-
1
-
-
0034652141
-
Positive and negative regulation of endogenous genes by designed transcription factors
-
Beerli, R. R., Dreier, B., and Barbas, C. F., III (2000) Positive and negative regulation of endogenous genes by designed transcription factors Proc. Natl. Acad. Sci. U.S.A. 97, 1495-1500
-
(2000)
Proc. Natl. Acad. Sci. U.S.A.
, vol.97
, pp. 1495-1500
-
-
Beerli, R.R.1
Dreier, B.2
Iii, F.B.C.3
-
2
-
-
0034923498
-
Design and selection of novel Cys2His2 zinc-finger proteins
-
Pabo, C. O., Peisach, E., and Grant, R. A. (2001) Design and selection of novel Cys2His2 zinc-finger proteins Annu. Rev. Biochem. 70, 313-340
-
(2001)
Annu. Rev. Biochem.
, vol.70
, pp. 313-340
-
-
Pabo, C.O.1
Peisach, E.2
Grant, R.A.3
-
3
-
-
0036168937
-
Engineering polydactyl zinc-finger transcription factors
-
Beerli, R. R. and Barbas, C. F., III (2002) Engineering polydactyl zinc-finger transcription factors Nat. Biotechnol. 20, 135-141
-
(2002)
Nat. Biotechnol.
, vol.20
, pp. 135-141
-
-
Beerli, R.R.1
Iii, F.B.C.2
-
4
-
-
0037711251
-
Drug discovery with engineered zinc-finger proteins
-
Jamieson, A. C., Miller, J. C., and Pabo, C. O. (2003) Drug discovery with engineered zinc-finger proteins Nat. Rev. Drug Discovery 2, 361-368
-
(2003)
Nat. Rev. Drug Discovery
, vol.2
, pp. 361-368
-
-
Jamieson, A.C.1
Miller, J.C.2
Pabo, C.O.3
-
5
-
-
9444230573
-
Designing transcription factor architectures for drug discovery
-
Blancafort, P., Segal, D. J., and Barbas, C. F., III (2004) Designing transcription factor architectures for drug discovery Mol. Pharmacol. 66, 1361-1371
-
(2004)
Mol. Pharmacol.
, vol.66
, pp. 1361-1371
-
-
Blancafort, P.1
Segal, D.J.2
Iii, F.B.C.3
-
6
-
-
55549129245
-
Progress and prospects: Zinc-finger nucleases as gene therapy agents
-
Carroll, D. (2008) Progress and prospects: Zinc-finger nucleases as gene therapy agents Gene Ther. 15, 1463-1468
-
(2008)
Gene Ther.
, vol.15
, pp. 1463-1468
-
-
Carroll, D.1
-
7
-
-
0041806648
-
Chimeric recombinases with designed DNA sequence recognition
-
Akopian, A., He, J., Boocock, M. R., and Stark, W. M. (2003) Chimeric recombinases with designed DNA sequence recognition Proc. Natl. Acad. Sci. U.S.A. 100, 8688-8691
-
(2003)
Proc. Natl. Acad. Sci. U.S.A.
, vol.100
, pp. 8688-8691
-
-
Akopian, A.1
He, J.2
Boocock, M.R.3
Stark, W.M.4
-
8
-
-
33847363901
-
Evolution of programmable zinc-finger-recombinases with activity in human cells
-
Gordley, R. M., Smith, J. D., Gräslund, T., and Barbas, C. F., III (2007) Evolution of programmable zinc-finger-recombinases with activity in human cells J. Mol. Biol. 367, 802-813
-
(2007)
J. Mol. Biol.
, vol.367
, pp. 802-813
-
-
Gordley, R.M.1
Smith, J.D.2
Gräslund, T.3
Iii, F.B.C.4
-
9
-
-
65249134039
-
Synthesis of programmable integrases
-
Gordley, R. M., Gersbach, C. A., and Barbas, C. F., III (2009) Synthesis of programmable integrases Proc. Natl. Acad. Sci. U.S.A. 106, 5053-5058
-
(2009)
Proc. Natl. Acad. Sci. U.S.A.
, vol.106
, pp. 5053-5058
-
-
Gordley, R.M.1
Gersbach, C.A.2
Iii, F.B.C.3
-
10
-
-
77955075475
-
Directed evolution of recombinase specificity by split gene reassembly
-
Gersbach, C. A., Gaj, T., Gordley, R. M., and Barbas, C. F., III (2010) Directed evolution of recombinase specificity by split gene reassembly Nucleic Acids Res. 38, 4198-4206
-
(2010)
Nucleic Acids Res.
