopus 로고
    • P21 gene expression as an indicator for the activity of adenovirus-p53 gene therapy in non-small cell lung cancer patients
    • Boulay JL, Perruchoud AP, Reuter J, Bolliger C, Herrmann R, and Rochlitz C (2000) P21 gene expression as an indicator for the activity of adenovirus-p53 gene therapy in non-small cell lung cancer patients. Cancer Gene Ther 7:1215-1219.
    • (2000) Cancer Gene Ther , vol.7 , pp. 1215-1219
    • Boulay, J.L.1    Perruchoud, A.P.2    Reuter, J.3    Bolliger, C.4    Herrmann, R.5    Rochlitz, C.6
  • 30
    • 0025907433 scopus 로고
    • Myc family DNA amplification in 107 tumors and tumor cell lines from patients with small cell lung cancer treated with different combination chemotherapy regimens
    • Brennan J, O'Connor T, Makuch RW, Simmons AM, Russell E, Linnoila RI, Phelps RM, Gazdar AF, Ihde DC, and Johnson BE (1991) Myc family DNA amplification in 107 tumors and tumor cell lines from patients with small cell lung cancer treated with different combination chemotherapy regimens. Cancer Res 51:1708-1712.
    • (1991) Cancer Res , vol.51 , pp. 1708-1712
    • Brennan, J.1    O'Connor, T.2    Makuch, R.W.3    Simmons, A.M.4    Russell, E.5    Linnoila, R.I.6    Phelps, R.M.7    Gazdar, A.F.8    Ihde, D.C.9    Johnson, B.E.10
  • 31
    • 0036534381 scopus 로고    scopus 로고
    • Trimodality treatment in Stage III non-small cell lung carcinoma: Prognostic impact of K-ras mutations after neoadjuvant therapy
    • Broermann P, Junker K, Brandt BH, Heinecke A, Freitag L, Klinke F, Berdel WE, and Thomas M (2002) Trimodality treatment in Stage III non-small cell lung carcinoma: prognostic impact of K-ras mutations after neoadjuvant therapy. Cancer 94:2055-2062.
    • (2002) Cancer , vol.94 , pp. 2055-2062
    • Broermann, P.1    Junker, K.2    Brandt, B.H.3    Heinecke, A.4    Freitag, L.5    Klinke, F.6    Berdel, W.E.7    Thomas, M.8
  • 32
    • 0035872199 scopus 로고    scopus 로고
    • Akt/protein kinase B is constitutively active in non-small cell lung cancer cells and promotes cellular survival and resistance to chemotherapy and radiation
    • Brognard J, Clark AS, Ni Y, and Dennis PA (2001) Akt/protein kinase B is constitutively active in non-small cell lung cancer cells and promotes cellular survival and resistance to chemotherapy and radiation. Cancer Res 61:3986-3997.
    • (2001) Cancer Res , vol.61 , pp. 3986-3997
    • Brognard, J.1    Clark, A.S.2    Ni, Y.3    Dennis, P.A.4
  • 33
    • 0034756278 scopus 로고    scopus 로고
    • Importance of weight loss definition in the prognostic evaluation of non-small-cell lung cancer
    • Buccheri G and Ferrigno D (2001) Importance of weight loss definition in the prognostic evaluation of non-small-cell lung cancer. Lung Cancer 34:433-440.
    • (2001) Lung Cancer , vol.34 , pp. 433-440
    • Buccheri, G.1    Ferrigno, D.2
  • 34
    • 0343238257 scopus 로고    scopus 로고
    • New therapeutic strategies for lung cancer. Biology and molecular biology come of age
    • Bunn PA Jr, Soriano A, Johnson G, and Heasley L (2000) New therapeutic strategies for lung cancer. Biology and molecular biology come of age. Chest 117:163S-168S.
    • (2000) Chest , vol.117
    • Bunn P.A., Jr.1    Soriano, A.2    Johnson, G.3    Heasley, L.4
  • 37
    • 0037066727 scopus 로고    scopus 로고
    • De novo ceramide regulates the alternative splicing of caspase 9 and Bcl-x in A549 lung adenocarcinoma cells. Dependence on protein phosphatase-1
    • Chalfant CE, Rathman K, Pinkerman RL, Wood RE, Obeid LM, Ogretmen B, and Hannun YA (2002) De novo ceramide regulates the alternative splicing of caspase 9 and Bcl-x in A549 lung adenocarcinoma cells. Dependence on protein phosphatase-1. J Biol Chem 277:12587-12595.
    • (2002) J Biol Chem , vol.277 , pp. 12587-12595
    • Chalfant, C.E.1    Rathman, K.2    Pinkerman, R.L.3    Wood, R.E.4    Obeid, L.M.5    Ogretmen, B.6    Hannun, Y.A.7
  • 38
    • 0034093597 scopus 로고    scopus 로고
    • Correlation of cisplatin sensitivity with differential alteration of EGFR expression in head and neck cancer cells
    • Chen Z, Ke LD, Yan XH, and Adler-Storthz K (2000) Correlation of cisplatin sensitivity with differential alteration of EGFR expression in head and neck cancer cells. Anticancer Res 20:899-902.
    • (2000) Anticancer Res , vol.20 , pp. 899-902
    • Chen, Z.1    Ke, L.D.2    Yan, X.H.3    Adler-Storthz, K.4
  • 40
    • 0034799139 scopus 로고    scopus 로고
    • A novel approach in the treatment of cancer: Targeting the epidermal growth factor receptor
    • Ciardiello F and Tortora G (2001) A novel approach in the treatment of cancer: targeting the epidermal growth factor receptor. Clin Cancer Res 7:2958-2970.
    • (2001) Clin Cancer Res , vol.7 , pp. 2958-2970
    • Ciardiello, F.1    Tortora, G.2
  • 41
    • 0035985288 scopus 로고    scopus 로고
    • Phase II trial of pemetrexed disodium (ALIMTA, LY231514) in chemotherapynaive patients with advanced non-small-cell lung cancer
    • Clarke SJ, Abratt R, Goedhals L, Boyer MJ, Millward MJ, and Ackland SP (2002) Phase II trial of pemetrexed disodium (ALIMTA, LY231514) in chemotherapynaive patients with advanced non-small-cell lung cancer. Ann Oncol 13:737-741.
    • (2002) Ann Oncol , vol.13 , pp. 737-741
    • Clarke, S.J.1    Abratt, R.2    Goedhals, L.3    Boyer, M.J.4    Millward, M.J.5    Ackland, S.P.6
  • 43
    • 0036293576 scopus 로고    scopus 로고
    • New treatment approaches for lung cancer and impact on survival
    • Cortes-Funes H (2002) New treatment approaches for lung cancer and impact on survival. Semin Oncol 29 (Suppl 8):26-29.
    • (2002) Semin Oncol , vol.29 , Issue.SUPPL. 8 , pp. 26-29
    • Cortes-Funes, H.1
  • 45
    • 0035874065 scopus 로고    scopus 로고
    • Herceptest: HER2 expression and gene amplification in non-small cell lung cancer
    • Cox G, Vyberg M, Melgaard B, Askaa J, Oster A, and O'Byrne KJ (2001) Herceptest: HER2 expression and gene amplification in non-small cell lung cancer. Int J Cancer 92:480-483.
    • (2001) Int J Cancer , vol.92 , pp. 480-483
    • Cox, G.1    Vyberg, M.2    Melgaard, B.3    Askaa, J.4    Oster, A.5    O'Byrne, K.J.6
  • 46
    • 0025924580 scopus 로고
    • N2 (clinical) non-small cell carcinoma of the lung: Prospective trials of radiation therapy with total doses 60 Gy by the radiation therapy oncology group
    • Cox JD, Azarnia N, Byhardt RW, Shin KH, Emami B, and Perez CA (1991) N2 (clinical) non-small cell carcinoma of the lung: prospective trials of radiation therapy with total doses 60 Gy by the radiation therapy oncology group. Int J Radiat Oncol Biol Phys 20:7-12.
    • (1991) Int J Radiat Oncol Biol Phys , vol.20 , pp. 7-12
    • Cox, J.D.1    Azarnia, N.2    Byhardt, R.W.3    Shin, K.H.4    Emami, B.5    Perez, C.A.6
  • 50
    • 0032969159 scopus 로고    scopus 로고
    • Methylation of selected CpGs in the human O6-methylguanine-DNA methyltransfe-rase promoter region as a marker of gene silencing
    • Danam RP, Qian XC, Howell SR, and Brent TP (1999) Methylation of selected CpGs in the human O6-methylguanine-DNA methyltransfe-rase promoter region as a marker of gene silencing. Mol Carcinog 24:85-89.
    • (1999) Mol Carcinog , vol.24 , pp. 85-89
    • Danam, R.P.1    Qian, X.C.2    Howell, S.R.3    Brent, T.P.4
  • 54
    • 0013357203 scopus 로고    scopus 로고
    • Pharmacogenetics of nucleoside metabolizing system in non small cell lung cancer: Implication for the chemotherapeutic efficacy of gemcitabine
    • De Braud F, Manzotti M, Fogli S, Danesi R, De Pas T, Giovannetti E, Viale G, and Del Tacca M (2001) Pharmacogenetics of nucleoside metabolizing system in non small cell lung cancer: implication for the chemotherapeutic efficacy of gemcitabine (Abstract 1433). Proc Am Assoc Cancer Res 42:265.
    • (2001) Proc Am Assoc Cancer Res , vol.42 , pp. 265
    • De Braud, F.1    Manzotti, M.2    Fogli, S.3    Danesi, R.4    De Pas, T.5    Giovannetti, E.6    Viale, G.7    Del Tacca, M.8
  • 56
    • 0035144916 scopus 로고    scopus 로고
    • Cisplatin and vinorelbine as second-line chemotherapy in patients with advanced non-small cell lung cancer (NSCLC) resistant to taxol plus gemcitabine
    • De Pas T, De Braud F, Mandalà M, Curigliano G, Catania C, Ferretti G, Sozzi P, Solli P and Goldhirsch A (2001) Cisplatin and vinorelbine as second-line chemotherapy in patients with advanced non-small cell lung cancer (NSCLC) resistant to taxol plus gemcitabine. Lung Cancer 31:267-270.
    • (2001) Lung Cancer , vol.31 , pp. 267-270
    • De Pas, T.1    De Braud, F.2    Mandalà, M.3    Curigliano, G.4    Catania, C.5    Ferretti, G.6    Sozzi, P.7    Solli, P.8    Goldhirsch, A.9
  • 57
    • 0033572577 scopus 로고    scopus 로고
    • DNA methylation analysis of the promoter region of the human telomerase reverse transcriptase (hTERT) gene
    • Devereux TR, Horikawa I, Anna CH, Annab LA, Afshari CA, and Barrett JC (1999) DNA methylation analysis of the promoter region of the human telomerase reverse transcriptase (hTERT) gene. Cancer Res 59:6087-6090.
    • (1999) Cancer Res , vol.59 , pp. 6087-6090
    • Devereux, T.R.1    Horikawa, I.2    Anna, C.H.3    Annab, L.A.4    Afshari, C.A.5    Barrett, J.C.6
  • 58
    • 0035364973 scopus 로고    scopus 로고
    • Inhibition of protein farnesylation enhances the chemotherapeutic efficacy of the novel geranylgeranyltransferase inhibitor BAL9611 in human colon cancer cells
    • Di Paolo A, Danesi R, Caputo S, Macchia M, Lastella M, Boggi U, Mosca F, Marchetti A, and Del Tacca M (2001) Inhibition of protein farnesylation enhances the chemotherapeutic efficacy of the novel geranylgeranyltransferase inhibitor BAL9611 in human colon cancer cells. Br J Cancer 84:1535-1543.
    • (2001) Br J Cancer , vol.84 , pp. 1535-1543
    • Di Paolo, A.1    Danesi, R.2    Caputo, S.3    Macchia, M.4    Lastella, M.5    Boggi, U.6    Mosca, F.7    Marchetti, A.8    Del Tacca, M.9
  • 61
    • 0032771490 scopus 로고    scopus 로고
    • Expression of DNA topoisomerase IIalpha and topoisomerase IIbeta genes predicts survival and response to chemotherapy in patients with small cell lung cancer
    • Dingemans AM, Witlox MA, Stallaert RA, van der Valk P, Postmus PE, and Giaccone G (1999) Expression of DNA topoisomerase IIalpha and topoisomerase IIbeta genes predicts survival and response to chemotherapy in patients with small cell lung cancer. Clin Cancer Res 5:2048-2058.
    • (1999) Clin Cancer Res , vol.5 , pp. 2048-2058
    • Dingemans, A.M.1    Witlox, M.A.2    Stallaert, R.A.3    Van der Valk, P.4    Postmus, P.E.5    Giaccone, G.6
  • 62
    • 0032924709 scopus 로고    scopus 로고
    • Bcl-2 expression in non-small cell lung cancers: Higher frequency of expression in squamous cell carcinomas with earlier pT status
    • Dosaka-Akita H, Katabami M, Hommura H, Fujioka Y, Katoh H, and Kawakami Y (1999) Bcl-2 expression in non-small cell lung cancers: higher frequency of expression in squamous cell carcinomas with earlier pT status. Oncology 56:259-264.
    • (1999) Oncology , vol.56 , pp. 259-264
    • Dosaka-Akita, H.1    Katabami, M.2    Hommura, H.3    Fujioka, Y.4    Katoh, H.5    Kawakami, Y.6
  • 63
    • 0034895749 scopus 로고    scopus 로고
    • Interactions of gemcitabine, carboplatin and paclitaxel in molecularly defined non-small cell lung cancer cell lines
    • Edelman MJ, Quam H, and Mullins B (2001) Interactions of gemcitabine, carboplatin and paclitaxel in molecularly defined non-small cell lung cancer cell lines. Cancer Chemother Pharmacol 48:141-144.
