메뉴 건너뛰기




Volumn 93, Issue 4, 2009, Pages 419-425

Antinociceptive and anti-allodynic effects of 3-alkynyl selenophene on different models of nociception in mice

Author keywords

Antinociceptive; Hyperalgesia; Mice; Nociception; Selenium; Selenophene

Indexed keywords

3 ALKYNYL SELENOPHENE; ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; BRADYKININ; CAPSAICIN; CREATININE; FORMALDEHYDE; FREUND ADJUVANT; GLUTAMIC ACID; NALOXONE; ORGANOSELENIUM DERIVATIVE; PHORBOL 13 ACETATE 12 MYRISTATE; UNCLASSIFIED DRUG; UREA;

EID: 67849119410     PISSN: 00913057     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pbb.2009.06.003     Document Type: Article
Times cited : (47)

References (64)
  • 1
    • 38349141558 scopus 로고    scopus 로고
    • Synthesis of 3-alkynylselenophene derivatives by a cooper-free sonogashira cross-coupling reaction
    • Alves D., Reis J.S., Luchese C., Nogueira C.W., and Zeni G. Synthesis of 3-alkynylselenophene derivatives by a cooper-free sonogashira cross-coupling reaction. Eur J Org Chem 2 (2008) 377-382
    • (2008) Eur J Org Chem , vol.2 , pp. 377-382
    • Alves, D.1    Reis, J.S.2    Luchese, C.3    Nogueira, C.W.4    Zeni, G.5
  • 2
    • 0016211087 scopus 로고
    • New hot plate tests to quantify antinociceptive and narcotic antagonists activities
    • Ankier S.I. New hot plate tests to quantify antinociceptive and narcotic antagonists activities. Eur J Pharmacol 27 (1974) 1-4
    • (1974) Eur J Pharmacol , vol.27 , pp. 1-4
    • Ankier, S.I.1
  • 3
    • 0037059594 scopus 로고    scopus 로고
    • Mechanisms underlying the nociception and paw oedema caused by injection of glutamate into the mouse paw
    • Beirith A., Santos A.R.S., and Calixto J.B. Mechanisms underlying the nociception and paw oedema caused by injection of glutamate into the mouse paw. Brain Res 924 (2002) 219-228
    • (2002) Brain Res , vol.924 , pp. 219-228
    • Beirith, A.1    Santos, A.R.S.2    Calixto, J.B.3
  • 4
    • 0037174794 scopus 로고    scopus 로고
    • Anti-allodynic action of the tormentic acid, a triterpene isolated from plant, against neuropathic and inflammatory persistent pain in mice
    • Bortolanza L.B., Ferreira J., Hess S.C., Delle Monache F., Yunes R.A., and Calixto J.B. Anti-allodynic action of the tormentic acid, a triterpene isolated from plant, against neuropathic and inflammatory persistent pain in mice. Eur J Pharmacol 453 (2002) 203-208
    • (2002) Eur J Pharmacol , vol.453 , pp. 203-208
    • Bortolanza, L.B.1    Ferreira, J.2    Hess, S.C.3    Delle Monache, F.4    Yunes, R.A.5    Calixto, J.B.6
  • 8
    • 0035824274 scopus 로고    scopus 로고
    • Antinociceptive profiles of aspirin and acetaminophen in formalin, substance P and glutamate pain models
    • Choi S.S., Lee J.K., and Suh H.W. Antinociceptive profiles of aspirin and acetaminophen in formalin, substance P and glutamate pain models. Brain Res 921 (2001) 233-239
    • (2001) Brain Res , vol.921 , pp. 233-239
    • Choi, S.S.1    Lee, J.K.2    Suh, H.W.3
  • 9
    • 0345310068 scopus 로고    scopus 로고
    • Chemopreventive agents: selenium
    • Combs G.F., and Gray W.P. Chemopreventive agents: selenium. Pharmacol Ther 79 (1998) 179-192
    • (1998) Pharmacol Ther , vol.79 , pp. 179-192
    • Combs, G.F.1    Gray, W.P.2
  • 10
    • 0014560164 scopus 로고
    • The effect of narcotics and narcotic antagonists on the tail-flick response in spinal mice
    • Dewey W.L., Snyder J.W., Harris L.S., and Howes J.F. The effect of narcotics and narcotic antagonists on the tail-flick response in spinal mice. J Pharm Pharmacol 21 (1969) 548-550
