Kinetic analysis of interaction of BRCA1 tandem breast cancer C-terminal domains with phosphorylated peptides reveals two binding conformations

Biochemistry

Volumn 47, Issue 37, 2008, Pages 9866-9879

  Nominé, Yves ^a   Botuyan, Maria Victoria ^a   Bajzer, Zeljko ^a   Owen, Whyte G ^a   Caride, Ariel J ^a   Wasielewski, Emeric ^a   Mer, Georges ^a  

^a MAYO GRADUATE SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINES; CHLORINE COMPOUNDS; CONFORMATIONS; CRYSTALLOGRAPHY; DATA FLOW ANALYSIS; DISSOCIATION; ENZYMES; EQUILIBRIUM CONSTANTS; FLOW INTERACTIONS; MECHANISMS; MINERALOGY; NUCLEAR MAGNETIC RESONANCE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; NUCLEIC ACIDS; ORGANIC ACIDS; PEPTIDES; PHOSPHORYLATION; PORT TERMINALS; PROTEINS; SURFACE PLASMON RESONANCE;

BINDING CONFORMATIONS; BINDING KINETICS; BRCT DOMAINS; BREAST CANCERS; C-TERMINAL DOMAINS; CELL CYCLING; CHECKPOINT SIGNALING; DISSOCIATION CONSTANTS; DNA-REPAIR; FREE STATES; GLOBAL ANALYSIS; KINETIC ANALYSES; NMR SPECTROS COPY; OVARIAN CANCERS; PHOSPHOPEPTIDE; PHOSPHOPROTEIN BINDING; PHOSPHORYLATED PEPTIDES; RECOGNITION MECHANISM; STOPPED-FLOW; STRUCTURAL DETERMINANTS; STRUCTURE AND DYNAMICS; SURFACE PLASMON RESONANCE (SPR); UBIQUITIN LIGASE;

X RAY CRYSTALLOGRAPHY;

BRCA1 PROTEIN; PHOSPHOPEPTIDE; TANDEM BREAST CANCER C TERMINAL DOMAIN; UNCLASSIFIED DRUG;

ANISOTROPY; ARTICLE; BINDING KINETICS; BREAST CANCER; CARBOXY TERMINAL SEQUENCE; DISSOCIATION CONSTANT; FLUORESCENCE SPECTROSCOPY; ISOTHERMAL TITRATION CALORIMETRY; MOLECULAR MECHANICS; MOLECULAR RECOGNITION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; STEADY STATE; SURFACE PLASMON RESONANCE;

BASIC-LEUCINE ZIPPER TRANSCRIPTION FACTORS; BINDING SITES; BRCA1 PROTEIN; BREAST NEOPLASMS; CALORIMETRY, DIFFERENTIAL SCANNING; FANCONI ANEMIA COMPLEMENTATION GROUP PROTEINS; FEMALE; HUMANS; KINETICS; PEPTIDES; PHOSPHORYLATION; PROTEIN STRUCTURE, TERTIARY; SURFACE PLASMON RESONANCE; TEMPERATURE; THERMODYNAMICS;

EID: 51849105183     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi702247d     Document Type: Article

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