    • (2001) Cancer Chemother Pharmacol , vol.48 , pp. 141-144
    • Edelman, M.J.1    Quam, H.2    Mullins, B.3
  • 64
    • 0035937375 scopus 로고    scopus 로고
    • Development of pulmonary bronchiolo-alveolar adenocarcinomas in transgenic mice overexpressing murine c-myc and epidermal growth factor in alveolar type II pneumocytes
    • Ehrhardt A, Bartels T, Geick A, Klocke R, Paul D, and Halter R (2001) Development of pulmonary bronchiolo-alveolar adenocarcinomas in transgenic mice overexpressing murine c-myc and epidermal growth factor in alveolar type II pneumocytes. Br J Cancer 84:813-818.
    • (2001) Br J Cancer , vol.84 , pp. 813-818
    • Ehrhardt, A.1    Bartels, T.2    Geick, A.3    Klocke, R.4    Paul, D.5    Halter, R.6
  • 66
    • 0033557903 scopus 로고    scopus 로고
    • Inactivation of the DNA repair gene O6-methylguanine-DNA methyl-transferase by promoter hypermethylation is a common event in primary human neoplasia
    • Esteller M, Hamilton SR, Burger PC, Baylin SB, and Herman JG (1999a) Inactivation of the DNA repair gene O6-methylguanine-DNA methyl-transferase by promoter hypermethylation is a common event in primary human neoplasia. Cancer Res 59:793-797.
    • (1999) Cancer Res , vol.59 , pp. 793-797
    • Esteller, M.1    Hamilton, S.R.2    Burger, P.C.3    Baylin, S.B.4    Herman, J.G.5
  • 67
    • 0032894125 scopus 로고    scopus 로고
    • Detection of aberrant promoter hypermethylation of tumor-suppressor genes in serum DNA from non-small cell lung cancer patients
    • Esteller M, Sanchez-Cespedes M, Rosell R, Sidransky D, Baylin SB, and Herman JG (1999b) Detection of aberrant promoter hypermethylation of tumor-suppressor genes in serum DNA from non-small cell lung cancer patients. Cancer Res 59:67-70.
    • (1999) Cancer Res , vol.59 , pp. 67-70
    • Esteller, M.1    Sanchez-Cespedes, M.2    Rosell, R.3    Sidransky, D.4    Baylin, S.B.5    Herman, J.G.6
  • 68
    • 19244370208 scopus 로고    scopus 로고
    • Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation is associated with G to A mutations in K-ras in colorectal tumorigenesis
    • Esteller M, Toyota M, Sanchez-Cespedes M, Capella G, Peinado MA, Watkins DN, Issa JP, Sidransky D, Baylin SB and Herman JG (2000) Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation is associated with G to A mutations in K-ras in colorectal tumorigenesis. Cancer Res 60:2368-2371.
    • (2000) Cancer Res , vol.60 , pp. 2368-2371
    • Esteller, M.1    Toyota, M.2    Sanchez-Cespedes, M.3    Capella, G.4    Peinado, M.A.5    Watkins, D.N.6    Issa, J.P.7    Sidransky, D.8    Baylin, S.B.9    Herman, J.G.10
  • 69
    • 0033569516 scopus 로고    scopus 로고
    • Pharmacogenomics: Translating functional genomics into rational therapeutics
    • Evans WE and Relling MV (1999) Pharmacogenomics: translating functional genomics into rational therapeutics. Science (Wash DC) 286:487-491.
    • (1999) Science (Wash DC) , vol.286 , pp. 487-491
    • Evans, W.E.1    Relling, M.V.2
  • 71
    • 0036250226 scopus 로고    scopus 로고
    • Neoadjuvant chemotherapy in non-small cell lung cancer
    • Felip E and Rosell R (2002) Neoadjuvant chemotherapy in non-small cell lung cancer. Curr Med Chem 9:893-898.
    • (2002) Curr Med Chem , vol.9 , pp. 893-898
    • Felip, E.1    Rosell, R.2
  • 72
    • 0034671206 scopus 로고    scopus 로고
    • Chemotherapy triggers apoptosis in a caspase-8-dependent and mitochondria-controlled manner in the non-small cell lung cancer cell line NCI-H460
    • Ferreira CG, Span SW, Peters GJ, Kruyt FA, and Giaccone G (2000a) Chemotherapy triggers apoptosis in a caspase-8-dependent and mitochondria-controlled manner in the non-small cell lung cancer cell line NCI-H460. Cancer Res 60:7133-7141.
    • (2000) Cancer Res , vol.60 , pp. 7133-7141
    • Ferreira, C.G.1    Span, S.W.2    Peters, G.J.3    Kruyt, F.A.4    Giaccone, G.5
  • 75
    • 0036143667 scopus 로고    scopus 로고
    • Novel approaches to the treatment of non-small cell lung cancer
    • Ferreira CG, Huisman C, and Giaccone G (2002) Novel approaches to the treatment of non-small cell lung cancer. Critical Rev Oncol / Hematol 41:57-77.
    • (2002) Critical Rev Oncol/Hematol , vol.41 , pp. 57-77
    • Ferreira, C.G.1    Huisman, C.2    Giaccone, G.3
  • 77
    • 0029029933 scopus 로고
    • Loss of heterozygosity frequently affects chromosome 17q in non-small cell lung cancer
    • Fong KM, Kida Y, Zimmerman PV, Ikenaga M, and Smith PJ (1995a) Loss of heterozygosity frequently affects chromosome 17q in non-small cell lung cancer. Cancer Res 55:4268-4272.
    • (1995) Cancer Res , vol.55 , pp. 4268-4272
    • Fong, K.M.1    Kida, Y.2    Zimmerman, P.V.3    Ikenaga, M.4    Smith, P.J.5
  • 78
    • 0028834103 scopus 로고
    • Tumor progression and loss of heterozygosity at 5q and 18q in non-small cell lung cancer
    • Fong KM, Zimmerman PV, and Smith PJ (1995b) Tumor progression and loss of heterozygosity at 5q and 18q in non-small cell lung cancer. Cancer Res 55:220-223.
    • (1995) Cancer Res , vol.55 , pp. 220-223
    • Fong, K.M.1    Zimmerman, P.V.2    Smith, P.J.3
  • 81
    • 0033227089 scopus 로고    scopus 로고
    • Comprehensive analysis of p53 gene mutation characteristics in lung carcinoma with special reference to histological subtypes
    • Fujita T, Kiyama M, Tomizawa Y, Kohno T, and Yokota J (1999) Comprehensive analysis of p53 gene mutation characteristics in lung carcinoma with special reference to histological subtypes. Int J Oncol 15:927-934.
    • (1999) Int J Oncol , vol.15 , pp. 927-934
    • Fujita, T.1    Kiyama, M.2    Tomizawa, Y.3    Kohno, T.4    Yokota, J.5
  • 82
    • 0028231586 scopus 로고
    • Induction of chemosensitivity in human lung cancer cells in vivo by adenovirus-mediated transfer of the wild-type p53 gene
    • Fujiwara T, Grimm EA, Mukhopadhyay T, Zhang WW, Owen-Schaub LB, and Roth JA (1994) Induction of chemosensitivity in human lung cancer cells in vivo by adenovirus-mediated transfer of the wild-type p53 gene. Cancer Res 54:2287-2291.
    • (1994) Cancer Res , vol.54 , pp. 2287-2291
    • Fujiwara, T.1    Grimm, E.A.2    Mukhopadhyay, T.3    Zhang, W.W.4    Owen-Schaub, L.B.5    Roth, J.A.6
  • 87
    • 0032055635 scopus 로고    scopus 로고
    • Chromosomal alterations, biological features and in vitro chemosensitivity of SCLC-R1, a new cell line from human metastatic small cell lung carcinoma
    • Gasperi-Campani A, Roncuzzi L, Zoli W, Lenzi L, Gruppioni R, Sensi A, Zini N, Farabegoli F and Amadori D (1998) Chromosomal alterations, biological features and in vitro chemosensitivity of SCLC-R1, a new cell line from human metastatic small cell lung carcinoma. Eur J Cancer 34:724-730.
    • (1998) Eur J Cancer , vol.34 , pp. 724-730
    • Gasperi-Campani, A.1    Roncuzzi, L.2    Zoli, W.3    Lenzi, L.4    Gruppioni, R.5    Sensi, A.6    Zini, N.7    Farabegoli, F.8    Amadori, D.9
  • 88
    • 0032926002 scopus 로고    scopus 로고
    • Correlation of abnormal RB, p16ink4a, and p53 expression with 3p loss of heterozygosity, other genetic abnormalities and clinical features in 103 primary non-small cell lung cancers
    • Geradts J, Fong KM, Zimmerman PV, Maynard R, and Minna JD (1999) Correlation of abnormal RB, p16ink4a, and p53 expression with 3p loss of heterozygosity, other genetic abnormalities and clinical features in 103 primary non-small cell lung cancers. Clin Cancer Res 5:791-800.
    • (1999) Clin Cancer Res , vol.5 , pp. 791-800
    • Geradts, J.1    Fong, K.M.2    Zimmerman, P.V.3    Maynard, R.4    Minna, J.D.5
  • 89
    • 0034282535 scopus 로고    scopus 로고
    • Genome-wide allelotyping of lung cancer identifies new regions of allelic loss, differences between small cell lung cancer and non-small cell lung cancer and loci clustering
    • Girard L, Zochbauer-Muller S, Virmani AK, Gazdar AF, and Minna JD (2000) Genome-wide allelotyping of lung cancer identifies new regions of allelic loss, differences between small cell lung cancer and non-small cell lung cancer and loci clustering. Cancer Res 60:4894-4906.
    • (2000) Cancer Res , vol.60 , pp. 4894-4906
    • Girard, L.1    Zochbauer-Muller, S.2    Virmani, A.K.3    Gazdar, A.F.4    Minna, J.D.5
  • 94
    • 0035991754 scopus 로고    scopus 로고
    • Chemotherapy of non-small cell lung cancer in elderly patients
    • Gridelli C, Maione P, Colantuoni G, and Rossi A (2002) Chemotherapy of non-small cell lung cancer in elderly patients. Curr Med Chem 9:1487-1495.
    • (2002) Curr Med Chem , vol.9 , pp. 1487-1495
    • Gridelli, C.1    Maione, P.2    Colantuoni, G.3    Rossi, A.4
  • 96
    • 0031418312 scopus 로고    scopus 로고
    • Adenovirus-mediated delivery of p16 to pl6-deficient human bladder cancer cells confers chemoresistance to cisplatin and paclitaxel
    • Grim J, D'Amico A, Frizelle S, Zhou J, Kratzke RA, and Curiel DT (1997) Adenovirus-mediated delivery of p16 to pl6-deficient human bladder cancer cells confers chemoresistance to cisplatin and paclitaxel. Clin Cancer Res 3:2415-2423.
    • (1997) Clin Cancer Res , vol.3 , pp. 2415-2423
    • Grim, J.1    D'Amico, A.2    Frizelle, S.3    Zhou, J.4    Kratzke, R.A.5    Curiel, D.T.6
  • 97
    • 0002520189 scopus 로고    scopus 로고
    • Recombinant DNA and genetich techniques
    • Jameson JL ed, Humana Press, Totowa
    • Grompe M, Johnson W, and Jameson JL (1998) Recombinant DNA and genetich techniques, in Principles of Molecular Medicine (Jameson JL ed), pp 9 -24, Humana Press, Totowa.
    • (1998) Principles of Molecular Medicine , pp. 9-24
    • Grompe, M.1    Johnson, W.2    Jameson, J.L.3
  • 98
    • 0035196674 scopus 로고    scopus 로고
    • Combined modality treatment using concurrent radiotherapy and pharmacologically-guided carboplatin for inoperable and incompletely resected non-small cell lung cancer
    • Grossi M, Millward M, Fisher R, Porceddu S, Mac Manus M, Ryan G, Wirth A, and Ball D (2001) Combined modality treatment using concurrent radiotherapy and pharmacologically-guided carboplatin for inoperable and incompletely resected non-small cell lung cancer. Lung Cancer 31:73-82.
    • (2001) Lung Cancer , vol.31 , pp. 73-82
    • Grossi, M.1    Millward, M.2    Fisher, R.3    Porceddu, S.4    Mac Manus, M.5    Ryan, G.6    Wirth, A.7    Ball, D.8
  • 99
    • 0031035693 scopus 로고    scopus 로고
    • Bcl2 is the guardian of microtubule integrity
    • Haldar S, Basu A, and Croce CM (1997) Bcl2 is the guardian of microtubule integrity. Cancer Res 57:229-233.
    • (1997) Cancer Res , vol.57 , pp. 229-233
    • Haldar, S.1    Basu, A.2    Croce, C.M.3
  • 100
    • 0002608471 scopus 로고    scopus 로고
    • Growth factor receptors in cell transformation
    • Peters G and Vousden KH eds, IRL Press, Oxford
    • Heldin C-H and Rönnstrand L (1997) Growth factor receptors in cell transformation, in Oncogenes and tumour suppressors (Peters G and Vousden KH eds) pp 55-85, IRL Press, Oxford.
    • (1997) Oncogenes and Tumour Suppressors , pp. 55-85
    • Heldin, C.-H.1    Rönnstrand, L.2
  • 101
    • 0031750262 scopus 로고    scopus 로고
    • Immunohistochemical p53 protein status in nonsmall cell lung cancer is a promising indicator in determining in vitro chemosensitivity to some anticancer drugs
    • Higashiyama M, Kodama K, Yokouchi H, Takami K, Doi O, Kobayashi H, Tanisaka K and Minamigawa K (1998) Immunohistochemical p53 protein status in nonsmall cell lung cancer is a promising indicator in determining in vitro chemosensitivity to some anticancer drugs. J Surg Oncol 68:19-24.
    • (1998) J Surg Oncol , vol.68 , pp. 19-24
    • Higashiyama, M.1    Kodama, K.2    Yokouchi, H.3    Takami, K.4    Doi, O.5    Kobayashi, H.6    Tanisaka, K.7    Minamigawa, K.8
  • 104
    • 0030738095 scopus 로고    scopus 로고
    • Differential cytotoxicity of clinically important camptothecin derivatives in P-glycoprotein-overexpressing cell lines
    • Hoki Y, Fujimori A, and Pommier Y (1997) Differential cytotoxicity of clinically important camptothecin derivatives in P-glycoprotein-overexpressing cell lines. Cancer Chemother Pharmacol 40:433-438.
