Antinociceptive Activity of a Synthetic Curcuminoid Analogue, 2,6-bis-(4-hydroxy-3-methoxybenzylidene)cyclohexanone, on Nociception-induced Models in Mice

Basic and Clinical Pharmacology and Toxicology

Volumn 110, Issue 3, 2012, Pages 275-282

  Ming Tatt, Lee ^a   Khalivulla, Shaik Ibrahim ^a   Akhtar, Muhammad Nadeem ^a   Mohamad, Azam Shah ^a   Perimal, Enoch Kumar ^a   Khalid, Mohamed Hanief ^a   Akira, Ahmad ^a   Lajis, Nordin ^a   Israf, Daud Ahmad ^a   Sulaiman, Mohd Roslan ^a  

^a UNIVERSITY PUTRA MALAYSIA   (Malaysia)

Author keywords

[No Author keywords available]

Indexed keywords

2,6 BIS(4 HYDROXY 3 METHOXYBENZYLIDENE)CYCLOHEXANONE; ACETYLSALICYLIC ACID; ANTINOCICEPTIVE AGENT; CYCLOHEXANONE DERIVATIVE; DIAZEPAM; MORPHINE; MUSCLE RELAXANT AGENT; NALOXONE; SEDATIVE AGENT; UNCLASSIFIED DRUG;

ANALGESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ANTINOCICEPTION; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFICACY; DRUG POTENTIATION; LATENT PERIOD; MOTOR PERFORMANCE; MOUSE; NOCICEPTION; NONHUMAN; PRIORITY JOURNAL;

ANALGESICS; ANIMALS; CURCUMIN; CYCLOHEXANONES; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; INFLAMMATION; INFLAMMATION MEDIATORS; INHIBITORY CONCENTRATION 50; INJECTIONS, INTRAPERITONEAL; MALE; MICE; MICE, INBRED BALB C; NALOXONE; NARCOTIC ANTAGONISTS; PAIN; TOXICITY TESTS, ACUTE;

MUS;

EID: 84857373604     PISSN: 17427835     EISSN: 17427843     Source Type: Journal    
DOI: 10.1111/j.1742-7843.2011.00804.x     Document Type: Article

References (47)

