Zerumbone-Induced Antinociception: Involvement of the l-Arginine-Nitric Oxide-cGMP -PKC-K+ATP Channel Pathways

Basic and Clinical Pharmacology and Toxicology

Volumn 108, Issue 3, 2011, Pages 155-162

  Perimal, Enoch Kumar ^a   Akhtar, Muhammad Nadeem ^a   Mohamad, Azam Shah ^a   Khalid, Mohd Hanief ^a   Ming, Ong Hui ^a   Khalid, Syamimi ^a   Tatt, Lee Ming ^a   Kamaldin, Mohd Nasier ^a   Zakaria, Zainul Amiruddin ^a   Israf, Daud Ahmad ^a   Lajis, Nordin ^a   Sulaiman, Mohd Roslan ^a  

^a UNIVERSITY PUTRA MALAYSIA   (Malaysia)

Author keywords

[No Author keywords available]

Indexed keywords

ACETIC ACID; ADENOSINE TRIPHOSPHATASE (POTASSIUM); ARGININE; BRADYKININ; CAPSAICIN; CYCLIC GMP; GLIBENCLAMIDE; METHYLENE BLUE; NITRIC OXIDE; PLANT EXTRACT; PROTEIN KINASE C; UNCLASSIFIED DRUG; ZERUMBONE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINOCICEPTION; ARTICLE; CLINICAL EVALUATION; CONTROLLED STUDY; DISEASE MODEL; MALE; MOTOR PERFORMANCE; MOUSE; NOCICEPTION; NONHUMAN; PRIORITY JOURNAL; WRITHING TEST;

ANALGESICS; ANIMALS; ARGININE; BEHAVIOR, ANIMAL; CYCLIC GMP; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; KATP CHANNELS; MALE; MICE; MICE, INBRED ICR; MOTOR ACTIVITY; NITRIC OXIDE; PAIN MEASUREMENT; POTASSIUM CHANNEL BLOCKERS; PROTEIN KINASE C; RECEPTOR, BRADYKININ B2; SESQUITERPENES; TIME FACTORS; TRPV CATION CHANNELS;

MUS;

EID: 79951747877     PISSN: 17427835     EISSN: 17427843     Source Type: Journal    
DOI: 10.1111/j.1742-7843.2010.00635.x     Document Type: Article

References (43)