    • (1997) Cancer Chemother Pharmacol , vol.40 , pp. 433-438
    • Hoki, Y.1    Fujimori, A.2    Pommier, Y.3
  • 105
    • 0034085044 scopus 로고    scopus 로고
    • Synergistic effects of adenovirus expressing wild-type p53 on chemosensitivity of non-small cell lung cancer cells
    • Horio Y, Hasegawa Y, Sekido Y, Takahashi M, Roth JA, and Shimokata K (2000) Synergistic effects of adenovirus expressing wild-type p53 on chemosensitivity of non-small cell lung cancer cells. Cancer Gene Ther 7:537-544.
    • (2000) Cancer Gene Ther , vol.7 , pp. 537-544
    • Horio, Y.1    Hasegawa, Y.2    Sekido, Y.3    Takahashi, M.4    Roth, J.A.5    Shimokata, K.6
  • 106
    • 0029116438 scopus 로고
    • Efficacy of topoisomerase I inhibitors, topotecan and irinotecan, administered at low dose levels in protracted schedules to mice bearing xenografts of human tumors
    • Houghton PJ, Cheshire PJ, Hallman JD, Lutz L, Friedman HS, Danks MK and Houghton JA (1995) Efficacy of topoisomerase I inhibitors, topotecan and irinotecan, administered at low dose levels in protracted schedules to mice bearing xenografts of human tumors. Cancer Chemother Pharmacol 36:393-401.
    • (1995) Cancer Chemother Pharmacol , vol.36 , pp. 393-401
    • Houghton, P.J.1    Cheshire, P.J.2    Hallman, J.D.3    Lutz, L.4    Friedman, H.S.5    Danks, M.K.6    Houghton, J.A.7
  • 108
    • 0035489609 scopus 로고    scopus 로고
    • Proteomics for studying cancer cells and the development of chemoresistance
    • Hutter G and Sinha P (2001) Proteomics for studying cancer cells and the development of chemoresistance. Proteomics 1:1233-1248.
    • (2001) Proteomics , vol.1 , pp. 1233-1248
    • Hutter, G.1    Sinha, P.2
  • 109
    • 0002415762 scopus 로고    scopus 로고
    • Mechanisms of oncogene perturbation
    • Peters G and Vousden KH eds, IRL Press, Oxford
    • Imreh S, Szekely L, Wiman KG, and Klein G (1997) Mechanisms of oncogene perturbation, in Oncogenes and tumour suppressors (Peters G and Vousden KH eds) pp 3-32, IRL Press, Oxford.
    • (1997) Oncogenes and Tumour Suppressors , pp. 3-32
    • Imreh, S.1    Szekely, L.2    Wiman, K.G.3    Klein, G.4
  • 110
    • 0034739331 scopus 로고    scopus 로고
    • Administration of wild-type p53 adenoviral vector synergistically enhances the cytotoxicity of anti-cancer drugs in human lung cancer cells irrespective of the status of p53 gene
    • Inoue A, Narumi K, Matsubara N, Sugawara S, Saijo Y, Satoh K, and Nukiwa T (2000) Administration of wild-type p53 adenoviral vector synergistically enhances the cytotoxicity of anti-cancer drugs in human lung cancer cells irrespective of the status of p53 gene. Cancer Lett 157:105-112.
    • (2000) Cancer Lett , vol.157 , pp. 105-112
    • Inoue, A.1    Narumi, K.2    Matsubara, N.3    Sugawara, S.4    Saijo, Y.5    Satoh, K.6    Nukiwa, T.7
  • 111
    • 0036079692 scopus 로고    scopus 로고
    • The SELDI-TOF MS approach to proteomics: Protein profiling and biomarker identification
    • Issaq HJ, Veenstra TD, Conrads TP, and Felschow D (2002) The SELDI-TOF MS approach to proteomics: protein profiling and biomarker identification. Biochem Biophys Res Commun 292:587-592.
    • (2002) Biochem Biophys Res Commun , vol.292 , pp. 587-592
    • Issaq, H.J.1    Veenstra, T.D.2    Conrads, T.P.3    Felschow, D.4
  • 113
    • 0036716727 scopus 로고    scopus 로고
    • Radiotherapy alone in technically operable, medically inoperable, early-stage (I/II) non-small-cell lung cancer
    • Jeremic B, Classen J, and Bamberg M (2002) Radiotherapy alone in technically operable, medically inoperable, early-stage (I/II) non-small-cell lung cancer. Int J Radiation Oncology Biol Phys 54:119-130.
    • (2002) Int J Radiation Oncology Biol Phys , vol.54 , pp. 119-130
    • Jeremic, B.1    Classen, J.2    Bamberg, M.3
  • 114
    • 0035553086 scopus 로고    scopus 로고
    • Drug target pharmacogenomics
    • Johnson JA (2001) Drug target pharmacogenomics. Am J Pharmacogenomics 1:271-281.
    • (2001) Am J Pharmacogenomics , vol.1 , pp. 271-281
    • Johnson, J.A.1
  • 116
    • 0032530604 scopus 로고    scopus 로고
    • A phase II study of all-trans-retinoic acid plus cisplatin and etoposide in patients with extensive stage small cell lung carcinoma: An Eastern Cooperative Oncology Group Study
    • Kalemkerian GP, Jiroutek M, Ettinger DS, Dorighi JA, Johnson DH, and Mabry M (1998) A phase II study of all-trans-retinoic acid plus cisplatin and etoposide in patients with extensive stage small cell lung carcinoma: an Eastern Cooperative Oncology Group Study. Cancer 83:1102-1108.
    • (1998) Cancer , vol.83 , pp. 1102-1108
    • Kalemkerian, G.P.1    Jiroutek, M.2    Ettinger, D.S.3    Dorighi, J.A.4    Johnson, D.H.5    Mabry, M.6
  • 119
    • 0035137213 scopus 로고    scopus 로고
    • Paclitaxel-based chemotherapy for non-small cell lung cancer: Predicting the response with 99mTctetrofosmin chest imaging
    • Kao CH, Hsieh JF, Tsai SC, Ho YJ, Changlai SP, and Lee JK (2001) Paclitaxel-based chemotherapy for non-small cell lung cancer: predicting the response with 99mTctetrofosmin chest imaging. J Nucl Med 42:17-20.
    • (2001) J Nucl Med , vol.42 , pp. 17-20
    • Kao, C.H.1    Hsieh, J.F.2    Tsai, S.C.3    Ho, Y.J.4    Changlai, S.P.5    Lee, J.K.6
  • 120
    • 0029416848 scopus 로고
    • Effect of v-rasH on sensitivity of NCI-H82 human small cell lung cancer cells to cisplatin, etoposide and camptothecin
    • Kaufmann SH, Kalemkerian GP, Jasti R, and Mabry M (1995) Effect of v-rasH on sensitivity of NCI-H82 human small cell lung cancer cells to cisplatin, etoposide and camptothecin. Biochem Pharmacol 50:1987-1993.
    • (1995) Biochem Pharmacol , vol.50 , pp. 1987-1993
    • Kaufmann, S.H.1    Kalemkerian, G.P.2    Jasti, R.3    Mabry, M.4
  • 121
    • 0032904694 scopus 로고    scopus 로고
    • Antisense oligonucleotides to class III beta-tubulin sensitize drug-resistant cells to Taxol
    • Kavallaris M, Burkhart CA, and Horwitz SB (1999) Antisense oligonucleotides to class III beta-tubulin sensitize drug-resistant cells to Taxol. Br J Cancer 80:1020-1025.
    • (1999) Br J Cancer , vol.80 , pp. 1020-1025
    • Kavallaris, M.1    Burkhart, C.A.2    Horwitz, S.B.3
  • 123
    • 0032431970 scopus 로고    scopus 로고
    • Genetic instability of microsatellite sequences in non-small cell lung cancers
    • Kim CH, Yoo CG, Han SK, Shim YS, and Kim YW (1998a) Genetic instability of microsatellite sequences in non-small cell lung cancers. Lung Cancer 21:21-25.
    • (1998) Lung Cancer , vol.21 , pp. 21-25
    • Kim, C.H.1    Yoo, C.G.2    Han, S.K.3    Shim, Y.S.4    Kim, Y.W.5
  • 124
    • 0033864030 scopus 로고    scopus 로고
    • Microsatellite instability (MSI) in non-small cell lung cancer (NSCLC) is highly associated with transforming growth factor-beta type II receptor (TGF-βRII) frameshift mutation
    • Kim WS, Park C, Hong SK, Park BK, Kim HS, and Park K (2000) Microsatellite instability (MSI) in non-small cell lung cancer (NSCLC) is highly associated with transforming growth factor-beta type II receptor (TGF-βRII) frameshift mutation. Anticancer Res 20:1499-1502.
    • (2000) Anticancer Res , vol.20 , pp. 1499-1502
    • Kim, W.S.1    Park, C.2    Hong, S.K.3    Park, B.K.4    Kim, H.S.5    Park, K.6
  • 125
    • 0032430664 scopus 로고    scopus 로고
    • The interactive effect of Ras, HER2, P53 and Bcl-2 expression in predicting the survival of non-small cell lung cancer patients
    • Kim YC, Park KO, Kern JA, Park CS, Lim SC, Jang AS, and Yang JB (1998b) The interactive effect of Ras, HER2, P53 and Bcl-2 expression in predicting the survival of non-small cell lung cancer patients. Lung Cancer 22:181-190.
    • (1998) Lung Cancer , vol.22 , pp. 181-190
    • Kim, Y.C.1    Park, K.O.2    Kern, J.A.3    Park, C.S.4    Lim, S.C.5    Jang, A.S.6    Yang, J.B.7
  • 126
    • 0034663195 scopus 로고    scopus 로고
    • p53 mutations do not predict response to paclitaxel in metastatic non-small cell lung carcinoma
    • King TC, Akerley W, Fan AC, Moore T, Mangray S, Hsiu Chen M, and Safran H (2000) p53 mutations do not predict response to paclitaxel in metastatic non-small cell lung carcinoma. Cancer 89:769-773.
    • (2000) Cancer , vol.89 , pp. 769-773
    • King, T.C.1    Akerley, W.2    Fan, A.C.3    Moore, T.4    Mangray, S.5    Hsiu Chen, M.6    Safran, H.7
  • 127
    • 0032948876 scopus 로고    scopus 로고
    • Role of p53 and p16 gene alterations in determining response to concurrent paclitaxel and radiation in solid tumor
    • King TC, Estalilla OC, and Safran H (1999) Role of p53 and p16 gene alterations in determining response to concurrent paclitaxel and radiation in solid tumor. Semin Radiat Oncol 9 (Suppl 1):4-11.
    • (1999) Semin Radiat Oncol , vol.9 , Issue.SUPPL. 1 , pp. 4-11
    • King, T.C.1    Estalilla, O.C.2    Safran, H.3
  • 128
    • 0015043748 scopus 로고
    • Mutation and cancer: Statistical study of retinoblastoma
    • Knudson AG (1971) Mutation and cancer: statistical study of retinoblastoma. Proc Natl Acad Sci USA 68:820-823.
    • (1971) Proc Natl Acad Sci USA , vol.68 , pp. 820-823
    • Knudson, A.G.1
  • 129
    • 0032950037 scopus 로고    scopus 로고
    • p53 mutation and allelic loss of chromosome 3p, 9p of preneoplastic lesions in patients with non-small cell lung carcinoma
    • Kohno H, Hiroshima K, Toyozaki T, Fujisawa T, and Ohwada H (1999) p53 mutation and allelic loss of chromosome 3p, 9p of preneoplastic lesions in patients with non-small cell lung carcinoma. Cancer 85:341-347.
    • (1999) Cancer , vol.85 , pp. 341-347
    • Kohno, H.1    Hiroshima, K.2    Toyozaki, T.3    Fujisawa, T.4    Ohwada, H.5
  • 133
    • 0000109509 scopus 로고    scopus 로고
    • bcl-2 and c-erbB-2 proteins are involved in the regulation of VEGF and of thymidine phosphorylase angiogenic activity in non-small-cell lung cancer
    • Koukourakis MI, Giatromanolaki A, O'Byrne KJ, Cox J, Krammer B, Gatter KC, and Harris AL (1999) bcl-2 and c-erbB-2 proteins are involved in the regulation of VEGF and of thymidine phosphorylase angiogenic activity in non-small-cell lung cancer. Clin Exp Metastasis 17:545-554.
    • (1999) Clin Exp Metastasis , vol.17 , pp. 545-554
    • Koukourakis, M.I.1    Giatromanolaki, A.2    O'Byrne, K.J.3    Cox, J.4    Krammer, B.5    Gatter, K.C.6    Harris, A.L.7
  • 135
    • 0033673332 scopus 로고    scopus 로고
    • Proteomics approach in classifying the biochemical basis of the anticancer activity of the new olomoucine-derived synthetic cyclin-dependent kinase inhibitor, bohemine
    • Kovarova H, Hajduch M, Korinkova G, Halada P, Krupickova S, Gouldsworthy A, Zhelev N and Strnad M (2000) Proteomics approach in classifying the biochemical basis of the anticancer activity of the new olomoucine-derived synthetic cyclin-dependent kinase inhibitor, bohemine. Electrophoresis 21:3757-3764.
    • (2000) Electrophoresis , vol.21 , pp. 3757-3764
    • Kovarova, H.1    Hajduch, M.2    Korinkova, G.3    Halada, P.4    Krupickova, S.5    Gouldsworthy, A.6    Zhelev, N.7    Strnad, M.8
  • 136
    • 0031939190 scopus 로고    scopus 로고
    • Immunohistochemical detection of DNA topoisomerase IIalpha, P-glycoprotein and multidrug resistance protein (MRP) in small-cell and non-small-cell lung cancer
    • Kreisholt J, Sorensen M, Jensen PB, Nielsen BS, Andersen CB, and Sehested M (1998) Immunohistochemical detection of DNA topoisomerase IIalpha, P-glycoprotein and multidrug resistance protein (MRP) in small-cell and non-small-cell lung cancer. Br J Cancer 77:1469-1473.