, vol.38
, pp. 4198-4206
-
-
Gersbach, C.A.1
Gaj, T.2
Gordley, R.M.3
Iii, F.B.C.4
-
11
-
-
79952260364
-
Structure-Guided Reprogramming of Serine Recombinase DNA Sequence Specificity
-
Gaj, T., Mercer, A. C., Gersbach, C. A., Gordley, R. M., and Barbas, C. F., III (2011) Structure-Guided Reprogramming of Serine Recombinase DNA Sequence Specificity Proc. Natl. Acad. Sci. U.S.A. 108, 498-503
-
(2011)
Proc. Natl. Acad. Sci. U.S.A.
, vol.108
, pp. 498-503
-
-
Gaj, T.1
Mercer, A.C.2
Gersbach, C.A.3
Gordley, R.M.4
Iii, F.B.C.5
-
12
-
-
80053218380
-
Targeted plasmid integration into the human genome by an engineered zinc-finger recombines
-
Gersbach, C. A., Gaj, T., Gordley, R. M., Mercer, A. C., and Barbas, C. F., III (2011) Targeted plasmid integration into the human genome by an engineered zinc-finger recombines Nucleic Acids Res. 39, 7868-7878
-
(2011)
Nucleic Acids Res.
, vol.39
, pp. 7868-7878
-
-
Gersbach, C.A.1
Gaj, T.2
Gordley, R.M.3
Mercer, A.C.4
Iii, F.B.C.5
-
13
-
-
84984766752
-
Cytosine methylation targeted to predetermined sequences
-
Xu, G.-L. and Bestor, T. H. (1997) Cytosine methylation targeted to predetermined sequences Nat. Genet. 17, 376-378
-
(1997)
Nat. Genet.
, vol.17
, pp. 376-378
-
-
Xu, G.-L.1
Bestor, T.H.2
-
14
-
-
0036712062
-
Characterisation of site-biased DNA methyltransferases: Specificity, affinity and subsite relationships
-
McNamara, A. R., Hurd, P. J., Smith, A. E., and Ford, K. G. (2002) Characterisation of site-biased DNA methyltransferases: Specificity, affinity and subsite relationships Nucleic Acids Res. 30, 3818-3130
-
(2002)
Nucleic Acids Res.
, vol.30
, pp. 3818-3130
-
-
McNamara, A.R.1
Hurd, P.J.2
Smith, A.E.3
Ford, K.G.4
-
15
-
-
0345531138
-
Site-selective in vivo targeting of cytosine-5 DNA methylation by zinc-finger proteins
-
Carvin, C. D., Parr, R. D., and Kladde, M. P. (2003) Site-selective in vivo targeting of cytosine-5 DNA methylation by zinc-finger proteins Nucleic Acids Res. 31, 6493-6501
-
(2003)
Nucleic Acids Res.
, vol.31
, pp. 6493-6501
-
-
Carvin, C.D.1
Parr, R.D.2
Kladde, M.P.3
-
16
-
-
33845916259
-
Sequence-specific modification of mitochondrial DNA using a chimeric zinc-finger methylase
-
Minczuk, M., Papworth, M. A., Kolasinska, P., Murphy, M. P., and Klug, A. (2006) Sequence-specific modification of mitochondrial DNA using a chimeric zinc-finger methylase Proc. Natl. Acad. Sci. U.S.A. 103, 19689-19694
-
(2006)
Proc. Natl. Acad. Sci. U.S.A.
, vol.103
, pp. 19689-19694
-
-
Minczuk, M.1
Papworth, M.A.2
Kolasinska, P.3
Murphy, M.P.4
Klug, A.5
-
17
-
-
33846686888
-
Chimeric DNA methyltransferases target DNA methylation to specific DNA sequences and repress expression of target genes
-
Li, F., Papworth, M., Minczuk, M., Rohde, C., Zhang, Y., Ragozin, S., and Jeltsch, A. (2007) Chimeric DNA methyltransferases target DNA methylation to specific DNA sequences and repress expression of target genes Nucleic Acids Res. 35, 100-112
-
(2007)
Nucleic Acids Res.
, vol.35
, pp. 100-112
-
-
Li, F.1
Papworth, M.2
Minczuk, M.3
Rohde, C.4
Zhang, Y.5
Ragozin, S.6
Jeltsch, A.7
-
18
-
-
33847377099
-
Specific targeting of cytosine methylation to DNA sequences in vivo
-
Smith, A. E. and Ford, K. G. (2007) Specific targeting of cytosine methylation to DNA sequences in vivo Nucleic Acids Res. 35, 740-754
-
(2007)
Nucleic Acids Res.