1. Murakami A, Takahashi M, Jiwajinda S, Koshimizu K, Ohigashi H. Identification of zerumbone in Zingiber zerumbet Smith as a potent inhibitor of 12-O-tetradecanoylphorbol-13-acetate-induced Epstein-Barr virus activation. Biosci Biotechnol Biochem 1999;63:1811-2.
2. Du gNX, Chinh TD, Ra gDD, Leclercq PA. The constituents of the rhizome oil of Zingiber zerumbet (L.) Sm. from Vietnam. J Essent Oil Res 1993;5:553-5.
3. Murakami A, Takahashi D, Kinoshita T, Koshimizu K, Kim HW, Yoshihiro A et al. Zerumbone, a Southeast Asian ginger sesquiterpene, markedly suppresses free radical generation, proinflammatory protein production, and cancer cell proliferation accompanied by apoptosis: the α, β-unsaturated carbonyl group is a prerequisite. Carcinogenesis 2002;23:795-802.
4. Tanaka T, Shimizu M, Kohno H, Yoshitani S, Tsukio Y, Murakami A et al. Chemoprevention of azoxymethane-induced rat aberrant crypt foci by dietary zerumbone isolated from Zingiber zerumbet. Life Sci 2001;69:1935-45.
5. Murakami A, Hayashi R, Takana T, Kwon KH, Ohigashi H, Safitri R. Suppression of dextran sodium sulfate-induced colitis in mice by zerumbone, a subtropical ginger sesquiterpene, and nimesulide: separately and in combination. Biochem Pharmacol 2003;66:1253-61.
6. Murakami A, Ohigashi H. Targeting NOX, INOS and COX-2 in inflammatory cells: chemoprevention using food phytochemicals. Int J Cancer 2007;121:2357-63.
7. Sulaiman MR, Perimal EK, Zakaria ZA, Mokhtar F, Akhtar MN, Lajis NH et al. Preliminary analysis of the antinociceptive activity of zerumbone. Fitoterapia 2009;80:230-2.
8. Sulaiman MR, Somchit MN, Israf DA, Ahmad Z, Moin S. Antinociceptive effect of Melastoma malabathricum ethanolic extract in mice. Fitoterapia 2004;75:667-72.
9. de Campos ROP, Santos ARS, Vaz ZR, Pinheiro TR, Pizzolatti MG. Antinociceptive properties of the hydroalcoholic extract and preliminary study of a xanthone isolated from Polygala cyparissias (Polygalaceae). Life Sci 1997;61:1619-30.
10. Beirith A, Santos AR, Calixto JB. Mechanisms underlying the nociception and paw oedema caused by injection of glutamate into the mouse paw. Brain Res 2002;924:219-28.
11. Ferreira J, da Silva GL, Calixto JB. Contribution of vanilloid receptors to the overt nociception induced by B2 kinin receptor activation in mice. Br J Pharmacol 2004;141:787-94.
12. Meotti FC, Luiz AP, Pizzolatti MG, Kassuya CAL, Calixto JB, Santos ARS. Analysis of the antinociceptive effect of the flavonoid myricitrin: evidence for a role of the L-arginine-nitric oxide and protein kinase C pathways. J Pharmacol Exp Ther 2006;316:789-96.
13. AbacIoglu N, Tun tan B, Akbulut E, akIcI I. Participation of the components of l-arginine/nitric oxide/cGMP cascade by chemically-induced abdominal constriction in the mouse. Life Sci 2000;67:1127-37.
14. Savegnago L, Pinto LG, Jesse CR, Alves D, Rocha JBT, Nogueira CW et al. Antinociceptive properties of diphenyl diselenide: evidences for the mechanism of action. Eur J Pharmacol 2007;555:129-38.
15. Alves D, Duarte I. Involvement of ATP-sensitive K(+) channels in the peripheral antinociceptive effect induced by dipyrone. Eur J Pharmacol 2002;444:47-52.
16. Sulaiman MR, Tengku Mohamad TA, Shaik Mossadeq WM, Moin S, Yusof M, Mokhtar AF et al. Antinociceptive activity of the essential oil of Zingiber zerumbet. Planta Med 2010;76:107-12.
17. Collier HO, Dinneen LC, Johnson CA, Schneider C. The abdominal constriction response and its suppression by analgesic drugs in the mouse. Br J Pharmacol Chemother 1968;32:295.
18. Bakir B, Him A, Özbek H, Düz E, Tütüncü M. Investigation of the anti-inflammatory and analgesic activities of β-caryophyllene. Int J Essent Oil Ther 2008;2:41-4.