    • (1998) Br J Cancer , vol.77 , pp. 1469-1473
    • Kreisholt, J.1    Sorensen, M.2    Jensen, P.B.3    Nielsen, B.S.4    Andersen, C.B.5    Sehested, M.6
  • 137
    • 0033778922 scopus 로고    scopus 로고
    • Sequence dependent effect of paclitaxel on gemcitabine metabolism in relation to cell cycle and cytotoxicity in non-small-cell lung cancer cell lines
    • Kroep JR, Giaccone G, Tolis C, Voorn DA, Loves WJ, Groeningen CJ, Pinedo HM, and Peters GJ (2000) Sequence dependent effect of paclitaxel on gemcitabine metabolism in relation to cell cycle and cytotoxicity in non-small-cell lung cancer cell lines. Br J Cancer 83:1069-1076.
    • (2000) Br J Cancer , vol.83 , pp. 1069-1076
    • Kroep, J.R.1    Giaccone, G.2    Tolis, C.3    Voorn, D.A.4    Loves, W.J.5    Groeningen, C.J.6    Pinedo, H.M.7    Peters, G.J.8
  • 138
    • 0035433015 scopus 로고    scopus 로고
    • Relations of the c-myc gene and chromosome 8 in non-small cell lung cancer: Analysis by fluorescence in situ hybridization
    • Kubokura H, Tenjin T, Akiyama H, Koizumi K, Nishimura H, Yamamoto M, and Tanaka S (2001) Relations of the c-myc gene and chromosome 8 in non-small cell lung cancer: analysis by fluorescence in situ hybridization. Ann Thorac Cardiovasc Surg 7:197-203.
    • (2001) Ann Thorac Cardiovasc Surg , vol.7 , pp. 197-203
    • Kubokura, H.1    Tenjin, T.2    Akiyama, H.3    Koizumi, K.4    Nishimura, H.5    Yamamoto, M.6    Tanaka, S.7
  • 139
    • 9344270526 scopus 로고    scopus 로고
    • Patterns of disease failure after trimodality therapy of non-small cell lung carcinoma pathologic stage IIIA (N2). Analysis of Cancer and Leukemia Group B Protocol 8935
    • Kumar P, Herndon J 2nd, Langer M, Kohman LJ, Elias AD, Kass FC, Eaton WL, Seagren SL, Green MR and Sugarbaker DJ (1996) Patterns of disease failure after trimodality therapy of non-small cell lung carcinoma pathologic stage IIIA (N2). Analysis of Cancer and Leukemia Group B Protocol 8935. Cancer 77:2393-2399.
    • (1996) Cancer , vol.77 , pp. 2393-2399
    • Kumar, P.1    Herndon J. II2    Langer, M.3    Kohman, L.J.4    Elias, A.D.5    Kass, F.C.6    Eaton, W.L.7    Seagren, S.L.8    Green, M.R.9    Sugarbaker, D.J.10
  • 141
    • 0002297938 scopus 로고    scopus 로고
    • The retinoblastoma gene product and its relatives
    • Peters G and Vousden KH eds, IRL Press, Oxford, UK
    • La Thangue NB (1997) The retinoblastoma gene product and its relatives, in Oncogenes and tumour suppressors (Peters G and Vousden KH eds) pp 233-259, IRL Press, Oxford, UK.
    • (1997) Oncogenes and Tumour Suppressors , pp. 233-259
    • La Thangue, N.B.1
  • 142
    • 0033957264 scopus 로고    scopus 로고
    • p53 gene status modulates the chemosensitivity of non-small cell lung cancer cells
    • Lai SL, Perng RP, and Hwang J (2000) p53 gene status modulates the chemosensitivity of non-small cell lung cancer cells. J Biomed Sci 7:64-70.
    • (2000) J Biomed Sci , vol.7 , pp. 64-70
    • Lai, S.L.1    Perng, R.P.2    Hwang, J.3
  • 143
    • 0035863292 scopus 로고    scopus 로고
    • Twice-weekly paclitaxel and weekly carboplatin with concurrent thoracic radiation followed by carboplatin/paclitaxel consolidation for stage III non-small-cell lung cancer: A California Cancer Consortium phase II trial
    • Lau D, Leigh B, Gandara D, Edelman M, Morgan R, Israel V, Lara P, Wilder R, Ryu J and Doroshow J (2001) Twice-weekly paclitaxel and weekly carboplatin with concurrent thoracic radiation followed by carboplatin/paclitaxel consolidation for stage III non-small-cell lung cancer: a California Cancer Consortium phase II trial. J Clin Oncol 19:442-447.
    • (2001) J Clin Oncol , vol.19 , pp. 442-447
    • Lau, D.1    Leigh, B.2    Gandara, D.3    Edelman, M.4    Morgan, R.5    Israel, V.6    Lara, P.7    Wilder, R.8    Ryu, J.9    Doroshow, J.10
  • 144
    • 0035019451 scopus 로고    scopus 로고
    • Prognostic significance of p53 and bcl-2 abnormalities in operable non-small cell lung cancer
    • Laudanski J, Niklinska W, Burzykowski T, Chyczewski L, and Niklinski J (2001) Prognostic significance of p53 and bcl-2 abnormalities in operable non-small cell lung cancer. Eur Respir J 17:660-666.
    • (2001) Eur Respir J , vol.17 , pp. 660-666
    • Laudanski, J.1    Niklinska, W.2    Burzykowski, T.3    Chyczewski, L.4    Niklinski, J.5
  • 146
    • 0032736229 scopus 로고    scopus 로고
    • Significance of P53 and Rb protein expression in surgically treated non-small cell lung cancers
    • Lee YC, Chang YL, Luh SP, Lee JM, and Chen JS (1999b) Significance of P53 and Rb protein expression in surgically treated non-small cell lung cancers. Ann Thorac Surg 68:343-347.
    • (1999) Ann Thorac Surg , vol.68 , pp. 343-347
    • Lee, Y.C.1    Chang, Y.L.2    Luh, S.P.3    Lee, J.M.4    Chen, J.S.5
  • 148
    • 0034093592 scopus 로고    scopus 로고
    • Induction of senescence-like phenotype and loss of paclitaxel sensitivity after wild-type p53 gene transfection of p53-null human non-small cell lung cancer H358 cells
    • Ling YH, Zou Y, and Perez-Soler R (2000) Induction of senescence-like phenotype and loss of paclitaxel sensitivity after wild-type p53 gene transfection of p53-null human non-small cell lung cancer H358 cells. Anticancer Res 20:693-702.
    • (2000) Anticancer Res , vol.20 , pp. 693-702
    • Ling, Y.H.1    Zou, Y.2    Perez-Soler, R.3
  • 150
    • 0035860969 scopus 로고    scopus 로고
    • Clinical proteomics - Personalized molecular medicine
    • Liotta LA, Kohn EC, and Petricoin EF (2001) Clinical proteomics - personalized molecular medicine. J Am Med Assoc 286:2211-2214.
    • (2001) J Am Med Assoc , vol.286 , pp. 2211-2214
    • Liotta, L.A.1    Kohn, E.C.2    Petricoin, E.F.3
  • 151
    • 0034105201 scopus 로고    scopus 로고
    • LRP-DIT, a putative endocytic receptor gene, is frequently inactivated in nonsmall cell lung cancer cell lines
    • Liu CX, Musco S, Lisitsina NM, Forgacs E, Minna JD, and Lisitsyn NA (2000) LRP-DIT, a putative endocytic receptor gene, is frequently inactivated in nonsmall cell lung cancer cell lines. Cancer Res 60:1961-1967.
    • (2000) Cancer Res , vol.60 , pp. 1961-1967
    • Liu, C.X.1    Musco, S.2    Lisitsina, N.M.3    Forgacs, E.4    Minna, J.D.5    Lisitsyn, N.A.6
  • 152
    • 0036206161 scopus 로고    scopus 로고
    • The importance of drug scheduling and recovery phases in determining drug activity. Improving etoposide efficacy in BCR-ABL-positive CML cells
    • Liu WM, Lawrence AJ, and Joel SP (2002) The importance of drug scheduling and recovery phases in determining drug activity. Improving etoposide efficacy in BCR-ABL-positive CML cells. Eur J Cancer 38:842-850.
    • (2002) Eur J Cancer , vol.38 , pp. 842-850
    • Liu, W.M.1    Lawrence, A.J.2    Joel, S.P.3
  • 153
    • 0028019398 scopus 로고
    • Microsatellite instability: Marker of a mutator phenotype in cancer
    • Loeb LA (1994) Microsatellite instability: marker of a mutator phenotype in cancer. Cancer Res 54:5059-5063.
    • (1994) Cancer Res , vol.54 , pp. 5059-5063
    • Loeb, L.A.1
  • 154
    • 0035900796 scopus 로고    scopus 로고
    • Pharmacogenetics of anticancer drugs in non-Hodgkin lymphomas
    • Loni L, Del Tacca M, and Danesi R (2001) Pharmacogenetics of anticancer drugs in non-Hodgkin lymphomas. Br J Cancer 85:1425-1431.
    • (2001) Br J Cancer , vol.85 , pp. 1425-1431
    • Loni, L.1    Del Tacca, M.2    Danesi, R.3
  • 158
    • 0034913052 scopus 로고    scopus 로고
    • Cryptophycin-induced hyperphosphorylation of Bcl-2, cell cycle arrest and growth inhibition in human H460 NSCLC cells
    • Lu K, Dempsey J, Schultz RM, Shih C, and Teicher BA (2001) Cryptophycin-induced hyperphosphorylation of Bcl-2, cell cycle arrest and growth inhibition in human H460 NSCLC cells. Cancer Chemother Pharmacol 47:170-178.
    • (2001) Cancer Chemother Pharmacol , vol.47 , pp. 170-178
    • Lu, K.1    Dempsey, J.2    Schultz, R.M.3    Shih, C.4    Teicher, B.A.5
  • 159
    • 0002254316 scopus 로고    scopus 로고
    • The RAS/RAF/ERK signal transduction pathway
    • Peters G and Vousden KH eds, IRL Press, Oxford
    • MacDonald SG and McCormick F (1997) The RAS/RAF/ERK signal transduction pathway, in Oncogenes and tumour suppressors (Peters G and Vousden KH eds) pp 121-153, IRL Press, Oxford.
    • (1997) Oncogenes and Tumour Suppressors , pp. 121-153
    • MacDonald, S.G.1    McCormick, F.2
  • 160
    • 0034755993 scopus 로고    scopus 로고
    • New drugs in the palliative chemotherapy of advanced non-small-cell lung cancer
    • Malayeri R, Pirker R, and Huber H (2001) New drugs in the palliative chemotherapy of advanced non-small-cell lung cancer. Onkologie 24:416-421.
    • (2001) Onkologie , vol.24 , pp. 416-421
    • Malayeri, R.1    Pirker, R.2    Huber, H.3
  • 161
    • 0035192268 scopus 로고    scopus 로고
    • Chemotherapy for advanced non-small cell lung cancer: Standards
    • Manegold C (2001) Chemotherapy for advanced non-small cell lung cancer: standards. Lung Cancer 34 (Suppl 2):S165-S170.
    • (2001) Lung Cancer , vol.34 , Issue.SUPPL. 2
    • Manegold, C.1
  • 162
    • 0034831375 scopus 로고    scopus 로고
    • Association of p53 gene mutation and telomerase activity in resectable non-small cell lung cancer
    • Maniwa Y, Yoshimura M, Obayashi C, Inaba M, Kiyooka K, Kanki M, and Okita Y (2001) Association of p53 gene mutation and telomerase activity in resectable non-small cell lung cancer. Chest 120:589-594.
    • (2001) Chest , vol.120 , pp. 589-594
    • Maniwa, Y.1    Yoshimura, M.2    Obayashi, C.3    Inaba, M.4    Kiyooka, K.5    Kanki, M.6    Okita, Y.7
  • 163
    • 0033503005 scopus 로고    scopus 로고
    • Clinical factors and prognosis in non-small cell lung cancer
    • Martins SJ and Pereira JR (1999) Clinical factors and prognosis in non-small cell lung cancer. Am J Clin Oncol 22:453-457.
    • (1999) Am J Clin Oncol , vol.22 , pp. 453-457
    • Martins, S.J.1    Pereira, J.R.2
  • 164
    • 0036253412 scopus 로고    scopus 로고
    • Characteristics of long-term survivors of untreated lung cancer
    • Mattern J, Koomagi R, and Volm M (2002) Characteristics of long-term survivors of untreated lung cancer. Lung Cancer 36:277-282.
    • (2002) Lung Cancer , vol.36 , pp. 277-282
    • Mattern, J.1    Koomagi, R.2    Volm, M.3
  • 165
    • 0027813132 scopus 로고
    • In vitro and in vivo effects of clinically important camptothecin analogues on multidrug-resistant cells
    • Mattern MR, Hofmann GA, Polsky RM, Funk LR, McCabe FL, and Johnson RK (1993) In vitro and in vivo effects of clinically important camptothecin analogues on multidrug-resistant cells. Oncol Res 5:467-474.
    • (1993) Oncol Res , vol.5 , pp. 467-474
    • Mattern, M.R.1    Hofmann, G.A.2    Polsky, R.M.3    Funk, L.R.4    McCabe, F.L.5    Johnson, R.K.6
  • 166
    • 0030941866 scopus 로고    scopus 로고
    • Frequent loss of heterozygosity in early non-small cell lung cancers at chromosome 9p21 proximal to the CDKN2a gene
    • Mead LJ, Gillespie MT, Hung JY, Rane US, Rayeroux KC, Irving LB, and Campbell LJ (1997) Frequent loss of heterozygosity in early non-small cell lung cancers at chromosome 9p21 proximal to the CDKN2a gene. Int J Cancer 71:213-217.