    • (1969) J Pharm Pharmacol , vol.21 , pp. 548-550
    • Dewey, W.L.1    Snyder, J.W.2    Harris, L.S.3    Howes, J.F.4
  • 12
    • 1842559782 scopus 로고    scopus 로고
    • Contribution of vanilloid receptors to the overt nociception induced by B2 kinin receptor activation in mice
    • Ferreira J., Da Silva G.L., and Calixto J.B. Contribution of vanilloid receptors to the overt nociception induced by B2 kinin receptor activation in mice. Br J Pharmacol 141 (2004) 787-794
    • (2004) Br J Pharmacol , vol.141 , pp. 787-794
    • Ferreira, J.1    Da Silva, G.L.2    Calixto, J.B.3
  • 13
    • 28844437406 scopus 로고    scopus 로고
    • Mechanisms involved in the nociception produced by peripheral protein kinase C activation in mice
    • Ferreira J., Trichês K.M., Medeiros R., and Calixto J.B. Mechanisms involved in the nociception produced by peripheral protein kinase C activation in mice. Pain 117 (2005) 171-181
    • (2005) Pain , vol.117 , pp. 171-181
    • Ferreira, J.1    Trichês, K.M.2    Medeiros, R.3    Calixto, J.B.4
  • 14
    • 0030245643 scopus 로고    scopus 로고
    • Enhanced withdrawal responses to heat and mechanical stimuli following intraplantar injection of capsaicin in rats
    • Gilchrist H.D., Allard B.L., and Simone D.A. Enhanced withdrawal responses to heat and mechanical stimuli following intraplantar injection of capsaicin in rats. Pain 67 (1996) 179-188
    • (1996) Pain , vol.67 , pp. 179-188
    • Gilchrist, H.D.1    Allard, B.L.2    Simone, D.A.3
  • 15
    • 84983725917 scopus 로고    scopus 로고
    • Antinociceptive properties of acetylenic thiophene and furan derivatives: evidence for the mechanism of action
    • Gonçales C.E.P., Araldi D., Panatieri R.B., Rocha J.B.T., Zeni G., and Nogueira C.W. Antinociceptive properties of acetylenic thiophene and furan derivatives: evidence for the mechanism of action. Life Sci 76 (2005) 2221-2234
    • (2005) Life Sci , vol.76 , pp. 2221-2234
    • Gonçales, C.E.P.1    Araldi, D.2    Panatieri, R.B.3    Rocha, J.B.T.4    Zeni, G.5    Nogueira, C.W.6
  • 16
    • 0024802860 scopus 로고
    • Photoactive antiviral and cytotoxic activities of synthetic thiophenes and their acetylenic derivatives
    • Hudson J.B., Graham E.A., Miki N., Towers G.H.N., Hudson L.L., Rossi R., et al. Photoactive antiviral and cytotoxic activities of synthetic thiophenes and their acetylenic derivatives. Chemosphere 19 (1989) 1329-1343
    • (1989) Chemosphere , vol.19 , pp. 1329-1343
    • Hudson, J.B.1    Graham, E.A.2    Miki, N.3    Towers, G.H.N.4    Hudson, L.L.5    Rossi, R.6
  • 17
    • 0030983492 scopus 로고    scopus 로고
    • Glutamate: a role in normal brain function, anaesthesia, analgesia and CNS injury
    • Hudspith M.J. Glutamate: a role in normal brain function, anaesthesia, analgesia and CNS injury. Br J Anaesth 78 (1997) 731-747
    • (1997) Br J Anaesth , vol.78 , pp. 731-747
    • Hudspith, M.J.1
  • 18
    • 0022534354 scopus 로고
    • A modified hot plate test sensitive to mild analgesics
    • Hunskaar S., Berge O.G., and Hole K. A modified hot plate test sensitive to mild analgesics. Behav Brain Res 21 (1986) 101-108
    • (1986) Behav Brain Res , vol.21 , pp. 101-108
    • Hunskaar, S.1    Berge, O.G.2    Hole, K.3
  • 19
    • 0023223448 scopus 로고
    • The formalin test in mice: dissociation between inflammatory and non-inflammatory pain
    • Hunskaar S., and Hole K. The formalin test in mice: dissociation between inflammatory and non-inflammatory pain. Pain 30 (1987) 103-114
    • (1987) Pain , vol.30 , pp. 103-114
    • Hunskaar, S.1    Hole, K.2
  • 21
    • 16244385519 scopus 로고
