메뉴 건너뛰기




Volumn 3, Issue 7, 2002, Pages 419-423

A TaqI polymorphism in the 3′ UTR of the IL-12 p40 gene correlates with increased IL-12 secretion

Author keywords

Crohn's disease; Gene polymorphism; IL 12; In vitro secretion

Indexed keywords

INTERLEUKIN 12; INTERLEUKIN 12P40; PROTEIN P70;

EID: 0346877501     PISSN: 14664879     EISSN: 14765470     Source Type: Journal    
DOI: 10.1038/sj.gene.6363919     Document Type: Article
Times cited : (153)

References (24)
  • 1
    • 0031943618 scopus 로고    scopus 로고
    • The interleukin-12/interleukin-12-receptor system: Role in normal and pathologic immune responses
    • Gately MK, Renzetti LM, Magram J et al. The interleukin-12/interleukin- 12-receptor system: role in normal and pathologic immune responses. Annu Rev Immunol 1998; 16: 495-521.
    • (1998) Annu Rev Immunol , vol.16 , pp. 495-521
    • Gately, M.K.1    Renzetti, L.M.2    Magram, J.3
  • 2
    • 13344259977 scopus 로고    scopus 로고
    • Interleukin-12 is produced by dendritic cells and mediates T helper 1 development as well as interferon-gamma production by T helper 1 cells
    • Heufler C, Koch F, Stanzl U et al. Interleukin-12 is produced by dendritic cells and mediates T helper 1 development as well as interferon-gamma production by T helper 1 cells. Eur J Immunol 1996; 26: 659-668.
    • (1996) Eur J Immunol , vol.26 , pp. 659-668
    • Heufler, C.1    Koch, F.2    Stanzl, U.3
  • 3
    • 0029831666 scopus 로고    scopus 로고
    • High level IL-12 production by murine dendritic cells: Upregulation via MHC class II and CD40 molecules and downregulation by IL-4 and IL-10
    • Koch F, Stanzl U, Jennewein P et al. High level IL-12 production by murine dendritic cells: upregulation via MHC class II and CD40 molecules and downregulation by IL-4 and IL-10. J Exp Med 1996; 184: 741-746.
    • (1996) J Exp Med , vol.184 , pp. 741-746
    • Koch, F.1    Stanzl, U.2    Jennewein, P.3
  • 4
    • 0035170378 scopus 로고    scopus 로고
    • Production of IL-12 by human monocyte-derived dendritic cells is optimal when the stimulus is given at the onset of maturation, and is further enhanced by IL-4
    • Ebner S, Ratzinger G, Krosbacher B et al. Production of IL-12 by human monocyte-derived dendritic cells is optimal when the stimulus is given at the onset of maturation, and is further enhanced by IL-4. J Immunol 2001; 166: 633-641.
    • (2001) J Immunol , vol.166 , pp. 633-641
    • Ebner, S.1    Ratzinger, G.2    Krosbacher, B.3
  • 5
    • 0031934079 scopus 로고    scopus 로고
    • Expression of interleukin-12 in synovial tissue from patients with rheumatoid arthritis
    • Morita Y, Yamamura M, Nishida K et al. Expression of interleukin-12 in synovial tissue from patients with rheumatoid arthritis. Arthritis Rheum 1998; 41: 306-314.
    • (1998) Arthritis Rheum , vol.41 , pp. 306-314
    • Morita, Y.1    Yamamura, M.2    Nishida, K.3
  • 6
    • 0035135215 scopus 로고    scopus 로고
    • Interleukin 12 and autoimmune diabetes
    • Adorini L. Interleukin 12 and autoimmune diabetes. Nat Genet 2001; 27: 131-132.
    • (2001) Nat Genet , vol.27 , pp. 131-132
    • Adorini, L.1
  • 7
    • 0028809507 scopus 로고
    • Expression of costimulatory molecules B7-1 (CD80), B7-2 (CD86), and interleukin 12 cytokine in multiple sclerosis lesions
    • Windhagen A, Newcombe J, Dangond F et al. Expression of costimulatory molecules B7-1 (CD80), B7-2 (CD86), and interleukin 12 cytokine in multiple sclerosis lesions. J Exp Med 1995; 182: 1985-1996.