, vol.35
, pp. 740-754
-
-
Smith, A.E.1
Ford, K.G.2
-
19
-
-
44349168309
-
Heritable Gene Repression through the Action of a Directed DNA Methyltransferase at a Chromosomal Locus
-
Smith, A. E., Hurd, P. J., Bannister, A. J., Kouzarides, T., and Ford, K. G. (2008) Heritable Gene Repression through the Action of a Directed DNA Methyltransferase at a Chromosomal Locus J. Biol. Chem. 283, 9878-9885
-
(2008)
J. Biol. Chem.
, vol.283
, pp. 9878-9885
-
-
Smith, A.E.1
Hurd, P.J.2
Bannister, A.J.3
Kouzarides, T.4
Ford, K.G.5
-
20
-
-
34548395961
-
In vivo site-specific DNA methylation with a designed sequence-enabled DNA methylase
-
Nomura, W. and Barbas, C. F., III (2007) In vivo site-specific DNA methylation with a designed sequence-enabled DNA methylase J. Am. Chem. Soc. 129, 8676-8677
-
(2007)
J. Am. Chem. Soc.
, vol.129
, pp. 8676-8677
-
-
Nomura, W.1
Iii, F.B.C.2
-
21
-
-
33746382212
-
Mechanisms of site-specific recombination
-
Grindley, N. D., Whiteson, K. L., and Rice, P. A. (2006) Mechanisms of site-specific recombination Annu. Rev. Biochem. 75, 567-605
-
(2006)
Annu. Rev. Biochem.
, vol.75
, pp. 567-605
-
-
Grindley, N.D.1
Whiteson, K.L.2
Rice, P.A.3
-
22
-
-
0029127032
-
Crystal structure of the site-specific recombinase gamma delta resolvase complexed with a 34 bp cleavage site
-
Yang, W. and Steitz, T. A. (1995) Crystal structure of the site-specific recombinase gamma delta resolvase complexed with a 34 bp cleavage site Cell 82, 193-207
-
(1995)
Cell
, vol.82
, pp. 193-207
-
-
Yang, W.1
Steitz, T.A.2
-
23
-
-
0033105367
-
Mutants of Tn3 resolvase which do not require accessory binding sites for recombination activity
-
Arnold, P. H., Blake, D. G., Grindley, N. D., Boocock, M. R., and Stark, W. M. (1999) Mutants of Tn3 resolvase which do not require accessory binding sites for recombination activity EMBO J. 18, 1407-1414
-
(1999)
EMBO J.
, vol.18
, pp. 1407-1414
-
-
Arnold, P.H.1
Blake, D.G.2
Grindley, N.D.3
Boocock, M.R.4
Stark, W.M.5
-
24
-
-
23844514076
-
Structure of a synaptic γδ resolvase tetramer covalently linked to two cleaved DNAs
-
Li, W., Kamtekar, S., Xiong, Y., Sarkis, G. J., Grindley, N. D., and Steitz, T. A. (2005) Structure of a synaptic γδ resolvase tetramer covalently linked to two cleaved DNAs Science 309, 1210-1215
-
(2005)
Science
, vol.309
, pp. 1210-1215
-
-
Li, W.1
Kamtekar, S.2
Xiong, Y.3
Sarkis, G.J.4
Grindley, N.D.5
Steitz, T.A.6
-
25
-
-
58749099785
-
Synapsis and catalysis by activated Tn3 resolvase mutants
-
Olorunniji, F. J., He, J., Wenwieser, S. V., Boocock, M. R., and Stark, W. M. (2008) Synapsis and catalysis by activated Tn3 resolvase mutants Nucleic Acids Res. 36, 7181-7191
-
(2008)
Nucleic Acids Res.
, vol.36
, pp. 7181-7191
-
-
Olorunniji, F.J.1
He, J.2
Wenwieser, S.V.3
Boocock, M.R.4
Stark, W.M.5
-
26
-
-
77953718304
-
Modular system for the construction of zinc-finger libraries and proteins
-
Gonzalez, B., Schwimmer, L. J., Fuller, R. P., Ye, Y., Asawapornmongkol, L., and Barbas, C. F., III (2010) Modular system for the construction of zinc-finger libraries and proteins Nat. Protoc. 5, 791-810
-
(2010)
Nat. Protoc.
, vol.5
, pp. 791-810
-
-
Gonzalez, B.1
Schwimmer, L.J.2
Fuller, R.P.3
Ye, Y.4
Asawapornmongkol, L.5
Iii, F.B.C.6
-
27
-
-
33747816812
-
Zinc Finger Tools: Custom DNA-binding domains for transcription factors and nucleases
-
Mandell, J. G. and Barbas, C. F., III (2006) Zinc Finger Tools: Custom DNA-binding domains for transcription factors and nucleases Nucleic Acids Res. 34, W516-W523
-
(2006)
Nucleic Acids Res.
