Functional genetic polymorphisms in interleukin-12B gene in association with systemic lupus erythematosus

Rheumatology International

Volumn 32, Issue 1, 2012, Pages 53-59

  Miteva, Lyuba D ^a   Manolova, Irena M ^b   Ivanova, Mariana G ^c   Rashkov, Rasho K ^c   Stoilov, Rumen M ^c   Gulubova, Maya V ^a   Stanilova, Spaska A ^a  

^a TRAKIA UNIVERSITY   (Bulgaria)

^b TRAKIA UNIVERSITY   (Bulgaria)

^c UNIVERSITY HOSPITAL ALEXANDROVSKA   (Bulgaria)

Author keywords

Gene polymorphism; IL12B; Systemic lupus erythematosus

Indexed keywords

GENOMIC DNA; INTERLEUKIN 12P40;

3' UNTRANSLATED REGION; ALLELE; ARTICLE; BULGARIA; CLINICAL FEATURE; CONTROLLED STUDY; FEMALE; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC RISK; GENETIC SUSCEPTIBILITY; GENOTYPE; HEMATOLOGIC DISEASE; HUMAN; INFLAMMATION; LUPUS ERYTHEMATOSUS NEPHRITIS; MAJOR CLINICAL STUDY; MENTAL DISEASE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROMOTER REGION; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; SINGLE NUCLEOTIDE POLYMORPHISM; SYSTEMIC LUPUS ERYTHEMATOSUS; VASCULITIS;

ADULT; BULGARIA; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; INTERLEUKIN-12 SUBUNIT P40; LUPUS ERYTHEMATOSUS, SYSTEMIC; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; RISK FACTORS; SEVERITY OF ILLNESS INDEX;

EID: 84857112217     PISSN: 01728172     EISSN: 1437160X     Source Type: Journal    
DOI: 10.1007/s00296-010-1547-6     Document Type: Article

References (26)