    • Methods determining creatinine
    • Jaffe M.Z. Methods determining creatinine. Physiol Chem 10 (1886) 39-40
    • (1886) Physiol Chem , vol.10 , pp. 39-40
    • Jaffe, M.Z.1
  • 22
    • 14644439234 scopus 로고    scopus 로고
    • Opioid tolerance and dependence
    • Jage J. Opioid tolerance and dependence. Do they matter? Eur J Pain 9 (2005) 157-162
    • (2005) Do they matter? Eur J Pain , vol.9 , pp. 157-162
    • Jage, J.1
  • 23
    • 84873788346 scopus 로고
    • The inhibitory effect of fentanyl and other morphine-like analgesics on the warn water induced tail withdrawal reflex in rats
    • Janssen P.A.J., Niemegeers C.J.E., and Dony J.H.G. The inhibitory effect of fentanyl and other morphine-like analgesics on the warn water induced tail withdrawal reflex in rats. Arzeneimittelforschung 13 (1963) 502-507
    • (1963) Arzeneimittelforschung , vol.13 , pp. 502-507
    • Janssen, P.A.J.1    Niemegeers, C.J.E.2    Dony, J.H.G.3
  • 24
    • 0022560622 scopus 로고
    • Comparison of antinociceptive action of morphine in the periaqueductal gray, medial and paramedialmedullal in rat
    • Jensen T.S., and Yaksh T.L. Comparison of antinociceptive action of morphine in the periaqueductal gray, medial and paramedialmedullal in rat. Brain Res 363 (1986) 99-113
    • (1986) Brain Res , vol.363 , pp. 99-113
    • Jensen, T.S.1    Yaksh, T.L.2
  • 25
    • 50649099045 scopus 로고    scopus 로고
    • Spinal mechanisms of antinociceptive effect caused by oral administration of bis-selenide in mice
    • Jesse C.R., Savegnago L., and Nogueira C.W. Spinal mechanisms of antinociceptive effect caused by oral administration of bis-selenide in mice. Brain Res 1231 (2008) 25-33
    • (2008) Brain Res , vol.1231 , pp. 25-33
    • Jesse, C.R.1    Savegnago, L.2    Nogueira, C.W.3
  • 26
    • 84984569833 scopus 로고    scopus 로고
    • Further analysis of the antinociceptive action caused by p-methoxyldiphenyl diselenide in mice
    • Jesse C.R., Rocha J.B.T., Nogueira C.W., and Savegnago L. Further analysis of the antinociceptive action caused by p-methoxyldiphenyl diselenide in mice. Pharmacol Biochem Behav 91 (2008) 573-580
    • (2008) Pharmacol Biochem Behav , vol.91 , pp. 573-580
    • Jesse, C.R.1    Rocha, J.B.T.2    Nogueira, C.W.3    Savegnago, L.4
  • 27
    • 0035116529 scopus 로고    scopus 로고
    • Neuronal plasticity and signal transduction in nociceptive neurons: implications for the initiation and maintenance of pathological pain
    • Ji R.R., and Woolf C.J. Neuronal plasticity and signal transduction in nociceptive neurons: implications for the initiation and maintenance of pathological pain. Neurobiol Dis 8 (2001) 1-10
    • (2001) Neurobiol Dis , vol.8 , pp. 1-10
    • Ji, R.R.1    Woolf, C.J.2
  • 28
    • 32644466788 scopus 로고    scopus 로고
    • Cell signaling and the genesis of neuropathic pain
    • Ji R.R., and Stricharstz G. Cell signaling and the genesis of neuropathic pain. Science 252 (2004) 1-19
    • (2004) Science , vol.252 , pp. 1-19
    • Ji, R.R.1    Stricharstz, G.2
  • 30
  • 31
    • 0035807743 scopus 로고    scopus 로고
    • Inhibition of C-fibre mediated sensory transmission in the rat following intraplantar formalin
    • Martindale J., Bland-Ward P.A., and Chessell I.P. Inhibition of C-fibre mediated sensory transmission in the rat following intraplantar formalin. Neurosci Lett 316 (2001) 33-36
    • (2001) Neurosci Lett , vol.316 , pp. 33-36
    • Martindale, J.1    Bland-Ward, P.A.2    Chessell, I.P.3
  • 33
    • 0032890162 scopus 로고    scopus 로고
    • The induction of pain: an integrative review