    • (1997) Int J Cancer , vol.71 , pp. 213-217
    • Mead, L.J.1    Gillespie, M.T.2    Hung, J.Y.3    Rane, U.S.4    Rayeroux, K.C.5    Irving, L.B.6    Campbell, L.J.7
  • 168
    • 0034824469 scopus 로고    scopus 로고
    • Correlation between c-erbB-4 receptor expression and response to gemcitabine-cisplatin chemotherapy in non-small-cell lung cancer
    • Merimsky O, Staroselsky A, Inbar M, Schwartz Y, Wigler N, Mann A, Marmor S, and Greif J (2001) Correlation between c-erbB-4 receptor expression and response to gemcitabine-cisplatin chemotherapy in non-small-cell lung cancer. Ann Oncol 12:1127-1131.
    • (2001) Ann Oncol , vol.12 , pp. 1127-1131
    • Merimsky, O.1    Staroselsky, A.2    Inbar, M.3    Schwartz, Y.4    Wigler, N.5    Mann, A.6    Marmor, S.7    Greif, J.8
  • 169
    • 0034062813 scopus 로고    scopus 로고
    • Phase II trial of docetaxel and vinorelbine in patients with advanced non-small-cell lung cancer
    • Miller VA, Krug LM, Ng KK, Pizzo B, Perez W, Heelan RT, and Kris MG (2000) Phase II trial of docetaxel and vinorelbine in patients with advanced non-small-cell lung cancer. J Clin Oncol 18:1346-1350.
    • (2000) J Clin Oncol , vol.18 , pp. 1346-1350
    • Miller, V.A.1    Krug, L.M.2    Ng, K.K.3    Pizzo, B.4    Perez, W.5    Heelan, R.T.6    Kris, M.G.7
  • 170
    • 0031913998 scopus 로고    scopus 로고
    • High susceptibility ofhuman cancer xenografts with higher levels of cytidine deaminase to a 2′-deoxycytidine antimetabolite, 2′-deoxy-2′-methylidenecytidine
    • Miwa M, Eda H, Ura M, Ouchi KF, Keith DD, Foley LH, and Ishitsuka H (1998) High susceptibility ofhuman cancer xenografts with higher levels of cytidine deaminase to a 2′-deoxycytidine antimetabolite, 2′-deoxy-2′-methylidenecytidine. Clin Cancer Res 4:493-497.
    • (1998) Clin Cancer Res , vol.4 , pp. 493-497
    • Miwa, M.1    Eda, H.2    Ura, M.3    Ouchi, K.F.4    Keith, D.D.5    Foley, L.H.6    Ishitsuka, H.7
  • 172
    • 0029789859 scopus 로고    scopus 로고
    • Effect of cisplatin exposure on the degree of N-myc amplification in small cell lung carcinoma cell lines with N-myc amplification
    • Mizushima Y, Kashii T, and Kobayashi M (1996) Effect of cisplatin exposure on the degree of N-myc amplification in small cell lung carcinoma cell lines with N-myc amplification. Oncology (Basel) 53:417-421.
    • (1996) Oncology (Basel) , vol.53 , pp. 417-421
    • Mizushima, Y.1    Kashii, T.2    Kobayashi, M.3
  • 175
    • 0032621404 scopus 로고    scopus 로고
    • The chemosensitizing potential of GF120918 is independent of the magnitude of P-glycoprotein-mediated resistance to conventional chemotherapeutic agents in a small cell lung cancer line
    • Myer MS, Joone G, Chasen MR, and van Rensburg CE (1999) The chemosensitizing potential of GF120918 is independent of the magnitude of P-glycoprotein-mediated resistance to conventional chemotherapeutic agents in a small cell lung cancer line. Oncol Rep 6:217-218.
    • (1999) Oncol Rep , vol.6 , pp. 217-218
    • Myer, M.S.1    Joone, G.2    Chasen, M.R.3    Van Rensburg, C.E.4
  • 176
    • 0035397916 scopus 로고    scopus 로고
    • Proteomics-post genomic cartography to understand gene function
    • Naaby-Hansen S, Waterfield MD, and Cramer R (2001) Proteomics-post genomic cartography to understand gene function. Trends Pharmacol Sci 22:376-384.
    • (2001) Trends Pharmacol Sci , vol.22 , pp. 376-384
    • Naaby-Hansen, S.1    Waterfield, M.D.2    Cramer, R.3
  • 180
    • 0035063183 scopus 로고    scopus 로고
    • The Rb/E2F pathway and cancer
    • Nevins JR (2001) The Rb/E2F pathway and cancer. Hum Mol Genet 10:699-703.
    • (2001) Hum Mol Genet , vol.10 , pp. 699-703
    • Nevins, J.R.1
  • 181
    • 0033046903 scopus 로고    scopus 로고
    • Altered expression of mRNAs for apoptosismodulating proteins in a low level multidrug resistant variant of a human lung carcinoma cell line that also expresses mdrl mRNA
    • NicAmhlaoibh R, Heenan M, Cleary I, Touhey S, O'Loughlin C, Daly C, Nunez G, Scanlon KJ and Clynes M (1999) Altered expression of mRNAs for apoptosismodulating proteins in a low level multidrug resistant variant of a human lung carcinoma cell line that also expresses mdrl mRNA. Int J Cancer 30:368-376.
    • (1999) Int J Cancer , vol.30 , pp. 368-376
    • NicAmhlaoibh, R.1    Heenan, M.2    Cleary, I.3    Touhey, S.4    O'Loughlin, C.5    Daly, C.6    Nunez, G.7    Scanlon, K.J.8    Clynes, M.9
  • 183
    • 0034986566 scopus 로고    scopus 로고
    • Molecular genetic abnormalities in premalignant lung lesions: Biological and clinical implications
    • Niklinski J, Niklinska W, Chyczewski L, Becker HD, and Pluygers E (2001) Molecular genetic abnormalities in premalignant lung lesions: biological and clinical implications. Eur J Cancer Prev 10:213-226.
    • (2001) Eur J Cancer Prev , vol.10 , pp. 213-226
    • Niklinski, J.1    Niklinska, W.2    Chyczewski, L.3    Becker, H.D.4    Pluygers, E.5
  • 185
    • 0034814353 scopus 로고    scopus 로고
    • Synergistic inhibition of human lung cancer cell growth by adenovirus-mediated wild-type p53 gene transfer in combination with docetaxel and radiation therapeutics in vitro and in vivo
    • Nishizaki M, Meyn RE, Levy LB, Atkinson EN, White RA, Roth JA, and Ji L (2001) Synergistic inhibition of human lung cancer cell growth by adenovirus-mediated wild-type p53 gene transfer in combination with docetaxel and radiation therapeutics in vitro and in vivo. Clin Cancer Res 7:2887-2897.
    • (2001) Clin Cancer Res , vol.7 , pp. 2887-2897
    • Nishizaki, M.1    Meyn, R.E.2    Levy, L.B.3    Atkinson, E.N.4    White, R.A.5    Roth, J.A.6    Ji, L.7
  • 187
    • 0028843552 scopus 로고
    • Chemotherapy in nonsmall cell lung cancer: A meta-analysis using updated data on individual patients from 52 randomised clinical trials
    • Non-Small Cell Lung Cancer Collaborative Group (1995) Chemotherapy in nonsmall cell lung cancer: a meta-analysis using updated data on individual patients from 52 randomised clinical trials. Br Med J 311:899-909.
    • (1995) Br Med J , vol.311 , pp. 899-909
  • 193
    • 0035890776 scopus 로고    scopus 로고
    • Heterogeneous transforming growth factor (TGF)-β unresponsiveness and loss of TGF-β receptor type II expression caused by histone deacetylation in lung cancer cell lines
    • Osada H, Tatematsu Y, Masuda A, Saito T, Sugiyama M, Yanagisawa K, and Takahashi T (2001) Heterogeneous transforming growth factor (TGF)-β unresponsiveness and loss of TGF-β receptor type II expression caused by histone deacetylation in lung cancer cell lines. Cancer Res 61:8331-8339.
    • (2001) Cancer Res , vol.61 , pp. 8331-8339
    • Osada, H.1    Tatematsu, Y.2    Masuda, A.3    Saito, T.4    Sugiyama, M.5    Yanagisawa, K.6    Takahashi, T.7
  • 194
    • 0034072882 scopus 로고    scopus 로고
    • Alteration of drug chemosensitivity caused by the adenovirus-mediated transfer of the wildtype p53 gene in human lung cancer cells
    • Osaki S, Nakanishi Y, Takayama K, Pei XH, Ueno H, and Hara N (2000) Alteration of drug chemosensitivity caused by the adenovirus-mediated transfer of the wildtype p53 gene in human lung cancer cells. Cancer Gene Ther 7:300-307.
    • (2000) Cancer Gene Ther , vol.7 , pp. 300-307
    • Osaki, S.1    Nakanishi, Y.2    Takayama, K.3    Pei, X.H.4    Ueno, H.5    Hara, N.6
  • 195
    • 0036645154 scopus 로고    scopus 로고
    • Prognostic impact of micrometastatic tumor cells in the lymph nodes and bone marrow of patients with completely resected stage I non-small-cell lung cancer
    • Osaki T, Oyama T, Gu CD, Yamashita T, So T, Takenoyama M, Sugio K, and Yasumoto K (2002) Prognostic impact of micrometastatic tumor cells in the lymph nodes and bone marrow of patients with completely resected stage I non-small-cell lung cancer. J Clin Oncol 20:2930-2936.
    • (2002) J Clin Oncol , vol.20 , pp. 2930-2936
    • Osaki, T.1    Oyama, T.2    Gu, C.D.3    Yamashita, T.4    So, T.5    Takenoyama, M.6    Sugio, K.7    Yasumoto, K.8
  • 198
    • 0029030143 scopus 로고
    • Prognostic factors for survival in advanced non-small-cell lung cancer: Univariate and multivariate analyses including recursive partitioning and amalgamation algorithms in 1, 052 patients
    • The European Lung Cancer Working Party
    • Paesmans M, Sculier JP, Libert P, Bureau G, Dabouis G, Thiriaux J, Michel J, Van Cutsem O, Sergysels R, Mommen P, and Klastersky J (1995) Prognostic factors for survival in advanced non-small-cell lung cancer: univariate and multivariate analyses including recursive partitioning and amalgamation algorithms in 1, 052 patients. The European Lung Cancer Working Party. J Clin Oncol 13:1221-1230.
    • (1995) J Clin Oncol , vol.13 , pp. 1221-1230
    • Paesmans, M.1    Sculier, J.P.2    Libert, P.3    Bureau, G.4    Dabouis, G.5    Thiriaux, J.6    Michel, J.7    Van Cutsem, O.8    Sergysels, R.9    Mommen, P.10    Klastersky, J.11
  • 199
    • 0029867674 scopus 로고    scopus 로고
    • Frequency and prognostic significance of isolated tumour cells in bone marrow of patients with non-small-cell lung cancer without overt metastases
    • Pantel K, Izbicki J, Passlick B, Angstwurm M, Haussinger K, Thetter O, and Riethmuller G (1996) Frequency and prognostic significance of isolated tumour cells in bone marrow of patients with non-small-cell lung cancer without overt metastases. Lancet 347:649-653.
    • (1996) Lancet , vol.347 , pp. 649-653
    • Pantel, K.1    Izbicki, J.2    Passlick, B.3    Angstwurm, M.4    Haussinger, K.5    Thetter, O.6    Riethmuller, G.7
  • 203
    • 0037199957 scopus 로고    scopus 로고
    • Induction of MUC2 and MUC5AC mucins by factors of the Epidermal Growth Factor (EGF) family is mediated by EGF reeeptor/Ras/Raf/extracellular signal-regulated kinase cascade and Sp1*
    • Perrais M, Pigny P, Copin MC, Aubert JP, and Van Seuningen I (2002) Induction of MUC2 and MUC5AC mucins by factors of the Epidermal Growth Factor (EGF) family is mediated by EGF reeeptor/Ras/Raf/extracellular signal-regulated kinase cascade and Sp1*. J Biol Chem 277:32258-32267.
    • (2002) J Biol Chem , vol.277 , pp. 32258-32267
    • Perrais, M.1    Pigny, P.2    Copin, M.C.3    Aubert, J.P.4    Van Seuningen, I.5
  • 205
    • 0002472622 scopus 로고    scopus 로고
    • Mammalian cell cycle control
    • Peters G and Vousden KH eds, IRL Press, Oxford
    • Pines J (1997) Mammalian cell cycle control, in Oncogenes and tumour suppressors (Peters G and Vousden KH eds) pp 189-232, IRL Press, Oxford.
    • (1997) Oncogenes and Tumour Suppressors , pp. 189-232
    • Pines, J.1
  • 208
    • 70449674065 scopus 로고    scopus 로고
    • Two-dimensional database of a Burkitt lymphoma cell line (DG 75) proteins: Protein pattern changes following treatment with 5′-azycytidine
    • Poirier F, Pontet M, Labas V, le Caer JP, Sghiouar-Imam N, Raphael M, Caron M, and Joubert-Caron R (2001) Two-dimensional database of a Burkitt lymphoma cell line (DG 75) proteins: protein pattern changes following treatment with 5′-azycytidine. Electrophoresis 22:1867-1877.
    • (2001) Electrophoresis , vol.22 , pp. 1867-1877
    • Poirier, F.1    Pontet, M.2    Labas, V.3    Le Caer, J.P.4    Sghiouar-Imam, N.5    Raphael, M.6    Caron, M.7    Joubert-Caron, R.8
  • 211
    • 0032566225 scopus 로고    scopus 로고
    • Postoperative radiotherapy in non-small cell lung cancer: Systematic review and meta-analysis of individual patient data from nine randomized controlled trials
    • PORT Meta-analysis Trialists Group (1998) Postoperative radiotherapy in non-small cell lung cancer: systematic review and meta-analysis of individual patient data from nine randomized controlled trials. Lancet 352:257-263.
