Arsenite down-regulates cytochrome P450 1A1 at the transcriptional and posttranslational levels in human HepG2 cells

Free Radical Biology and Medicine

Volumn 48, Issue 10, 2010, Pages 1399-1409

  Anwar Mohamed, Anwar ^a   El Kadi, Ayman O S ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

Author keywords

Arsenite; Aryl hydrocarbon receptor; CYP1A1; Free radicals; Gene expression; Heavy metals; Heme oxygenase 1

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; AROMATIC HYDROCARBON RECEPTOR; ARSENIC TRIOXIDE; CYTOCHROME P450 1A1; CYTOCHROME P450 1A2; HEME; HEME OXYGENASE 1; HEMOGLOBIN; LUCIFERASE; MESOPORPHYRIN TIN; MESSENGER RNA; PROTOPORPHYRIN COBALT; SMALL INTERFERING RNA;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL STRAIN HEPG2; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVITY; ENZYME INHIBITION; GENE EXPRESSION; GENETIC TRANSCRIPTION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; INHIBITION KINETICS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INDUCTION; REPORTER GENE; RNA STABILITY;

ARSENITES; CYTOCHROME P-450 CYP1A1; ENVIRONMENTAL EXPOSURE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HEME OXYGENASE-1; HEP G2 CELLS; HUMANS; METALLOPORPHYRINS; PROTEIN PROCESSING, POST-TRANSLATIONAL; RECEPTORS, ARYL HYDROCARBON; RNA, SMALL INTERFERING; TETRACHLORODIBENZODIOXIN;

EID: 77951937895     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2010.02.027     Document Type: Article

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