    • Millan M.J. The induction of pain: an integrative review. Prog Neurobiol 57 (1999) 1-164
    • (1999) Prog Neurobiol , vol.57 , pp. 1-164
    • Millan, M.J.1
  • 34
    • 55249100472 scopus 로고    scopus 로고
    • Antinociceptive action of 4-methyl-5-trifluoromethyl-5-hydroxy-4,5-dihydro-1H-pyrazole methyl ester in models of inflammatory pain in mice
    • Milano J., Rossato M.F., Oliveira S.M., Drewes C., Machado P., Beck P., et al. Antinociceptive action of 4-methyl-5-trifluoromethyl-5-hydroxy-4,5-dihydro-1H-pyrazole methyl ester in models of inflammatory pain in mice. Life Sci 83 (2008) 739-746
    • (2008) Life Sci , vol.83 , pp. 739-746
    • Milano, J.1    Rossato, M.F.2    Oliveira, S.M.3    Drewes, C.4    Machado, P.5    Beck, P.6
  • 36
    • 84984583119 scopus 로고    scopus 로고
    • Organoselenium and organotellurium compounds: toxicology and pharmacology
    • Nogueira C.W., Zeni G., and Rocha J.B.T. Organoselenium and organotellurium compounds: toxicology and pharmacology. Chem Rev 104 (2004) 6255-6285
    • (2004) Chem Rev , vol.104 , pp. 6255-6285
    • Nogueira, C.W.1    Zeni, G.2    Rocha, J.B.T.3
  • 38
    • 0037306774 scopus 로고    scopus 로고
    • Atropine reverses the antinociception of nonsteroidal anti-inflammatory drugs in the tail-flick test of mice
    • Pinardi G., Sierralta F., and Miranda H.F. Atropine reverses the antinociception of nonsteroidal anti-inflammatory drugs in the tail-flick test of mice. Pharmacol Biochem Behav 74 (2003) 603-608
    • (2003) Pharmacol Biochem Behav , vol.74 , pp. 603-608
    • Pinardi, G.1    Sierralta, F.2    Miranda, H.F.3
  • 39
    • 37249013016 scopus 로고    scopus 로고
    • Evidence for the involvement of glutamatergic and GABAergic systems and protein kinase A pathway in the antinociceptive effect caused by p-methoxy-diphenyl diselenide in mice
    • Pinto L.G., Jesse C.R., Nogueira C.W., and Savegnago L. Evidence for the involvement of glutamatergic and GABAergic systems and protein kinase A pathway in the antinociceptive effect caused by p-methoxy-diphenyl diselenide in mice. Pharmacol Biochem Behav 88 (2008) 487-496
    • (2008) Pharmacol Biochem Behav , vol.88 , pp. 487-496
    • Pinto, L.G.1    Jesse, C.R.2    Nogueira, C.W.3    Savegnago, L.4
  • 40
    • 66349129125 scopus 로고
    • A colorimetric method for the determination of serum glutamic oxalacetic and glutamic pyruvic transaminases
    • Reitman S., and Frankel S. A colorimetric method for the determination of serum glutamic oxalacetic and glutamic pyruvic transaminases. Am J Clin Pathol 28 (1957) 56-63
    • (1957) Am J Clin Pathol , vol.28 , pp. 56-63
    • Reitman, S.1    Frankel, S.2
  • 42
    • 0027180826 scopus 로고
    • Antinociception induced by CP 96345, a non-peptide NK-1 receptor antagonist, in the formalin and capsaicin tests
    • Sakurada T., Katsumata K., Yogo H., Tan-No K., Sakurada S., and Kisara K. Antinociception induced by CP 96345, a non-peptide NK-1 receptor antagonist, in the formalin and capsaicin tests. Neurosci Lett 151 (1993) 142-145
    • (1993) Neurosci Lett , vol.151 , pp. 142-145
    • Sakurada, T.1    Katsumata, K.2    Yogo, H.3    Tan-No, K.4    Sakurada, S.5    Kisara, K.6
  • 45
    • 84984548871 scopus 로고    scopus 로고
    • Diphenyl diselenide attenuates acute thermal hyperalgesia and persistent inflammatory and neuropathic pain behavior in mice
    • Savegnago L., Jesse C.R., Pinto L.G., Rocha J.B.T., and Nogueira C.W. Diphenyl diselenide attenuates acute thermal hyperalgesia and persistent inflammatory and neuropathic pain behavior in mice. Brain Res 1175 (2007) 54-59