1. V Magnusson B Nakken AI Bolstad ME Alarcón-Riquelme 2001 Cytokine polymorphisms in systemic lupus erythematosus and Sjögren's syndrome Scand J Immunol 54 55 61 10.1046/j.1365-3083.2001.00965.x 11439148 1:CAS:528:DC%2BD3MXltl2nsrg%3D (Pubitemid 32592328)
2. MV Hollegaard JL Bidwell 2006 Cytokine gene polymorphism in human disease: on-line databases, supplement 3 Genes Immun 7 269 276 10.1038/sj.gene.6364301 16642032 1:CAS:528:DC%2BD28XltlGltb8%3D (Pubitemid 43871527)
3. G Trinchieri 2003 Interleukin-12 and the regulation of innate resistance and adaptive immunity Nat Rev Immunol 3 133 146 10.1038/nri1001 12563297 1:CAS:528:DC%2BD3sXot12gug%3D%3D (Pubitemid 37328691)
4. C Holscher 2004 The power of combinatorial immunology: IL-12 and IL-12-related dimeric cytokines in infectious diseases Med Microbiol Immunol 193 1 17 10.1007/s00430-003-0186-x 12836019 (Pubitemid 40585301)
5. AM Cooper SA Khader 2007 IL-12p40 an inherently agonistic cytokine Trends Immunol 28 33 38 10.1016/j.it.2006.11.002 17126601 1:CAS:528: DC%2BD2sXhsFCjtw%3D%3D (Pubitemid 44960157)
6. BR Lauwerys J Van Snick FA Houssiau 2002 Serum IL-12 in systemic lupus erythematosus: absence of p70 heterodimers but presence of p40 monomers correlating with disease activity Lupus 11 384 387 10.1191/0961203302lu213oa 12139377 1:CAS:528:DC%2BD38XlvFyrtL8%3D (Pubitemid 34760637)
7. TF Liu BM Jones RW Wong G Srivastava 1999 Impaired production of IL-12 in systemic lupus erythematosus III deficient IL-12 p40 gene expression and cross-regulation of IL-12, IL-10 and IFN-gamma gene expression Cytokine 11 805 811 10.1006/cyto.1999.0512 10525320 1:CAS:528:DyaK1MXms1Crtrs%3D (Pubitemid 29460480)
8. M Ivanova I Manolova R Stoilov 2005 An elevated level of the circulating interleukin (IL)-12 in systemic lupus erythematosus Rheumatology 13 79 82 (Pubitemid 41679881)
9. X Huang J Hua N Shen S Chen 2007 Dysregulated expression of interleukin-23 and interleukin-12 subunits in systemic lupus erythematosus patients Mod Rheumatol 17 220 223 10.1007/s10165-007-0568-9 17564777 1:CAS:528:DC%2BD2sXmtl2juro%3D (Pubitemid 46929907)
10. G Morahan D Huang SI Ymer MR Cancilla K Stephen P Dabadghao G Werther BD Tait LC Harrison PG Colman 2001 Linkage disequilibrium of a type 1 diabetes susceptibility locus with a regulatory IL12B allele Nat Genet 27 218 221 10.1038/84872 11175794 1:CAS:528:DC%2BD3MXhtFKqtb4%3D (Pubitemid 32157453)
11. G Morahan D Huang M Wu BJ Holt GP White GE Kendall PD Sly PG Holt 2002 Association of IL12B promoter polymorphism with severity of atopic and non-atopic asthma in children Lancet 360 455 459 10.1016/S0140-6736(02)09676-9 12241719 1:CAS:528:DC%2BD38XlvF2ksbk%3D (Pubitemid 34880144)
12. A Zwiers D Seegers R Heijmans A Koch J Hampe S Nikolaus AS Peña S Schreiber G Bouma 2004 Definition of polymorphisms and haplotypes in the interleukin-12B gene: association with IL-12 production but not with Crohn's disease Genes Immun 5 675 677 10.1038/sj.gene.6364131 15483662 1:CAS:528:DC%2BD2cXhtVars7fP (Pubitemid 40045306)
13. J Muller-Berghaus K Kern A Paschen XD Nguyen H Kluter G Morahan D Schadendorf 2004 Deficient IL-12p70 secretion by dendritic cells based on IL12B promoter genotype Genes Immun 5 431 434 10.1038/sj.gene.6364102 15175646 1:STN:280:DC%2BD2czmt1eksA%3D%3D (Pubitemid 39139772)
14. D Seegers A Zwiers W Strober AS Pena GA Bouma 2002 TaqI polymorphism in the 3′UTR of the IL-12 p40 gene correlates with increased IL-12 secretion Genes Immun 3 419 423 10.1038/sj.gene.6363919 12424624 1:CAS:528: DC%2BD38XosFamur8%3D (Pubitemid 41656541)
15. S Stanilova L Miteva 2005 Taq-I polymorphism in 3′UTR of the IL-12 and association with IL-12p40 production from human PBMC Genes Immun 6 364 366 10.1038/sj.gene.6364213 15858599 1:CAS:528:DC%2BD2MXks1Gmt74%3D (Pubitemid 40903410)
16. L Nistico G Giorgi M Giordano A Galgani A Petrone S D'Alfonso M Federici U Di Mario P Pozzilli R Buzzetti I Cascino 2002 IL12B polymorphism and type 1 diabetes in the Italian population: a case-control study Diabetes 51 1649 1650 10.2337/diabetes.51.5.1649 11978670 1:CAS:528:DC%2BD38XjtlGmu74%3D (Pubitemid 34826639)
17. T Hirota Y Suzuki K Hasegawa K Obara A Matsuda M Akahoshi K Nakashima L Cheng N Takahashi M Shimizu S Doi K Fujita T Enomoto M Ebisawa S Yoshihara Y Nakamura F Kishi T Shirakawa M Tamari 2005 Functional haplotypes of IL-12B are associated with childhood atopic asthma J Allergy Clin Immunol 116 789 795 10.1016/j.jaci.2005.06.010 16210052 1:CAS:528:DC%2BD2MXhtVyntL3N (Pubitemid 41400543)
18. E Sánchez S Morales L Paco MA López-Nevot C Hidalgo J Jiménez-Alonso B Torres MA González-Gay JL Callejas N Ortego-Centeno J Sánchez-Roman MF González-Escribano J Martín 2005 Interleukin 12 (IL12B), interleukin 12 receptor (IL12RB1) and interleukin 23 (IL23A) gene polymorphism in systemic lupus erythematosus Rheumatology 44 1136 1139 10.1093/rheumatology/keh697 15941730 (Pubitemid 41236020)
19. N Hirankarn M Tangwattanachuleeporn J Wongpiyabovorn J Wongchinsri Y Avihingsanon 2009 Association of IL-18 gene polymorphism (-137C) with arthritis manifestations in SLE: combined effect with IFN gamma gene polymorphism (+874A) Clin Rheumatol 28 219 223 10.1007/s10067-008-1036-4 19031096
20. EM Tan AS Cohen JF Fries AT Masi DJ McShane NF Rothfield JG Schaller N Talal RJ Winchester 1982 The 1982 revised criteria for the classification of systemic lupus erythematosus Arthritis Rheum 25 1271 1277 7138600 1:STN:280:DyaL3s%2FkvVCmtA%3D%3D (Pubitemid 13221242)
21. C Bombardier DD Gladman MB Urowitz D Caron CH Chang 1992 Derivation of the SLEDAI: a disease activity index for lupus patients Arthritis Rheum 35 630 640 1599520 1:STN:280:DyaK383oslWrtg%3D%3D
22. S Stanilova L Miteva G Prakova 2008 IL-12Bpro and GSTP1 polymorphisms in association with silicosis Tissue Antigens 71 169 174 10.1111/j.1399-0039.2007. 00985.x 18086266 1:CAS:528:DC%2BD1cXjtVKmsbg%3D
23. L Miteva N Stanilov T Deliysky N Mintchev S Stanilova 2009 Association of polymorphisms in regulatory regions of interleukin-12p40 gene and cytokine serum level with colorectal cancer Cancer Invest 27 924 931 10.3109/ 07357900902918486 19832040 1:CAS:528:DC%2BD1MXhsVyisrjL
24. CK Wong LC Lit LS Tam EK Li PT Wong CW Lam 2008 Hyperproduction of IL-23 and IL-17 in patients with systemic lupus erythematosus: implications for Th17-mediated inflammation in auto-immunity Clin Immunol 127 385 393 10.1016/j.clim.2008.01.019 18373953 1:CAS:528:DC%2BD1cXmt12qsrs%3D
25. JC Peng S Abu Bakar M Richardson JJ Jonsson IH Frazer LK Nielsen G Morahan R Thomas 2006 IL10 and IL12B polymorphisms each influence IL-12p70 secretion by dendritic cells in response to LPS Immunol Cell Biol 84 227 232 10.1111/j.1440-1711.2006.01419.x 16519741 1:CAS:528:DC%2BD28XjvF2hsL8%3D (Pubitemid 43344677)
26. G Morahan G Kaur M Singh CC Rapthap N Kumar K Katoch NK Mehra D Huang 2007 Association of variants in the IL12B gene with leprosy and tuberculosis Tissue Antigens 69 234 236 10.1111/j.1399-0039.2006.773-3.x 17445208 1:CAS:528:DC%2BD2sXmt1CntLs%3D (Pubitemid 46625891)