1. Merskey H, Albe-Fessard D, Bonica JJ, Carmon A, Dubner R, Kerr FWL et al. Pain terms: a list with definitions and notes on usage. Recommended by the IASP Subcommittee on Taxonomy. Pain 1979;6:249.
2. Rustoen T, Stubhaug A, Eidsmo I, Westheim A, Paul SM, Miaskowski C. Pain and quality of life in hospitalized patients with heart failure. J Pain Symptom Manage 2008;36:497-504.
3. Gureje O, Von Korff M, Simon GE, Gater R. Persistent pain and well-being: a World Health Organization Study in Primary Care. JAMA 1998;280:147-51.
4. Williams M, Kowaluk EA, Arneric SP. Emerging molecular approaches to pain therapy. J Med Chem 1999;42:1481-500.
5. Levine JD. New directions in pain research: molecules to maladies. Neuron 1998;20:649-54.
6. Walsh TD. Prevention of opioid side effects. J Pain Symptom Manage 1990;5:362-7.
7. Allison MC, Howatson AG, Torrance CJ, Lee FD, Russell RI. Gastrointestinal damage associated with the use of nonsteroidal antiinflammatory drugs. N Engl J Med 1992;327:749-54.
8. Wilhelm EA, Jesse CR, Bortolatto CF, Nogueira CW, Savegnago L. Antinociceptive and anti-allodynic effects of 3-alkynyl selenophene on different models of nociception in mice. Pharmacol Biochem Behav 2009;93:419-25.
9. Tham CL, Liew CY, Lam KW, Mohamad AS, Kim MK, Cheah YK et al.A synthetic curcuminoid derivative inhibits nitric oxide and proinflammatory cytokine synthesis. Eur J Pharmacol 2010;628:247-54.
10. Tham CL, Lam KW, Rajajendram R, Cheah YK, Sulaiman MR, Lajis NH et al. The effects of a synthetic curcuminoid analogue, 2, 6-bis-(4-hydroxyl-3-methoxybenzylidine)cyclohexanone on proinflammatory signaling pathways and CLP-induced lethal sepsis in mice. Eur J Pharmacol 2011;652:136-44.
11. Boettger MK, Üceyler N, Zelenka M, Schmitt A, Reif A, Chen Y et al. Differences in inflammatory pain in nNOS-, iNOS- and eNOS-deficient mice. Eur J Pain 2007;11:810-8.
12. Liu M-G, Wang R-R, Chen X-F, Zhang F-K, Cui X-Y, Chen J. Differential roles of ERK, JNK and p38 MAPK in pain-related spatial and temporal enhancement of synaptic responses in the hippocampal formation of rats: multi-electrode array recordings. Brain Res 2011;1382:57-69.
13. Leung L, Cahill C. TNF-alpha and neuropathic pain - a review. J Neuroinflammation 2010;7:27.
14. De Jongh RF, Vissers KC, Meert TF, Booij LH, De Deyne CS, Heylen RJ. The role of interleukin-6 in nociception and pain. Anesth Analg 2003;96:1096-103.
15. Zimmermann M. Ethical guidelines for investigations of experimental pain in conscious animals. Pain 1983;16:109-10.
16. Sulaiman MR, Perimal EK, Zakaria ZA, Mokhtar F, Akhtar MN, Lajis NH et al. Preliminary analysis of the antinociceptive activity of zerumbone. Fitoterapia 2009;80:230-2.
17. Khalid S, Shaik Mossadeq WM, Israf DA, Hashim P, Rejab S, Shaberi AM et al. In vivo analgesic effect of aqueous extract of Tamarindus indica L. fruits. Med Princ Pract 2010;19:255-9.
18. Beirith A, Santos AR, Calixto JB. Mechanisms underlying the nociception and paw oedema caused by injection of glutamate into the mouse paw. Brain Res 2002;924:219-28.
19. Santos AR, Miguel OG, Yunes RA, Calixto JB. Antinociceptive properties of the new alkaloid, cis-8, 10-di-N-propyllobelidiol hydrochloride dihydrate isolated from Siphocampylus verticillatus: evidence for the mechanism of action. J Pharmacol Exp Ther 1999;289:417-26.
20. Sulaiman MR, Hussain MK, Zakaria ZA, Somchit MN, Moin S, Mohamad AS et al. Evaluation of the antinociceptive activity of Ficus deltoidea aqueous extract. Fitoterapia 2008;79:557-61.
21. Mohamad AS, Akhtar MN, Zakaria ZA, Perimal EK, Khalid S, Mohd PA et al. Antinociceptive activity of a synthetic chalcone, flavokawin B on chemical and thermal models of nociception in mice. Eur J Pharmacol 2010;647:103-9.
22. Gene RM, Segura L, Adzet T, Marin E, Iglesias J. Heterotheca inuloides: anti-inflammatory and analgesic effect. J Ethnopharmacol 1998;60:157-62.
23. Bentley GA, Newton SH, Starr J. Evidence for an action of morphine and the enkephalins on sensory nerve endings in the mouse peritoneum. Br J Pharmacol 1981;73:325-32.
24. Julius D, Basbaum AI. Molecular mechanisms of nociception. Nature 2001;413:203-10.
25. Derardt R, Jougney S, Delevalcese F, Falhout M. Release of prostaglandins E and F in an algogenic reaction and it inhibition. Eur J Pharmacol 1980;51:17-24.
