Definition of polymorphisms and haplotypes in the interleukin-12B gene: Association with IL-12 production but not with Crohn's disease

Genes and Immunity

Volumn 5, Issue 8, 2004, Pages 675-677

  Zwiers, A ^a   Seegers, D ^a   Heijmans, R ^a   Koch, A ^b   Hampe, J ^b   Nikolaus, S ^b   Pena A S ^a   Schreiber, S ^b   Bouma, G ^a  

^a VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^b UNIVERSITY OF KIEL   (Germany)

Author keywords

Crohn's disease; Haplotypes; Interluekin 12B polymorphisms; TDT

Indexed keywords

INTERLEUKIN 12; INTERLEUKIN 12P40;

ARTICLE; AUTOIMMUNE DISEASE; CASE CONTROL STUDY; CHRONIC DISEASE; COHORT ANALYSIS; CONTROLLED STUDY; CROHN DISEASE; CYTOKINE PRODUCTION; ENTERITIS; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC CONSERVATION; GENETIC POLYMORPHISM; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; GENOTYPE; HAPLOTYPE; HUMAN; HUMAN CELL; IN VITRO STUDY; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION;

BASE SEQUENCE; CASE-CONTROL STUDIES; CROHN DISEASE; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HAPLOTYPES; HUMANS; INTERLEUKIN-12; INTERLEUKIN-12 SUBUNIT P40; LINKAGE DISEQUILIBRIUM; MOLECULAR SEQUENCE DATA; POLYMORPHISM, GENETIC;

EID: 11044220304     PISSN: 14664879     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.gene.6364131     Document Type: Article

References (11)

1. Trinchieri G, Pflanz S, Kastelein RA. The IL-12 family of heterodimeric cytokines. New players in the regulation of T cell responses. Immunity 2003; 19: 641-644.
2. Trinchieri G. Interleukin-12 and the regulation of innate resistance and adaptive immunity. Nat Rev Immunol 2003; 3: 133-146.
3. Morahan G, Huang D, Ymer SI et al. Linkage disequilibrium of a type 1 diabetes susceptibility locus with a regulatory IL12B allele. Nat Genet 2001; 27: 218-221.
4. Morahan G, Huang D, Wu M et al. Association of IL12B promoter polymorphism with severity of atopic and non-atopic asthma in children. Lancet 2002; 360: 455-459.
5. Bouma G, Strober W. The immunological and genetic basis of inflammatory bowel disease. Nat Rev Immunol 2003; 3: 521-533.
6. Bouma G, Kaushiva A, Strober W. Experimental murine colitis is regulated by two genetic loci, including one on chromosome 11 that regulates IL-12 responses. Gastroenterology 2002; 123: 554-565.
7. Seegers D, Zwiers A, Strober W, Pena AS, Bouma G. A Taq polymorphism in the 3′UTR of the IL-12 p40 gene correlates with increased IL-12 secretion. Genes Immun 2002; 3: 419-423.
8. Huang D, Cancilla MR, Morahan G. Complete primary structure, chromosomal localisation, and definition of polymorphisms of the gene encoding the human interleukin-12 p40 subunit. Genes Immun 2000; 1: 515-520.
9. Ymer SI, Huang D, Penna G et al. Polymorphisms in the Il12b gene affect structure and expression of IL-12 in NOD and other autoimmune-prone mouse strains. Genes Immun 2002; 3: 151-157.
10. Hampe J, Grebe J, Nikolaus S et al. Association of NOD2 (CARD 15) genotype with clinical course of Crohn's disease: a cohort study. Lancet 2002; 359: 1661-1665.
11. Hall MA, McGlinn E, Coakley G D et al. Genetic polymorphism of IL-12 p40 gene in immune-mediated disease. Genes Immun 2000; 1: 219-224.