    • (1995) J Exp Med , vol.182 , pp. 1985-1996
    • Windhagen, A.1    Newcombe, J.2    Dangond, F.3
  • 8
    • 0030995575 scopus 로고    scopus 로고
    • Interleukin 12 is expressed and actively released by Crohn's disease intestinal lamina propria mononuclear cells
    • Monteleone G, Biancone L, Marasco R et al. Interleukin 12 is expressed and actively released by Crohn's disease intestinal lamina propria mononuclear cells. Gastroenterology 1997; 112: 1169-1178.
    • (1997) Gastroenterology , vol.112 , pp. 1169-1178
    • Monteleone, G.1    Biancone, L.2    Marasco, R.3
  • 9
    • 0036158322 scopus 로고    scopus 로고
    • Inherited interleukin-12 deficiency: IL12B genotype and clinical phenotype of 13 patients from six kindreds
    • Picard C, Fieschi C, Altare F et al. Inherited interleukin-12 deficiency: IL12B genotype and clinical phenotype of 13 patients from six kindreds. Am J Hum Genet 2002; 70: 336-348.
    • (2002) Am J Hum Genet , vol.70 , pp. 336-348
    • Picard, C.1    Fieschi, C.2    Altare, F.3
  • 10
    • 18244428735 scopus 로고    scopus 로고
    • Impairment of mycobacterial immunity in human interleukin-12 receptor deficiency
    • Altare F, Durandy A, Lammas D et al. Impairment of mycobacterial immunity in human interleukin-12 receptor deficiency. Science 1998; 280: 1432-1435.
    • (1998) Science , vol.280 , pp. 1432-1435
    • Altare, F.1    Durandy, A.2    Lammas, D.3
  • 11
    • 0028861975 scopus 로고    scopus 로고
    • Antibodies to interleukin 12 abrogate established experimental colitis in mice
    • Neurath MF, Fuss I, Kelsall BL, Stuber E, Strober W. Antibodies to interleukin 12 abrogate established experimental colitis in mice. J Exp Med 1996; 182: 1281-1290.
    • (1996) J Exp Med , vol.182 , pp. 1281-1290
    • Neurath, M.F.1    Fuss, I.2    Kelsall, B.L.3    Stuber, E.4    Strober, W.5
  • 12
    • 0036327730 scopus 로고    scopus 로고
    • Identification of a genetic region that regulates susceptibility to experimental murine colitis and the interleukin-12 response to LPS
    • Bouma G, Kaushiva A, Strober W. Identification of a genetic region that regulates susceptibility to experimental murine colitis and the interleukin-12 response to LPS. Gastroenterology 2002; 123: 554-565.
    • (2002) Gastroenterology , vol.123 , pp. 554-565
    • Bouma, G.1    Kaushiva, A.2    Strober, W.3
  • 13
    • 0026693587 scopus 로고
    • Assignment of genes encoding a unique cytokine (IL12) composed of two unrelated subunits to chromosomes 3 and 5
    • Sieburth D, Jabs EW, Warrington JA et al. Assignment of genes encoding a unique cytokine (IL12) composed of two unrelated subunits to chromosomes 3 and 5. Genomics 1992; 14: 59-62.
    • (1992) Genomics , vol.14 , pp. 59-62
    • Sieburth, D.1    Jabs, E.W.2    Warrington, J.A.3
  • 14
    • 0034564291 scopus 로고    scopus 로고
    • Complete primary structure, chromosomal localisation, and definition of polymorphisms of the gene encoding the human interleukin-12 p40 subunit
    • Huang D, Cancilla MR, Morahan G. Complete primary structure, chromosomal localisation, and definition of polymorphisms of the gene encoding the human interleukin-12 p40 subunit. Genes Immun 2000; 1: 515-520.
    • (2000) Genes Immun , vol.1 , pp. 515-520
    • Huang, D.1    Cancilla, M.R.2    Morahan, G.3
  • 15
    • 0029097948 scopus 로고