    • (1998) Lancet , vol.352 , pp. 257-263
  • 212
    • 0036018909 scopus 로고    scopus 로고
    • Induction chemotherapy followed by concurrent chemotherapy and definitive high-dose radiotherapy for patients with locally advanced non-small-cell lung cancer (stages IIIa/IIIb:) a pilot phase I/II trial
    • Pottgen C, Eberhardt W, Bildat S, Stuben G, Stamatis G, Hillejan L, Sohrab S, Teschler H, Seeber S, Sack H, and Stuschke M (2002) Induction chemotherapy followed by concurrent chemotherapy and definitive high-dose radiotherapy for patients with locally advanced non-small-cell lung cancer (stages IIIa/IIIb:) a pilot phase I/II trial. Ann Oncol 13:403-411.
    • (2002) Ann Oncol , vol.13 , pp. 403-411
    • Pottgen, C.1    Eberhardt, W.2    Bildat, S.3    Stuben, G.4    Stamatis, G.5    Hillejan, L.6    Sohrab, S.7    Teschler, H.8    Seeber, S.9    Sack, H.10    Stuschke, M.11
  • 214
    • 1842371454 scopus 로고    scopus 로고
    • No evidence of microsatellite instability but frequent loss of heterozygosity in primary resected lung cancer
    • Pylkkanen L, Karjalainen A, Anttila S, Vainio H, and Husgafvel-Pursiainen K (1997) No evidence of microsatellite instability but frequent loss of heterozygosity in primary resected lung cancer. Environ Mol Mutagen 30:217-223.
    • (1997) Environ Mol Mutagen , vol.30 , pp. 217-223
    • Pylkkanen, L.1    Karjalainen, A.2    Anttila, S.3    Vainio, H.4    Husgafvel-Pursiainen, K.5
  • 215
    • 0030823671 scopus 로고    scopus 로고
    • Methylation hot spots in the 5′-flanking region denote silencing of the O6-methylguanine-DNA methyltrans-ferase gene
    • Qian XC and Brent TP (1997) Methylation hot spots in the 5′-flanking region denote silencing of the O6-methylguanine-DNA methyltrans-ferase gene. Cancer Res 57:3672-3677.
    • (1997) Cancer Res , vol.57 , pp. 3672-3677
    • Qian, X.C.1    Brent, T.P.2
  • 217
    • 0034523656 scopus 로고    scopus 로고
    • Ploidy, expression of erbB1, erbB2, P53 and amplification of erbB1, erbB2 and erbB3 in non-small cell lung cancer
    • Reinmuth N, Brandt B, Kunze WP, Junker K, Thomas M, Achatzy R, Scheld HH, and Semik M (2000) Ploidy, expression of erbB1, erbB2, P53 and amplification of erbB1, erbB2 and erbB3 in non-small cell lung cancer. Eur Respir J 16:991-996.
    • (2000) Eur Respir J , vol.16 , pp. 991-996
    • Reinmuth, N.1    Brandt, B.2    Kunze, W.P.3    Junker, K.4    Thomas, M.5    Achatzy, R.6    Scheld, H.H.7    Semik, M.8
  • 218
    • 0032928459 scopus 로고    scopus 로고
    • Amplification and overexpression of the cyclin D1 and epidermal growth factor receptor genes in non-small-cell lung cancer
    • Lung Cancer Study Group
    • Reissmann PT, Koga H, Figlin RA, Holmes EC, and Slamon DJ (1999) Amplification and overexpression of the cyclin D1 and epidermal growth factor receptor genes in non-small-cell lung cancer. Lung Cancer Study Group. J Cancer Res Clin Oncol 125:61-70.
    • (1999) J Cancer Res Clin Oncol , vol.125 , pp. 61-70
    • Reissmann, P.T.1    Koga, H.2    Figlin, R.A.3    Holmes, E.C.4    Slamon, D.J.5
  • 220
    • 0035195446 scopus 로고    scopus 로고
    • Induction chemotherapy with gemeitabine and cisplatin in stage III non-small cell lung cancer
    • Rinaldi M and Crinò L (2001) Induction chemotherapy with gemeitabine and cisplatin in stage III non-small cell lung cancer. Lung Cancer 34 (Suppl 4):S25-S30.
    • (2001) Lung Cancer , vol.34 , Issue.SUPPL. 4
    • Rinaldi, M.1    Crinò, L.2
  • 221
    • 0032190466 scopus 로고    scopus 로고
    • Chem synthesis and biological properties of novel fluorescent antifolates in Pgp- and MRP-overexpressing tumour cell lines
    • Robson C, Wright KA, Twentyman PR, Lambert PA, and Griffin RJ (1998) Chem synthesis and biological properties of novel fluorescent antifolates in Pgp- and MRP-overexpressing tumour cell lines. Biochem Pharmacol 56:807-816.
    • (1998) Biochem Pharmacol , vol.56 , pp. 807-816
    • Robson, C.1    Wright, K.A.2    Twentyman, P.R.3    Lambert, P.A.4    Griffin, R.J.5
  • 222
    • 0031023137 scopus 로고    scopus 로고
    • Mutational activation of the K-ras oncogene and the effect of chemotherapy in advanced adenocarcinoma of the lung: A prospective study
    • Rodenhuis S, Boerrigter L, Top B, Slebos RJ, Mooi WJ, van't Veer L and van Zandwijk N (1997) Mutational activation of the K-ras oncogene and the effect of chemotherapy in advanced adenocarcinoma of the lung: a prospective study. J Clin Oncol 15:285-291.
    • (1997) J Clin Oncol , vol.15 , pp. 285-291
    • Rodenhuis, S.1    Boerrigter, L.2    Top, B.3    Slebos, R.J.4    Mooi, W.J.5    Van't Veer, L.6    Van Zandwijk, N.7
  • 223
    • 0000012871 scopus 로고    scopus 로고
    • A multicenter, randomized phase III study of docetaxel + cisplatin (DC) and docetaxel + carboplatin (DCB)vs. vinorelbine + cisplatin (VC) in chemotherapy-naive patients with advanced and metastatic non-small cell lung cancer
    • Rodriguez J, Pawel J, Pluzanska A, Gorbounova V, Fossella F, Kaukel E, Mattson K, Millward M, Kim YS, Gamza F, Berille J and Belani CP (2001) A multicenter, randomized phase III study of docetaxel + cisplatin (DC) and docetaxel + carboplatin (DCB)vs. vinorelbine + cisplatin (VC) in chemotherapy-naive patients with advanced and metastatic non-small cell lung cancer (Abstract 1252). Proc Am Soc Clin Oncol 20:314a.
    • (2001) Proc Am Soc Clin Oncol , vol.20
    • Rodriguez, J.1    Pawel, J.2    Pluzanska, A.3    Gorbounova, V.4    Fossella, F.5    Kaukel, E.6    Mattson, K.7    Millward, M.8    Kim, Y.S.9    Gamza, F.10    Berille, J.11    Belani, C.P.12
  • 225
    • 0034786834 scopus 로고    scopus 로고
    • Predicting response to paclitaxel/carboplatin-based therapy in non-small cell lung cancer
    • Rosell R and Felip E (2001) Predicting response to paclitaxel/carboplatin-based therapy in non-small cell lung cancer. Semin Oncol 28 (Suppl 14):37-44.
    • (2001) Semin Oncol , vol.28 , Issue.SUPPL. 14 , pp. 37-44
    • Rosell, R.1    Felip, E.2
  • 227
    • 0035085972 scopus 로고    scopus 로고
    • Adv in the treatment of non-small cell lung cancer: Molecular markers take the stage
    • Rosell R, Green M, and Gumerlock P (2001) Adv in the treatment of non-small cell lung cancer: molecular markers take the stage. Semin Oncol 28 (Suppl 2):28-34.
    • (2001) Semin Oncol , vol.28 , Issue.SUPPL. 2 , pp. 28-34
    • Rosell, R.1    Green, M.2    Gumerlock, P.3
  • 231
    • 0034660560 scopus 로고    scopus 로고
    • Pharmacogenetics and the practice of medicine
    • Roses AD (2000) Pharmacogenetics and the practice of medicine. Nature (Lond) 405:857-865.
    • (2000) Nature (Lond) , vol.405 , pp. 857-865
    • Roses, A.D.1
  • 233
    • 0033212143 scopus 로고    scopus 로고
    • p53 tumor suppressor gene therapy for cancer
    • Roth JA, Swisher SG, and Meyn RE (1999) p53 tumor suppressor gene therapy for cancer. Oncology (Huntingt) 13 (Suppl 5):148-154.
    • (1999) Oncology (Huntingt) , vol.13 , Issue.SUPPL. 5 , pp. 148-154
    • Roth, J.A.1    Swisher, S.G.2    Meyn, R.E.3
  • 234
    • 0028840535 scopus 로고
    • Aberrant p53 expression predicts clinical resistance to cisplatin-based chemotherapy in locally advanced non-small cell lung cancer
    • Rusch V, Klimstra D, Venkatraman E, Oliver J, Martini N, Gralla R, Kris M, and Dmitrovsky E (1995) Aberrant p53 expression predicts clinical resistance to cisplatin-based chemotherapy in locally advanced non-small cell lung cancer. Cancer Res 55:5038-5042.
    • (1995) Cancer Res , vol.55 , pp. 5038-5042
    • Rusch, V.1    Klimstra, D.2    Venkatraman, E.3    Oliver, J.4    Martini, N.5    Gralla, R.6    Kris, M.7    Dmitrovsky, E.8
  • 235
    • 0032908148 scopus 로고    scopus 로고
    • Multitargeted antifolate LY231514 as first-line chemotherapy for patients with advanced non-small-cell lung cancer: A phase II study
    • National Cancer Institute of Canada Clinical Trials Group
    • Rusthoven JJ, Eisenhauer E, Butts C, Gregg R, Dancey J, Fisher B and Iglesias J (1999) Multitargeted antifolate LY231514 as first-line chemotherapy for patients with advanced non-small-cell lung cancer: A phase II study. National Cancer Institute of Canada Clinical Trials Group. J Clin Oncol 17:1194-1198.
    • (1999) J Clin Oncol , vol.17 , pp. 1194-1198
    • Rusthoven, J.J.1    Eisenhauer, E.2    Butts, C.3    Gregg, R.4    Dancey, J.5    Fisher, B.6    Iglesias, J.7
  • 238
    • 0031934761 scopus 로고    scopus 로고
    • Molecular abnormalities in lung cancer
    • Salgia R and Skarin AT (1998) Molecular abnormalities in lung cancer. J Clin Oncol 16:1207-1217.
    • (1998) J Clin Oncol , vol.16 , pp. 1207-1217
    • Salgia, R.1    Skarin, A.T.2
  • 239
  • 243
    • 0037050735 scopus 로고    scopus 로고
    • Upregulation of Bcl-2 is involved in the mediation of chemotherapy resistance in human small cell lung cancer cell lines
    • Sartorius UA and Krammer PH (2002) Upregulation of Bcl-2 is involved in the mediation of chemotherapy resistance in human small cell lung cancer cell lines. Int J Cancer 97:584-592.
    • (2002) Int J Cancer , vol.97 , pp. 584-592
    • Sartorius, U.A.1    Krammer, P.H.2
  • 247
    • 0032547380 scopus 로고    scopus 로고
    • Progress in understanding the molecular pathogenesis of of human lung cancer
    • Sekido Y, Fong KM, and Minna JD (1998) Progress in understanding the molecular pathogenesis of of human lung cancer. Biochin Biophys Acta 1978:F21-F59.
    • (1998) Biochin Biophys Acta , vol.1978
    • Sekido, Y.1    Fong, K.M.2    Minna, J.D.3
  • 248
    • 13144257716 scopus 로고    scopus 로고
    • Role of epidermal growth factor receptor overexpression, K-ras point mutation and c-myc amplification in the carcinogenesis of non-small cell lung cancer
    • Sekine I, Takami S, Guang SG, Yokose T, Kodama T, Nishiwaki Y, Kinoshita M, Matsumoto H, Ogura T, and Nagai K (1998) Role of epidermal growth factor receptor overexpression, K-ras point mutation and c-myc amplification in the carcinogenesis of non-small cell lung cancer. Oncol Rep 5:351-354.
    • (1998) Oncol Rep , vol.5 , pp. 351-354
    • Sekine, I.1    Takami, S.2    Guang, S.G.3    Yokose, T.4    Kodama, T.5    Nishiwaki, Y.6    Kinoshita, M.7    Matsumoto, H.8    Ogura, T.9    Nagai, K.10
  • 249
    • 0030883915 scopus 로고    scopus 로고
    • Common patterns of genetic evolution in human solid tumors
    • Shackney SE and Shankey TV (1997) Common patterns of genetic evolution in human solid tumors. Cytometry 29:1-27.
    • (1997) Cytometry , vol.29 , pp. 1-27
    • Shackney, S.E.1    Shankey, T.V.2
  • 253
    • 0035721487 scopus 로고    scopus 로고
    • Technetium-99m tetrofosmin chest imaging related to p-glycoprotein expression for predicting the response with paclitaxel-based chemotherapy for non-small cell lung cancer
    • Shiau YC, Tsai SC, Wang JJ, Ho YJ, Ho ST, and Kao CH (2001) Technetium-99m tetrofosmin chest imaging related to p-glycoprotein expression for predicting the response with paclitaxel-based chemotherapy for non-small cell lung cancer. Lung 179:197-207.
    • (2001) Lung , vol.179 , pp. 197-207
    • Shiau, Y.C.1    Tsai, S.C.2    Wang, J.J.3    Ho, Y.J.4    Ho, S.T.5    Kao, C.H.6
  • 256
    • 0027960585 scopus 로고
    • Frequent allelic losses on chromosomes 2q, 18q and 22q in advanced non-small cell lung carcinoma
    • Shiseki M, Kohno T, Nishikawa R, Sameshima Y, Mizoguchi H, and Yokota J (1994) Frequent allelic losses on chromosomes 2q, 18q and 22q in advanced non-small cell lung carcinoma. Cancer Res 54:5643-5648.