19. Valencia E, Feria M, Diaz JG, Gonzalez A, Bermejo J. Antinociceptive, anti-inflammatory and antipyretic effects of lapidin, a bicyclic sesquiterpene. Planta Med 1994;60:395-9.
20. Malheiros A, Filho VC, Schmitt CB, Santos ARS, Scheidt C, Calixto JB et al. A sesquiterpene drimane with antinociceptive activity from Drimys winteri bark. Phytochemistry 2001;57:103-7.
21. Akkol EK, Arif R, Ergun F, Yesilada E. Sesquiterpene lactones with antinociceptive and antipyretic activity from two Centaurea species. J Ethnopharmacol 2009;122:210-5.
22. Bleakman D, Alt A, Nisenbaum ES. Glutamate receptors and pain. Semin Cell Dev Biol 2006;17:592-604.
23. Carlton SM. Peripheral excitatory amino acids. Curr Opin Pharmacol 2001;1:52-6.
24. Minami T, Matsumura S, Okuda-Ashitaka E, Shimamoto K, Sakimura K, Mishina M et al. Characterization of the glutamatergic system for induction and maintenance of allodynia. Brain Res 2001;895:178-85.
25. Neugebauer V. Metabotropic glutamate receptors: novel targets for pain relief. Expert Rev Neurother 2001;1:207-24.
26. Goudet C, Magnaghi V, Landry M, Nagy F, Gereau RWt, Pin JP. Metabotropic receptors for glutamate and GABA in pain. Brain Res Rev 2009;60:43-56.
27. Neugebauer V. Peripheral metabotropic glutamate receptors: fight the pain where it hurts. Trends Neurosci 2001;24:550-2.
28. Ikeda Y, Ueno A, Naraba H, Oh-ishi S. Involvement of vanilloid receptor VR1 and prostanoids in the acid-induced writhing responses of mice. Life Sci 2001;69:2911-20.
29. Julius D, Basbaum AI. Molecular mechanisms of nociception. Nature 2001;413:203-10.
30. Calixto JB, Otuki MF, Santos ARS. Antiinflammatory compounds of plant origin. Part I. Action on arachidonic acid pathway, nitric oxide and nuclear factor-B (NF-B). Planta Med 2003;69:973-83.
31. Premkumar LS, Ahern GP. Induction of vanilloid receptor channel activity by protein kinase C. Nature 2000;408:985-90.
32. Calixto JB, Cabrini DA, Ferreira J, Campos MM. Kinins in pain and inflammation. Pain 2000;87:1-5.
33. Ferreira J, Trichês KM, Medeiros R, Cabrini DA, Mori MAS, Pesquero JB et al. The role of kinin B1 receptors in the nociception produced by peripheral protein kinase C activation in mice. Neuropharmacology 2007;54:597-604.
34. Meller ST, Dykstra C, Gebhart GF. Production of endogenous nitric oxide and activation of soluble guanylate cyclase are required for N-methyl-d-aspartate-produced facilitation of the nociceptive tail-flick reflex. Eur J Pharmacol 1992;214:93-6.
35. Schmidtko A, Tegeder I, Geisslinger G. No NO, no pain? The role of nitric oxide and cGMP in spinal pain processing. Trends Neurosci 2009;32:339-46.
36. Anbar M, Gratt BM. Role of nitric oxide in the physiopathology of pain. J Pain Symptom Manage 1997;14:225-54.
37. de Moura S. Role of the NO-cGMP pathway in the systemic antinociceptive effect of clonidine in rats and mice. Pharmacol Biochem Behav 2004;78:247-53.
38. Jain NK, Patil CS, Singh A, Kulkarni SK. Sildenafil-induced peripheral analgesia and activation of the nitric oxide-cyclic GMP pathway. Brain Res 2001;909:170-8.
39. Pyne NJ, Arshavsky V, Lochhead A. cGMP signal termination. Biochem Soc Trans 1996;24:1019.
40. Lazaro-Ibanez GG, Torres-Lopez JE, Granados-Soto V. Participation of the nitric oxide-cyclic GMP-ATP-sensitive K(+) channel pathway in the antinociceptive action of ketorolac. Eur J Pharmacol 2001;426:39-44.
41. Jesse CR, Savegnago L, Nogueira CW. Role of nitric oxide/cyclic GMP/K(+) channel pathways in the antinociceptive effect caused by 2, 3-bis(mesitylseleno)propenol. Life Sci 2007;81:1694-702.
42. Amoroso S, Schmid-Antomarchi H, Fosset M, Lazdunski M. Glucose, sulfonylureas, and neurotransmitter release: role of ATP-sensitive K+ channels. Science 1990;247:852-4.
43. Lawson K. Potassium channel activation: a potential therapeutic approach? Pharmacol Ther 1996;70:39-63.