    • (2007) Brain Res , vol.1175 , pp. 54-59
    • Savegnago, L.1    Jesse, C.R.2    Pinto, L.G.3    Rocha, J.B.T.4    Nogueira, C.W.5
  • 46
    • 84983719301 scopus 로고    scopus 로고
    • Antinociceptive properties of diphenyl diselenide: evidences for the mechanism of action
    • Savegnago L., Pinto L.G., Jesse C.R., Alves D., Rocha J.B.T., Nogueira C.W., et al. Antinociceptive properties of diphenyl diselenide: evidences for the mechanism of action. Eur J Pharmacol 555 (2007) 129-138
    • (2007) Eur J Pharmacol , vol.555 , pp. 129-138
    • Savegnago, L.1    Pinto, L.G.2    Jesse, C.R.3    Alves, D.4    Rocha, J.B.T.5    Nogueira, C.W.6
  • 48
    • 84983725609 scopus 로고    scopus 로고
    • Mechanisms involved in the antinociceptive effect caused by diphenyl diselenide in the formalin test
    • Savegnago L., Jesse C.R., Santos A.R., Rocha J.B., and Nogueira C.W. Mechanisms involved in the antinociceptive effect caused by diphenyl diselenide in the formalin test. J Pharm Pharmacol 60 (2008) 1679-1686
    • (2008) J Pharm Pharmacol , vol.60 , pp. 1679-1686
    • Savegnago, L.1    Jesse, C.R.2    Santos, A.R.3    Rocha, J.B.4    Nogueira, C.W.5
  • 49
    • 41949122628 scopus 로고    scopus 로고
    • 2B receptor antagonist but not imidazoline receptor antagonists modulate antinociception induced by diphenyl diselenide in mice
    • 2B receptor antagonist but not imidazoline receptor antagonists modulate antinociception induced by diphenyl diselenide in mice. Neurosci Lett 436 (2008) 120-123
    • (2008) Neurosci Lett , vol.436 , pp. 120-123
    • Savegnago, L.1    Jesse, C.R.2    Nogueira, C.W.3
  • 50
    • 0029114721 scopus 로고
    • Molecular actions of ebselen-an anti-inflammatory antioxidant
    • Schewe T. Molecular actions of ebselen-an anti-inflammatory antioxidant. Gen Pharmacol 26 (1995) 1153-1169
    • (1995) Gen Pharmacol , vol.26 , pp. 1153-1169
    • Schewe, T.1
  • 51
    • 0024438481 scopus 로고
    • Modified formalin test: characteristic biphasic pain response
    • Shibata M., Ohkubo T., Takahashi H., and Inoki R. Modified formalin test: characteristic biphasic pain response. Pain 38 (1989) 347-352
    • (1989) Pain , vol.38 , pp. 347-352
    • Shibata, M.1    Ohkubo, T.2    Takahashi, H.3    Inoki, R.4
  • 52
    • 0027533505 scopus 로고
    • Ebselen, a selenoorganic compounds as glutathione peroxidase mimic
    • Sies H. Ebselen, a selenoorganic compounds as glutathione peroxidase mimic. Free Radic Biol Med 14 (1993) 313-323
    • (1993) Free Radic Biol Med , vol.14 , pp. 313-323
    • Sies, H.1
  • 53
    • 0025900405 scopus 로고
    • Analgesic activity of a novel bivalent opioid peptide compared to morphine via different routes of administration
    • Silbert B.S., Lipkowski A.W., Cepeda M.S., Szyfelbein S.K., Osgood P.F., and Carr D.B. Analgesic activity of a novel bivalent opioid peptide compared to morphine via different routes of administration. Agents Actions. 33 (1991) 382-387
    • (1991) Agents Actions. , vol.33 , pp. 382-387
    • Silbert, B.S.1    Lipkowski, A.W.2    Cepeda, M.S.3    Szyfelbein, S.K.4    Osgood, P.F.5    Carr, D.B.6
  • 55
    • 0032970173 scopus 로고    scopus 로고
    • Vanilloid (capsaicin) receptors and mechanisms
    • Szallasi A., and Blumberg P.M. Vanilloid (capsaicin) receptors and mechanisms. Pharm Rev 51 (1999) 159-212
    • (1999) Pharm Rev , vol.51 , pp. 159-212
    • Szallasi, A.1    Blumberg, P.M.2
  • 56
    • 12344296557 scopus 로고    scopus 로고
    • A tachykinin NK1 receptor antagonist attenuates the 4beta-phorbol-12-myristate-13-acetate-induced nociceptive behaviour in the rat