    • (1994) Cancer Res , vol.54 , pp. 5643-5648
    • Shiseki, M.1    Kohno, T.2    Nishikawa, R.3    Sameshima, Y.4    Mizoguchi, H.5    Yokota, J.6
  • 258
    • 0004949475 scopus 로고    scopus 로고
    • Trinucleotide repeat length variation in the human ribosomal protein L14 gene (RPL14): Localization to 3p21.3 and loss of heterozygosity in lung and oral cancers
    • Shriver SP, Shriver MD, Tirpak DL, Bloch LM, Hunt JD, Ferrell RE and Siegfried JM (1998) Trinucleotide repeat length variation in the human ribosomal protein L14 gene (RPL14): localization to 3p21.3 and loss of heterozygosity in lung and oral cancers. Mutat Res 406:9-23.
    • (1998) Mutat Res , vol.406 , pp. 9-23
    • Shriver, S.P.1    Shriver, M.D.2    Tirpak, D.L.3    Bloch, L.M.4    Hunt, J.D.5    Ferrell, R.E.6    Siegfried, J.M.7
  • 259
    • 0034671945 scopus 로고    scopus 로고
    • Oncogenic mutations of the p53 tumor suppressor: The demons of the guardian of the genome
    • Sigal A and Rotter V (2000) Oncogenic mutations of the p53 tumor suppressor: the demons of the guardian of the genome. Cancer Res 60:6788-6793.
    • (2000) Cancer Res , vol.60 , pp. 6788-6793
    • Sigal, A.1    Rotter, V.2
  • 260
    • 0027000816 scopus 로고
    • Increased deoxycytidine kinase activity in cancer cells and inhibition by difluorodeoxycytidine
    • Singhal RL, Yeh YA, Szekeres T, and Weber G (1992) Increased deoxycytidine kinase activity in cancer cells and inhibition by difluorodeoxycytidine. Oncol Res 4:517-522.
    • (1992) Oncol Res , vol.4 , pp. 517-522
    • Singhal, R.L.1    Yeh, Y.A.2    Szekeres, T.3    Weber, G.4
  • 261
    • 0036162719 scopus 로고    scopus 로고
    • Apoptosis: A guide for the perplexed
    • Sloviter RS (2002) Apoptosis: a guide for the perplexed. Trends Pharmacol Sci 23:19-24.
    • (2002) Trends Pharmacol Sci , vol.23 , pp. 19-24
    • Sloviter, R.S.1
  • 262
    • 0036499649 scopus 로고    scopus 로고
    • Phase III trial comparing a defined duration of therapy versus continuous therapy followed by second-line therapy in advanced-stage IIIB/IV non-small-cell lung cancer
    • Socinski MA, Schell MJ, Peterman A, Bakri K, Yates S, Gitten R, Unger P, Lee J, Lee JH, Tynan M, Moore M, and Kies MS (2002) Phase III trial comparing a defined duration of therapy versus continuous therapy followed by second-line therapy in advanced-stage IIIB/IV non-small-cell lung cancer. J Clin Oncol 20:1335-1343.
    • (2002) J Clin Oncol , vol.20 , pp. 1335-1343
    • Socinski, M.A.1    Schell, M.J.2    Peterman, A.3    Bakri, K.4    Yates, S.5    Gitten, R.6    Unger, P.7    Lee, J.8    Lee, J.H.9    Tynan, M.10    Moore, M.11    Kies, M.S.12
  • 263
    • 0035196281 scopus 로고    scopus 로고
    • The role of chemotherapy in early stage of non-small cell lung cancer
    • Souquet PJ and Geriniere L (2001) The role of chemotherapy in early stage of non-small cell lung cancer. Lung Cancer 34 (Suppl 2):S155-S158.
    • (2001) Lung Cancer , vol.34 , Issue.SUPPL. 2
    • Souquet, P.J.1    Geriniere, L.2
  • 266
    • 0033198465 scopus 로고    scopus 로고
    • 1 checkpoint function as determinants of resistance of human lung cancer cells against the antisignaling drug UCN-01 (7-Hydroxystaurosporine)
    • 1 checkpoint function as determinants of resistance of human lung cancer cells against the antisignaling drug UCN-01 (7-Hydroxystaurosporine). Cancer Res 59:4406-4412.
    • (1999) Cancer Res , vol.59 , pp. 4406-4412
    • Sugiyama, K.1    Akiyama, T.2    Shimizu, M.3    Tamaoki, T.4    Courage, C.5    Gescher, A.6    Akinaga, S.7
  • 267
    • 0033214457 scopus 로고    scopus 로고
    • Antitumor efficacy of a novel class of non-thiol-containing peptidomimetic inhibitors of farnesyltransferase and geranylgeranyltransferase I: Combination therapy with the cytotoxic agents cisplatin, taxol and gemcitabine
    • Sun J, Blaskovich MA, Knowles D, Qian Y, Ohkanda J, Bailey RD, Hamilton AD, and Sebti SM (1999) Antitumor efficacy of a novel class of non-thiol-containing peptidomimetic inhibitors of farnesyltransferase and geranylgeranyltransferase I: combination therapy with the cytotoxic agents cisplatin, taxol and gemcitabine. Cancer Res 59:4919-4926.
    • (1999) Cancer Res , vol.59 , pp. 4919-4926
    • Sun, J.1    Blaskovich, M.A.2    Knowles, D.3    Qian, Y.4    Ohkanda, J.5    Bailey, R.D.6    Hamilton, A.D.7    Sebti, S.M.8
  • 268
    • 0031913515 scopus 로고    scopus 로고
    • Microsatellite instability in female non-small-cell lung cancer patients with familial clustering of malignancy
    • Suzuki K, Ogura T, Yokose T, Sekine I, Nagai K, Kodama T, Mukai K, Nishiwaki Y, and Esumi H (1998) Microsatellite instability in female non-small-cell lung cancer patients with familial clustering of malignancy. Br J Cancer 77:1003-1008.
    • (1998) Br J Cancer , vol.77 , pp. 1003-1008
    • Suzuki, K.1    Ogura, T.2    Yokose, T.3    Sekine, I.4    Nagai, K.5    Kodama, T.6    Mukai, K.7    Nishiwaki, Y.8    Esumi, H.9
  • 269
    • 0030886084 scopus 로고    scopus 로고
    • Combined chromosome microdissection and comparative genomic hybridization detect multiple sites of amplification DNA in a human lung carcinoma cell line
    • Taguchi T, Cheng GZ, Bell DW, Balsara B, Liu Z, Siegfried JM, and Testa JR (1997) Combined chromosome microdissection and comparative genomic hybridization detect multiple sites of amplification DNA in a human lung carcinoma cell line. Genes Chromosomes Cancer 20:208-212.
    • (1997) Genes Chromosomes Cancer , vol.20 , pp. 208-212
    • Taguchi, T.1    Cheng, G.Z.2    Bell, D.W.3    Balsara, B.4    Liu, Z.5    Siegfried, J.M.6    Testa, J.R.7
  • 270
    • 0034456656 scopus 로고    scopus 로고
    • Multidrug resistance transporters and modulation
    • Tan B, Piwnica-Worms D, and Ratner L (2000) Multidrug resistance transporters and modulation. Curr Opin Oncol 12:450-458.
    • (2000) Curr Opin Oncol , vol.12 , pp. 450-458
    • Tan, B.1    Piwnica-Worms, D.2    Ratner, L.3
  • 272
    • 0034692447 scopus 로고    scopus 로고
    • Hypermethylation of the death-associated protein (DAP) kinase promoter and aggressiveness in stage I non-small cell lung cancer
    • Tang X, Khuri FR, Lee JJ, Kemp BL, Liu D, Hong WK, and Mao L (2000) Hypermethylation of the death-associated protein (DAP) kinase promoter and aggressiveness in stage I non-small cell lung cancer. J Natl Cancer Inst 92:1511-1516.
    • (2000) J Natl Cancer Inst , vol.92 , pp. 1511-1516
    • Tang, X.1    Khuri, F.R.2    Lee, J.J.3    Kemp, B.L.4    Liu, D.5    Hong, W.K.6    Mao, L.7
  • 273
    • 0031416518 scopus 로고    scopus 로고
    • Infrequent mutations of the transforming growth factor beta-type II receptor gene at chromosome 3p22 in human lung cancers with chromosome 3p deletions
    • Tani M, Takenoshita S, Kohno T, Hagiwara K, Nagamachi Y, Harris CC, and Yokota J (1997) Infrequent mutations of the transforming growth factor beta-type II receptor gene at chromosome 3p22 in human lung cancers with chromosome 3p deletions. Carcinogenesis 18:1119-1121.
    • (1997) Carcinogenesis , vol.18 , pp. 1119-1121
    • Tani, M.1    Takenoshita, S.2    Kohno, T.3    Hagiwara, K.4    Nagamachi, Y.5    Harris, C.C.6    Yokota, J.7
  • 278
    • 0032998028 scopus 로고    scopus 로고
    • Cell cycle disturbances and apoptosis induced by topotecan and gemcitabine on human lung cancer cell lines
    • Tolis C, Peters GJ, Ferreira CG, Pinedo HM, and Giaccone G (1999) Cell cycle disturbances and apoptosis induced by topotecan and gemcitabine on human lung cancer cell lines. Eur J Cancer 35:796-807.
    • (1999) Eur J Cancer , vol.35 , pp. 796-807
    • Tolis, C.1    Peters, G.J.2    Ferreira, C.G.3    Pinedo, H.M.4    Giaccone, G.5
  • 280
    • 0032585642 scopus 로고    scopus 로고
    • Novel regions of allelic deletion on chromosome 18p in tumors of the lung, brain and breast
    • Tran Y, Benbatoul K, Gorse K, Rempel S, Futreal A, Green M, and Newsham I (1998) Novel regions of allelic deletion on chromosome 18p in tumors of the lung, brain and breast. Oncogene 17:3499-3505.
    • (1998) Oncogene , vol.17 , pp. 3499-3505
    • Tran, Y.1    Benbatoul, K.2    Gorse, K.3    Rempel, S.4    Futreal, A.5    Green, M.6    Newsham, I.7
  • 281
    • 0029936996 scopus 로고    scopus 로고
    • High-density marker analysis of 11p15.5 in non-small cell lung carcinomas reveals allelic deletion of one shared and one distinct region when compared to breast carcinomas
    • Tran YK and Newsham IF (1996) High-density marker analysis of 11p15.5 in non-small cell lung carcinomas reveals allelic deletion of one shared and one distinct region when compared to breast carcinomas. Cancer Res 56:2916-2921.
    • (1996) Cancer Res , vol.56 , pp. 2916-2921
    • Tran, Y.K.1    Newsham, I.F.2
  • 283
    • 0030019658 scopus 로고    scopus 로고
    • Cytotoxic effects of gemcitabine-containing regimens against human non-small cell lung cancer cell lines which express different levels of p185neu
    • Tsai CM, Chang KT, Chen JY, Chen YM, Chen MH, and Perng RP (1996a) Cytotoxic effects of gemcitabine-containing regimens against human non-small cell lung cancer cell lines which express different levels of p185neu. Cancer Res 56:794-801.
    • (1996) Cancer Res , vol.56 , pp. 794-801
    • Tsai, C.M.1    Chang, K.T.2    Chen, J.Y.3    Chen, Y.M.4    Chen, M.H.5    Perng, R.P.6
  • 284
    • 0034105946 scopus 로고    scopus 로고
    • Inter-relationships between cellular nucleotide excision repair, cisplatin cytotoxicity, HER-2/neu gene expression and epidermal growth factor receptor level in non-small cell lung cancer cells
    • Tsai CM, Chang KT, Li L, Perng RP, and Yang LY (2000) Inter-relationships between cellular nucleotide excision repair, cisplatin cytotoxicity, HER-2/neu gene expression and epidermal growth factor receptor level in non-small cell lung cancer cells. Jpn J Cancer Res 91:213-222.
    • (2000) Jpn J Cancer Res , vol.91 , pp. 213-222
    • Tsai, C.M.1    Chang, K.T.2    Li, L.3    Perng, R.P.4    Yang, L.Y.5
  • 285
    • 0027215146 scopus 로고
    • Correlation of intrinsic chemoresistance of non-small-cell lung cancer cell lines with HER-2/neu gene expression but not with ras gene mutations
    • Tsai CM, Chang KT, Perng RP, Mitsudomi T, Chen MH, Kadoyama C, and Gazdar AF (1993) Correlation of intrinsic chemoresistance of non-small-cell lung cancer cell lines with HER-2/neu gene expression but not with ras gene mutations. J Natl Cancer Inst 85:897-901.
    • (1993) J Natl Cancer Inst , vol.85 , pp. 897-901
    • Tsai, C.M.1    Chang, K.T.2    Perng, R.P.3    Mitsudomi, T.4    Chen, M.H.5    Kadoyama, C.6    Gazdar, A.F.7
  • 286
    • 0030031576 scopus 로고    scopus 로고
    • Correlations between intrinsic chemoresistance and HER-2/neu gene expression, p53 gene mutations and cell proliferation characteristics in non-small cell lung cancer cell lines
    • Tsai CM, Chang KT, Wu LH, Chen JY, Gazdar AF, Mitsudomi T, Chen MH, and Perng RP (1996b) Correlations between intrinsic chemoresistance and HER-2/neu gene expression, p53 gene mutations and cell proliferation characteristics in non-small cell lung cancer cell lines. Cancer Res 56:206-209.
    • (1996) Cancer Res , vol.56 , pp. 206-209
    • Tsai, C.M.1    Chang, K.T.2    Wu, L.H.3    Chen, J.Y.4    Gazdar, A.F.5    Mitsudomi, T.6    Chen, M.H.7    Perng, R.P.8
  • 287
    • 0030044628 scopus 로고    scopus 로고
    • Enhancement of chemosensitivity by tyrphostin AG825 in high-p185(neu) expressing non-small cell lung cancer cells
    • Tsai CM, Levitzki A, Wu LH, Chang KT, Cheng CC, Gazit A, and Perng RP (1996c) Enhancement of chemosensitivity by tyrphostin AG825 in high-p185(neu) expressing non-small cell lung cancer cells. Cancer Res 56:1068-1074.