    • Transcriptional repression, a novel function for 3′ untranslated regions
    • Le Cam A, Legraverend C. Transcriptional repression, a novel function for 3′ untranslated regions. Eur J Biochem 1995; 231: 620-627.
    • (1995) Eur J Biochem , vol.231 , pp. 620-627
    • Le Cam, A.1    Legraverend, C.2
  • 17
    • 0034903707 scopus 로고    scopus 로고
    • Interleukin-12p40 genotype plays a role in the susceptibility to multiple sclerosis
    • van Veen T, Crusius JB, Schrijver HM et al. Interleukin-12p40 genotype plays a role in the susceptibility to multiple sclerosis. Ann Neurol 2001; 50: 275.
    • (2001) Ann Neurol , vol.50 , pp. 275
    • Van Veen, T.1    Crusius, J.B.2    Schrijver, H.M.3
  • 18
    • 0035132568 scopus 로고    scopus 로고
    • Linkage disequilibrium of a type 1 diabetes susceptibility locus with a regulatory IL12B allele
    • Morahan G, Huang D, Ymer SI et al. Linkage disequilibrium of a type 1 diabetes susceptibility locus with a regulatory IL12B allele. Nat Genet 2001; 27: 218-221.
    • (2001) Nat Genet , vol.27 , pp. 218-221
    • Morahan, G.1    Huang, D.2    Ymer, S.I.3
  • 19
    • 0031132212 scopus 로고    scopus 로고
    • In vivo production and function of IL-12 p40 homodimers
    • Heinzel FP, Hujer AM, Ahmed FN, Rerko RM. In vivo production and function of IL-12 p40 homodimers. J Immunol 1997; 158: 4381-4388.
    • (1997) J Immunol , vol.158 , pp. 4381-4388
    • Heinzel, F.P.1    Hujer, A.M.2    Ahmed, F.N.3    Rerko, R.M.4
  • 20
    • 0034679726 scopus 로고    scopus 로고
    • Charged residues dominate a unique interlocking topography in the heterodimeric cytokine interleukin-12
    • Yoon C, Johnston SC, Tang J et al. Charged residues dominate a unique interlocking topography in the heterodimeric cytokine interleukin-12. Embo J 2000; 19: 3530-3541.
    • (2000) Embo J , vol.19 , pp. 3530-3541
    • Yoon, C.1    Johnston, S.C.2    Tang, J.3
  • 21
    • 0036560003 scopus 로고    scopus 로고
    • Polymorphisms in the IL12b gene affect structure and expression of IL-12 in NOD and other autoimmune-prone strains
    • Ymer SI, Huang D, Penna G et al. Polymorphisms in the IL12b gene affect structure and expression of IL-12 in NOD and other autoimmune-prone strains. Genes Immun 2002; 3: 151-157.
    • (2002) Genes Immun , vol.3 , pp. 151-157
    • Ymer, S.I.1    Huang, D.2    Penna, G.3
  • 22
    • 0035978651 scopus 로고    scopus 로고
    • Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease
    • Hugot JP, Chamaillard M, Zouali H et al. Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease. Nature 2001; 411: 599-603.
    • (2001) Nature , vol.411 , pp. 599-603
    • Hugot, J.P.1    Chamaillard, M.2    Zouali, H.3
  • 23
    • 0035978533 scopus 로고    scopus 로고
    • A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease
    • Ogura Y, Bonen DK, Inohara N et al. A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease. Nature 2001; 411: 603-606.
    • (2001) Nature , vol.411 , pp. 603-606
    • Ogura, Y.1    Bonen, D.K.2    Inohara, N.3
  • 24
    • 18544380387 scopus 로고    scopus 로고
    • Parameters for reliable results in genetic association studies in common disease
    • Dahlman I, Eaves IA, Kosoy R et al. Parameters for reliable results in genetic association studies in common disease. Nat Genet 2002; 30: 149-150.
    • (2002) Nat Genet , vol.30 , pp. 149-150
    • Dahlman, I.1    Eaves, I.A.2    Kosoy, R.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.