    • Tsuchiya M., Sakakibara A., and Yamamoto M. A tachykinin NK1 receptor antagonist attenuates the 4beta-phorbol-12-myristate-13-acetate-induced nociceptive behaviour in the rat. Eur J Pharmacol 507 (2005) 29-34
    • (2005) Eur J Pharmacol , vol.507 , pp. 29-34
    • Tsuchiya, M.1    Sakakibara, A.2    Yamamoto, M.3
  • 57
    • 0028169759 scopus 로고
    • 2 enhances bradykinin-stimulated release of neuropeptides from rat sensory neurons in culture
    • 2 enhances bradykinin-stimulated release of neuropeptides from rat sensory neurons in culture. J Neurosci 14 (1994) 4987-4997
    • (1994) J Neurosci , vol.14 , pp. 4987-4997
    • Vasko, M.R.1    Campbell, W.B.2    Waite, K.J.3
  • 58
    • 12644304889 scopus 로고    scopus 로고
    • Antinociceptive action of 2-(4-bromobenzoyl)-3-methyl-4,6-dimethoxy benzofuran, a novel xanthoxyline derivative on chemical and thermal models of nociception in mice
    • Vaz Z.R., Filho V.C., Yunes R.A., and Calixto J.B. Antinociceptive action of 2-(4-bromobenzoyl)-3-methyl-4,6-dimethoxy benzofuran, a novel xanthoxyline derivative on chemical and thermal models of nociception in mice. J Pharmacol Exp Ther 278 (1996) 304-312
    • (1996) J Pharmacol Exp Ther , vol.278 , pp. 304-312
    • Vaz, Z.R.1    Filho, V.C.2    Yunes, R.A.3    Calixto, J.B.4
  • 59
    • 67349188037 scopus 로고    scopus 로고
    • Anticonvulsant and antioxidant effects of 3-alkynyl selenophene in 21-day-old rats on pilocarpine model of seizures
    • Wilhelm E.A., Jesse C.R., Bortolatto C.F., Nogueira C.W., and Savegnago L. Anticonvulsant and antioxidant effects of 3-alkynyl selenophene in 21-day-old rats on pilocarpine model of seizures. Brain Res Bull 79 (2009) 281-287
    • (2009) Brain Res Bull , vol.79 , pp. 281-287
    • Wilhelm, E.A.1    Jesse, C.R.2    Bortolatto, C.F.3    Nogueira, C.W.4    Savegnago, L.5
  • 60
    • 67649416056 scopus 로고    scopus 로고
    • Hepatoprotective effect of 3-alkynyl selenophene on acute liver injury induced by D-galactosamine and lipopolysaccharide
    • 10.1016/j.yexmp.2009.03.004
    • Wilhelm E.A., Jesse C.R., Roman S.S., Nogueira C.W., and Savegnago L. Hepatoprotective effect of 3-alkynyl selenophene on acute liver injury induced by D-galactosamine and lipopolysaccharide. Exp Mol Pathol (2009) 10.1016/j.yexmp.2009.03.004
    • (2009) Exp Mol Pathol
    • Wilhelm, E.A.1    Jesse, C.R.2    Roman, S.S.3    Nogueira, C.W.4    Savegnago, L.5
  • 61
    • 0000811019 scopus 로고
    • The evaluation of the analgesic action of pethidine hydrochloride
    • Woolfre H.G., and MacDonald A.D. The evaluation of the analgesic action of pethidine hydrochloride. J Pharmacol Exp Ther 80 (1944) 300-307
    • (1944) J Pharmacol Exp Ther , vol.80 , pp. 300-307
    • Woolfre, H.G.1    MacDonald, A.D.2
  • 62
    • 0031963836 scopus 로고    scopus 로고
    • Ebselen in acute ischemic stroke: a placebocontrolled, double-blind clinical trial
    • Yamagushi T., Sano K., Takakura K., Saito I., Shinohara Y., Asano T., et al. Ebselen in acute ischemic stroke: a placebocontrolled, double-blind clinical trial. Stroke 29 (1998) 12-17
    • (1998) Stroke , vol.29 , pp. 12-17
    • Yamagushi, T.1    Sano, K.2    Takakura, K.3    Saito, I.4    Shinohara, Y.5    Asano, T.6
  • 64
    • 0020525719 scopus 로고
    • Ethical guidelines for investigations of experimental pain in conscious animals
    • Zimmermann M. Ethical guidelines for investigations of experimental pain in conscious animals. Pain 16 (1983) 109-110
    • (1983) Pain , vol.16 , pp. 109-110
    • Zimmermann, M.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.