    • (1996) Cancer Res , vol.56 , pp. 1068-1074
    • Tsai, C.M.1    Levitzki, A.2    Wu, L.H.3    Chang, K.T.4    Cheng, C.C.5    Gazit, A.6    Perng, R.P.7
  • 291
    • 0036716721 scopus 로고    scopus 로고
    • Sensitivity to ionizing radiation and chemotherapeutic agents in gemcitabine-resistant human tumor cell lines
    • van Bree C, Kreder N, Loves W, Franken N, Peters G, and Haveman J (2002) Sensitivity to ionizing radiation and chemotherapeutic agents in gemcitabine-resistant human tumor cell lines. Int J Radiat Oncol Biol Phys 54:237-244.
    • (2002) Int J Radiat Oncol Biol Phys , vol.54 , pp. 237-244
    • Van Bree, C.1    Kreder, N.2    Loves, W.3    Franken, N.4    Peters, G.5    Haveman, J.6
  • 294
    • 0031465779 scopus 로고    scopus 로고
    • Effects of an inducible anti-sense c-myc gene transfer in a drug-resistant human small-cell-lung-carcinoma cell line
    • Van Waardenburg RC, Meijer C, Burger H, Nooter K, De Vries EG, Mulder NH, and De Jong S (1997) Effects of an inducible anti-sense c-myc gene transfer in a drug-resistant human small-cell-lung-carcinoma cell line. Int J Cancer 73:544-550.
    • (1997) Int J Cancer , vol.73 , pp. 544-550
    • Van Waardenburg, R.C.1    Meijer, C.2    Burger, H.3    Nooter, K.4    De Vries, E.G.5    Mulder, N.H.6    De Jong, S.7
  • 295
    • 0029763897 scopus 로고    scopus 로고
    • Effects of c-myc oncogene modulation on drug resistance in human small cell lung carcinoma cell lines
    • Van Waardenburg RC, Prins J, Meijer C, Uges DR, De Vries EG, and Mulder NH (1996) Effects of c-myc oncogene modulation on drug resistance in human small cell lung carcinoma cell lines. Anticancer Res 16:1963-1970.
    • (1996) Anticancer Res , vol.16 , pp. 1963-1970
    • Van Waardenburg, R.C.1    Prins, J.2    Meijer, C.3    Uges, D.R.4    De Vries, E.G.5    Mulder, N.H.6
  • 297
    • 0034678960 scopus 로고    scopus 로고
    • Detection network gives early cancer tests a push
    • Vastag B (2000) Detection network gives early cancer tests a push. J Natl Cancer Inst 92:786-788.
    • (2000) J Natl Cancer Inst , vol.92 , pp. 786-788
    • Vastag, B.1
  • 302
    • 0026536320 scopus 로고
    • Oncoprotein (c-myc, c-erbB1, c-erbB2, c-fos) and suppressor gene product (p53) expression in squamous cell carcinomas of the lung. Clinical and biological correlations
    • Volm M, Efferth T, and Mattern J (1992) Oncoprotein (c-myc, c-erbB1, c-erbB2, c-fos) and suppressor gene product (p53) expression in squamous cell carcinomas of the lung. Clinical and biological correlations. Anticancer Res 12:11-20.
    • (1992) Anticancer Res , vol.12 , pp. 11-20
    • Volm, M.1    Efferth, T.2    Mattern, J.3
  • 303
    • 0036278826 scopus 로고    scopus 로고
    • Expression profile of genes in non-small cell lung carcinomas from long-term surviving patients
    • Volm M, Koomagi R, Mattern J, and Efferth T (2002) Expression profile of genes in non-small cell lung carcinomas from long-term surviving patients. Clin Cancer Res 8:1843-1848.
    • (2002) Clin Cancer Res , vol.8 , pp. 1843-1848
    • Volm, M.1    Koomagi, R.2    Mattern, J.3    Efferth, T.4
  • 304
    • 0034236299 scopus 로고    scopus 로고
    • Expression of LRP, MRP and MDR1 in nonsmall-cell lung cancer and its clinical significance
    • Wang J, Liu X, and Jiang W (2000) Expression of LRP, MRP and MDR1 in nonsmall-cell lung cancer and its clinical significance. Zhonghua Zhong Liu Za Zhi 22:304-307.
    • (2000) Zhonghua Zhong Liu Za Zhi , vol.22 , pp. 304-307
    • Wang, J.1    Liu, X.2    Jiang, W.3
  • 305
    • 0032880829 scopus 로고    scopus 로고
    • The effect of antimicrotubule agents on signal transduction pathways of apoptosis: A review
    • Wang LG, Liu XM, Kreis W, and Budman DR (1999) The effect of antimicrotubule agents on signal transduction pathways of apoptosis: a review. Cancer Chemother Pharmacol 44:355-361.
    • (1999) Cancer Chemother Pharmacol , vol.44 , pp. 355-361
    • Wang, L.G.1    Liu, X.M.2    Kreis, W.3    Budman, D.R.4
  • 307
    • 0030874380 scopus 로고    scopus 로고
    • Methylation of discrete regions of the O6-methylguanine DNA methyltransferase (MGMT) CpG island is associated with heterochromatinization of the MGMT transcription start site and silencing of the gene
    • Watts GS, Pieper RO, Costello JF, Peng YM, Dalton WS and Futscher BW (1997) Methylation of discrete regions of the O6-methylguanine DNA methyltransferase (MGMT) CpG island is associated with heterochromatinization of the MGMT transcription start site and silencing of the gene. Mol Cell Biol 17:5612-5619.
    • (1997) Mol Cell Biol , vol.17 , pp. 5612-5619
    • Watts, G.S.1    Pieper, R.O.2    Costello, J.F.3    Peng, Y.M.4    Dalton, W.S.5    Futscher, B.W.6
  • 308
    • 0034564180 scopus 로고    scopus 로고
    • Recursive partitioning analysis of 1999 Radiation Therapy Oncology Group (RTOG) patients with locally-advanced non-small-cell lung cancer (LA-NSCLC): Identification of five groups with different survival
    • Werner-Wasik M, Scott C, Cox JD, Sause WT, Byhardt RW, Asbell S, Russell A, Komaki R, and Lee JS (2000) Recursive partitioning analysis of 1999 Radiation Therapy Oncology Group (RTOG) patients with locally-advanced non-small-cell lung cancer (LA-NSCLC): identification of five groups with different survival. Int J Radiat Oncol Biol Phys 48:1475-1482.
    • (2000) Int J Radiat Oncol Biol Phys , vol.48 , pp. 1475-1482
    • Werner-Wasik, M.1    Scott, C.2    Cox, J.D.3    Sause, W.T.4    Byhardt, R.W.5    Asbell, S.6    Russell, A.7    Komaki, R.8    Lee, J.S.9
  • 309
    • 0035757524 scopus 로고    scopus 로고
    • Proteomics - Making sense of genomic information for drug discovery
    • Whitelegge JP and Le Coutre J (2001) Proteomics - Making sense of genomic information for drug discovery. Am J Pharmacogenomics 1:29-35.
    • (2001) Am J Pharmacogenomics , vol.1 , pp. 29-35
    • Whitelegge, J.P.1    Le Coutre, J.2
  • 310
    • 0034910622 scopus 로고    scopus 로고
    • Molecular genetics of small cell lung carcinoma
    • Wistuba II, Gazdar AF, and Minna JD (2001) Molecular genetics of small cell lung carcinoma. Semin Oncol 28 (Suppl 4):3-13.
    • (2001) Semin Oncol , vol.28 , Issue.SUPPL. 4 , pp. 3-13
    • Wistuba, I.I.1    Gazdar, A.F.2    Minna, J.D.3
  • 311
    • 0035890742 scopus 로고    scopus 로고
    • 6-Methylguanine-DNA methyltransferase promoter hypermethylation shifts the p53 mutational spectrum in non-small cell lung cancer
    • 6-Methylguanine-DNA methyltransferase promoter hypermethylation shifts the p53 mutational spectrum in non-small cell lung cancer. Cancer Res 61:8113-8117.
    • (2001) Cancer Res , vol.61 , pp. 8113-8117
    • Wolf, P.1    Hu, Y.C.2    Doffek, K.3    Sidransky, D.4    Ahrendt, S.A.5
  • 314
    • 0032530140 scopus 로고    scopus 로고
    • Overexpression of cdc25A and cdc25B is frequent in primary non-small cell lung cancer but is not associated with overexpression of c-myc
    • Wu W, Fan YH, Kemp BL, Walsh G, and Mao L (1998) Overexpression of cdc25A and cdc25B is frequent in primary non-small cell lung cancer but is not associated with overexpression of c-myc. Cancer Res 58:4082-4085.
    • (1998) Cancer Res , vol.58 , pp. 4082-4085
    • Wu, W.1    Fan, Y.H.2    Kemp, B.L.3    Walsh, G.4    Mao, L.5
  • 316
    • 0031910770 scopus 로고    scopus 로고
    • RB protein status and chemosensitivity in non-small cell lung cancers
    • Yamamoto Y, Shimizu E, Masuda N, Takada M, and Sone S (1998) RB protein status and chemosensitivity in non-small cell lung cancers. Oncol Rep 5:447-451.
    • (1998) Oncol Rep , vol.5 , pp. 447-451
    • Yamamoto, Y.1    Shimizu, E.2    Masuda, N.3    Takada, M.4    Sone, S.5
  • 317
    • 0034900063 scopus 로고    scopus 로고
    • In vitro establishment of cis-diammine-dichloroplatinum(II) resistant lung cancer cell line and modulation of apoptotic gene expression as a mechanism of resistant phenotype
    • Yoon SS, Ahn KS, Kim SH, Shim YM, and Kim J (2001) In vitro establishment of cis-diammine-dichloroplatinum(II) resistant lung cancer cell line and modulation of apoptotic gene expression as a mechanism of resistant phenotype. Lung Cancer 33:221-228.
    • (2001) Lung Cancer , vol.33 , pp. 221-228
    • Yoon, S.S.1    Ahn, K.S.2    Kim, S.H.3    Shim, Y.M.4    Kim, J.5
  • 318
    • 0032542281 scopus 로고    scopus 로고
    • Dual effect of erbB-2 depletion on the regulation of DNA repair and cell cycle mechanisms in non-small cell lung cancer cells
    • You XL, Yen L, Zeng-Rong N, Al Moustafa AE, and Alaoui-Jamali MA (1998) Dual effect of erbB-2 depletion on the regulation of DNA repair and cell cycle mechanisms in non-small cell lung cancer cells. Oncogene 17:3177-3186.
    • (1998) Oncogene , vol.17 , pp. 3177-3186
    • You, X.L.1    Yen, L.2    Zeng-Rong, N.3    Al Moustafa, A.E.4    Alaoui-Jamali, M.A.5
  • 319
    • 0034895918 scopus 로고    scopus 로고
    • Multidrug resistance proteins MRP3, MRP1 and MRP2 in lung cancer: Correlation of protein levels with drug response and messenger RNA levels
    • Young LC, Campling BG, Cole SP, Deeley RG, and Gerlach JH (2001) Multidrug resistance proteins MRP3, MRP1 and MRP2 in lung cancer: correlation of protein levels with drug response and messenger RNA levels. Clin Cancer Res 7:1798-1804.
    • (2001) Clin Cancer Res , vol.7 , pp. 1798-1804
    • Young, L.C.1    Campling, B.G.2    Cole, S.P.3    Deeley, R.G.4    Gerlach, J.H.5
  • 321
    • 0030067015 scopus 로고    scopus 로고
    • Sensitization of HER-2/neu-overexpressing non-small cell lung cancer cells to chemotherapeutic drugs by tyrosine kinase inhibitor emodin
    • Zhang L and Hung MC (1996) Sensitization of HER-2/neu-overexpressing non-small cell lung cancer cells to chemotherapeutic drugs by tyrosine kinase inhibitor emodin. Oncogene 12:571-576.
    • (1996) Oncogene , vol.12 , pp. 571-576
    • Zhang, L.1    Hung, M.C.2
  • 322
    • 0032585893 scopus 로고    scopus 로고
    • Waf1/Cip1 acts in synergy with bcl-2 to confer multidrug resistance in a camptothecin-selected human lung-cancer cell line
    • Waf1/Cip1 acts in synergy with bcl-2 to confer multidrug resistance in a camptothecin-selected human lung-cancer cell line. Int J Cancer 83:790-797.
    • (1999) Int J Cancer , vol.83 , pp. 790-797
    • Zhang, Y.1    Fujita, N.2    Tsuruo, T.3
  • 323
    • 0033982645 scopus 로고    scopus 로고
    • Prognostic implication of microsatellite alteration profiles in early-stage non-small cell lung cancer
    • Zhou X, Kemp BL, Khuri FR, Liu D, Lee JJ, Wu W, Hong WK, and Mao L (2000) Prognostic implication of microsatellite alteration profiles in early-stage non-small cell lung cancer. Clin Cancer Res 6:559-565.
    • (2000) Clin Cancer Res , vol.6 , pp. 559-565
    • Zhou, X.1    Kemp, B.L.2    Khuri, F.R.3    Liu, D.4    Lee, J.J.5    Wu, W.6    Hong, W.K.7    Mao, L.8
  • 325
    • 0035866353 scopus 로고    scopus 로고
    • DNA methyltransferase inhibition enhances apoptosis induced by histone deacetylase inhibitors
    • Zhu WG, Lakshmanan RR, Beal MD, and Otterson GA (2001b) DNA methyltransferase inhibition enhances apoptosis induced by histone deacetylase inhibitors, Cancer Res 61:1327-1333.
    • (2001) Cancer Res , vol.61 , pp. 1327-1333
    • Zhu, W.G.1    Lakshmanan, R.R.2    Beal, M.D.3    Otterson, G.A.4
  • 326
    • 0035150974 scopus 로고    scopus 로고
    • Loss of heterozygosity is related to p53 mutations and smoking in lung cancer
    • Zienolddiny S, Ryberg D, Arab MO, Skaug V, and Haugen A (2001) Loss of heterozygosity is related to p53 mutations and smoking in lung cancer. Br J Cancer 84:226-231.
    • (2001) Br J Cancer , vol.84 , pp. 226-231
    • Zienolddiny, S.1    Ryberg, D.2    Arab, M.O.3    Skaug, V.4    Haugen, A.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.