, vol.34
-
-
Mandell, J.G.1
Iii, F.B.C.2
-
28
-
-
0029662017
-
A 2.2 Angstroms resolution crystal structure of a designed zinc finger protein bound to DNA
-
Kim, C. A. and Berg, J. M. (1996) A 2.2 Angstroms resolution crystal structure of a designed zinc finger protein bound to DNA Nat. Struct. Mol. Biol. 3, 940-945
-
(1996)
Nat. Struct. Mol. Biol.
, vol.3
, pp. 940-945
-
-
Kim, C.A.1
Berg, J.M.2
-
29
-
-
0032981699
-
Toward controlling gene expression at will: Selection and design of zinc finger domains recognizing each of the 5′-GNN-3′ DNA target sequences
-
Segal, D. J., Dreier, B., Beerli, R. R., and Barbas, C. F., III (1999) Toward controlling gene expression at will: Selection and design of zinc finger domains recognizing each of the 5′-GNN-3′ DNA target sequences Proc. Natl. Acad. Sci. U.S.A. 96, 2758-2763
-
(1999)
Proc. Natl. Acad. Sci. U.S.A.
, vol.96
, pp. 2758-2763
-
-
Segal, D.J.1
Dreier, B.2
Beerli, R.R.3
Iii, F.B.C.4
-
30
-
-
0034602243
-
Insights into the molecular recognition of the 5′-GNN-3′ family of DNA sequences by zinc-finger domains
-
Dreier, B., Segal, D. J., and Barbas, C. F., III (2000) Insights into the molecular recognition of the 5′-GNN-3′ family of DNA sequences by zinc-finger domains J. Mol. Biol. 303, 489-502
-
(2000)
J. Mol. Biol.
, vol.303
, pp. 489-502
-
-
Dreier, B.1
Segal, D.J.2
Iii, F.B.C.3
-
31
-
-
0035800769
-
Development of zinc finger domains for recognition of the 5′-ANN-3′ family of DNA sequences and their use in the construction of artificial transcription factors
-
Dreier, B., Beerli, R. R., Segal, D. J., Flippin, J. D., and Barbas, C. F., III (2001) Development of zinc finger domains for recognition of the 5′-ANN-3′ family of DNA sequences and their use in the construction of artificial transcription factors J. Biol. Chem. 276, 29466-29478
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 29466-29478
-
-
Dreier, B.1
Beerli, R.R.2
Segal, D.J.3
Flippin, J.D.4
Iii, F.B.C.5
-
32
-
-
27444444925
-
Development of zinc finger domains for recognition of the 5′-CNN-3′ family DNA sequences and their use in the construction of artificial transcription factors
-
Dreier, B., Fuller, R. P., Segal, D. J., Lund, C., Blancafort, P., Huber, A., Koksch, B., and Barbas, C. F., III (2005) Development of zinc finger domains for recognition of the 5′-CNN-3′ family DNA sequences and their use in the construction of artificial transcription factors J. Biol. Chem. 280, 35588-35597
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 35588-35597
-
-
Dreier, B.1
Fuller, R.P.2
Segal, D.J.3
Lund, C.4
Blancafort, P.5
Huber, A.6
Koksch, B.7
Iii, F.B.C.8
-
33
-
-
0032578492
-
Artificial nine zinc-finger peptide with 30 base pair binding sites
-
Kamiuchi, T., Abe, E., Imanishi, M., Kaji, T., Nagaoka, M., and Sugiura, Y. (1998) Artificial nine zinc-finger peptide with 30 base pair binding sites Biochemistry 37, 13827-13834
-
(1998)
Biochemistry
, vol.37
, pp. 13827-13834
-
-
Kamiuchi, T.1
Abe, E.2
Imanishi, M.3
Kaji, T.4
Nagaoka, M.5
Sugiura, Y.6
-
34
-
-
77953702888
-
Directed evolution of an enhanced and highly efficient FokI cleavage domain for zinc finger nuclease
-
Guo, J., Gaj, T., and Barbas, C. F., III (2010) Directed evolution of an enhanced and highly efficient FokI cleavage domain for zinc finger nuclease J. Mol. Biol. 400, 96-107
-
(2010)
J. Mol. Biol.
, vol.400
, pp. 96-107
-
-
Guo, J.1
Gaj, T.2
Iii, F.B.C.3
|