26. Levini JD, Lau W, Kwait G, Goetzl EJ. Leukotriene B4 produces hyperalgesia that is dependent on the polymorphonuclear leucocytes. Science 1984;225:743-5.
27. Ribeiro RA, Vale ML, Thomazzi SM, Paschoalato AB, Poole S, Ferreira SH et al. Involvement of resident macrophages and mast cells in the writhing nociceptive response induced by zymosan and acetic acid in mice. Eur J Pharmacol 2000;387:111-8.
28. Larson AA, Kovacs KJ, Cooper JC, Kitto KF. Transient changes in the synthesis of nitric oxide result in long-term as well as short-term changes in acetic acid-induced writhing in mice. Pain 2000;86:103-11.
29. Srinivasan K, Muruganandan S, Lal J, Chandra S, Tandan SK, Raviprakash V et al. Antinociceptive and antipyretic activities of Pongamia pinnata leaves. Phytother Res 2003;17:259-64.
30. Gao YJ, Zhang L, Samad OA, Suter MR, Yasuhiko K, Xu ZZ et al.JNK-induced MCP-1 production in spinal cord astrocytes contributes to central sensitization and neuropathic pain. J Neurosci 2009;29:4096-108.
31. Schmidtko A, Tegeder I, Geisslinger G. No NO, no pain? The role of nitric oxide and cGMP in spinal pain processing. Trends Neurosci 2009;32:339-46.
32. Le Bars D, Gozariu M, Cadden SW. Animal models of nociception. Pharmacol Rev 2001;53:597-652.
33. McNamara CR, Mandel-Brehm J, Bautista DM, Siemens J, Deranian KL, Zhao M et al.TRPA1 mediates formalin-induced pain. Proc Natl Acad Sci U S A 2007;104:13525-30.
34. Tjolsen A, Berge OG, Hunskaar S, Rosland JH, Hole K. The formalin test: an evaluation of the method. Pain 1992;51:5-17.
35. Parada CA, Tambeli CH, Cunha FQ, Ferreira SH. The major role of peripheral release of histamine and 5-hydroxytryptamine in formalin-induced nociception. Neuroscience 2001;102:937-44.
36. Abbott FV, Melzack R. Brainstem lesions dissociate neural mechanisms of morphine analgesia in different kinds of pain. Brain Res 1982;251:149-55.
37. Gazerani P, Wang K, Cairns BE, Svensson P, Arendt-Nielsen L. Effects of subcutaneous administration of glutamate on pain, sensitization and vasomotor responses in healthy men and women. Pain 2006;124:338-48.
38. Garthwaite J. Glutamate, nitric oxide and cell-cell signalling in the nervous system. Trends Neurosci 1991;14:60-7.
39. Davidson EM, Carlton SM. Intraplantar injection of dextrorphan, ketamine or memantine attenuates formalin-induced behaviors. Brain Res 1998;785:136-42.
40. Perimal EK, Akhtar MN, Mohamad AS, Khalid MH, Ming OH, Khalid S et al. Zerumbone-induced antinociception: involvement of the l-arginine-nitric oxide-cGMP -PKC-K+ ATP channel pathways. Basic Clin Pharmacol Toxicol 2011;108:155-62.
41. Quintans-Junior LJ, Melo MS, De Sousa DP, Araujo AA, Onofre AC, Gelain DP et al. Antinociceptive effects of citronellal in formalin-, capsaicin-, and glutamate-induced orofacial nociception in rodents and its action on nerve excitability. J Orofac Pain 2010;24:305-12.
42. Beirith A, Santos AR, Rodrigues AL, Creczynski-Pasa TB, Calixto JB. Spinal and supraspinal antinociceptive action of dipyrone in formalin, capsaicin and glutamate tests. Study of the mechanism of action. Eur J Pharmacol 1998;345:233-45.
43. Caterina MJ, Schumacher MA, Tominaga M, Rosen TA, Levine JD, Julius D. The capsaicin receptor: a heat-activated ion channel in the pain pathway. Nature 1997;389:816-24.
44. Sakurada T, Yogo H, Katsumata K, Tan-No K, Sakurada S, Kisara K et al. Differential antinociceptive effects of sendide, a NK1-receptor antagonist, and morphine in the capsaicin test. Brain Res 1994;649:319-22.
45. Santos AR, Calixto JB. Ruthenium red and capsazepine antinociceptive effect in formalin and capsaicin models of pain in mice. Neurosci Lett 1997;235:73-6.
46. Mohamad AS, Akhtar MN, Khalivulla SI, Perimal EK, Khalid MH, Ong HM et al. Possible participation of nitric oxide/cyclic guanosine monophosphate/protein kinase C/ATP-sensitive K(+) channels pathway in the systemic antinociception of flavokawin B. Basic Clin Pharmacol Toxicol 2011;108:400-5.
47. Jesse CR, Rocha JB, Nogueira CW, Savegnago L. Further analysis of the antinociceptive action caused by p-methoxyl-diphenyl diselenide in mice. Pharmacol Biochem Behav 2009;91:573-80.